LOCUS       NM_025286               1841 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus solute carrier family 31, member 2 (Slc31a2),
            transcript variant 1, mRNA.
ACCESSION   NM_025286 XM_981201 XM_981234
VERSION     NM_025286.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1841)
  AUTHORS   Haberkiewicz,O., Lipinski,P., Starzynski,R.R., Jonczy,A.,
            Kurowska,P., Ogorek,M., Bednarz,A., Herman,S., Hatala,D.,
            Grzmil,P., Rajfur,Z., Baster,Z. and Lenartowicz,M.
  TITLE     Decreased Expression of the Slc31a1 Gene and Cytoplasmic
            Relocalization of Membrane CTR1 Protein in Renal Epithelial Cells:
            A Potent Protective Mechanism against Copper Nephrotoxicity in a
            Mouse Model of Menkes Disease
  JOURNAL   Int J Mol Sci 23 (19), 11441 (2022)
   PUBMED   36232742
  REMARK    GeneRIF: Decreased Expression of the Slc31a1 Gene and Cytoplasmic
            Relocalization of Membrane CTR1 Protein in Renal Epithelial Cells:
            A Potent Protective Mechanism against Copper Nephrotoxicity in a
            Mouse Model of Menkes Disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1841)
  AUTHORS   Logeman,B.L., Wood,L.K., Lee,J. and Thiele,D.J.
  TITLE     Gene duplication and neo-functionalization in the evolutionary and
            functional divergence of the metazoan copper transporters Ctr1 and
            Ctr2
  JOURNAL   J Biol Chem 292 (27), 11531-11546 (2017)
   PUBMED   28507097
  REMARK    GeneRIF: Gene duplication and neo-functionalization in the
            evolutionary and functional divergence of the metazoan copper
            transporters Ctr1 and Ctr2
REFERENCE   3  (bases 1 to 1841)
  AUTHORS   Ohrvik,H., Logeman,B., Noguchi,G., Eriksson,I., Kjellen,L.,
            Thiele,D.J. and Pejler,G.
  TITLE     Ctr2 Regulates Mast Cell Maturation by Affecting the Storage and
            Expression of Tryptase and Proteoglycans
  JOURNAL   J Immunol 195 (8), 3654-3664 (2015)
   PUBMED   26342034
  REMARK    GeneRIF: The increase in granular staining and heparin content is
            compatible with an impact of Ctr2 on mast cell maturation and, in
            support of this, the absence of Ctr2 resulted in markedly increased
            mRNA expression, storage, and enzymatic activity of tryptase.
REFERENCE   4  (bases 1 to 1841)
  AUTHORS   Huang,C.P., Fofana,M., Chan,J., Chang,C.J. and Howell,S.B.
  TITLE     Copper transporter 2 regulates intracellular copper and sensitivity
            to cisplatin
  JOURNAL   Metallomics 6 (3), 654-661 (2014)
   PUBMED   24522273
  REMARK    GeneRIF: In mouse embryo fibroblasts, reduction of CTR1 expression
            renders cells resistant to cisplatin whereas reduction of CTR2
            makes them hypersensitive both in vitro and in vivo.
REFERENCE   5  (bases 1 to 1841)
  AUTHORS   Ohrvik,H., Nose,Y., Wood,L.K., Kim,B.E., Gleber,S.C., Ralle,M. and
            Thiele,D.J.
  TITLE     Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal
            transporter lacking the copper- and cisplatin-binding ecto-domain
  JOURNAL   Proc Natl Acad Sci U S A 110 (46), E4279-E4288 (2013)
   PUBMED   24167251
  REMARK    GeneRIF: Ctr2 regulates biogenesis of a cleaved form of mammalian
            Ctr1 metal transporter lacking the copper- and cisplatin-binding
            ecto-domain.
REFERENCE   6  (bases 1 to 1841)
  AUTHORS   Hald,J., Galbo,T., Rescan,C., Radzikowski,L., Sprinkel,A.E.,
            Heimberg,H., Ahnfelt-Ronne,J., Jensen,J., Scharfmann,R.,
            Gradwohl,G., Kaestner,K.H., Stoeckert,C. Jr., Jensen,J.N. and
            Madsen,O.D.
  TITLE     Pancreatic islet and progenitor cell surface markers with cell
            sorting potential
  JOURNAL   Diabetologia 55 (1), 154-165 (2012)
   PUBMED   21947380
REFERENCE   7  (bases 1 to 1841)
  AUTHORS   Blair,B.G., Larson,C.A., Adams,P.L., Abada,P.B., Pesce,C.E.,
            Safaei,R. and Howell,S.B.
  TITLE     Copper transporter 2 regulates endocytosis and controls tumor
            growth and sensitivity to cisplatin in vivo
  JOURNAL   Mol Pharmacol 79 (1), 157-166 (2011)
   PUBMED   20930109
  REMARK    GeneRIF: Copper transporter 2 regulates the transport of cisplatin
            through control of the rate of macropinocytosis.
            Erratum:[Mol Pharmacol. 2011 May;79(5):894-8]
REFERENCE   8  (bases 1 to 1841)
  AUTHORS   Willnow,T., Antignac,C., Brandli,A., Christensen,E., Cox,R.,
            Davidson,D., Davies,J., Devuyst,O., Eichele,G., Hastie,N.,
            Verroust,P., Schedl,A. and Meij,I.
