LOCUS       NM_175090               3764 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus solute carrier family 31, member 1 (Slc31a1), mRNA.
ACCESSION   NM_175090
VERSION     NM_175090.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3764)
  AUTHORS   Akhter,J., Goswami,P., Ali Beg,M.M., Ahmad,S., Najmi,A.K. and
            Raisuddin,S.
  TITLE     Protective effect of rosmarinic acid on the transmembrane
            transporter Ctr1 expression in cisplatin-treated mice
  JOURNAL   J Cancer Res Ther 19 (7), 1753-1759 (2023)
   PUBMED   38376274
  REMARK    GeneRIF: Protective effect of rosmarinic acid on the transmembrane
            transporter Ctr1 expression in cisplatin-treated mice.
REFERENCE   2  (bases 1 to 3764)
  AUTHORS   Ito,F., Kato,K., Yanatori,I., Maeda,Y., Murohara,T. and Toyokuni,S.
  TITLE     Matrigel-based organoid culture of malignant mesothelioma
            reproduces cisplatin sensitivity through CTR1
  JOURNAL   BMC Cancer 23 (1), 487 (2023)
   PUBMED   37254056
  REMARK    GeneRIF: Matrigel-based organoid culture of malignant mesothelioma
            reproduces cisplatin sensitivity through CTR1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3764)
  AUTHORS   Huo,S., Wang,Q., Shi,W., Peng,L., Jiang,Y., Zhu,M., Guo,J.,
            Peng,D., Wang,M., Men,L., Huang,B., Lv,J. and Lin,L.
  TITLE     ATF3/SPI1/SLC31A1 Signaling Promotes Cuproptosis Induced by
            Advanced Glycosylation End Products in Diabetic Myocardial Injury
  JOURNAL   Int J Mol Sci 24 (2), 1667 (2023)
   PUBMED   36675183
  REMARK    GeneRIF: ATF3/SPI1/SLC31A1 Signaling Promotes Cuproptosis Induced
            by Advanced Glycosylation End Products in Diabetic Myocardial
            Injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3764)
  AUTHORS   Haberkiewicz,O., Lipinski,P., Starzynski,R.R., Jonczy,A.,
            Kurowska,P., Ogorek,M., Bednarz,A., Herman,S., Hatala,D.,
            Grzmil,P., Rajfur,Z., Baster,Z. and Lenartowicz,M.
  TITLE     Decreased Expression of the Slc31a1 Gene and Cytoplasmic
            Relocalization of Membrane CTR1 Protein in Renal Epithelial Cells:
            A Potent Protective Mechanism against Copper Nephrotoxicity in a
            Mouse Model of Menkes Disease
  JOURNAL   Int J Mol Sci 23 (19), 11441 (2022)
   PUBMED   36232742
  REMARK    GeneRIF: Decreased Expression of the Slc31a1 Gene and Cytoplasmic
            Relocalization of Membrane CTR1 Protein in Renal Epithelial Cells:
            A Potent Protective Mechanism against Copper Nephrotoxicity in a
            Mouse Model of Menkes Disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3764)
  AUTHORS   Yuan,S., Korolnek,T. and Kim,B.E.
  TITLE     Oral Elesclomol Treatment Alleviates Copper Deficiency in Animal
            Models
  JOURNAL   Front Cell Dev Biol 10, 856300 (2022)
   PUBMED   35433682
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3764)
  AUTHORS   Lee,J., Petris,M.J. and Thiele,D.J.
  TITLE     Characterization of mouse embryonic cells deficient in the ctr1
            high affinity copper transporter. Identification of a
            Ctr1-independent copper transport system
  JOURNAL   J Biol Chem 277 (43), 40253-40259 (2002)
   PUBMED   12177073
REFERENCE   7  (bases 1 to 3764)
  AUTHORS   Lee,J., Prohaska,J.R. and Thiele,D.J.
  TITLE     Essential role for mammalian copper transporter Ctr1 in copper
            homeostasis and embryonic development
  JOURNAL   Proc Natl Acad Sci U S A 98 (12), 6842-6847 (2001)
   PUBMED   11391005
REFERENCE   8  (bases 1 to 3764)
  AUTHORS   Kuo,Y.M., Zhou,B., Cosco,D. and Gitschier,J.
  TITLE     The copper transporter CTR1 provides an essential function in
            mammalian embryonic development
  JOURNAL   Proc Natl Acad Sci U S A 98 (12), 6836-6841 (2001)
   PUBMED   11391004
REFERENCE   9  (bases 1 to 3764)
  AUTHORS   Lee,J., Prohaska,J.R., Dagenais,S.L., Glover,T.W. and Thiele,D.J.
  TITLE     Isolation of a murine copper transporter gene, tissue specific
            expression and functional complementation of a yeast copper
            transport mutant
  JOURNAL   Gene 254 (1-2), 87-96 (2000)
   PUBMED   10974539
REFERENCE   10 (bases 1 to 3764)
  AUTHORS   Nishihara,E., Furuyama,T., Yamashita,S. and Mori,N.
