LOCUS       NM_001033286            5836 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus solute carrier family 30, member 10 (Slc30a10), mRNA.
ACCESSION   NM_001033286 XM_136506 XM_916382 XM_924244 XM_924247 XM_924250
VERSION     NM_001033286.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5836)
  AUTHORS   Hutchens,S., Melkote,A., Jursa,T., Shawlot,W., Trasande,L.,
            Smith,D.R. and Mukhopadhyay,S.
  TITLE     Elevated thyroid manganese reduces thyroid iodine to induce
            hypothyroidism in mice, but not rats, lacking SLC30A10 transporter
  JOURNAL   Metallomics 16 (7) (2024)
   PUBMED   38866719
  REMARK    GeneRIF: Elevated thyroid manganese reduces thyroid iodine to
            induce hypothyroidism in mice, but not rats, lacking SLC30A10
            transporter.
REFERENCE   2  (bases 1 to 5836)
  AUTHORS   Prajapati,M., Zhang,J.Z., Chiu,L., Chong,G.S., Mercadante,C.J.,
            Kowalski,H.L., Delaney,B., Anderson,J.A., Guo,S., Aghajan,M. and
            Bartnikas,T.B.
  TITLE     Hepatic HIF2 is a key determinant of manganese excess and
            polycythemia in SLC30A10 deficiency
  JOURNAL   JCI Insight 9 (10), e169738 (2024)
   PUBMED   38652538
  REMARK    GeneRIF: Hepatic HIF2 is a key determinant of manganese excess and
            polycythemia in SLC30A10 deficiency.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5836)
  AUTHORS   Prajapati,M., Quenneville,C.B., Zhang,J.Z., Chong,G.S., Chiu,L.,
            Ma,B., Ward,L.D., Tu,H.C. and Bartnikas,T.B.
  TITLE     AAV-mediated hepatic expression of SLC30A10 and the Thr95Ile
            variant attenuates manganese excess and other phenotypes in
            Slc30a10-deficient mice
  JOURNAL   J Biol Chem 300 (3), 105732 (2024)
   PUBMED   38336290
  REMARK    GeneRIF: AAV-mediated hepatic expression of SLC30A10 and the
            Thr95Ile variant attenuates manganese excess and other phenotypes
            in Slc30a10-deficient mice.
REFERENCE   4  (bases 1 to 5836)
  AUTHORS   Warden,A., Mayfield,R.D., Gurol,K.C., Hutchens,S., Liu,C. and
            Mukhopadhyay,S.
  TITLE     Loss of SLC30A10 manganese transporter alters expression of
            neurotransmission genes and activates hypoxia-inducible factor
            signaling in mice
  JOURNAL   Metallomics 16 (2) (2024)
   PUBMED   38285613
  REMARK    GeneRIF: Loss of SLC30A10 manganese transporter alters expression
            of neurotransmission genes and activates hypoxia-inducible factor
            signaling in mice.
REFERENCE   5  (bases 1 to 5836)
  AUTHORS   Shi,J.H., Chen,Y.X., Feng,Y., Yang,X., Lin,J., Wang,T., Wei,C.C.,
            Ma,X.H., Yang,R., Cao,D., Zhang,H., Xie,X., Xie,Z. and Zhang,W.J.
  TITLE     Fructose overconsumption impairs hepatic manganese homeostasis and
            ammonia disposal
  JOURNAL   Nat Commun 14 (1), 7934 (2023)
   PUBMED   38040719
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5836)
  AUTHORS   Taylor,C.A., Hutchens,S., Liu,C., Jursa,T., Shawlot,W., Aschner,M.,
            Smith,D.R. and Mukhopadhyay,S.
  TITLE     SLC30A10 transporter in the digestive system regulates brain
            manganese under basal conditions while brain SLC30A10 protects
            against neurotoxicity
  JOURNAL   J Biol Chem 294 (6), 1860-1876 (2019)
   PUBMED   30559290
  REMARK    GeneRIF: when manganese levels increase, activity of SLC30A10 in
            the brain protects against neurotoxicity
REFERENCE   7  (bases 1 to 5836)
  AUTHORS   Liu,C., Hutchens,S., Jursa,T., Shawlot,W., Polishchuk,E.V.,
            Polishchuk,R.S., Dray,B.K., Gore,A.C., Aschner,M., Smith,D.R. and
            Mukhopadhyay,S.
