LOCUS       NM_011392               3081 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus solute carrier family 34 (sodium phosphate), member 1
            (Slc34a1), mRNA.
ACCESSION   NM_011392
VERSION     NM_011392.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3081)
  AUTHORS   Chung,E., Nosrati,F., Adam,M., Potter,A., Sayed,M., Humphreys,B.D.,
            Lim,H.W., Hu,Y.C., Potter,S.S. and Park,J.S.
  TITLE     The thin descending limb of the loop of Henle originates from
            proximal tubule cells during mouse kidney development
  JOURNAL   bioRxiv (2025)
   PUBMED   39868227
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3081)
  AUTHORS   Thomas,L., Dissanayake,L.V., Tahmasbi,M., Staruschenko,A.,
            Al-Masri,S., Dominguez Rieg,J.A. and Rieg,T.
  TITLE     Vitamin D3 suppresses Npt2c abundance and differentially modulates
            phosphate and calcium homeostasis in Npt2a knockout mice
  JOURNAL   Sci Rep 14 (1), 16997 (2024)
   PUBMED   39043847
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3081)
  AUTHORS   Naillat,F., Deshar,G., Hankkila,A., Rak-Raszewska,A., Sharma,A.,
            Prunskaite-Hyyrylainen,R., Railo,A., Shan,J. and Vainio,S.J.
  TITLE     Calcium signaling induces partial EMT and renal fibrosis in a
            Wnt4mCherry knock-in mouse model
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167180 (2024)
   PUBMED   38653356
REFERENCE   4  (bases 1 to 3081)
  AUTHORS   Stewart,B.Z., Mamonova,T., Sneddon,W.B., Javorsky,A., Yang,Y.,
            Wang,B., Nolin,T.D., Humbert,P.O., Friedman,P.A. and Kvansakul,M.
  TITLE     Scribble scrambles parathyroid hormone receptor interactions to
            regulate phosphate and vitamin D homeostasis
  JOURNAL   Proc Natl Acad Sci U S A 120 (23), e2220851120 (2023)
   PUBMED   37252981
REFERENCE   5  (bases 1 to 3081)
  AUTHORS   Liu,Y., Xu,C., Li,J., Zhang,Y., Wang,X., Wang,Y., Qin,J., Zheng,Z.
            and Xia,Y.
  TITLE     YAP promotes AP-1 expression in tubular epithelial cells in the
            kidney
  JOURNAL   Am J Physiol Renal Physiol 324 (6), F581-F589 (2023)
   PUBMED   37141146
REFERENCE   6  (bases 1 to 3081)
  AUTHORS   Hartmann,C.M., Hewson,A.S., Kos,C.H., Hilfiker,H., Soumounou,Y.,
            Murer,H. and Tenenhouse,H.S.
  TITLE     Structure of murine and human renal type II Na+-phosphate
            cotransporter genes (Npt2 and NPT2)
  JOURNAL   Proc Natl Acad Sci U S A 93 (14), 7409-7414 (1996)
   PUBMED   8693007
REFERENCE   7  (bases 1 to 3081)
  AUTHORS   Kos,C.H., Tihy,F., Murer,H., Lemieux,N. and Tenenhouse,H.S.
  TITLE     Comparative mapping of Na+-phosphate cotransporter genes, NPT1 and
            NPT2, in human and rabbit
  JOURNAL   Cytogenet Cell Genet 75 (1), 22-24 (1996)
   PUBMED   8995482
REFERENCE   8  (bases 1 to 3081)
  AUTHORS   Hartmann,C.M., Wagner,C.A., Busch,A.E., Markovich,D., Biber,J.,
            Lang,F. and Murer,H.
  TITLE     Transport characteristics of a murine renal Na/Pi-cotransporter
  JOURNAL   Pflugers Arch 430 (5), 830-836 (1995)
   PUBMED   7478940
  REMARK    Erratum:[Pflugers Arch 1996 May;432(1):158]
REFERENCE   9  (bases 1 to 3081)
  AUTHORS   Cole,T.J., Blendy,J.A., Monaghan,A.P., Krieglstein,K., Schmid,W.,
            Aguzzi,A., Fantuzzi,G., Hummler,E., Unsicker,K. and Schutz,G.
