LOCUS       NM_009579               5230 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus solute carrier family 30 (zinc transporter), member 1
            (Slc30a1), mRNA.
ACCESSION   NM_009579
VERSION     NM_009579.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5230)
  AUTHORS   Na-Phatthalung,P., Sun,S., Xie,E., Wang,J., Min,J. and Wang,F.
  TITLE     The zinc transporter Slc30a1 (ZnT1) in macrophages plays a
            protective role against attenuated Salmonella
  JOURNAL   Elife 13, e89509 (2024)
   PUBMED   39475776
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5230)
  AUTHORS   Mellone,M., Pelucchi,S., Alberti,L., Genazzani,A.A., Di Luca,M. and
            Gardoni,F.
  TITLE     Zinc transporter-1: a novel NMDA receptor-binding protein at the
            postsynaptic density
  JOURNAL   J Neurochem 132 (2), 159-168 (2015)
   PUBMED   25319628
REFERENCE   3  (bases 1 to 5230)
  AUTHORS   Sindreu,C., Bayes,A., Altafaj,X. and Perez-Clausell,J.
  TITLE     Zinc transporter-1 concentrates at the postsynaptic density of
            hippocampal synapses
  JOURNAL   Mol Brain 7, 16 (2014)
   PUBMED   24602382
  REMARK    GeneRIF: This study has identified ZnT1 as a novel postsynaptic
            density protein.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5230)
  AUTHORS   Beharier,O., Dror,S., Levy,S., Kahn,J., Mor,M., Etzion,S.,
            Gitler,D., Katz,A., Muslin,A.J., Moran,A. and Etzion,Y.
  TITLE     ZnT-1 protects HL-1 cells from simulated ischemia-reperfusion
            through activation of Ras-ERK signaling
  JOURNAL   J Mol Med (Berl) 90 (2), 127-138 (2012)
   PUBMED   22193398
  REMARK    GeneRIF: C-terminal domain of ZnT-1 was responsible for its
            protective effect against ischemia-reperfusion , while this part of
            the ZnT-1 protein did not have a protective effect against the
            toxicity of zinc
REFERENCE   5  (bases 1 to 5230)
  AUTHORS   Karol,N., Brodski,C., Bibi,Y., Kaisman,T., Forberg,M.,
            Hershfinkel,M., Sekler,I. and Silverman,W.F.
  TITLE     Zinc homeostatic proteins in the CNS are regulated by crosstalk
            between extracellular and intracellular zinc
  JOURNAL   J Cell Physiol 224 (3), 567-574 (2010)
   PUBMED   20432464
  REMARK    GeneRIF: Data suggest that expression of zinc homeostatic proteins
            such as ZnT1 and 3, and metallothioneins 1 and 2, is regulated by
            crosstalk between synaptic and intracellular pools of Zn(2+).
REFERENCE   6  (bases 1 to 5230)
  AUTHORS   Langmade,S.J., Ravindra,R., Daniels,P.J. and Andrews,G.K.
  TITLE     The transcription factor MTF-1 mediates metal regulation of the
            mouse ZnT1 gene
  JOURNAL   J Biol Chem 275 (44), 34803-34809 (2000)
   PUBMED   10952993
REFERENCE   7  (bases 1 to 5230)
  AUTHORS   Davis,S.R., McMahon,R.J. and Cousins,R.J.
  TITLE     Metallothionein knockout and transgenic mice exhibit altered
            intestinal processing of zinc with uniform zinc-dependent zinc
            transporter-1 expression
  JOURNAL   J Nutr 128 (5), 825-831 (1998)
   PUBMED   9566988
REFERENCE   8  (bases 1 to 5230)
  AUTHORS   Fowler,K.J., Saffery,R., Irvine,D.V., Trowell,H.E. and Choo,K.H.
  TITLE     Mouse centromere protein F (Cenpf) gene maps to the distal region
            of chromosome 1 by interspecific backcross analysis
  JOURNAL   Cytogenet Cell Genet 82 (3-4), 180-181 (1998)
   PUBMED   9858811
REFERENCE   9  (bases 1 to 5230)
  AUTHORS   Palmiter,R.D., Cole,T.B. and Findley,S.D.
  TITLE     ZnT-2, a mammalian protein that confers resistance to zinc by
            facilitating vesicular sequestration
  JOURNAL   EMBO J 15 (8), 1784-1791 (1996)
   PUBMED   8617223
REFERENCE   10 (bases 1 to 5230)
  AUTHORS   Palmiter,R.D. and Findley,S.D.