  TITLE     The European renal genome project: an integrated approach towards
            understanding the genetics of kidney development and disease
  JOURNAL   Organogenesis 2 (2), 42-47 (2005)
   PUBMED   19521566
REFERENCE   9  (bases 1 to 1841)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 1841)
  AUTHORS   Nishihara,E., Furuyama,T., Yamashita,S. and Mori,N.
  TITLE     Expression of copper trafficking genes in the mouse brain
  JOURNAL   Neuroreport 9 (14), 3259-3263 (1998)
   PUBMED   9831461
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB853212.1, BC029183.1 and BY482108.1.
            
            On Mar 14, 2014 this sequence version replaced NM_025286.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008473.1, AK007579.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               BB853212.1         2-110
            110-1840            BC029183.1         1-1731
            1841-1841           BY482108.1         410-410
FEATURES             Location/Qualifiers
     source          1..1841
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 33.07 cM"
     gene            1..1841
                     /gene="Slc31a2"
                     /gene_synonym="CTR2"
                     /note="solute carrier family 31, member 2"
                     /db_xref="GeneID:20530"
                     /db_xref="MGI:MGI:1333844"
     exon            1..146
                     /gene="Slc31a2"
                     /gene_synonym="CTR2"
                     /inference="alignment:Splign:2.1.0"
     exon            147..213
                     /gene="Slc31a2"
                     /gene_synonym="CTR2"
                     /inference="alignment:Splign:2.1.0"
     exon            214..403
                     /gene="Slc31a2"
                     /gene_synonym="CTR2"
                     /inference="alignment:Splign:2.1.0"
     exon            404..1841
                     /gene="Slc31a2"
                     /gene_synonym="CTR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1816..1821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc31a2"
                     /gene_synonym="CTR2"
                     /note="hexamer: AATAAA"
     polyA_site      1840
                     /gene="Slc31a2"
                     /gene_synonym="CTR2"
                     /note="major polyA site"
ORIGIN      
        1 cacgtgactc gcgtggccag ggcgcggtag cagccgcaat cctagtcgag tcccaagtag
       61 agtcctgagt agagtcccgg gctgagtccc gagcagcgag cggacagacg cgacccgggc
      121 ggccgtctag tgtgctcacc atgccgatgc atttcatctt ctcagatgag gccgtgcttc
      181 tctttgattt ctggagggtc cacagcccta caggcatggc tctctcagtg ctggtagtct
      241 tgctcctggc agtactgtat gagggcatca aggttggcaa agccaaattg ctccacaaga
      301 ctctggagag cctgcctgcc accaacagcc agcagttcat cttgggacca gaccaggatt
      361 ctacaggctc cagatcaact tcagacaata ggacccgcct caggtggttt ttgtgttact
      421 ttggccagtc cctagtccat gtcattcagg tggtaattgg ctactttgtg atgctggctg
      481 tcatgtccta caacacctgg attttcctcg gtgtggtcct gggctcggct gtgggctact
      541 acctagccta cccacttctc aacatgactt agtgggccag agatgtgcag tgcggagggc
      601 tggagagagc tggggcctct gttccagaca ttgtacttca gctgcttttc cttatggtgg
      661 ccattgctca cctctttccc agttcctgga gactttgaga tgaaaccagc aaatggtccc
      721 tggagcttag aagccattga agctacctcc ctccccagcc tctctagggc ccaggctcct
      781 gtggtgcctt aagcaagtag ctgtgaccaa agggaacatg gagagaccag aagctggagg
      841 tagggtggcc agcctgtgac acagatctct gactgcaaat taaagttttc caaagagctt
      901 cagtggtcaa ggccatggaa cctggatact ctcttctgct ttgtgcctta atgtcagggt
      961 catctccagc ctttagggga cagaccacgc cagctccttg ttctcacctt tttgccttgg
     1021 aacacatgag gattgtcatt gacaaaacaa gcttttcatt ttcaactcct ggttggcagt
     1081 tttgcacatt catacaaaac aaaatttcta atgaactcat tgtattcagg atggatggca
     1141 gtgtctgttg agacttgtct ccccttctcg agggaagact gatgctgatt aaaggcagag
     1201 acccaggact gttactgagg ctgtgggctt gtcctgtgta cagatgagct cttcctgtct
     1261 gacagcactg cctgcagcag gttagtggtc agagccttgc ccgagcctct tgtgtgcacc
     1321 agagaggaca gcatctgata acagagctga ctgcccctta tatttcctta ctgctaactc
     1381 ctaatgatct ggtaggaaat gtgagtcagt cactttagta ctgactcagc aggggtgtgc
     1441 tggggctggg tactgactga gggtgcaata gcaatcaaac caaagctagg tcattttaag
     1501 agtttggtgg actccagata tttgagcctt ttcactttac acagaaaagt taagacagga
     1561 atggggacat atacctgtaa tcttcaggat gtgggaggct gaggcaggag attgcgactt
     1621 tgaggccagc ttgagctaca tagagagttg caggccagcc tgagatacac agtaaaacac
     1681 acacacacac acacacacac acacacacac aacaatcact gctacatact ttataatgtc
     1741 tgtgttcaag tacctcatgg gcccaatgaa aagatggttt taagaagttt tgggaattaa
     1801 aaacaaatac actttaataa atttctattt ttgaacagtc t
//