  TITLE     Targeted disruption of the glucocorticoid receptor gene blocks
            adrenergic chromaffin cell development and severely retards lung
            maturation
  JOURNAL   Genes Dev 9 (13), 1608-1621 (1995)
   PUBMED   7628695
REFERENCE   10 (bases 1 to 3081)
  AUTHORS   Collins,J.F. and Ghishan,F.K.
  TITLE     Molecular cloning, functional expression, tissue distribution, and
            in situ hybridization of the renal sodium phosphate (Na+/P(i))
            transporter in the control and hypophosphatemic mouse
  JOURNAL   FASEB J 8 (11), 862-868 (1994)
   PUBMED   8070635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB952922.1, AB163922.1 and CT009762.8.
            
            On Dec 8, 2006 this sequence version replaced NM_011392.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK018740.2, AB163922.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                CB952922.1         4-59
            57-2477             AB163922.1         1-2421
            2478-3081           CT009762.8         118095-118698       c
FEATURES             Location/Qualifiers
     source          1..3081
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 29.81 cM"
     gene            1..3081
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-IIa; Npt2; Npt2a; Slc17a2"
                     /note="solute carrier family 34 (sodium phosphate), member
                     1"
                     /db_xref="GeneID:20505"
                     /db_xref="MGI:MGI:1345284"
     exon            1..88
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-IIa; Npt2; Npt2a; Slc17a2"
                     /inference="alignment:Splign:2.1.0"
     exon            89..218
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-IIa; Npt2; Npt2a; Slc17a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..2023
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-IIa; Npt2; Npt2a; Slc17a2"
                     /note="type IIa Na+/Pi-cotransporter; naPi-7; naPi-2a;
                     sodium/phosphate cotransporter 2A; solute carrier family
                     34 member 1; sodium-phosphate transport protein 2A;
                     Na(+)/Pi cotransporter 2A; Na(+)-dependent phosphate
                     cotransporter 2A; Na/Pi cotransporter; solute carrier
                     family 17 (sodium/hydrogen exchanger), member 2; renal
                     Na+/Pi transporter; Na+-phosphate cotransporter type II"
                     /codon_start=1
                     /product="sodium-dependent phosphate transport protein 2A"
                     /protein_id="NP_035522.2"
                     /db_xref="CCDS:CCDS49271.1"
                     /db_xref="GeneID:20505"
                     /db_xref="MGI:MGI:1345284"
                     /translation="MMSYSERLGGPAVSPLPVRGRHMVHGATFAYVPSPQVLHRIPGT
                     STYAISSLSPVTLTEHSCPCGEVLECHDPLPTKLAQEEEQKPEPRLSQKLAQVGTKLL
                     KVPLMLAFLYLFVCSLDVLSSAFQLAGGKVAGDIFKDNAILSNPVAGLVVGILVTVLV
                     QSSSTSTSIIVSMVSSGLLEVSSAIPIIMGSNIGTSVTNTIVALMQAGDRTDFRRAFA
                     GATVHDCFNWLSVLVLLPLEAATGYLHHVTGLVVASFNIRGGRDAPDLLKVITEPFTR
                     LIIQLDKSVITSIAVGDESLRNHSLIRIWCHPDTTEASTSMSRVEAIGSLANTTMEKC
                     NHIFVDTGLPDLAVGLILLAGSLVVLCTCLILLVKMLNSLLKGQVANVIQKVINTDFP
                     APFTWVTGYFAMVVGASMTFVVQSSSVFTSAITPLIGLGVISIERAYPLTLGSNIGTT
