LOCUS       NM_015728               3122 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus solute carrier family 33 (acetyl-CoA transporter),
            member 1 (Slc33a1), transcript variant 1, mRNA.
ACCESSION   NM_015728
VERSION     NM_015728.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3122)
  AUTHORS   Braun,M.M., Sheehan,B.K., Shapiro,S.L., Ding,Y., Rubinstein,C.D.,
            Lehman,B.P. and Puglielli,L.
  TITLE     Ca+2 and Nepsilon-lysine acetylation regulate the CALR-ATG9A
            interaction in the lumen of the endoplasmic reticulum
  JOURNAL   Sci Rep 14 (1), 25532 (2024)
   PUBMED   39462136
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3122)
  AUTHORS   Sheehan,B.K., Orefice,N.S., Peng,Y., Shapiro,S.L. and Puglielli,L.
  TITLE     ATG9A regulates proteostasis through reticulophagy receptors
            FAM134B and SEC62 and folding chaperones CALR and HSPB1
  JOURNAL   iScience 24 (4), 102315 (2021)
   PUBMED   33870132
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3122)
  AUTHORS   Dieterich,I.A., Cui,Y., Braun,M.M., Lawton,A.J., Robinson,N.H.,
            Peotter,J.L., Yu,Q., Casler,J.C., Glick,B.S., Audhya,A., Denu,J.M.,
            Li,L. and Puglielli,L.
  TITLE     Acetyl-CoA flux from the cytosol to the ER regulates engagement and
            quality of the secretory pathway
  JOURNAL   Sci Rep 11 (1), 2013 (2021)
   PUBMED   33479349
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3122)
  AUTHORS   Cooley,M.M., Thomas,D.D.H., Deans,K., Peng,Y., Lugea,A.,
            Pandol,S.J., Puglielli,L. and Groblewski,G.E.
  TITLE     Deficient Endoplasmic Reticulum Acetyl-CoA Import in Pancreatic
            Acinar Cells Leads to Chronic Pancreatitis
  JOURNAL   Cell Mol Gastroenterol Hepatol 11 (3), 725-738 (2021)
   PUBMED   33080365
  REMARK    GeneRIF: Deficient Endoplasmic Reticulum Acetyl-CoA Import in
            Pancreatic Acinar Cells Leads to Chronic Pancreatitis.
REFERENCE   5  (bases 1 to 3122)
  AUTHORS   Dieterich,I.A., Lawton,A.J., Peng,Y., Yu,Q., Rhoads,T.W.,
            Overmyer,K.A., Cui,Y., Armstrong,E.A., Howell,P.R., Burhans,M.S.,
            Li,L., Denu,J.M., Coon,J.J., Anderson,R.M. and Puglielli,L.
  TITLE     Acetyl-CoA flux regulates the proteome and acetyl-proteome to
            maintain intracellular metabolic crosstalk
  JOURNAL   Nat Commun 10 (1), 3929 (2019)
   PUBMED   31477734
  REMARK    GeneRIF: Results suggest that solute carrier family 33 (acetyl-CoA
            transporter) member 1 (AT-1) acts as an important metabolic
            regulator that maintains acetyl-CoA homeostasis by promoting
            functional crosstalk between different intracellular organelles.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3122)
  AUTHORS   Peng,Y., Li,M., Clarkson,B.D., Pehar,M., Lao,P.J., Hillmer,A.T.,
            Barnhart,T.E., Christian,B.T., Mitchell,H.A., Bendlin,B.B.,
            Sandor,M. and Puglielli,L.
  TITLE     Deficient import of acetyl-CoA into the ER lumen causes
            neurodegeneration and propensity to infections, inflammation, and
            cancer
  JOURNAL   J Neurosci 34 (20), 6772-6789 (2014)
   PUBMED   24828632
REFERENCE   7  (bases 1 to 3122)
  AUTHORS   Bora,R.S., Ichikawa,S., Kanamori,A. and Hirabayashi,Y.
  TITLE     Genomic structure and promoter analysis of putative mouse
            acetyl-CoA transporter gene
  JOURNAL   FEBS Lett 473 (2), 169-172 (2000)
   PUBMED   10812068
REFERENCE   8  (bases 1 to 3122)
  AUTHORS   Bora,R.S., Kanamori,A. and Hirabayashi,Y.
  TITLE     Cloning and characterization of a putative mouse acetyl-CoA
            transporter cDNA
  JOURNAL   Gene 238 (2), 455-462 (1999)
   PUBMED   10570973
REFERENCE   9  (bases 1 to 3122)
  AUTHORS   Bora,R.S., Kanamori,A. and Hirabayashi,Y.
  TITLE     Assignment1 of a putative acetyl-CoA transporter gene (Acatn) to
            mouse chromosome band 3E1-E3 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 83 (1-2), 78-79 (1998)
   PUBMED   9925934
REFERENCE   10 (bases 1 to 3122)
  AUTHORS   Kanamori,A., Nakayama,J., Fukuda,M.N., Stallcup,W.B., Sasaki,K.,
            Fukuda,M. and Hirabayashi,Y.
