LOCUS       NM_178651               3410 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus solute carrier family 30 (zinc transporter), member 9
            (Slc30a9), transcript variant 1, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_178651
VERSION     NM_178651.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3410)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3410)
  AUTHORS   Chen,Y.H., Beischlag,T.V., Kim,J.H., Perdew,G.H. and Stallcup,M.R.
  TITLE     Role of GAC63 in transcriptional activation mediated by the aryl
            hydrocarbon receptor
  JOURNAL   J Biol Chem 281 (18), 12242-12247 (2006)
   PUBMED   16513642
  REMARK    GeneRIF: GAC63 has a role in transcriptional activation mediated by
            the aryl hydrocarbon receptor
REFERENCE   3  (bases 1 to 3410)
  AUTHORS   Chen,Y.H., Kim,J.H. and Stallcup,M.R.
  TITLE     GAC63, a GRIP1-dependent nuclear receptor coactivator
  JOURNAL   Mol Cell Biol 25 (14), 5965-5972 (2005)
   PUBMED   15988012
  REMARK    GeneRIF: GAC63 is a physiologically relevant part of the p160
            coactivator signaling pathway that mediates transcriptional
            activation by nuclear receptors.
REFERENCE   4  (bases 1 to 3410)
  AUTHORS   Sim,D.L., Yeo,W.M. and Chow,V.T.
  TITLE     The novel human HUEL (C4orf1) protein shares homology with the
            DNA-binding domain of the XPA DNA repair protein and displays
            nuclear translocation in a cell cycle-dependent manner
  JOURNAL   Int J Biochem Cell Biol 34 (5), 487-504 (2002)
   PUBMED   11906820
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY237302.1, AK035541.1 and AK082853.1.
            
            On Jul 16, 2015 this sequence version replaced NM_178651.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082853.1, AK035541.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BY237302.1         2-18
            18-3051             AK035541.1         3-3036
            3052-3410           AK082853.1         3052-3410
FEATURES             Location/Qualifiers
     source          1..3410
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 36.02 cM"
     gene            1..3410
                     /gene="Slc30a9"
                     /gene_synonym="2310024J23Rik; GAC63; HUEL; znT-9"
                     /note="solute carrier family 30 (zinc transporter), member
                     9"
                     /db_xref="GeneID:109108"
                     /db_xref="MGI:MGI:1923690"
     exon            1..243
                     /gene="Slc30a9"
                     /gene_synonym="2310024J23Rik; GAC63; HUEL; znT-9"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1844
                     /gene="Slc30a9"
                     /gene_synonym="2310024J23Rik; GAC63; HUEL; znT-9"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     transporter 9; GRIP1-associated coactivator 1;
                     GRIP1-associated coactivator 63; proton-coupled zinc
                     antiporter SLC30A9, mitochondrial"
                     /codon_start=1
                     /product="proton-coupled zinc antiporter SLC30A9,
                     mitochondrial isoform 1"
                     /protein_id="NP_848766.2"
                     /db_xref="CCDS:CCDS39103.1"
                     /db_xref="GeneID:109108"
                     /db_xref="MGI:MGI:1923690"
                     /translation="MFPGLAAAAAAHRCSWAALCRLGGGRAATRGRSQGWKNVMTFES
                     FTYVVPDIHPHLSIINQVKLYSTNVQKGGQGSQTPKADKVPSLTQTVENIGAELKAPL
                     KQDPLQVRVKAVLKKRDYGSKYTKNNFITGVRAINEFCLKSSDLEQLRKIRRRSPHDD
                     TESFTVFLRSDVEAKALEVWGSLEALAREKKLRKEAEIEYRERLFRNQRILREYGDFL
                     GNTKPRSRAVSVFLKGPGKVVMVAICINGLNCFFKFLAWIYTGSASMFSEAIHSLSDT
                     CNQGLLALGISKSVQTPDPSHPYGFSNMRYISSLISGVGIFMMGAGLSWYHGIMGLLH
                     PQPMESLLWAYCILAGSLVSEGATLLVAINELRRSAQAKGTTFYKYVMESRDPSTNVI
                     LLEDTAAVLGVIIAATCMGLTSITGNPLYDSLGSLGVGTLLGVVSAFLIYTNTEALLG
                     RSIQPEQVQRLTELLESDPSVRAIHDVKATDLGLGKVRFKAEVDFDGRVVTRSYLEKQ
