LOCUS       NM_144798               2156 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus solute carrier family 30 (zinc transporter), member 6
            (Slc30a6), transcript variant 2, mRNA.
ACCESSION   NM_144798
VERSION     NM_144798.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2156)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2156)
  AUTHORS   Zhang,L., Chi,Z.H., Ren,H., Rong,M., Dahlstrom,A., Huang,L. and
            Wang,Z.Y.
  TITLE     Imunoreactivity of zinc transporter 7 (ZNT7) in mouse dorsal root
            ganglia
  JOURNAL   Brain Res Bull 74 (4), 278-283 (2007)
   PUBMED   17720550
  REMARK    GeneRIF: Our results revealed that ZNT7 immunoreactivity was
            abundantly expressed in the nerve cells of the mouse DRG.Double
            immunofluorescence labeling of ZNT7 and TGN38 revealed a
            colocalization of the two antigens in the Golgi apparatus.
REFERENCE   3  (bases 1 to 2156)
  AUTHORS   Lovell,M.A., Smith,J.L. and Markesbery,W.R.
  TITLE     Elevated zinc transporter-6 in mild cognitive impairment, Alzheimer
            disease, and pick disease
  JOURNAL   J Neuropathol Exp Neurol 65 (5), 489-498 (2006)
   PUBMED   16772872
  REMARK    GeneRIF: Increased ZnT-6 immunostaining in neurons containing
            cytoplasmic inclusions in MCI, AD, and PD suggests a role for ZnT-6
            in the pathogenesis of these lesions.
REFERENCE   4  (bases 1 to 2156)
  AUTHORS   Asano,N., Kondoh,M., Ebihara,C., Fujii,M., Nakanishi,T.,
            Soares,M.J., Nakashima,E., Tanaka,K., Sato,M. and Watanabe,Y.
  TITLE     Expression profiles of zinc transporters in rodent placental models
  JOURNAL   Toxicol Lett 154 (1-2), 45-53 (2004)
   PUBMED   15475177
  REMARK    GeneRIF: There were no differences between the mRNA expression
            levels of ZnT family members in undifferentiated Rcho-1 cells and
            differentiated Rcho-1 cells.
REFERENCE   5  (bases 1 to 2156)
  AUTHORS   Wang,Z.Y., Stoltenberg,M., Jo,S.M., Huang,L., Larsen,A.,
            Dahlstrom,A. and Danscher,G.
  TITLE     Dynamic zinc pools in mouse choroid plexus
  JOURNAL   Neuroreport 15 (11), 1801-1804 (2004)
   PUBMED   15257151
  REMARK    GeneRIF: Expression of zinc transporter ZnT6 in mouse choroid
            epithelial cells suggests that the choroid plexus plays an
            important role in regulation of zinc homeostasis in the brain.
REFERENCE   6  (bases 1 to 2156)
  AUTHORS   Kambe,T., Yamaguchi-Iwai,Y., Sasaki,R. and Nagao,M.
  TITLE     Overview of mammalian zinc transporters
  JOURNAL   Cell Mol Life Sci 61 (1), 49-68 (2004)
   PUBMED   14704853
  REMARK    Review article
REFERENCE   7  (bases 1 to 2156)
  AUTHORS   Huang,L., Kirschke,C.P. and Gitschier,J.
  TITLE     Functional characterization of a novel mammalian zinc transporter,
            ZnT6
  JOURNAL   J Biol Chem 277 (29), 26389-26395 (2002)
   PUBMED   11997387
  REMARK    GeneRIF: overexpression of ZnT6 causes growth inhibition, znT6
            functions in zinc homeostasis and transport
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC169506.1, AK082907.1 and CT033749.8.
