LOCUS       NM_172816               1971 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus solute carrier family 30 (zinc transporter), member 8
            (Slc30a8), mRNA.
ACCESSION   NM_172816
VERSION     NM_172816.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1971)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1971)
  AUTHORS   Firth,G., Georgiadou,E., Griffiths,A., Amrahli,M., Kim,J., Yu,Z.,
            Hu,M., Stewart,T.J., Leclerc,I., Okamoto,H., Gomez,D., Blower,P.J.
            and Rutter,G.A.
  TITLE     Impact of an SLC30A8 loss-of-function variant on the pancreatic
            distribution of zinc and manganese: laser ablation-ICP-MS and
            positron emission tomography studies in mice
  JOURNAL   Front Endocrinol (Lausanne) 14, 1171933 (2023)
   PUBMED   37396167
  REMARK    GeneRIF: Impact of an SLC30A8 loss-of-function variant on the
            pancreatic distribution of zinc and manganese: laser
            ablation-ICP-MS and positron emission tomography studies in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1971)
  AUTHORS   Chi,Y., Zhang,X., Liang,D., Wang,Y., Cai,X., Dong,J., Li,L. and
            Chi,Z.
  TITLE     ZnT8 Exerts Anti-apoptosis of Kidney Tubular Epithelial Cell in
            Diabetic Kidney Disease Through TNFAIP3-NF-kappaB Signal Pathways
  JOURNAL   Biol Trace Elem Res 201 (5), 2442-2457 (2023)
   PUBMED   35871203
  REMARK    GeneRIF: ZnT8 Exerts Anti-apoptosis of Kidney Tubular Epithelial
            Cell in Diabetic Kidney Disease Through TNFAIP3-NF-kappaB Signal
            Pathways.
REFERENCE   4  (bases 1 to 1971)
  AUTHORS   Kim,Y.K., Walters,J.A., Moss,N.D., Wells,K.L., Sheridan,R.,
            Miranda,J.G., Benninger,R.K.P., Pyle,L.L., O'Brien,R.M., Sussel,L.
            and Davidson,H.W.
  TITLE     Zinc transporter 8 haploinsufficiency protects against beta cell
            dysfunction in type 1 diabetes by increasing mitochondrial
            respiration
  JOURNAL   Mol Metab 66, 101632 (2022)
   PUBMED   36347424
  REMARK    GeneRIF: Zinc transporter 8 haploinsufficiency protects against
            beta cell dysfunction in type 1 diabetes by increasing
            mitochondrial respiration.
REFERENCE   5  (bases 1 to 1971)
  AUTHORS   Karsai,M., Zuellig,R.A., Lehmann,R., Cuozzo,F., Nasteska,D.,
            Luca,E., Hantel,C., Hodson,D.J., Spinas,G.A., Rutter,G.A. and
            Gerber,P.A.
  TITLE     Lack of ZnT8 protects pancreatic islets from hypoxia- and
            cytokine-induced cell death
  JOURNAL   J Endocrinol 253 (1), 1-11 (2022)
   PUBMED   35017316
  REMARK    GeneRIF: Lack of ZnT8 protects pancreatic islets from hypoxia- and
            cytokine-induced cell death.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1971)
  AUTHORS   Pound,L.D., Sarkar,S.A., Benninger,R.K., Wang,Y., Suwanichkul,A.,
            Shadoan,M.K., Printz,R.L., Oeser,J.K., Lee,C.E., Piston,D.W.,
            McGuinness,O.P., Hutton,J.C., Powell,D.R. and O'Brien,R.M.
  TITLE     Deletion of the mouse Slc30a8 gene encoding zinc transporter-8
            results in impaired insulin secretion
  JOURNAL   Biochem J 421 (3), 371-376 (2009)
   PUBMED   19450229
  REMARK    GeneRIF: Slc30a8 gene deletion is accompanied by a modest
            impairment in insulin secretion without major alterations in
            glucose metabolism.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1971)
  AUTHORS   Murgia,C., Devirgiliis,C., Mancini,E., Donadel,G., Zalewski,P. and
            Perozzi,G.