                     TTAILAALASPREKLSSSFQIALCHFFFNISGILLWYPLPCTRLPIRMAKALGKRTAK
                     YRWFAVLYLLVCFLLLPSLVFGISMAGWQAMVGVGTPFGALLAFVVLVNVLQSRSPGH
                     LPKWLQTWDFLPRWMHSLQPLDGLITRATLCYARPEPRSPQLPPRVFLEELPPATPSP
                     RLALPAHHNATRL"
     exon            219..368
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-IIa; Npt2; Npt2a; Slc17a2"
                     /inference="alignment:Splign:2.1.0"
     exon            369..497
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-IIa; Npt2; Npt2a; Slc17a2"
                     /inference="alignment:Splign:2.1.0"
     exon            498..641
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-IIa; Npt2; Npt2a; Slc17a2"
                     /inference="alignment:Splign:2.1.0"
     exon            642..753
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-IIa; Npt2; Npt2a; Slc17a2"
                     /inference="alignment:Splign:2.1.0"
     exon            754..949
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-IIa; Npt2; Npt2a; Slc17a2"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1045
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-IIa; Npt2; Npt2a; Slc17a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1109
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-IIa; Npt2; Npt2a; Slc17a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1277
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-IIa; Npt2; Npt2a; Slc17a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1394
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-IIa; Npt2; Npt2a; Slc17a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1519
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-IIa; Npt2; Npt2a; Slc17a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..3081
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-IIa; Npt2; Npt2a; Slc17a2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2227..2232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-IIa; Npt2; Npt2a; Slc17a2"
                     /note="hexamer: AATACA"
     polyA_site      2261
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-IIa; Npt2; Npt2a; Slc17a2"
                     /note="major polyA site"
     polyA_site      2479
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-IIa; Npt2; Npt2a; Slc17a2"
     regulatory      2509..2514
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-IIa; Npt2; Npt2a; Slc17a2"
                     /note="hexamer: AAGAAA"
     polyA_site      2532
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-IIa; Npt2; Npt2a; Slc17a2"
     regulatory      2635..2640
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-IIa; Npt2; Npt2a; Slc17a2"
                     /note="hexamer: TATAAA"
     polyA_site      2658
                     /gene="Slc34a1"
                     /gene_synonym="NaPi-IIa; Npt2; Npt2a; Slc17a2"
ORIGIN      
        1 gcccttgacc cgagggtata aagaagaggg tcttagttcc tctttagact tccccaagca
       61 gccgggctgg agctgagcca cagtcaagga ctcattgtgg gtgcccaaca tgatgtccta
      121 cagcgagaga ttggggggac cggctgtctc cccacttcca gtccgtggga gacacatggt
      181 gcatggggca acctttgctt atgtgcccag cccacaagtc ctgcacagga ttcctggaac
      241 atccacctat gccatctcca gtctgagccc ggtcaccctc acagagcaca gctgtccctg
      301 tggggaagtc ctggaatgtc atgacccact acctaccaag ctggctcagg aagaggagca
      361 aaagccagag cccaggctgt cccagaagct tgcccaggtt ggcacgaagc tcctgaaggt