            
            On Nov 16, 2011 this sequence version replaced NM_144798.5.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the coding region, but maintains the reading frame, compared to
            variant 1. The encoded isoform (2) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082907.1, BC068169.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AC169506.1         201082-201105
            25-1872             AK082907.1         2-1849
            1873-2156           CT033749.8         96906-97189         c
FEATURES             Location/Qualifiers
     source          1..2156
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 45.64 cM"
     gene            1..2156
                     /gene="Slc30a6"
                     /gene_synonym="9530029F08Rik; ZnT6"
                     /note="solute carrier family 30 (zinc transporter), member
                     6"
                     /db_xref="GeneID:210148"
                     /db_xref="MGI:MGI:2386741"
     exon            1..61
                     /gene="Slc30a6"
                     /gene_synonym="9530029F08Rik; ZnT6"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1441
                     /gene="Slc30a6"
                     /gene_synonym="9530029F08Rik; ZnT6"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     transporter-like 3; solute carrier family 30 member 6;
                     zinc transporter 6; solute carrier family 30 (zinc
                     transporter), member 4"
                     /codon_start=1
                     /product="zinc transporter 6 isoform 2"
                     /protein_id="NP_659047.2"
                     /db_xref="CCDS:CCDS37691.1"
                     /db_xref="GeneID:210148"
                     /db_xref="MGI:MGI:2386741"
                     /translation="MGTIHLFRKPQRSFFGKLLQEFRLVAADRRSWKILLFGAINVLC
                     TGFLLMWCSSTNSIALTAYTYLTIFDLFSLITCLISYWVMMRKPSPVYSFGFERLEVL
                     AVFASTVLAQLGALFILKESAERFLEQPEIHTGRLLVGTFVALSFNLFTMLSIRNKPF
                     AYVSEAASTSWLQEHVADLSRSLCGLIPGLSSIFLPRMNPFVLIDLAGAFALCITYML
                     IEINNYFAVDTASAIAIALMTFGTMYPMSVYSGKVLLQTTPPHVIGQLDKLIREVSTL
                     DGVLEVRNEHFWTLGFGSLAGSVHVRIRRDANEQMVLAHVSNRLCTLVSTLTVQIFKD
                     DWIRPALSSGPVAPNVLNFSDHHVIPMPLLKNVDERTPVTSTPAKPSSPPPEFSFNTP
                     GKNVSPVILLNTQTRPYSLGLNRGHTPYSSVFSQGLAFPGVGAGQGLRPTFPHIPSRY
                     GINRMGQPRP"
     exon            62..148
                     /gene="Slc30a6"
                     /gene_synonym="9530029F08Rik; ZnT6"
                     /inference="alignment:Splign:2.1.0"
     exon            149..233
                     /gene="Slc30a6"
                     /gene_synonym="9530029F08Rik; ZnT6"
                     /inference="alignment:Splign:2.1.0"
     exon            234..276
                     /gene="Slc30a6"
                     /gene_synonym="9530029F08Rik; ZnT6"
                     /inference="alignment:Splign:2.1.0"
     exon            277..342
                     /gene="Slc30a6"
                     /gene_synonym="9530029F08Rik; ZnT6"
                     /inference="alignment:Splign:2.1.0"
     exon            343..423
                     /gene="Slc30a6"
                     /gene_synonym="9530029F08Rik; ZnT6"
                     /inference="alignment:Splign:2.1.0"
     exon            424..459
                     /gene="Slc30a6"
                     /gene_synonym="9530029F08Rik; ZnT6"
                     /inference="alignment:Splign:2.1.0"
     exon            460..554
                     /gene="Slc30a6"
                     /gene_synonym="9530029F08Rik; ZnT6"
                     /inference="alignment:Splign:2.1.0"
     exon            555..603
                     /gene="Slc30a6"
                     /gene_synonym="9530029F08Rik; ZnT6"
                     /inference="alignment:Splign:2.1.0"
     exon            604..723
                     /gene="Slc30a6"
                     /gene_synonym="9530029F08Rik; ZnT6"
                     /inference="alignment:Splign:2.1.0"
     exon            724..826