  TITLE     Diabetes-linked zinc transporter ZnT8 is a homodimeric protein
            expressed by distinct rodent endocrine cell types in the pancreas
            and other glands
  JOURNAL   Nutr Metab Cardiovasc Dis 19 (6), 431-439 (2009)
   PUBMED   19095428
  REMARK    GeneRIF: Diabetes-linked zinc transporter ZnT8 is a homodimeric
            protein expressed by distinct rodent endocrine cell types in the
            pancreas and other glands.
REFERENCE   8  (bases 1 to 1971)
  AUTHORS   Juhl,K., Sarkar,S.A., Wong,R., Jensen,J. and Hutton,J.C.
  TITLE     Mouse pancreatic endocrine cell transcriptome defined in the
            embryonic Ngn3-null mouse
  JOURNAL   Diabetes 57 (10), 2755-2761 (2008)
   PUBMED   18599526
REFERENCE   9  (bases 1 to 1971)
  AUTHORS   Wang,V.E., Schmidt,T., Chen,J., Sharp,P.A. and Tantin,D.
  TITLE     Embryonic lethality, decreased erythropoiesis, and defective
            octamer-dependent promoter activation in Oct-1-deficient mice
  JOURNAL   Mol Cell Biol 24 (3), 1022-1032 (2004)
   PUBMED   14729950
REFERENCE   10 (bases 1 to 1971)
  AUTHORS   Neophytou,P.I., Muir,E.M. and Hutton,J.C.
  TITLE     A subtractive cloning approach to the identification of mRNAs
            specifically expressed in pancreatic beta-cells
  JOURNAL   Diabetes 45 (2), 127-133 (1996)
   PUBMED   8549854
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127562.3.
            
            On Jul 12, 2018 this sequence version replaced NM_172816.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050494.1, AK050482.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849378,
                                           SAMN00849383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-404               AC127562.3         122834-123237       c
            405-601             AC127562.3         112144-112340       c
            602-748             AC127562.3         101369-101515       c
            749-902             AC127562.3         96938-97091         c
            903-1053            AC127562.3         93080-93230         c
            1054-1159           AC127562.3         87118-87223         c
            1160-1294           AC127562.3         85135-85269         c
            1295-1971           AC127562.3         82992-83668         c
FEATURES             Location/Qualifiers
     source          1..1971
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 19.88 cM"
     gene            1..1971
                     /gene="Slc30a8"
                     /gene_synonym="C820002P14Rik; ZnT-8; ZnT8"
                     /note="solute carrier family 30 (zinc transporter), member
                     8"
                     /db_xref="GeneID:239436"
                     /db_xref="MGI:MGI:2442682"
     exon            1..404
                     /gene="Slc30a8"
                     /gene_synonym="C820002P14Rik; ZnT-8; ZnT8"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..1437
                     /gene="Slc30a8"
                     /gene_synonym="C820002P14Rik; ZnT-8; ZnT8"
                     /note="zinc transporter 8"
                     /codon_start=1
                     /product="proton-coupled zinc antiporter SLC30A8"
                     /protein_id="NP_766404.1"
                     /db_xref="CCDS:CCDS27464.1"
                     /db_xref="GeneID:239436"
                     /db_xref="MGI:MGI:2442682"
                     /translation="MEFLERTYLVNDQATKMYAFPLDRELRQKPVNKDQCPGDRPEHP
                     EAGGIYHCHNSAKATGNRSSKQAHAKWRLCAASAICFIFMVAEVVGGHVAGSLAILTD
                     AAHLLIDLTSFLLSLFSLWLSSRPPSKRLTFGWYRAEILGALLSVLCIWVVTGVLLYL
                     ACERLLYPDYQIQAGIMITVSGCAVAANIVLTMILHQRNFGYNHKDVQANASVRAAFV
                     HALGDVFQSISVLISALIIYFKPDYKIADPVCTFIFSILVLASTVMILKDFSILLMEG