  TITLE     Cloning and functional characterization of a mammalian zinc
            transporter that confers resistance to zinc
  JOURNAL   EMBO J 14 (4), 639-649 (1995)
   PUBMED   7882967
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX217007.1, BC052166.1 and AC114603.15.
            
            On Jan 6, 2006 this sequence version replaced NM_009579.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145100.1, BC052166.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               CX217007.1         1-216
            217-2088            BC052166.1         208-2079
            2089-5230           AC114603.15        219220-222361
FEATURES             Location/Qualifiers
     source          1..5230
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 97.01 cM"
     gene            1..5230
                     /gene="Slc30a1"
                     /gene_synonym="C130040I11Rik; Znt1"
                     /note="solute carrier family 30 (zinc transporter), member
                     1"
                     /db_xref="GeneID:22782"
                     /db_xref="MGI:MGI:1345281"
     exon            1..833
                     /gene="Slc30a1"
                     /gene_synonym="C130040I11Rik; Znt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..1738
                     /gene="Slc30a1"
                     /gene_synonym="C130040I11Rik; Znt1"
                     /note="znT-1; solute carrier family 30 member 1; zinc
                     transporter 1"
                     /codon_start=1
                     /product="proton-coupled zinc antiporter SLC30A1"
                     /protein_id="NP_033605.1"
                     /db_xref="CCDS:CCDS15625.1"
                     /db_xref="GeneID:22782"
                     /db_xref="MGI:MGI:1345281"
                     /translation="MGCWGRNRGRLLCMLLLTFMFMVLEVVVSRVTASLAMLSDSFHM
                     LSDVLALVVALVAERFARRTHATQKNTFGWIRAEVMGALVNAIFLTGLCFAILLEAVE
                     RFIEPHEMQQPLVVLSVGVAGLLVNVLGLCLFHHHSGEGQGAGHGHSHGHGHGHLAKG
                     ARKAGRAGVEAGAPPGRAPDQEETNTLVANTSNSNGLKADQAEPEKLRSDDPVDVQVN
                     GNLIQESDNLEAEDNRAGQLNMRGVFLHVLGDALGSVIVVVNALVFYFNWKGCTEDDF
                     CTNPCFPDPCKSSVEIINSTQAPMRDAGPCWVLYLDPTLCIIMVCILLYTTYPLLKES
                     ALILLQTVPKQIDIKHLVKELRDVDGVEEVHELHVWQLAGSRIIATAHIKCEDPASYM
                     QVAKTIKDVFHNHGIHATTIQPEFASVGSKSSVLPCELACRTQCALKQCCGTRPQVHS
                     GKDAEKAPTVSISCLELSENLEKKARRTKAEGSLPAVVIEIKNVPNKQPESSL"
     exon            834..5230
                     /gene="Slc30a1"
                     /gene_synonym="C130040I11Rik; Znt1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2070..2075
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc30a1"
                     /gene_synonym="C130040I11Rik; Znt1"
                     /note="hexamer: AATAAA"
     polyA_site      2088
                     /gene="Slc30a1"
                     /gene_synonym="C130040I11Rik; Znt1"
                     /note="major polyA site"
     regulatory      5147..5152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc30a1"
                     /gene_synonym="C130040I11Rik; Znt1"
                     /note="hexamer: TATAAA"
     polyA_site      5171
                     /gene="Slc30a1"
                     /gene_synonym="C130040I11Rik; Znt1"
                     /note="major polyA site"
     regulatory      5212..5217
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc30a1"