  TITLE     Hypothyroidism induced by loss of the manganese efflux transporter
            SLC30A10 may be explained by reduced thyroxine production
  JOURNAL   J Biol Chem 292 (40), 16605-16615 (2017)
   PUBMED   28860195
  REMARK    GeneRIF: the hypothyroidism phenotype of Slc30a10 single knockouts
            is induced by elevated thyroid manganese, which blocks thyroxine
            production. These findings provide new insights into the mechanisms
            of manganese detoxification and manganese-induced thyroid
            dysfunction.
REFERENCE   8  (bases 1 to 5836)
  AUTHORS   Go,S., Kurita,H., Yokoo,K., Inden,M., Kambe,T. and Hozumi,I.
  TITLE     Protective function of SLC30A10 induced via PERK-ATF4 pathway
            against 1-methyl-4-phenylpyridinium
  JOURNAL   Biochem Biophys Res Commun 490 (4), 1307-1313 (2017)
   PUBMED   28688763
  REMARK    GeneRIF: SLC30A10 has a protective role in
            1-methyl-4-phenylpyridinium-induced toxicity via PERK-ATF4 pathway.
REFERENCE   9  (bases 1 to 5836)
  AUTHORS   Hutchens,S., Liu,C., Jursa,T., Shawlot,W., Chaffee,B.K., Yin,W.,
            Gore,A.C., Aschner,M., Smith,D.R. and Mukhopadhyay,S.
  TITLE     Deficiency in the manganese efflux transporter SLC30A10 induces
            severe hypothyroidism in mice
  JOURNAL   J Biol Chem 292 (23), 9760-9773 (2017)
   PUBMED   28461334
  REMARK    GeneRIF: discovery highlights the importance of determining the
            role of thyroid dysfunction in the onset and progression of
            manganese-induced disease and identifies Slc30a10 knock-out mice as
            a new model for studying thyroid biology.
REFERENCE   10 (bases 1 to 5836)
  AUTHORS   Zhao,Y., Feresin,R.G., Falcon-Perez,J.M. and Salazar,G.
  TITLE     Differential Targeting of SLC30A10/ZnT10 Heterodimers to
            Endolysosomal Compartments Modulates EGF-Induced MEK/ERK1/2
            Activity
  JOURNAL   Traffic 17 (3), 267-288 (2016)
   PUBMED   26728129
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB665136.1, AK136932.1 and AC131980.9.
            
            On Jan 14, 2006 this sequence version replaced NM_001033286.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.112266.1, AK136932.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               BB665136.1         2-215
            215-2853            AK136932.1         23-2661
            2854-5836           AC131980.9         106796-109778       c
FEATURES             Location/Qualifiers
     source          1..5836
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 89.53 cM"
     gene            1..5836
                     /gene="Slc30a10"
                     /gene_synonym="E130106K10Rik; Gm212"
                     /note="solute carrier family 30, member 10"
                     /db_xref="GeneID:226781"
                     /db_xref="MGI:MGI:2685058"
     exon            1..832
                     /gene="Slc30a10"
                     /gene_synonym="E130106K10Rik; Gm212"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..1629
                     /gene="Slc30a10"
                     /gene_synonym="E130106K10Rik; Gm212"
                     /note="zinc transporter 10; znT-10"
