LOCUS       NM_022885               3193 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus solute carrier family 30 (zinc transporter), member 5
            (Slc30a5), mRNA.
ACCESSION   NM_022885
VERSION     NM_022885.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3193)
  AUTHORS   Brommage,R., Liu,J., Hansen,G.M., Kirkpatrick,L.L., Potter,D.G.,
            Sands,A.T., Zambrowicz,B., Powell,D.R. and Vogel,P.
  TITLE     High-throughput screening of mouse gene knockouts identifies
            established and novel skeletal phenotypes
  JOURNAL   Bone Res 2, 14034 (2014)
   PUBMED   26273529
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3193)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   3  (bases 1 to 3193)
  AUTHORS   Nishida,K., Hasegawa,A., Nakae,S., Oboki,K., Saito,H., Yamasaki,S.
            and Hirano,T.
  TITLE     Zinc transporter Znt5/Slc30a5 is required for the mast
            cell-mediated delayed-type allergic reaction but not the
            immediate-type reaction
  JOURNAL   J Exp Med 206 (6), 1351-1364 (2009)
   PUBMED   19451265
  REMARK    GeneRIF: Data suggest that Znt5 is selectively required for the
            mast cell-mediated delayed-type allergic response, and it is a
            novel player in mast cell activation.
REFERENCE   4  (bases 1 to 3193)
  AUTHORS   Corbetta,S., Gualdoni,S., Ciceri,G., Monari,M., Zuccaro,E.,
            Tybulewicz,V.L. and de Curtis,I.
  TITLE     Essential role of Rac1 and Rac3 GTPases in neuronal development
  JOURNAL   FASEB J 23 (5), 1347-1357 (2009)
   PUBMED   19126596
REFERENCE   5  (bases 1 to 3193)
  AUTHORS   Ishihara,K., Yamazaki,T., Ishida,Y., Suzuki,T., Oda,K., Nagao,M.,
            Yamaguchi-Iwai,Y. and Kambe,T.
  TITLE     Zinc transport complexes contribute to the homeostatic maintenance
            of secretory pathway function in vertebrate cells
  JOURNAL   J Biol Chem 281 (26), 17743-17750 (2006)
   PUBMED   16636052
  REMARK    GeneRIF: ZnT5(-)ZnT7(-/-) cells showed exacerbation of the unfolded
            protein response as did the wild-type cells cultured under a
            zinc-deficient condition, revealing that both complexes play a role
            in homeostatic maintenance of secretory pathway function
REFERENCE   6  (bases 1 to 3193)
  AUTHORS   Kambe,T., Yamaguchi-Iwai,Y., Sasaki,R. and Nagao,M.
  TITLE     Overview of mammalian zinc transporters
  JOURNAL   Cell Mol Life Sci 61 (1), 49-68 (2004)
   PUBMED   14704853
  REMARK    Review article
REFERENCE   7  (bases 1 to 3193)
  AUTHORS   Inoue,K., Matsuda,K., Itoh,M., Kawaguchi,H., Tomoike,H., Aoyagi,T.,
            Nagai,R., Hori,M., Nakamura,Y. and Tanaka,T.
  TITLE     Osteopenia and male-specific sudden cardiac death in mice lacking a
            zinc transporter gene, Znt5
  JOURNAL   Hum Mol Genet 11 (15), 1775-1784 (2002)
   PUBMED   12095919
  REMARK    GeneRIF: results indicate that Znt5 protein plays an important role
            in maturation of osteoblasts and in maintenance of the cells
            involved in the cardiac conduction system, partly owing to
            dysregulated expression of IEGs and HSPs
REFERENCE   8  (bases 1 to 3193)
  AUTHORS   Cragg,R.A., Christie,G.R., Phillips,S.R., Russi,R.M., Kury,S.,
            Mathers,J.C., Taylor,P.M. and Ford,D.
  TITLE     A novel zinc-regulated human zinc transporter, hZTL1, is localized
            to the enterocyte apical membrane
  JOURNAL   J Biol Chem 277 (25), 22789-22797 (2002)
   PUBMED   11937503
REFERENCE   9  (bases 1 to 3193)
  AUTHORS   Kambe,T., Narita,H., Yamaguchi-Iwai,Y., Hirose,J., Amano,T.,
            Sugiura,N., Sasaki,R., Mori,K., Iwanaga,T. and Nagao,M.