                     DFDQMMQEIQEVKTPEQLEAFMLKHGENIIDTLGAEVDRLEKELKKRNPEVRHVDLEI
                     L"
     exon            244..411
                     /gene="Slc30a9"
                     /gene_synonym="2310024J23Rik; GAC63; HUEL; znT-9"
                     /inference="alignment:Splign:2.1.0"
     exon            412..471
                     /gene="Slc30a9"
                     /gene_synonym="2310024J23Rik; GAC63; HUEL; znT-9"
                     /inference="alignment:Splign:2.1.0"
     exon            472..571
                     /gene="Slc30a9"
                     /gene_synonym="2310024J23Rik; GAC63; HUEL; znT-9"
                     /inference="alignment:Splign:2.1.0"
     exon            572..664
                     /gene="Slc30a9"
                     /gene_synonym="2310024J23Rik; GAC63; HUEL; znT-9"
                     /inference="alignment:Splign:2.1.0"
     exon            665..747
                     /gene="Slc30a9"
                     /gene_synonym="2310024J23Rik; GAC63; HUEL; znT-9"
                     /inference="alignment:Splign:2.1.0"
     exon            748..806
                     /gene="Slc30a9"
                     /gene_synonym="2310024J23Rik; GAC63; HUEL; znT-9"
                     /inference="alignment:Splign:2.1.0"
     exon            807..874
                     /gene="Slc30a9"
                     /gene_synonym="2310024J23Rik; GAC63; HUEL; znT-9"
                     /inference="alignment:Splign:2.1.0"
     exon            875..977
                     /gene="Slc30a9"
                     /gene_synonym="2310024J23Rik; GAC63; HUEL; znT-9"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1033
                     /gene="Slc30a9"
                     /gene_synonym="2310024J23Rik; GAC63; HUEL; znT-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1169
                     /gene="Slc30a9"
                     /gene_synonym="2310024J23Rik; GAC63; HUEL; znT-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1209
                     /gene="Slc30a9"
                     /gene_synonym="2310024J23Rik; GAC63; HUEL; znT-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1281
                     /gene="Slc30a9"
                     /gene_synonym="2310024J23Rik; GAC63; HUEL; znT-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1389
                     /gene="Slc30a9"
                     /gene_synonym="2310024J23Rik; GAC63; HUEL; znT-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1555
                     /gene="Slc30a9"
                     /gene_synonym="2310024J23Rik; GAC63; HUEL; znT-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1685
                     /gene="Slc30a9"
                     /gene_synonym="2310024J23Rik; GAC63; HUEL; znT-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1799
                     /gene="Slc30a9"
                     /gene_synonym="2310024J23Rik; GAC63; HUEL; znT-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..3410
                     /gene="Slc30a9"
                     /gene_synonym="2310024J23Rik; GAC63; HUEL; znT-9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3032..3037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc30a9"
                     /gene_synonym="2310024J23Rik; GAC63; HUEL; znT-9"
                     /note="hexamer: AATAAA"
     regulatory      3044..3049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc30a9"
                     /gene_synonym="2310024J23Rik; GAC63; HUEL; znT-9"
                     /note="hexamer: ATTAAA"
     polyA_site      3052
                     /gene="Slc30a9"
                     /gene_synonym="2310024J23Rik; GAC63; HUEL; znT-9"
                     /note="major polyA site"
     polyA_site      3080
                     /gene="Slc30a9"
                     /gene_synonym="2310024J23Rik; GAC63; HUEL; znT-9"
ORIGIN      
        1 atgacttccg ggtcgccgag gccgccggcc gcggcgcaca catccgtgct cgccggggtc
       61 cggtctatgg agtcagttgg cgcggcaggc ggctcggagg caggaggtgg tgtccgagtg
      121 ggggcctctg ccccgccagg atgtttccgg gcttggccgc cgccgccgcg gcgcacaggt