                     /codon_start=1
                     /product="calcium/manganese antiporter SLC30A10"
                     /protein_id="NP_001028458.1"
                     /db_xref="CCDS:CCDS15599.1"
                     /db_xref="GeneID:226781"
                     /db_xref="MGI:MGI:2685058"
                     /translation="MGRYSGKTCRLLFMLVLTAAFFVAELVSGYLGNSIALLSDSFNM
                     LSDLISLCVGLGSGYIARRGPRGSSATYGYVRAEVVGALSNAVFLTALCFTIFVEAVL
                     RLARPERIDDPELVLIVGALGLAVNVVGLLIFQDCGACFSRCTRGRRTRPSQQPSQGD
                     PRGALGCPQEAATATAPGSGTAVTLRGSSAGRKQQEGATVFSNVAGDSLNTENEPEET
                     TKKEKKSEALNIRGVLLHVMGDALGSVVVVITAIIFYVQPLRREDPCNWQCYIDPSLT
                     VVMVIIILSSAFPLIKETAVILLQMVPKGVNMEELMSQLSTVPGISSVHEVHIWELIS
                     GKIIATLHIKHQKGTEYQDASRKIREIFHHAGIHNVTIQFETLDLKEALEQKDFLLTC
                     SAPCITQSCAKKLCCPPGTLPLALVNGCAEHNGRSSRESYRSIEAPEVAIDVDGCPRE
                     QGQTLSKTQERQHYENSTHF"
     exon            833..910
                     /gene="Slc30a10"
                     /gene_synonym="E130106K10Rik; Gm212"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1150
                     /gene="Slc30a10"
                     /gene_synonym="E130106K10Rik; Gm212"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..5836
                     /gene="Slc30a10"
                     /gene_synonym="E130106K10Rik; Gm212"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2800..2805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc30a10"
                     /gene_synonym="E130106K10Rik; Gm212"
                     /note="hexamer: AATAAA"
     polyA_site      2824
                     /gene="Slc30a10"
                     /gene_synonym="E130106K10Rik; Gm212"
     regulatory      5813..5818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc30a10"
                     /gene_synonym="E130106K10Rik; Gm212"
                     /note="hexamer: ATTAAA"
     polyA_site      5836
                     /gene="Slc30a10"
                     /gene_synonym="E130106K10Rik; Gm212"
                     /note="major polyA site"
ORIGIN      
        1 aaatcaagct tgggcggcga gggaggaggg gcaggggccc cgggaggtgg cctttgcgac
       61 tctggggcca ctcctgcaga ctctggtccc gcgagcgcga gctggaagca taaaaggtcc
      121 gggcgggtaa gggcgggcct gcagcaggag gtgggctcca gaccgccccc cccacccccc
      181 ccgccaacct gttgcggggc gcagcgggct gtagagatgg gccgttactc aggcaagacg
      241 tgccggctgc tgttcatgct ggtgctcacc gcggccttct tcgtggccga gctggtgtcg
      301 ggttacctgg gcaactccat cgcgctgctc tcggactcgt tcaacatgct gtcagacctg
      361 atctcgctgt gcgtgggcct gggctccggc tacatcgcgc ggcgcggtcc ccgcggctcc
      421 agtgccacct acggctacgt gcgggccgag gtggtgggcg cgctcagcaa cgcagtcttc
      481 ctcactgcgc tctgcttcac catcttcgtg gaggccgtgt tgcgccttgc gcggcccgag
      541 cgcatcgacg acccggagct ggtgcttatc gtgggagccc tggggctggc ggtcaacgtg
      601 gtggggctgc tcatcttcca ggactgcggc gcctgcttct cccgctgcac gcggggtcgc
      661 cggacccgcc cttcgcagca gccaagccag ggggatcctc gtggcgcttt ggggtgtccc
      721 caagaggctg cgacagccac agctcctggc tcgggcacag cagtgactct ccgggggtcc
      781 tcggccggaa gaaagcagca ggagggcgcg accgtgttct ctaatgtagc aggtgattcc