                     /gene_synonym="C130040I11Rik; Znt1"
                     /note="hexamer: AATAAA"
     polyA_site      5217
                     /gene="Slc30a1"
                     /gene_synonym="C130040I11Rik; Znt1"
                     /note="major polyA site"
ORIGIN      
        1 gggggcgaag acggcggacg cctccgggcc gagcgcagtc gccgcggacg ccgtctcccg
       61 agcgcttcgg tccgatgctc ggcagcccct cggcacgcag tggcccgccg cgccctccgc
      121 ctcgccagcc cagccgagcg ccggcgcttg agtagctgcg cggccggcgg tttccccaca
      181 gcgccgctcc cgttcccgcg tcagcgccga gcctcaggcc gccgccatgg gctgctgggg
      241 ccgcaaccgc ggccggctgc tgtgcatgct gctgctgacc ttcatgttca tggtgctgga
      301 ggtggtggtg agccgggtga ccgcgtcgct cgccatgctg tccgactcct tccacatgct
      361 gtcggacgtg ctggcgctcg tagtggcgct ggtggccgag cgcttcgccc ggaggactca
      421 cgccacgcag aagaacacgt tcggctggat ccgcgctgag gtgatgggcg cactggtgaa
      481 cgccatcttc ctcacggggc tgtgcttcgc catcctgctg gaagccgtcg agcgcttcat
      541 cgagccgcat gagatgcagc agccgctcgt ggtgctgagc gtcggcgtgg cggggctgct
      601 ggtcaacgtg ctggggctct gtctgttcca ccatcacagc ggcgagggcc agggcgcggg
      661 ccacggccac tcgcacggcc acggccacgg ccacctcgcc aagggcgcgc gcaaggcggg
      721 ccgcgcgggg gtcgaggcgg gcgcgccgcc gggccgggcg ccggaccagg aggagaccaa
      781 cacgctggtg gccaacacca gcaattccaa cgggctgaag gcggaccagg cagagccaga
      841 aaaattgaga agtgatgacc cagtggatgt acaagtaaat gggaatctca tccaggagtc
      901 tgacaatctg gaagcggaag acaacagggc tgggcagctg aatatgcgag gagtgtttct
      961 gcacgtcctt ggagatgcct tgggctccgt gatcgtggtc gtgaatgcct tggtctttta
     1021 ctttaactgg aagggttgta ctgaagacga cttttgtacg aacccgtgtt ttcctgatcc
     1081 ctgcaaatcg tctgtagaga taattaacag cacccaggcc ccgatgcgtg acgctggccc
     1141 atgctgggtg ctctacctag acccaaccct ttgtattata atggtttgta tacttctgta
     1201 cacgacttac ccattgctca aggagtctgc tctcattctt ctacaaactg tccctaagca
     1261 aatcgatatc aaacacttgg tgaaagagct tcgagacgtt gacggcgttg aggaagtcca
     1321 tgagctacat gtctggcagc tggcgggaag caggatcatc gccactgccc acataaaatg
     1381 tgaggacccc gcttcctaca tgcaggtggc caagaccatt aaagatgtct ttcataatca
     1441 tggaatccac gctaccacca tccagcctga attcgctagc gtcggctcta agtcaagtgt
     1501 gctcccgtgt gagctcgcct gcagaactca gtgtgccctg aagcagtgct gcgggacacg
     1561 gccacaggtg cattctggga aggatgcaga gaaggcgcca acagttagca tttcttgttt
     1621 agaactcagt gagaatctag agaagaaggc caggaggact aaagctgaag gcagtctccc
     1681 tgctgtggtg atagagatta aaaacgtgcc aaacaaacag cccgaatcat ctttgtgagt
     1741 cttgaaaaag atgtgatatt tgacttttgc ttttaaactg caagagaaaa tagactccat
     1801 tgaaatacta agtttgccaa gtagtgtaat tgaagtcctt gtctggtcgc acagtttaat
     1861 tctatttttg taagaacata atggaactgc ctaatagaga gtgctacatt gcagccttgt
     1921 gattcttagt gcatagtgca gctatgctgg aacacgtttg aaagccagtt ttaacactat
     1981 gttacatttt tgtttaaagt aagtataaat cttatatgac ataatgaaat ttgattcctg
     2041 gttttcccat gataaaaatt agggggataa ataaaattgt tactggaatt tctctgcttt
     2101 tcttcccccc ccccccccat tgctatatct tatctgttag gattataatt gctaggcctt
     2161 taaaatcatc aagtttgtct cctttgatgt ttgaggggat ggttgcttgc cctttgagat
     2221 cataaacaga ccataatggc agcatatttc cagagtcatg actcttagca gaaagtcagt
     2281 ttagttacta ctttgttttc tctgctgctg aggaatagtc tagtaaactc tgagataatt
     2341 cacaagatga gttgtagtta cacatcgtgg agcatatagg ggctaagagc agggaggaag
     2401 gcaagctaca gctacgtccg ttacttcaca gtaataatgc tgattatagc tctaaagtat
     2461 cttgaaaatc tctaatggct ttattctacc aaagtcagtc taaacatgtt tgccagtgtt