  TITLE     Expression of copper trafficking genes in the mouse brain
  JOURNAL   Neuroreport 9 (14), 3259-3263 (1998)
   PUBMED   9831461
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY097629.1, BC058227.1 and BC065147.1.
            
            On Apr 21, 2009 this sequence version replaced NM_175090.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151337.1, BC058227.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                BY097629.1         2-61
            61-3247             BC058227.1         1-3187
            3248-3764           BC065147.1         3658-4174
FEATURES             Location/Qualifiers
     source          1..3764
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 33.11 cM"
     gene            1..3764
                     /gene="Slc31a1"
                     /gene_synonym="4930445G01Rik; Ctr1"
                     /note="solute carrier family 31, member 1"
                     /db_xref="GeneID:20529"
                     /db_xref="MGI:MGI:1333843"
     exon            1..143
                     /gene="Slc31a1"
                     /gene_synonym="4930445G01Rik; Ctr1"
                     /inference="alignment:Splign:2.1.0"
     exon            144..330
                     /gene="Slc31a1"
                     /gene_synonym="4930445G01Rik; Ctr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..774
                     /gene="Slc31a1"
                     /gene_synonym="4930445G01Rik; Ctr1"
                     /note="solute carrier family 13 (sodium/sulphate
                     symporters), member 1; copper transporter 1"
                     /codon_start=1
                     /product="high affinity copper uptake protein 1"
                     /protein_id="NP_780299.2"
                     /db_xref="CCDS:CCDS18237.1"
                     /db_xref="GeneID:20529"
                     /db_xref="MGI:MGI:1333843"
                     /translation="MNHMGMNHMEMHHHMGMNHTDDNITMPPHHHPTTSASHSHGGGD
                     SMMMMPMTFYFDFKNVNLLFSGLVINTPGEMAGAFVAVFLLAMFYEGLKIAREGLLRK
                     SQVSIRYNSMPVPGPNGTILMETHKTVGQQMLSFPHLLQTVLHIIQVVISYFLMLIFM
                     TYNGYLCIAVAAGAGTGYFLFSWKKAVVVDITEHCH"
     exon            331..403
                     /gene="Slc31a1"
                     /gene_synonym="4930445G01Rik; Ctr1"
                     /inference="alignment:Splign:2.1.0"
     exon            404..572
                     /gene="Slc31a1"
                     /gene_synonym="4930445G01Rik; Ctr1"
                     /inference="alignment:Splign:2.1.0"
     exon            573..3744
                     /gene="Slc31a1"
                     /gene_synonym="4930445G01Rik; Ctr1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1476..1481
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc31a1"
                     /gene_synonym="4930445G01Rik; Ctr1"
                     /note="hexamer: AATAAA"
     polyA_site      1496
                     /gene="Slc31a1"
                     /gene_synonym="4930445G01Rik; Ctr1"
                     /note="major polyA site"
     regulatory      3717..3722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc31a1"
                     /gene_synonym="4930445G01Rik; Ctr1"
                     /note="hexamer: AATAAA"
     polyA_site      3739
                     /gene="Slc31a1"
                     /gene_synonym="4930445G01Rik; Ctr1"
                     /note="major polyA site"
ORIGIN      
        1 agggcgggaa tccgcggcct ttactgcggt cgtgggacac gtcgagccgg gcagtagtgg
       61 cgggggcttg gtagaagtcc gtaccggact aggggatcca gttctgagag gaagactaag
      121 gcggcggggc ttaccctgtg aagacttttc cactgaatct catctttttc tggaaaactg
      181 gcaatgaacc atatggggat gaaccatatg gagatgcacc accatatggg tatgaaccac
      241 acggacgaca acattaccat gccacctcac caccacccga ccacctcagc ctcacactcc
      301 cacggtggag gggacagcat gatgatgatg cctatgacct tctactttga ctttaagaat
      361 gtgaatctat tgttttccgg tttggtaatc aatacacctg gagaaatggc tggagccttc
      421 gtggcagtgt ttttactagc aatgttttat gaaggactca agatagcccg agagggtctg
      481 cttcgaaagt ctcaagtcag cattcgctac aattccatgc ctgtcccagg accaaatgga