                     VPKGLSYNSVKEIILAVDGVISVHSLHIWSLTVNQVILSVHVATAASQDSQSVRTGIA
                     QALSSFDLHSLTIQIESAADQDPSCLLCEDPQD"
     exon            405..601
                     /gene="Slc30a8"
                     /gene_synonym="C820002P14Rik; ZnT-8; ZnT8"
                     /inference="alignment:Splign:2.1.0"
     exon            602..748
                     /gene="Slc30a8"
                     /gene_synonym="C820002P14Rik; ZnT-8; ZnT8"
                     /inference="alignment:Splign:2.1.0"
     exon            749..902
                     /gene="Slc30a8"
                     /gene_synonym="C820002P14Rik; ZnT-8; ZnT8"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1053
                     /gene="Slc30a8"
                     /gene_synonym="C820002P14Rik; ZnT-8; ZnT8"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1159
                     /gene="Slc30a8"
                     /gene_synonym="C820002P14Rik; ZnT-8; ZnT8"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1294
                     /gene="Slc30a8"
                     /gene_synonym="C820002P14Rik; ZnT-8; ZnT8"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1971
                     /gene="Slc30a8"
                     /gene_synonym="C820002P14Rik; ZnT-8; ZnT8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtgcgcgc acgcgcgcgc gcacacacac acacacacac acacacacac acacacacac
       61 acacttatta caattgtacc tttgagtctc ccagaaaagc agtttctgtg agtgatagaa
      121 tgagtctagg tgattttcca aggagactgt taattttcac agatttaccc acaacactga
      181 tataggaggc ctcattaact caagtactgg aagaattttt ctaatttctt aggaagttgt
      241 gtgaatataa taatatcagt gcttctttac ttccaaaact ggacagcgca tcaaacatca
      301 gaaacaacag tatcagctcc tgtcccaact accatggagt ttcttgagag aacttatctt
      361 gtgaatgatc aagccaccaa gatgtacgcc ttccctctag acagagaact tcgacagaag
      421 cctgtgaata aagatcagtg tcctggagac aggccagagc atccagaggc aggaggcatc
      481 tatcactgcc acaacagcgc caaggccaca gggaacaggt cgagcaagca agcgcatgcc
      541 aagtggagac tctgtgctgc ttcagcaata tgcttcatct ttatggtggc agaggtggtg
      601 ggtggacacg ttgctgggag tctggctatc ctcactgatg cggctcatct cttaattgac
      661 ctgactagtt tcctgctcag tctcttttct ttgtggttgt catcgaggcc cccttccaag
      721 cggctgacat ttgggtggta tcgagcagag atcctcggtg ccctgctgtc tgtcctttgc
      781 atctgggtgg tgactggtgt gctgctgtac cttgcctgtg agcgcctttt gtatcctgat
      841 taccagatcc aagcaggtat catgatcact gtttcaggct gtgcagtggc agccaacatt
      901 gtactaacta tgattttgca ccaacggaac tttggctaca accacaagga tgtacaagct
      961 aatgccagtg tccgagcagc ctttgtgcat gccctggggg atgtatttca gagcatcagt
     1021 gtgctaatta gtgctctcat tatctacttt aagcctgact acaaaattgc tgatccagtg
     1081 tgcacattta tcttttccat cctggttttg gccagcaccg tcatgatctt aaaagacttc
     1141 tccatcttac tcatggaagg tgttccaaag ggcctgagtt acaacagtgt gaaagagatc
     1201 atcctcgcag ttgatggcgt gatctccgtg cacagtctac acatctggtc actgactgtg
     1261 aaccaagtga ttctctctgt tcatgttgct acagctgcca gccaggacag ccagtctgtg
     1321 cggacaggaa ttgctcaagc cctcagcagc tttgatcttc actctcttac cattcagata
     1381 gaatctgcag cagaccagga ccccagctgc cttctctgcg aagaccctca ggactagctc
     1441 ggtcacactg tcagcttcct gtgtttccta ggccatgata agatgcagca aagtttctgc
     1501 aatgcacaat gaggcagccg tcggaataga tttgagaaag tcatgatgat gcaatgtgca
     1561 cactcttcct ttgtatttat ctctatccac catgaacgag gatgcatggg atttgtcggc
     1621 ttcttggatt atacactaat cagtagttgt gctcaattgt agtatatata gattattcct
     1681 aactggagct gaaataacag atgtttgcaa tcataggtaa tgaatgattc acttgcctac
     1741 aatagtgggt atagttttac tcggaaatgc ctttctagga atccacagca tgagaaacaa
     1801 acatttgaag agaatttgag gccttagaat ttgattctgc caccatactc aatgagatct
     1861 ttattttttg tgaaacagta aaacttccct cttttgacct tgcatgtaaa ttatggtgtt
     1921 gtgtgtgtga agtattgaat tctattttaa ttctatgtgc aaagggtatg g
//