      841 ctgaacaccg agaatgaacc agaagagacg acgaaaaaag agaagaagtc tgaagcactc
      901 aatatcagag gtgttctttt gcacgtgatg ggagatgcct tggggtccgt ggttgtggtc
      961 atcacggcta tcatattcta tgttcagccc ctgagacgtg aagacccgtg taactggcag
     1021 tgctacattg accccagttt gactgttgtc atggtcatca ttatcttatc gtcagctttc
     1081 ccactgatca aagagactgc tgtcatcttg ctgcagatgg tccccaaggg ggtcaacatg
     1141 gaagagctga tgagccagct gtctaccgtg cctgggatta gcagtgtgca tgaagtgcac
     1201 atctgggaac ttataagtgg gaagatcatt gccaccttgc acatcaaaca ccagaagggc
     1261 acggaatacc aggatgccag cagaaaaatc cgagagatct tccaccatgc tggaatccac
     1321 aacgtgacta tccagttcga aaccctggac ttgaaggaag ccctggagca gaaggacttc
     1381 ttgctgacct gcagtgctcc ctgcatcacc cagagctgcg ctaagaagct gtgctgtccc
     1441 ccggggacac tgcctctggc tctcgtcaac ggttgtgcag agcacaatgg caggtcctct
     1501 cgagagtctt accgaagcat agaagctcca gaagtggcca tcgatgtgga tggctgtcca
     1561 agggagcagg gacagactct cagcaagact caggagagac aacattatga aaacagtact
     1621 catttttagt gggttcccac acaattcaaa atgtctgaac agacactttg gtgtcaccag
     1681 ctctgcttat gggaagagct ttgtgggtgt gtatcctgtc agtaggggtc agctgtttga
     1741 gatgttagtg gaacaagcct gctgattttc atgtgatgga taaccccttt ccagtaccct
     1801 gggcatctca tggttttctg tgacagtttc agtatggaca tgaacttcct aaagcagatt
     1861 gccctaatgt atataccagg agtgctgaag gactcagtga ctatgacatg ggactcgaag
     1921 tcggtcttgt ctgtcttgtg gtgctgggga attgcataca gggcttgtgc atgctaagga
     1981 actgctctgt taccgagatg aaccctgtag cctttgcttt taaacccatc ggaacttcta
     2041 gctgactctc aagcgagctc aaagcttaag tgggtagaaa agaagttaag caccttatgt
     2101 ttccttctct tcccctcaaa gaccataaaa ggtgaacgtc agcttattta tagcacttat
     2161 agaacttata gcattgcaga agtatatatt cttaagtcca ttcttggacc gtgagacatg
     2221 aacacctaat aaatgaatgc aaaatgcata gctattaaga tggaaagaca gattgcctct
     2281 taagacaggg agtgctctca aaacattaga gggggtacgc tttgctgagg tggagggaaa
     2341 ggtgggttct ggactgttgc tttgctttgt gaggtggcta aagtttactt cctgctggaa
     2401 ctaagctgcg gctatgatgt gttccttctc cttttcttat ttaccaagtt atcatctctg
     2461 aaagtttcca ggtaggattg ttgccgcatc tagttctgat aatgattttc ttatccagaa
     2521 ttcctcacag tcttttatga tcacattgat ctgtgcagca ttgatcaggg ggagatgaat
     2581 cttctgggaa tgggagaata ctcattcttg ctaaacaaat aagctagctt gcctttgctt
     2641 taattaggca tattttaaag tatttattgc agttgccaac tagtaactgg gtggaaaagt
     2701 taatttccca gtgagaaatg aaaagtaatt tggttgctga ctttaatgtg ttcagaggct
     2761 cttagagttt tatgtctgtg acccatgtta ctaagttcaa ataaattatg atctgattca
     2821 ggcacataac tgaactgtat tgagagaaga aagtgcaaaa aatgtctgtc ccgtgttttt
     2881 ataccttgtt tggcatccat gtttaaatca aagcctcaga ggtatgacat gggggtacct
     2941 gatggagcca acatcttgtt agacaagttt caaggctcac tgaaagtggt cttgtcgtag
     3001 gctttgatcc ttctgagaaa ctacatagga ttcatcagaa gtggtgcacg gtcacagaaa
     3061 aggcagccac acttgtcaat gtaagcatca ttttaaagaa aatgccttca ttgggcacca
     3121 tggcgcatgc ctatagtccc ggctactcag gaggctgaga cagaagagtt gcttgagcct
     3181 aggagttcaa aaccagccca ggcaaaatgg tgcgactcag ggtgttttgt tttgtgtttt
     3241 taatattagt cttaaatttg gaggctgatg ggcagctgtg atctgggtta ttgggaaatc