                     /gene="Slc30a6"
                     /gene_synonym="9530029F08Rik; ZnT6"
                     /inference="alignment:Splign:2.1.0"
     exon            827..874
                     /gene="Slc30a6"
                     /gene_synonym="9530029F08Rik; ZnT6"
                     /inference="alignment:Splign:2.1.0"
     exon            875..943
                     /gene="Slc30a6"
                     /gene_synonym="9530029F08Rik; ZnT6"
                     /inference="alignment:Splign:2.1.0"
     exon            944..2156
                     /gene="Slc30a6"
                     /gene_synonym="9530029F08Rik; ZnT6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1573..1578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc30a6"
                     /gene_synonym="9530029F08Rik; ZnT6"
                     /note="hexamer: TATAAA"
     polyA_site      1594
                     /gene="Slc30a6"
                     /gene_synonym="9530029F08Rik; ZnT6"
                     /note="major polyA site"
     regulatory      1910..1915
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc30a6"
                     /gene_synonym="9530029F08Rik; ZnT6"
                     /note="hexamer: AATAAA"
     polyA_site      1936
                     /gene="Slc30a6"
                     /gene_synonym="9530029F08Rik; ZnT6"
ORIGIN      
        1 gcttgagaaa tgcgacttct cagagcgtct tccggcggga gctgtacggc tccttaccat
       61 ggggacgatt catctctttc gaaagccaca gagatctttt tttggaaagt tactacagga
      121 atttagactt gtcgcagctg accggaggtc ctggaagatc cttctgttcg gtgcaatcaa
      181 cgtgctgtgc actggcttcc tgctcatgtg gtgcagctcc accaacagca tcgcattaac
      241 tgcctatact tacctcacca tctttgatct ctttagttta ataacatgtt taataagcta
      301 ctgggtaatg atgaggaaac ctagccctgt ctattcattt gggtttgaaa gattagaagt
      361 cctggctgta tttgcttcta ctgtcttggc acaattggga gccctcttta tactaaaaga
      421 aagtgcagaa cgctttttgg agcagcccga gatacacacg ggaagattgt tagttggtac
      481 ttttgtggcc ctttctttca acctgttcac gatgctttct attcggaata agccttttgc
      541 ttacgtctct gaagctgcta gtacgagctg gcttcaggag cacgtggcag accttagccg
      601 cagcttgtgt ggccttatcc caggactcag cagtatcttc ctgccccgca tgaatccgtt
      661 tgttctgatt gatcttgctg gggcgtttgc tctgtgtata acatacatgc tgattgagat
      721 taataactac tttgccgtgg acactgcgtc agccattgcc attgccctga tgacgtttgg
      781 caccatgtac cccatgagtg tgtacagtgg gaaagtgctc ctccagacaa caccacctca
      841 tgttatcggt cagttggaca aactgattag agaggtgtct accttggatg gggtgctaga
      901 agtccgaaat gaacactttt ggacccttgg atttggctca ttggctgggt cagtgcatgt
      961 acggatccga cgagatgcga acgaacaaat ggtccttgct catgtgagca acaggctgtg
     1021 cacgctggtg tccacgctga ctgttcagat cttcaaggac gactggattc ggcctgcctt
     1081 atcctctggg cctgttgcgc ccaacgtcct aaacttctca gaccatcacg taatcccaat
     1141 gcctttatta aagaacgtgg atgagaggac ccccgtcacg tcaaccccag ccaagcccag
     1201 cagcccacct ccggagtttt catttaatac gcctgggaaa aacgtgagcc cggttattct
     1261 tctgaacaca cagacaaggc catatagttt gggtcttaat cgcggacaca caccatacag
     1321 cagcgtgttc agccaaggac tcgcatttcc aggagttgga gcaggccagg gattgaggcc
     1381 caccttccca catataccaa gtagatatgg aatcaacagg atggggcagc caagaccctg
     1441 acagactcta acttattgtg atggggaata gcgacttctt gccttccaat gtatttagta
     1501 atccaacttg cattgactgt tcaaccactt acatgtcaga ttattccagg cttgttcata
     1561 tttcataaaa cctataaact atatttttgt aaaatgttct tgtggcagtg aggtctttgg
     1621 aaatgtcatg ggcattaggt aggcctcctt caaaaagttt ggatatgagc tgctttgtag
     1681 cagcctatga tgtgatagtc tggcctccag cagtaaagcc atgtgctgag tggatctgca
     1741 tcttaccaaa aattcataat tccttcagta gaatttataa acatacttca tgtatggtgc
     1801 ccaactaagt aaatgaaact taggtgtcca tttgaaaagt aaattctctt ttatagcttt
     1861 ttaaagctta attgctacat tttttgaggc cctcccaaat catttgttaa ataaaaagta
     1921 acagtttcta ttggaagttg tgaggtatat tctactatgt agcacaattt aattattact
     1981 gatcttttga aacaggtttt gctgcataga tcaggctggc ttcaaaccca taatccttct
     2041 gcctcagtct cccacatgcc aggatttagg ttttgagcca ccatagaagt atgtcctaaa
     2101 attttaagta acaggttttg aataaagagt gtttggcttt tttttttttc ccattt
//
