LOCUS       NM_011773               2006 bp    mRNA    linear   ROD 08-NOV-2023
DEFINITION  Mus musculus solute carrier family 30 (zinc transporter), member 3
            (Slc30a3), transcript variant 1, mRNA.
ACCESSION   NM_011773
VERSION     NM_011773.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2006)
  AUTHORS   Wu S, Liu C, Tang J, Wu C, Zhang Q, Liu Z, Han J, Xue J, Lin J,
            Chen Y, Yang J, Zhuo Y and Li Y.
  TITLE     Tafluprost promotes axon regeneration after optic nerve crush via
            Zn2+-mTOR pathway
  JOURNAL   Neuropharmacology 242, 109746 (2023)
   PUBMED   37832634
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 2006)
  AUTHORS   Bender PTR, McCollum M, Boyd-Pratt H, Mendelson BZ and Anderson CT.
  TITLE     Synaptic zinc potentiates AMPA receptor function in mouse auditory
            cortex
  JOURNAL   Cell Rep 42 (8), 112932 (2023)
   PUBMED   37585291
REFERENCE   3  (bases 1 to 2006)
  AUTHORS   Kouvaros S, Bizup B, Solis O, Kumar M, Ventriglia E, Curry FP,
            Michaelides M and Tzounopoulos T.
  TITLE     A CRE/DRE dual recombinase transgenic mouse reveals synaptic
            zinc-mediated thalamocortical neuromodulation
  JOURNAL   Sci Adv 9 (23), eadf3525 (2023)
   PUBMED   37294760
REFERENCE   4  (bases 1 to 2006)
  AUTHORS   Wu T, Kumar M, Zhang J, Zhao S, Drobizhev M, McCollum M, Anderson
            CT, Wang Y, Pokorny A, Tian X, Zhang Y, Tzounopoulos T and Ai HW.
  TITLE     A genetically encoded far-red fluorescent indicator for imaging
            synaptically released Zn2
  JOURNAL   Sci Adv 9 (9), eadd2058 (2023)
   PUBMED   36857451
REFERENCE   5  (bases 1 to 2006)
  AUTHORS   Wu X, Sosunov AA, Lado W, Teoh JJ, Ham A, Li H, Al-Dalahmah O, Gill
            BJA, Arancio O, Schevon CA, Frankel WN, McKhann GM 2nd, Sulzer D,
            Goldman JE and Tang G.
  TITLE     Synaptic hyperexcitability of cytomegalic pyramidal neurons
            contributes to epileptogenesis in tuberous sclerosis complex
  JOURNAL   Cell Rep 40 (3), 111085 (2022)
   PUBMED   35858542
REFERENCE   6  (bases 1 to 2006)
  AUTHORS   Chen H, Bagri A, Zupicich JA, Zou Y, Stoeckli E, Pleasure SJ,
            Lowenstein DH, Skarnes WC, Chedotal A and Tessier-Lavigne M.
  TITLE     Neuropilin-2 regulates the development of selective cranial and
            sensory nerves and hippocampal mossy fiber projections
  JOURNAL   Neuron 25 (1), 43-56 (2000)
   PUBMED   10707971
REFERENCE   7  (bases 1 to 2006)
  AUTHORS   Cole TB, Wenzel HJ, Kafer KE, Schwartzkroin PA and Palmiter RD.
  TITLE     Elimination of zinc from synaptic vesicles in the intact mouse
            brain by disruption of the ZnT3 gene
  JOURNAL   Proc Natl Acad Sci U S A 96 (4), 1716-1721 (1999)
   PUBMED   9990090
REFERENCE   8  (bases 1 to 2006)
  AUTHORS   Wenzel HJ, Cole TB, Born DE, Schwartzkroin PA and Palmiter RD.