     3301 tttgttcctt agaagttgat tagatctaaa ccaaccaccc ataagtaaat agaaaaatat
     3361 ctaaagcctt tctaattccc agaagtttat tgtgttagat tatgtatgca ctttataagc
     3421 cagaggagga aaaaagacaa agtttctact ttaggcacca aacctgtgaa gtagacttac
     3481 agggaccaga ggattcccca ggaagcccag cgtggggatg tgcatgcaga tgccgctgct
     3541 gtgccaactc tgttccatgc cttagttgaa gccaaagtag aaatttgtct ctaatgtcca
     3601 aatctcaatt cactgtgcct tattcttaaa ggaaaagaat gataatttta cagtttctcc
     3661 tactagctag aggaatgtat tttagtttgc atgtaaataa catcctttaa tttctgaagt
     3721 actttttttt ttatggaaag aaagtacact tagttccaac ataattaaat ttaaccttga
     3781 ttgacactca actagcaaat tatagacagg agccagtatg aagacagcca gagcatgttt
     3841 actaattgga cattagttga aagggttcga tgcttttgct acatggctgt gtttaacacc
     3901 tccaccctgg ctgcctggtg tttttgtctg gggtttcctg catccgtgat tgtcttgatt
     3961 tttaattctc tgaagaagag cttgatgttt tcccctccct ggatcagctg tgcacctggt
     4021 ggacaagacg atctcgtttc tttgagcctg tgtaaacact gaccttcagt tcacgccctg
     4081 catgctcagg ttcatcctag agcccctccc accttcctcc ttcctgcctg tcctccacat
     4141 ttcccctgga aggggtggtg ctcaggccca ggtccttcaa ggctgtgagg cacgttttac
     4201 tgatgagcta caatccccaa ccccaaagac taattttcta tagtctgtgt cacaccctgt
     4261 atgggacagg ttagtattag gtgtcctgcg tgccatcctt ctaggatttt tcgtgctttc
     4321 ctgtatttgt ttctctgtgg agcacagcac ttccttccag cgcgtcagca ccagttgtag
     4381 gaaagaattg cttcccttcc cttcacatct tccaatcgga gtttttaaaa ctgggatatt
     4441 tcttgacaat ttggttatta tgaacacaca cagggatacc aatctccatt acacacacac
     4501 acacacacac acacacacac acacacacac actgcaaatt aggaacttca agattcaatg
     4561 gagtgggtgt tagggagttt ccatcttgat acgttggcat tctgagctag gtgtgtccag
     4621 gtcatattat gtattattta gtagcattgt tgatttctag tcacaactcc caaatcatct
     4681 tcccaagcta tgacaaccaa aagttcctct agacattgtc atgtattccc tggggggggg
     4741 gggagggcac taccaaccct tctctatttc taaacctcga gctataatca tatttaagca
     4801 ttattgatgg atctgctcct cccaagtcca atagtgtact ctattctgca ggattcatag
     4861 cctcccccca cccccagcct ggaactctct gtcctgcagc cccagcctcc tgagttcagg
     4921 ttttataggc atccgtcacc atacttacat caggatttac tgtttacgag cagtatttta
     4981 acaggacttt catttgctgt gctgaggctt gaagccaccc ttgctacagg gacacgcact
     5041 tggagggaag ctcttagtaa cctgaggcag ccactgatca catagtaagc ttgagactag
     5101 cctttctacg tgagacttga gttaggttgc actttgtatt tgggttttga atctggttag
     5161 caatcactga cgtgtgcctt ctctagagct ctgtcattgc cttatgtcct gtcacccttt
     5221 gtgcttcaga gtgtatttcc actcaagtga ccatgagtgg gaacaaggtg gtcaaaccgg
     5281 gaaagcagtt tcttaagcag aacctgtatc ggatccaaat cttcagtgta gaaaatgttc
     5341 ttagcatctg gaaaatatat gttgttttct ggcatttcct ctctttctaa ctaccctacc
     5401 ctgacccaag actttctatt tacatggact tttcttagtt aggtgggact ggcgccttca
     5461 tgccagagtc gctgaatggc ctctgaactg gagtgagcac tatccagaaa gggttgacac
     5521 gggagagcca tcctttcctg gaggcttgag gttatgttac agtaattgtg gagttttgtt
     5581 gctttaaaat cctccttctc ttctcaaggg caagattgcc aaagtgtagc atcgcatttg
     5641 gggtgggggt tgttaaaact tctgagtttc aataacttct tgctcgttgc atgggaacca
     5701 accccctccc catggatgtg cacgtgcaca cctgttgctg gtgaagagca ttcaatggtg
     5761 ctgtaaatga cgtgttttga aaactagaaa tgccaatcag atgttcgtgg aaattaaaca
     5821 gacagctcaa agcaaa
//