      421 gcctctgatg ctggctttcc tttacctctt tgtctgctcc ctggatgtgc tcagctccgc
      481 cttccagttg gctggaggga aggtggctgg ggacatcttc aaggacaatg ccatcctatc
      541 caacccagtg gcagggctgg tggtggggat cctggtgaca gttctggtgc agagttccag
      601 tacctctaca tccatcattg tcagcatggt ctcctccggc ttgttggagg tgagctccgc
      661 cattccgatc atcatgggct ccaacatcgg aacctctgtc accaacacca ttgtggccct
      721 gatgcaggca ggggacagga ctgacttcag gcgggctttt gcaggggcga ccgtgcatga
      781 ctgttttaac tggctgtctg ttctggtcct actgcccctg gaggctgcca cgggctacct
      841 acaccatgtc accgggcttg tggttgcttc cttcaacatc cgaggtggcc gtgatgcccc
      901 cgaccttctc aaagtcatca cagagccctt cacaagactc atcatccagc tggacaagtc
      961 tgtgatcacc agcattgccg tgggggatga gtccctgagg aatcacagtc tcattcggat
     1021 ttggtgtcac ccagacacaa cagaggcttc cacttctatg tccagggtag aggccatcgg
     1081 cagccttgca aacaccacca tggagaaatg caaccatatc ttcgtggata cggggctgcc
     1141 cgacctggcc gtggggctca ttctgctggc gggctccctg gtggttctct gcacttgtct
     1201 tatcctcctt gtgaagatgc tcaactccct gctcaagggc caagtggcca atgtcatcca
     1261 gaaggtcatc aacacagact ttcctgcccc cttcacctgg gtcacgggct actttgccat
     1321 ggtggtgggt gccagcatga cctttgttgt ccagagcagc tccgtgttca cctcagccat
     1381 caccccactc attggcctgg gtgtgatcag cattgagcgg gcctaccctc tcaccctggg
     1441 ctccaacatt ggcactacca ctacagccat cctggcagcg cttgccagcc ccagggagaa
     1501 gctatccagc tcatttcaga ttgccctctg ccacttcttc ttcaacatct cgggcatcct
     1561 actgtggtac ccgctgccct gcacacgcct gcccatacgc atggccaagg ccctgggcaa
     1621 acgcaccgcc aagtaccgct ggtttgctgt cctctacctg ctcgtgtgct tcctgctctt
     1681 gccctcgctg gtgtttggca tttccatggc aggctggcag gctatggtcg gagtgggcac
     1741 gccctttggg gctctactgg cctttgtggt gcttgttaat gtcctgcaga gccgaagtcc
     1801 cgggcacctc cccaagtggc tgcagacatg ggacttccta cctcgctgga tgcactcttt
     1861 gcagcccctg gatggcctta tcacaagagc caccttgtgt tatgccaggc ccgagccccg
     1921 ttcaccccaa cttcccccta gagtcttcct ggaggagctt cccccagcca cgccctcccc
     1981 ccgcctggca ctgcctgctc accacaatgc cacccgtctc taggctacag gccccgacta
     2041 ctgcctggaa cgaggagtgg tatttttaca atgcccacag tagaaagaca gagcatgtgt
     2101 gtgtgtgtgc acacatgtgt agatgcgtgt cacttgaggt acatgctttt gtgccaccct
     2161 tgggtacctg tgcatattaa gggccacagt ggcatgggct tttgtaatta agaggtagtg
     2221 tgcacaaata catgctaggt actgagcctg tgtgaccatt agtgcgggtg taatgtgagt
     2281 acactgtgtg ggtacagggg ggtgcagatg cctagggagt ctccaaactt ttctggaaag
     2341 agtcagctat accctctcat cttctcacaa ctcttgtacc aacaggaggg acagaagaac
     2401 agctggcctt ctgtatacat gggccttact tctgccaatt ctgctaactg tgcatagaaa
     2461 aaaaaagttg aaagttgcat ctgtcctgat catatatggg cttttttaaa gaaatcatat
     2521 tccttacccc tacggcacaa taattcttta catggctttt atattgggta tctaaatcac
     2581 ctggaggtca cacaccaggg gatgcaggtt gattctttgc aaacactgtc gctttataaa
     2641 agagacttga gcacctgagg atttaagtat tctgaggtat catggagcca aatctccaag
     2701 catacagagg gacactcgcc tttagtctga atcccacaga ccttggctgg tgtgtgctgg
     2761 ggagggagat gctgagagac actccgttgt tcactgtgaa gcctacttgt gtggaaagtt
     2821 ctgtgagaaa gattgctgaa gcctgaggta gagtttgaga atttgccacc ccaatattcc
     2881 taatcaggtg tggggtctct ggaaccctgg gaaggtgcca ggaccaaagg cctctatatg
     2941 gcatctacca caggagtagg gaacagggcc caggaggcct ggaggaccac caggattatt
     3001 ttgttctgca agaatctccc cataagctag ttttcttgtt tgcaactcct cacaaataca
     3061 cagaggatac ctctcagagc a
//