  TITLE     Cloning and characterization of a novel mammalian zinc transporter,
            zinc transporter 5, abundantly expressed in pancreatic beta cells
  JOURNAL   J Biol Chem 277 (21), 19049-19055 (2002)
   PUBMED   11904301
REFERENCE   10 (bases 1 to 3193)
  AUTHORS   Lacourse,K.A., Swanberg,L.J., Gillespie,P.J., Rehfeld,J.F.,
            Saunders,T.L. and Samuelson,L.C.
  TITLE     Pancreatic function in CCK-deficient mice: adaptation to dietary
            protein does not require CCK
  JOURNAL   Am J Physiol 276 (5), G1302-G1309 (1999)
   PUBMED   10330022
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK051183.1 and AF461761.1.
            
            On Jun 15, 2005 this sequence version replaced NM_022885.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK051183.1, SRR1660813.209490.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3078              AK051183.1         1-3078
            3079-3193           AF461761.1         2978-3092
FEATURES             Location/Qualifiers
     source          1..3193
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 53.23 cM"
     gene            1..3193
                     /gene="Slc30a5"
                     /gene_synonym="1810010K08Rik; ZnT-5; ZNT5; Zntl1; ZTL1"
                     /note="solute carrier family 30 (zinc transporter), member
                     5"
                     /db_xref="GeneID:69048"
                     /db_xref="MGI:MGI:1916298"
     exon            1..327
                     /gene="Slc30a5"
                     /gene_synonym="1810010K08Rik; ZnT-5; ZNT5; Zntl1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..2536
                     /gene="Slc30a5"
                     /gene_synonym="1810010K08Rik; ZnT-5; ZNT5; Zntl1; ZTL1"
                     /note="zinc transporter 5; solute carrier family 30 member
                     5; zinc transporter like 1"
                     /codon_start=1
                     /product="proton-coupled zinc antiporter SLC30A5"
                     /protein_id="NP_075023.2"
                     /db_xref="CCDS:CCDS26739.1"
                     /db_xref="GeneID:69048"
                     /db_xref="MGI:MGI:1916298"
                     /translation="MEEKYGGDARPGPGGGLGPVDVPSARLTRYILLLCLTKCLKAVG
                     LFESYDLLKAVHIVQFIFILKLGTAFFMVLFQKPFSSGKPITKHQWIKIFKHAVAGCI
                     ISLLWFFGLTLCGPLRTLLLFEHSDIVVISLLSVLFTSSGGGPAKTRGAAFFIIAVIC
                     LLLFDNDDLMAKMAEHPEGHHDSALTHMLYTAIAFLGVADHKGGVLLLVLALCCKVGF
                     HTASRKLSIDVGGAKRLQALSQLVSVFLLCPWVIVLSVTTESKVESWFSLIMPFTTVI
                     FFVMILDFYMDSVCSVKMDVSKCARYGSFPIFISALLFGNFWTHPITDQLRAMNRAAH
                     QESTEHVLSGGVVVSAVFFILSANILSSPSKRGQKGTLIGYSPEGTPLYHFMGDAFQH
                     SSQSVPRFIKDSLKQVLEESDSRQIFYFLCLNLLFTFVELFYGVLTNSLGLISDGFHM
                     LFDCSALVMGLFAALMSRWKATRIFSYGYGRIEILSGFINGLFLIVIAFFVFMESVAR
                     LIDPPELDTNMLTPVSVGGLIVNLIGICAFSHAHSHGHGASQGNCHSDHGHSHHAHGH
                     GHDHGHSHGFTGGGMNANMRGVFLHVLADTLGSIGVIVSTVLIEQFGWFIADPLCSLF
                     IAVLIFLSVIPLIKDACQVLLLRLPPDHEKELHIALEKIQKIEGLISYRDPHFWRHSA
                     SIVAGTIHIQVTSEVLEQRIVQQVTGILKDAGVNNLTIQVEKEAYFQHMSGLSTGFHD
                     VLAMTKQMESLKYCKDGTYIM"
     exon            328..450
                     /gene="Slc30a5"
                     /gene_synonym="1810010K08Rik; ZnT-5; ZNT5; Zntl1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            451..517
                     /gene="Slc30a5"