     2521 gctttctttc aaagactggt attagcaaca ttgagttaaa tggttctaaa tgcatgagta
     2581 ttttttgaga atgcaggctt gtcttggctc cttaactgca aactattaat cttaaattat
     2641 gtcttaaaga aacttccata gtgacccatc agatggaatg aatacatttc ttcatgggca
     2701 gccaacacag tgtgtgctta gccaagagcc agtgacttaa aaatgaaatc acatggctca
     2761 tgcaatttgg atattacttt agaaagcaaa accagtaaga ggaaggcttg gatctttagc
     2821 caccgtgcct tggcatgctg gcttgcaaag tgctttctct gcaggactct gcactttgca
     2881 cccaggaagt cattcacggc tgctccattg ccacagattt caaatccaac gcagacattt
     2941 gaagattttt aagttatttt ttccagaaag gttaatgctt tgtgaaggaa atgtagattt
     3001 ttgtcttcaa aagagtgatt attaatatca gttatgtata gctctatttt tctaggaaca
     3061 aagtattctg actacttcaa taacttttat agctgactac ttttgggaaa gttaactttt
     3121 gggatttgaa ataattcatt gcttaataat ctgaaaatgg aagtgttaga gtatgacagt
     3181 tactttaagg aatggtcgct cccctagtgt aataagcctg ttgctggcaa tgggcctaca
     3241 taagaacagc tgggttttct gataagaaat gtaatttttg gaacatagtt tgtaagctca
     3301 catttactac actgggccaa ccttcaacct acataatact tgactaatat gtgatctgac
     3361 cccttggcag gtggttactt tgactttaac aaaacatttg ttttttaaaa aaaacatgaa
     3421 attgagagct ctgtgagtgg tgtgagcggg agctccagtt gtctcggatg gtactgtgca
     3481 gaagggttca gtgtttccac aggggtacag gaggccatcc aggaggtggc cttcagaacc
     3541 tctgggcagg tttatgtcat ggggaggagg gctgtgtcag tctgattttc agaagtgctt
     3601 taaggtggtg gtggcctggg ttaagtgggt tctatgtata aaagtggtac cgtaggcttt
     3661 tttttttttt ttcaaaggtg tttgttacag caaagtccat gggcgccaac tcaccttgag
     3721 gttttagaga attatttatt tctttacaat gcactttcta acccattttt tagctatatt
     3781 agcattatct ttaagaagaa aagatgtttt tatatttaaa tgttgtggga tttgagtgtc
     3841 ttttccaaaa atagcatatt tcttgaaaga aaatgaggag ctaccttggc ctcttgggga
     3901 ctatcccatt gtttaaatgt gcttcctctc ccaagtcagg gctgcagggg ggttggggtg
     3961 ggggttgggg tagggggagg cttccctggt tccttctcac ttgagccagg tcagtgtgga
     4021 gctgagtgag gaagcataca ctcaaacagg atccttccaa gccatgtgca gccttggaac
     4081 aatggacttg ctttcccatg gtcagctttt accttgtggg agtaattctt ttctgggggg
     4141 ttgggggtgg attatctaca ttgtagatgg acaagccaga acatgaaaaa caattctgga
     4201 acattttact gtattttcac acccaaaaca aaatgctggg tacctttatc ctaagaggca
     4261 taatttgagc agggagggtt tccatcaagt ttaccttgga gggtctcggg aggctgtttg
     4321 tatgtgtgtg tcttgtcagc atctgttatt ttgagttcct gaaaattttg agggaaaaga
     4381 aaacctaatg tgaagtattt ggtaggtaaa ctgtttttga gtgtttttac tgttttacaa
     4441 gcagatacca tttgaacaaa aaaatgtcat taacctgctg tcttaaggta gtcctacaca
     4501 aatctggaga gcggattggc aataggaaat gtttatttta gtactgcatt tcagttaagt
     4561 ggttaacagt gttaagaggt cttgggaaag tggagaaggc ttttgttgtc ttcgaaatcg
     4621 aaactgccct agtgcttcac gacctggaaa atgggactgt aatcacacta ttttgataca
     4681 gtgctgcata tatacatatg tgtatgtata tgctgatctt gttttgtttt actaacaagc
     4741 tctggaatat ttagcagtca ttttcactgg cacaagagcc ttttgtatat taatcaattt
     4801 aaacttttaa accaaaaatg ttaaggttca gtgtcaggca aaaaaagatg ctgaggagaa
     4861 tgtaacatag aattgatatg tggttatata aaaagacaca aatggccatg atatgggtct
     4921 gccttgaaac agcacaatgg ggtgtcagtg tgtctgattc tctgagacgc tctcgagttg
     4981 gtcctgtcta ctgccgcctg tgctctgggc cacaggcata gttgatgggg ctcatcttga
     5041 actcgagtgc ggcaaccttt tccctaactt gtgtgtgttt tatgactgtg tgttatttcc
     5101 aaagctgttc ctacctcacc atgaggcttt atggattgtt atgtactata aatgttctat
     5161 atgagacaag actactgtgt ttcttctcat ttattaaaag ttaagtagaa aaataaacta
     5221 attctaattt
//