  TITLE     Ultrastructural localization of zinc transporter-3 (ZnT-3) to
            synaptic vesicle membranes within mossy fiber boutons in the
            hippocampus of mouse and monkey
  JOURNAL   Proc Natl Acad Sci U S A 94 (23), 12676-12681 (1997)
   PUBMED   9356509
REFERENCE   9  (bases 1 to 2006)
  AUTHORS   Wightman PJ, Hayward BE and Bonthron DT.
  TITLE     The genes encoding glucokinase regulatory protein and
            ketohexokinase co-localize to mouse chromosome 5
  JOURNAL   Mamm Genome 8 (9), 700-701 (1997)
   PUBMED   9271679
REFERENCE   10 (bases 1 to 2006)
  AUTHORS   Palmiter RD, Cole TB, Quaife CJ and Findley SD.
  TITLE     ZnT-3, a putative transporter of zinc into synaptic vesicles
  JOURNAL   Proc Natl Acad Sci U S A 93 (25), 14934-14939 (1996)
   PUBMED   8962159
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY718969.1, AK165796.1, BC066199.1 and U76007.1.
            
            [WARNING] On Nov 18, 2023 this sequence was replaced by
            NM_011773.4.
            
            On Jul 16, 2008 this sequence version replaced NM_011773.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U76007.1, AK144568.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                BY718969.1         3-40
            39-1357             AK165796.1         2-1320
            1358-1985           BC066199.1         1340-1967
            1986-2006           U76007.1           1932-1952
FEATURES             Location/Qualifiers
     source          1..2006
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 16.97 cM"
     gene            1..2006
                     /gene="Slc30a3"
                     /gene_synonym="Znt3"
                     /note="solute carrier family 30 (zinc transporter), member
                     3"
                     /db_xref="GeneID:22784"
                     /db_xref="MGI:MGI:1345280"
     exon            1..265
                     /gene="Slc30a3"
                     /gene_synonym="Znt3"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1337
                     /gene="Slc30a3"
                     /gene_synonym="Znt3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     znT-3; solute carrier family 30 member 3; zinc transporter
                     3; probable proton-coupled zinc antiporter SLC30A3"
                     /codon_start=1
                     /product="probable proton-coupled zinc antiporter SLC30A3
                     isoform 1"
                     /protein_id="NP_035903.2"
                     /db_xref="CCDS:CCDS51455.1"
                     /db_xref="GeneID:22784"
                     /db_xref="MGI:MGI:1345280"
                     /translation="MEPSLATGGSETTRLVSARDRSSAGGGLRLKSLFTEPSEPLPEE
                     PKLEGMAFHHCHKDPVPQSGLSPERVQARRQLYAACAVCFIFMAGEVVGGYLAHSLAI
                     MTDAAHLLADIGSMLASLFSLWLSTRPATRTMTFGWHRSETLGALASVVSLWIVTGIL
                     LYLAFLRLLHSDYHIEAGAMLLTASIAVCANLLMAFVLHQTGAPHSHGSTGAEYAPLE
                     EGHGYPMSLGNTSVRAAFVHVLGDLLQSFGVLAASILIYFKPQYKVADPISTFLFSIC
                     ALGSTAPTLRDVLLVLMEGAPRSVEFEPVRDTLLSVPGVRATHDLHLWALTLTYHVAS
                     AHLAIDSTADPEAVLAEASSRLYSRFGFSSCTLQVEQYQPEMAQCLRCQEPSQA"
     exon            266..447
                     /gene="Slc30a3"
                     /gene_synonym="Znt3"
                     /inference="alignment:Splign:2.1.0"
     exon            448..594