                     /gene_synonym="1810010K08Rik; ZnT-5; ZNT5; Zntl1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..603
                     /gene="Slc30a5"
                     /gene_synonym="1810010K08Rik; ZnT-5; ZNT5; Zntl1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            604..691
                     /gene="Slc30a5"
                     /gene_synonym="1810010K08Rik; ZnT-5; ZNT5; Zntl1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            692..779
                     /gene="Slc30a5"
                     /gene_synonym="1810010K08Rik; ZnT-5; ZNT5; Zntl1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            780..856
                     /gene="Slc30a5"
                     /gene_synonym="1810010K08Rik; ZnT-5; ZNT5; Zntl1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1027
                     /gene="Slc30a5"
                     /gene_synonym="1810010K08Rik; ZnT-5; ZNT5; Zntl1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1316
                     /gene="Slc30a5"
                     /gene_synonym="1810010K08Rik; ZnT-5; ZNT5; Zntl1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1525
                     /gene="Slc30a5"
                     /gene_synonym="1810010K08Rik; ZnT-5; ZNT5; Zntl1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1683
                     /gene="Slc30a5"
                     /gene_synonym="1810010K08Rik; ZnT-5; ZNT5; Zntl1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1813
                     /gene="Slc30a5"
                     /gene_synonym="1810010K08Rik; ZnT-5; ZNT5; Zntl1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..2009
                     /gene="Slc30a5"
                     /gene_synonym="1810010K08Rik; ZnT-5; ZNT5; Zntl1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2236
                     /gene="Slc30a5"
                     /gene_synonym="1810010K08Rik; ZnT-5; ZNT5; Zntl1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2365
                     /gene="Slc30a5"
                     /gene_synonym="1810010K08Rik; ZnT-5; ZNT5; Zntl1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..3179
                     /gene="Slc30a5"
                     /gene_synonym="1810010K08Rik; ZnT-5; ZNT5; Zntl1; ZTL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2961..2966
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc30a5"
                     /gene_synonym="1810010K08Rik; ZnT-5; ZNT5; Zntl1; ZTL1"
                     /note="hexamer: AATAAA"
     polyA_site      2982
                     /gene="Slc30a5"
                     /gene_synonym="1810010K08Rik; ZnT-5; ZNT5; Zntl1; ZTL1"
                     /note="major polyA site"
     regulatory      3156..3161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc30a5"
                     /gene_synonym="1810010K08Rik; ZnT-5; ZNT5; Zntl1; ZTL1"
                     /note="hexamer: AATAAA"
     polyA_site      3179
                     /gene="Slc30a5"
                     /gene_synonym="1810010K08Rik; ZnT-5; ZNT5; Zntl1; ZTL1"
                     /note="major polyA site"
ORIGIN      
        1 ggcggatgac gtggcccggt aacgttcctg cccgtacggc ctccggggaa cggcgctgcc
       61 ggaacagccc gcggcctagt cccgcccagc gtgcgtgtgc ctgcttgccg agcccgggct
      121 agcggcggag actgccgagc ttgcgaggac gctgctgaca tgggggagtg acgcgcctgc
      181 gcccgcgctt ccgcagcggc ggcgagccat gaggagagcc cgcggcgcgg gcagcggctc
      241 ctgagcctgc atggaggaga agtacggcgg ggacgcgcgg cccgggcccg gcggtggcct
      301 cgggccggtg gacgtgccca gcgcccgatt aacaagatac attttattgc tgtgtttaac
      361 caaatgtttg aaggctgtgg gactttttga atcatatgat ctcctaaaag ctgttcacat