      541 accatcctaa tggagacaca caaaactgtt gggcagcaga tgctgagctt cccccacctc
      601 ctgcagacag tgctgcacat catccaggta gtcatcagct acttcctcat gctcatcttc
      661 atgacctaca atgggtacct atgcattgca gtagcagcag gggctgggac gggatacttt
      721 ctcttcagct ggaagaaggc agtggtggtg gacatcacag agcactgcca ttgatatcag
      781 actccacata tggccttatt aattgctgta ggaagcatct tgggactgga agatatgatt
      841 ccctttccaa tcatcccttc tctctcctgt ctatacatac acacctactg aatagaagcc
      901 tagctgacag tctctgaata gtggtttttc taataagatg agattttttt ctcttgggaa
      961 gtcacctgtg agatgtcttc tccctcatca tcctgagcct tatctaatcc aggtagcttc
     1021 ctagttaaag acttggttat ctgcttcttt ttacttctcc aggttttgat ttgttttgtt
     1081 ttgttttatt tgcgggggga gtgggataca ttttgtttta aacagatatg tgtatttgat
     1141 aggtgggatt ctgggtcagt gataaaaaag gattgtaaca ggattgatgg cacttaggga
     1201 catctcatcc aaccgggact taaatttcac actagaaatg agctccagtc ttaactcagt
     1261 gaatgggaaa cacatgttcc tctctccagg ttacactgaa acctgtgtag tgtgtacaga
     1321 gtgggtaggg actaaacaca ggcctagcgt ctatgagtct gtattcctgc tcagtcatca
     1381 acttgtgttc ctattgaaca tttgatcaga atgaacttgc caatcaaaac aaaaacagga
     1441 caatcaattt aagacaacag aaatagagat tgttaaataa aaccattagt attttacttt
     1501 gactcagtac cttggtttgt cccaactgaa taagagtttg tattgtgtgt gtgttccttg
     1561 aaaccaatga ttttcaaact ttacagcttc agaatcaccc agagggcttg ttaagacact
     1621 acttggtgga cctcaacccc agaaccacca aatttggcat ttctaagttc ctaggtgatg
     1681 ttctactcac agtcagtcca gaggattacc ttaagagtct ctgcattaaa ctagaaaagt
     1741 tgcacctaga agggacagag ggtggggcta cctgctatca ggcatgaaca tgtgaattgc
     1801 tggttagtag gtggtatgcc ttgggcacat gtcacatcta aatgctgctg gtcgatactt
     1861 tatcattcca caaacattta ttcacttcca aatatgtttt atgtataccc acatacagtg
     1921 tgtgggatta cagccaaagt atacttgtca acatatacga agtctctagt cctaactttt
     1981 aaagatctaa ggttccttgg aagttatttg aaggccaaga gacctttgct ctgctgtgtg
     2041 agtcagccag tcaaaagccc agaaaggcaa aaacccagct ttcttgtttg gagagacatg
     2101 gggcatgtgt ctgccaatag ccagttgttc tcagtgtgca ctatgtaggt ccccatccac
     2161 tacttgacca cctttatcat ttacggggat ttacatagat tacagtggcc aagacccctt
     2221 tctcaatgaa ggatctcatt ggacgtcctg tcaatcatta atctacatgc aggcttgttc
     2281 ccacactacc tctttaaagc gattcttcct atgctggtct gttcaatcct gccctctttg
     2341 gtgctagatc cagttgtgcc tcagagcaga agaaacaaac ctgctgtctt gttggcccag
     2401 tgtttcagtt ttgaagtgtg tactttctcc tctgtgtgtg ccaattacat attagagaac
     2461 aaggaatgtg tactttggtg gctttgaacc aagaaaaggt tttaagccta ctggatggag
     2521 tctaaaattc ttagaaatca actttagagc tttgcttttc tctgagttca tcctgcagtg
     2581 aatgacaggt actgacagcc caacattaag gtgcaaatag cctgtttgtc atatcagaag
     2641 ccatggaata ataaacccag gggaatccag aaaccacact tagtggtaac cctggtgctc
     2701 tctagaatct ccaaatgagc tgctataaaa cacctttcag gggctgagat gcagctctgg
     2761 tgtgagtcac ttacctagct tatgtcaggc ccctaaaagt aatgcataaa ctgtcagaat
     2821 cgggacctta tcgttgaggt gaaaagaacc aaggcccgta ggaacaaggt gctatgaatc
     2881 tgaaaccaag agaaacctca gtttggcatg gttcttcagg gtagcttccg agtagaaata
     2941 gtctgctgca aatcctaaac ttaagatccc tgcgctaggt tgctagagac tgcggttagt
     3001 gcagaacaga ggtaagccta agtcccatcc tcatgaactt caatgcccag cctttgtgtt
     3061 tattttatct aaatgtctcc tttcatctgt gggaaagcta tagctgagtg tctttagccc
     3121 ctgccctact tttccctctc tgactttttt cccaggtagc ttagtgttta acatctctct
     3181 caccatcctg atgcagtagc atggctattg ctgaggttat tttacctaat aattagaact
     3241 ttgtatttac aaagcaagta gaggtcttaa atttgcttca agaagcagtt gctccactgg
     3301 aatttctata aagctgggta aagggttagc agaattacag atcttaagta ctaactgcag
     3361 tccaagatgg aagagtactc agcagccact gccctcatca ggaacctcct cggcatccat
     3421 cagtctcctc actgctcctg tgcgcagggc tgtccctccc acactccctt ccaggccgtg
     3481 gccttcgctt cctcattaga atcaggagag tgaggcacag tgtccatcat gccatttaat
     3541 cttgtgcctg ccctttccag cctcttcaaa agatgcatcc aaacaacagg tctgcatttg
     3601 atgtaatgcc ttaattactg gggccacatt cacgttgact gtctcagaga ctgtaagctc
     3661 ccggagagca gggttgctgt aatgggaatg tttaagtgtt gtgtgcaaga aaacaaaata
     3721 aatattttga ttttcgtgat tctaaaaaaa aaaaaaaaaa aaaa
//