                     /gene="Slc30a3"
                     /gene_synonym="Znt3"
                     /inference="alignment:Splign:2.1.0"
     exon            595..748
                     /gene="Slc30a3"
                     /gene_synonym="Znt3"
                     /inference="alignment:Splign:2.1.0"
     exon            749..947
                     /gene="Slc30a3"
                     /gene_synonym="Znt3"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1053
                     /gene="Slc30a3"
                     /gene_synonym="Znt3"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1188
                     /gene="Slc30a3"
                     /gene_synonym="Znt3"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..2001
                     /gene="Slc30a3"
                     /gene_synonym="Znt3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggccgcgg gctctgcagt tcggactccg agcgccacag tcgccgcagt tccctccaca
       61 ctggtggccc agcggggagt ccgagtggtc cttggaccgc tcggatttgg cgcaaggcct
      121 gccccgcctc tccccctctg tgcggcctag acggtctggg cagcggggac atggagcctt
      181 ctctggccac cggaggctcg gagaccaccc gcctagtgag tgcccgagac cgcagcagcg
      241 ctggcggcgg cctgcgattg aagagtcttt tcacagagcc ctcagagccc ctgcctgagg
      301 agcccaagct tgaggggatg gccttccacc actgccacaa ggaccccgtg cctcagtcag
      361 gcctctctcc agagagggtg caagcccgga ggcagctgta tgccgcctgc gctgtgtgct
      421 tcatcttcat ggccggggag gtggttggtg ggtatttagc acacagcttg gccatcatga
      481 ctgatgccgc ccacttgcta gcagacatag gcagcatgtt ggccagcctc ttttccctct
      541 ggctttccac tcggccagcc acccgcacca tgacctttgg ctggcaccgc tcagagactc
      601 tgggagcttt ggcctctgtg gtctccctct ggatagtcac tggcatcctc ctgtacctgg
      661 ccttcctccg cctgcttcat agtgactatc acattgaggc gggtgccatg ctgctgactg
      721 ccagcatcgc tgtctgtgcc aatctgctaa tggcctttgt gctgcaccag actggagccc
      781 cccacagcca tggatctaca ggtgcagagt atgcacctct agaggaaggg catggatacc
      841 caatgtccct gggaaacacg agtgtccggg ctgcctttgt gcatgtgctg ggagacctcc
      901 ttcagagctt tggggtcctg gcagcctcga tcctcatcta cttcaagcct cagtacaagg
      961 tagctgaccc catcagcacc ttcctcttct ccatctgcgc ccttgggtcc acagctccca
     1021 cacttcgaga tgttctcctt gtcctcatgg aaggcgcccc tcggagtgtg gaatttgaac
     1081 ccgtaaggga caccttgttg tccgtgccgg gagtccgagc aacccatgat ctccatctgt
     1141 gggccctgac gcttacttac cacgttgcct ctgcacacct ggctattgac tccacggctg
     1201 accctgaagc tgtcctggct gaagcctcat cccggctcta ttcccggttt ggattctcca
     1261 gctgcaccct gcaggtggag caataccagc ctgagatggc ccagtgtctg cgctgccagg
     1321 agccctccca agcctgagcc tcagccccac cctcacccca ctgccaggcc caggctctcg
     1381 cctggactct cagcacctgc ctcccagatc agaagggacc tctctctctc tccatcttcc
     1441 acctgccaaa agccctagcc catgccctgg tggccaagac caaagtgtat atgaaggcaa
     1501 tggggggagg ggaggctcag attgaatagc tgtaagcagt tcagggctgt ggggcgtgtg
     1561 gaagccctgc catccatgct ccacatggag agtcatgctt gtccctctac gattcatgtg
     1621 tccctgtggc aggctggctg gctagctggg gacatctgcc tgtctgtgtg ctgtttatgt
     1681 gtgcctgtgc ctggggaggt catcaggggc ccccctcccc atgtgaccct tgctctgtct
     1741 atgcagcggc cccaaagcct gcactttgtt tgtgtgccct agtcctgtgg ttttgtctgt
     1801 tgtgaatgtg tgttctttgg tgctgtggcc tgtgtgtccc tgtgcctgtg tagctgtgct
     1861 ggtttgtgag tctgctccac ctgtgtgtcc atatgggatc tgtctgtcca tccctgtgtt
     1921 ggtgctgtgt cctcagcttt ccccaaggga gagggaggac tccactgcag ctccacaaat
     1981 aaaaacttgg atctaactgt aaaaaa
//