      421 tgttcaattt atttttatat taaaacttgg gactgcattt tttatggttt tgtttcaaaa
      481 accgttttct tctgggaaac ctattacaaa gcatcagtgg atcaaaatat ttaaacatgc
      541 agttgctgga tgtatcatat cacttttatg gttttttggc cttactcttt gtggaccact
      601 aaggaccttg ctgctgtttg aacacagtga cattgtcgta atctctctgc tcagtgttct
      661 gttcactagc tctggaggag gaccagcaaa gacaagaggg gctgcttttt tcattattgc
      721 tgtgatctgc ttactgcttt tcgacaatga tgatctcatg gcaaagatgg ctgaacaccc
      781 ggaaggacat catgatagtg ctctaactca catgctctat acagccattg cctttttagg
      841 ggtggcagat cacaagggtg gagtactctt gctggtgctg gctttatgtt gtaaagttgg
      901 ttttcatacg gcttccagaa agctctctat agatgttggt ggagctaagc gccttcaggc
      961 cttatctcag cttgtttctg tgtttctcct gtgcccatgg gtgattgttc tttctgtgac
     1021 gactgagagt aaggttgagt cttggttctc tctcatcatg cctttcacca cagtcatctt
     1081 ttttgtcatg atcctggatt tctatatgga ttctgtttgt tcagtcaaaa tggacgtgtc
     1141 caaatgtgcc cgctatgggt cctttcccat ttttattagt gccctcctgt ttggaaattt
     1201 ctggacacac ccaataacag accaactccg ggctatgaac agagcagcac accaggagag
     1261 cacagagcac gtcctgtctg gaggagtggt agtgagcgct gtgttcttca ttttgtcggc
     1321 caacattcta tcatctccct ctaagagagg acagaaaggt acccttattg gatattctcc
     1381 tgaaggaaca ccactctatc acttcatggg ggacgctttt cagcacagct ctcagtcggt
     1441 gcctaggttc attaaggact cactaaagca ggttctcgag gagagcgact ctaggcagat
     1501 cttttacttc ttgtgcttga atctgctttt tacctttgtg gagttgttct atggcgtgct
     1561 aaccaacagt ctaggcctga tctcagatgg atttcacatg ctctttgact gctcggcttt
     1621 ggtcatggga ctgtttgctg ccctgatgag ccgctggaaa gccacccgga ttttctccta
     1681 tgggtatggc cgaatagaga ttctctctgg ctttattaat gggctttttc tgatcgtgat
     1741 agcatttttt gtgtttatgg aatcagtggc tagactgatc gatcctccgg aactagacac
     1801 aaacatgctg acaccagttt ccgtcggagg gctgatagta aaccttattg gtatctgtgc
     1861 cttcagccac gcccacagcc atggccatgg cgcttctcaa ggaaactgcc actctgatca
     1921 cggccattca caccatgcac atggacacgg ccatgatcac ggtcacagcc acggcttcac
     1981 gggtggaggc atgaatgcga acatgagggg tgtatttctc catgtgttgg cagacacact
     2041 gggcagcatc ggcgtgattg tgtccacagt tctcatagag cagtttggat ggttcattgc
     2101 tgatcccctg tgttctcttt ttattgccgt gttgatattt ctcagtgtga tcccactgat
     2161 taaagatgcc tgtcaagttc tacttctgag actaccacct gaccatgaaa aagaactgca
     2221 tattgcttta gaaaagatac agaaaattga gggattaata tcataccgag accctcattt
     2281 ttggcgccat tctgccagta ttgtagcggg aacaattcat atacaagtga catctgaggt
     2341 gctggagcag agaattgtac agcaggttac agggatactt aaagatgcag gagtaaacaa
     2401 cctaaccata caagtggaaa aggaggcata ctttcagcat atgtccggcc tgagtactgg
     2461 atttcatgat gttctggcta tgacgaagca gatggaatcc ctgaaatact gcaaagatgg
     2521 cacttacatc atgtgagacg cagccctgcg gcatgaacag tgaacagcgg aggtcggatg
     2581 aggtgataat gtcagagcag agtgaaagtt gcacataatt gtacgaaaac tttttaagct
     2641 ccctactgtt agattaagga gtctgtttta aaagaaaatt gagatgcaga atgaagcatt
     2701 cattgaataa gaaaattgtc gctctgtttg aattatgtgc ttgaaaggaa tcttgcattg
     2761 gaatgaacat gatgtaaccg tacacatcat cttcaggaat ggacgcataa tgatggattc
     2821 tggtgaagac caaaatttct tctgtgcatt tactctcagt caggaagcat ccccactgta
     2881 aatatgtatt tacatgttta ttacaaagac tcagatgaag tttttagtcg attttttgca
     2941 tatctgaagg acaaaatgag aataaaattc tatatttatg aattttctgt atataaaact
     3001 aatttctaat tataacttaa gtctttaagt acaagctgta tatctacttg aaatgtaaac
     3061 tattcaggag aaattacaac cactgatttg agataaagag aatagagaac tatgatatag
     3121 ttcttggtgt atttcaagat ttaaccactc cattaaataa atttttttta tttttggtaa
     3181 aaaaaaaaaa aaa
//