  TITLE     Expression cloning and characterization of a cDNA encoding a novel
            membrane protein required for the formation of O-acetylated
            ganglioside: a putative acetyl-CoA transporter
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 2897-2902 (1997)
   PUBMED   9096318
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116732.10 and AW519598.1.
            
            On Jan 1, 2013 this sequence version replaced NM_015728.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments and
            orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054395.1, AK144703.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1318              AC116732.10        182458-183775       c
            1319-1509           AC116732.10        172856-173046       c
            1510-1521           AC116732.10        167287-167298       c
            1522-2121           AW519598.1         1-600
            2122-3122           AC116732.10        161365-162365       c
FEATURES             Location/Qualifiers
     source          1..3122
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 30.08 cM"
     gene            1..3122
                     /gene="Slc33a1"
                     /gene_synonym="Acatn; D630022N01Rik"
                     /note="solute carrier family 33 (acetyl-CoA transporter),
                     member 1"
                     /db_xref="GeneID:11416"
                     /db_xref="MGI:MGI:1332247"
     exon            1..1318
                     /gene="Slc33a1"
                     /gene_synonym="Acatn; D630022N01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             544..2196
                     /gene="Slc33a1"
                     /gene_synonym="Acatn; D630022N01Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     acetyl-coenzyme A transporter 1; AT-1; acetyl-CoA
                     transporter 1; solute carrier family 33 member 1"
                     /codon_start=1
                     /product="acetyl-coenzyme A transporter 1 isoform 1"
                     /protein_id="NP_056543.2"
                     /db_xref="CCDS:CCDS17382.1"
                     /db_xref="GeneID:11416"
                     /db_xref="MGI:MGI:1332247"
                     /translation="MSPTISHKDSSRQRRSGMFSHALDMKSGPLPPGGWDDSRRDSVG
                     GEGDREVLLGDAGPGDLPKAPRSYRSELSSILLLLFLYVLQGIPLGLAGSIPLILQSK
                     NVSYTDQAFFSFVFWPFSLKLLWAPLVDAVYFKNFGRRKSWLVPTQYTLGIFMIYLST
                     QVDRLLGNIDGRTPDVVALTVTFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNS
                     VGQTAGYFLGNVLFLALESADFCNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVA
                     LLKKENREASIVKEETQGITDTYKLLFSIIKMPAVLAFCLLILTSKIGFSAADAVTGL
                     KLVEEGVPKEHLALLAVPMVPLQIILPLLISKYTAGPQPLNIFYKAMPYRLLLGLEYA
                     LLVWWTPKVEHQGGFPLYYYIIVLLSYALHQVTLYSMYVSIMAFNAKVSDPLIGGTYM
                     TLLNTVSNLGGNWPSTVALWLVDPLTVKECVGASNQNCRTPDAIELCKKLGGSCVTAL
                     DGYYVESIICVLIGFGWWFFLGPKFKKLQDEGPSSWKCKRNN"
     exon            1319..1509
                     /gene="Slc33a1"
                     /gene_synonym="Acatn; D630022N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1694
                     /gene="Slc33a1"
                     /gene_synonym="Acatn; D630022N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1812
                     /gene="Slc33a1"
                     /gene_synonym="Acatn; D630022N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..2028
                     /gene="Slc33a1"
                     /gene_synonym="Acatn; D630022N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..3122
                     /gene="Slc33a1"
                     /gene_synonym="Acatn; D630022N01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3014..3019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc33a1"
                     /gene_synonym="Acatn; D630022N01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3031
                     /gene="Slc33a1"
                     /gene_synonym="Acatn; D630022N01Rik"
     regulatory      3087..3092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc33a1"