      181 gcagctgggc ggcgctgtgc aggctcggtg gcggccgggc agcgacccgc ggccgcagcc
      241 agggatggaa gaatgtaatg acatttgaaa gctttacata tgtggttccc gacattcacc
      301 cacatttatc tattataaat caagtcaagt tgtactctac gaatgtccag aaaggagggc
      361 agggctcaca gactccaaaa gctgacaaag tcccatcact tacacaaaca gtagaaaata
      421 taggcgcaga actcaaagct ccacttaagc aagaccctct ccaagtaaga gtcaaagcag
      481 tccttaagaa aagggattat ggatcaaaat acactaagaa taatttcatc actggagtga
      541 gagcaataaa cgagttctgc cttaagtcca gtgatttaga acaacttcga aaaatcaggc
      601 ggcgaagtcc ccacgatgac accgagtcct ttactgtgtt cttgaggtca gatgtggaag
      661 caaaagcttt ggaagtttgg ggaagccttg aagctcttgc cagagagaaa aaattgcgta
      721 aagaagcaga aatagaatac agagaacggc tatttagaaa ccaaagaata ttaagagaat
      781 atggtgattt cttgggaaac acaaagccac gttccagagc ggtctcagtg ttccttaagg
      841 gaccaggaaa agtggtcatg gttgctattt gcattaatgg cttaaactgc ttctttaaat
      901 ttcttgcctg gatttatacg ggttcagcaa gtatgttctc agaagctata cactcattat
      961 ctgatacttg taaccagggc ttgctagcac tgggcatcag caaatctgtt caaacaccag
     1021 atccttctca cccgtacggc ttttcaaata tgcgctatat ttcttcattg attagtggtg
     1081 ttggtatttt catgatgggc gcaggactct cttggtatca tggaatcatg ggattacttc
     1141 atcctcaacc aatggaatcc ctgctatggg catattgtat tttagcagga tctttggtgt
     1201 ctgaaggagc aacacttctc gttgccataa atgaacttcg caggagcgcg caggccaagg
     1261 gcacgacatt ttataagtat gtcatggaaa gtcgtgatcc gagtacaaat gttattctat
     1321 tggaggacac tgcagctgtc ttaggagtga taatagcggc tacctgcatg ggccttacct
     1381 ccataacagg caatccactg tatgacagcc tgggttcctt gggtgtaggc accttactag
     1441 gtgtggtctc ggcattcctc atctatacca acacagaagc actcctagga cgctccatcc
     1501 aaccggagca agtgcagcgg cttactgaac tcctggagag cgacccgtca gtaagggcaa
     1561 tccatgatgt taaagccaca gatttgggat tagggaaagt cagatttaag gcagaagttg
     1621 attttgatgg acgagttgtt acgagatcat atttggaaaa gcaagatttt gaccaaatga
     1681 tgcaagaaat tcaagaagtg aagactcctg aacaattaga agcctttatg cttaaacatg
     1741 gagaaaatat tattgatact ctaggagctg aagtagacag acttgagaaa gagctgaaaa
     1801 aacgaaaccc tgaagttcgg cacgtagacc ttgagatcct atagatagga tgagtcactc
     1861 gggacgtgga ggtgccttcc tccccactga atgggtcagt gccgtccaca tgctgactct
     1921 ttccaggtgg atgggacgtg gctttcatgt gctgagtaac tgaacaggct gaaggactca
     1981 aactctctct tctaatcatg tctttgtgct tctgtaggga cattggctgc ttaggtcacc
     2041 cacggtctct catttcagcc agcctgtgtt gaaccatgaa atcatgtttt ctttgttaac
     2101 atggtacagc gtgtctctgt ggacttgaaa cttaggttac aactgaaaag tttggtccac
     2161 caaaggtctc atcttgagca ttctggttaa atcgcactgc gtggttttgg aacaggcagt
     2221 gttttgaggg ctgtctttcc tgcccacttg ggaaaatatt tctgtctact ttgtggtttt
     2281 gacccgaaca ctaagaggtg cgtctcctaa cgtcattctc tagaagcaga cgtgcattcc
     2341 agaagcaaca cacttactga atggagtgga gacatttcca catcttttag atcatagtag
     2401 ttgccacttt gtaaaacttc ttttctctct tttacctttt tttccatatt tggtttaatt
     2461 tttgtaatgt taaagacata atcctagatg tatgactttt tttaaactgg cttcagtgcc
     2521 atagtgttta tttactggaa atatttgtaa atgttttacc attctgtaat atggactaga
     2581 aatatttata actttacagg caggataaca ttttgtttta atttatttaa gagaaggcac
     2641 tgcttgtata agtgtgaacc gtgggttcct ttggcgttga gagaagtaaa tctccaaccc
     2701 cgaagcgtgg gctgtgctgt gtgtgcgacc gatgccctgc ggctcaagtg ggcattagca
     2761 tagcacgctg gctggaacac aggacgaaag cacagagctc gctggtgacc aacgtgccgg
     2821 tgccgagggc aagaacattc actttagtag ctgaagactc tgaaaagctg tagctgtctg
     2881 cccaacagct catgagctgt gctgcagttg gtggctgccc tgctggagag agtgctcggc
     2941 gcacagccct cacacctctg ggaacccagg gtccccagat tttctgagac ggaagttcgt
     3001 gtattataga aaactgtaat gtggaaacaa aaataaatct ccaattaaag gatttgttac
     3061 ggtagttttc aatccagaaa tgacacttgg tggaaaatca tgagaatttg taacgtgctt
     3121 tgtgctccct agggagcatg cttgttaccc tttgttcgag cctaaggagg gtctgtctgt
     3181 ggaggtcaag ctggcctgga actcactaca tagagcctag gctctctgaa gataggaaat
     3241 tggagccagt gggatagata ggtcattggg tagagtattg gccaccaagc cttccaacct
     3301 gaatttgatc tccaggaacc acatgtgggt acagaaaact gactgctcca cttgtgtggt
     3361 atggtatgct cccttcccca aatatatgta ataaaattgg acttcttctt
//