                     /gene_synonym="Acatn; D630022N01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3111
                     /gene="Slc33a1"
                     /gene_synonym="Acatn; D630022N01Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggggttagaa tcgagggaat taatggttcc tagcaaacgt tgctcgcggt cgccgccacc
       61 ggaacttgtt ctgattcgct ggctccgtcg ggaggcacgg aacccatttt ggcagggaac
      121 cacttcccga agcgcgaggc aggaagttat cctttacctc tggtgtctac tgaggagggt
      181 gcccgctgca gtgtcagctg gtggacgggc aagagagcgt tcgagtcccc gctgcagtta
      241 agagccagac tccgtcgcag cgccacggca cgctccgcca gcctcaagcc gggtgcggct
      301 gcacggggag ctcttgccgg ctccctgaag tcgctcctgt gggcagcgac ccaggcttcg
      361 cctgggccac ctgccaggga tctggctccc tgctgcaaaa cagcgaccag tctctccgcg
      421 tccgccctcc cggcgttgaa ccaccgtgac ccgggtccag agagactgcc ttggacctgg
      481 gactagactg atcaaaacgc cagcctcagg cccccacaca ccgggctctg cgtcgtctct
      541 gatatgtcac cgaccatctc ccacaaggac agcagtcggc agcggcggtc aggcatgttt
      601 agccacgctc tggatatgaa gagtggcccg ctgccaccgg gcggctggga tgacagtcgc
      661 cgagactcgg tgggcgggga gggggaccgg gaagttcttc taggtgatgc cggccctggt
      721 gacttaccta aagccccgcg gagctataga tccgaactaa gtagcatttt gttactactc
      781 tttctttacg tgcttcaggg cattccctta ggcctggcgg ggagcatccc cctcattttg
      841 caaagcaaaa atgttagcta tacagatcag gctttcttca gttttgtctt ctggccattc
      901 agtcttaagt tgctctgggc tcccttggtt gatgccgtct actttaagaa ctttggtcgt
      961 cgcaagtcct ggcttgtccc tactcagtat acactaggaa tcttcatgat atatttatcc
     1021 actcaagtgg accgtttgct cggaaatatt gatggcagaa caccggatgt agttgctctc
     1081 actgtgacat tcttcttgtt tgaattcctg gctgccacac aggacatcgc tgtggatggt
     1141 tgggcattaa ctatgttatc ccgggaaaac gtgggctatg cttcgacatg caattctgtg
     1201 ggccaaacag ctggctactt tttgggcaat gttttatttt tggctcttga atctgctgac
     1261 ttttgtaaca aatacttgcg gtttcagcct caacccaggg gaatcgttac cctttcagat
     1321 tttctatttt tctggggaac tgtattttta ataacaacaa cattagtagc ccttctgaaa
     1381 aaagaaaaca gagaagcgtc aatagtaaaa gaagagaccc aagggatcac agacacttac
     1441 aagctgctat tctcaattat aaaaatgcca gcagttctgg ccttttgcct tctgattcta
     1501 acgtcaaaga ttggcttctc agcagctgat gctgtgacag gcctgaagct ggtggaagaa
     1561 ggggtgccta aagagcacct ggccttacta gctgtcccaa tggtccctct gcagataatc
     1621 ctgccactcc tcatcagcaa gtatactgca ggtccccagc ctctgaacat attttacaaa
     1681 gccatgccct acagattatt gcttggatta gaatatgctc tacttgtttg gtggactcct
     1741 aaagtagagc atcaaggagg attccctcta tattactata ttatagtgct gctgagttat
     1801 gcattacatc aggtcactct gtacagcatg tatgtgtcga taatggcttt caatgccaag
     1861 gtcagtgatc ctcttattgg gggaacatac atgacccttt taaacactgt gtctaatctg
     1921 ggaggaaact ggccttctac agtggctctt tggctagtgg atcccctcac agtgaaggaa
     1981 tgtgtaggag cttcaaacca gaattgtcgg acacctgatg ctatcgaact ttgcaaaaaa
     2041 cttggaggct cgtgtgttac agctctggat ggttactatg tggaatccat tatctgtgtt
     2101 ctcattggat ttggttggtg gttctttctt ggtccaaaat ttaaaaagtt acaggatgaa
     2161 ggaccatcct catggaagtg caaaaggaac aactgatgcc aacattactg gacattctag
     2221 aaggtaactg tagcttagtg ttaccaagaa agcaatgata atcagtgtgt aggagtgtaa
     2281 aataccgttt taggaaattt ttaatttaaa atgccaaata gttgaaaagt acagatgtat
     2341 ttgtatgttt gattatattt tcctttgcct tatcaatgta ttgaaagttt acttaaggct
     2401 aggaaacaac ccttttggtt ttattacttg atttctgtta atttactgac caaagcatat
     2461 tttaagctgc agtggaatag tcatgggtgg tcaccatgct gccaagtatt gttagtgcct
     2521 gtcattgagt cgtatttaac atgttggtac aatgtatcaa gtggagcaaa gcttaatatg
     2581 caggtactca ctaactagat taaccttatt ggaagttaat tctcactttg aattgtaaat
     2641 ttgtaaaaat gtatgtgaaa tttgattgaa agaaaatgta gactactaaa acattgagtt
     2701 gtttttctga ctataaccac attgtacaaa tgaatctgtt aaaaataact attttaaatg
     2761 tactttctgc ttttgtaagc atgaaagatt tataaaaaga ttatccaaac tattttttta
     2821 taaaatgaga gctatggttt ttaatttatt gatttcccta tctctccctc cctttggggg
     2881 aagctatttt gatttcttgt taactcttgc cctaggttta catatgattt tgtcacaaat
     2941 acatcatgac acacagacaa ctaatgaggg gatcaagttt gtggtgtgtt tgtgattatg
     3001 actgagttgt aaaaataaaa atttaatgtc attcttactg tagttttttt taattaccat
     3061 gagaagaaaa tgtaaactta taattaaata aaatttaaat gagtaacact ataaatctca
     3121 aa
//
