LOCUS       NM_001102414            3602 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus solute carrier family 2 (facilitated glucose
            transporter), member 9 (Slc2a9), transcript variant 1, mRNA.
ACCESSION   NM_001102414
VERSION     NM_001102414.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3602)
  AUTHORS   Yang,J., Jiang,T., Lu,X., Li,X., Zhou,X., Guo,X., Ma,C., Xie,X.,
            Li,D., Yu,S., An,J., Zhao,B. and Li,H.
  TITLE     METTL14 downregulates GLUT9 through m6A methylation and attenuates
            hyperuricemia-induced fibrosis in mouse renal tubular epithelial
            cells
  JOURNAL   Int Immunopharmacol 143 (Pt 1), 113308 (2024)
   PUBMED   39393275
  REMARK    GeneRIF: METTL14 downregulates GLUT9 through m6A methylation and
            attenuates hyperuricemia-induced fibrosis in mouse renal tubular
            epithelial cells.
REFERENCE   2  (bases 1 to 3602)
  AUTHORS   Johnston,S.N., Silagi,E.S., Madhu,V., Nguyen,D.H., Shapiro,I.M. and
            Risbud,M.V.
  TITLE     GLUT1 is redundant in hypoxic and glycolytic nucleus pulposus cells
            of the intervertebral disc
  JOURNAL   JCI Insight 8 (8), e164883 (2023)
   PUBMED   36917198
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3602)
  AUTHORS   Zeng,H., Tang,C., Lin,B., Yu,M., Wang,X., Wang,J., Chen,S. and
            Yu,C.
  TITLE     The regulation effect of GLUT9/SLC2A9 on intrahepatic uric acid
            level and metabolic associated fatty liver disease
  JOURNAL   Hepatol Int 16 (5), 1064-1074 (2022)
   PUBMED   36006548
  REMARK    GeneRIF: The regulation effect of GLUT9/SLC2A9 on intrahepatic uric
            acid level and metabolic associated fatty liver disease.
REFERENCE   4  (bases 1 to 3602)
  AUTHORS   Kappen,C., Kruger,C., Jones,S. and Salbaum,J.M.
  TITLE     Nutrient Transporter Gene Expression in the Early
            Conceptus-Implications From Two Mouse Models of Diabetic Pregnancy
  JOURNAL   Front Cell Dev Biol 10, 777844 (2022)
   PUBMED   35478964
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3602)
  AUTHORS   Luscher,B.P., Albrecht,C., Stieger,B., Surbek,D.V. and Baumann,M.U.
  TITLE     Glucose Transporter 9 (GLUT9) Plays an Important Role in the
            Placental Uric Acid Transport System
  JOURNAL   Cells 11 (4), 633 (2022)
   PUBMED   35203284
  REMARK    GeneRIF: Glucose Transporter 9 (GLUT9) Plays an Important Role in
            the Placental Uric Acid Transport System.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3602)
  AUTHORS   Kim,S.T. and Moley,K.H.
  TITLE     The expression of GLUT8, GLUT9a, and GLUT9b in the mouse testis and
            sperm
  JOURNAL   Reprod Sci 14 (5), 445-455 (2007)
   PUBMED   17913964
  REMARK    GeneRIF: Glucose uptake via GLUT9a and GLUT9b likely affects normal
            spermatogenesis, steroidogenesis, and sperm function in the mouse.
REFERENCE   7  (bases 1 to 3602)
  AUTHORS   Keembiyehetty,C., Augustin,R., Carayannopoulos,M.O., Steer,S.,
            Manolescu,A., Cheeseman,C.I. and Moley,K.H.
  TITLE     Mouse glucose transporter 9 splice variants are expressed in adult
            liver and kidney and are up-regulated in diabetes
  JOURNAL   Mol Endocrinol 20 (3), 686-697 (2006)
   PUBMED   16293642
  REMARK    GeneRIF: mGLUT9 protein expression was significantly increased in
            the kidney and liver from streptozotocin-induced diabetic mice
            compared with nondiabetic animals
REFERENCE   8  (bases 1 to 3602)
  AUTHORS   Carayannopoulos,M.O., Schlein,A., Wyman,A., Chi,M.,
            Keembiyehetty,C. and Moley,K.H.
  TITLE     GLUT9 is differentially expressed and targeted in the
            preimplantation embryo
  JOURNAL   Endocrinology 145 (3), 1435-1443 (2004)
   PUBMED   14657010
  REMARK    GeneRIF: blocking GLUT9 expression during preimplantation
            development had no effect on glucose transport or apoptosis but
            transfer of these embryos resulted in increased pregnancy loss,
            suggesting that GLUT9 is critical for early preimplantation
            development.
REFERENCE   9  (bases 1 to 3602)
  AUTHORS   Hurle,B., Ignatova,E., Massironi,S.M., Mashimo,T., Rios,X.,
            Thalmann,I., Thalmann,R. and Ornitz,D.M.
  TITLE     Non-syndromic vestibular disorder with otoconial agenesis in
            tilted/mergulhador mice caused by mutations in otopetrin 1
  JOURNAL   Hum Mol Genet 12 (7), 777-789 (2003)
   PUBMED   12651873
REFERENCE   10 (bases 1 to 3602)
  AUTHORS   Hurle,B., Lane,K., Kenney,J., Tarantino,L.M., Bucan,M.,
            Brownstein,B.H. and Ornitz,D.M.
  TITLE     Physical mapping of the mouse tilted locus identifies an
            association between human deafness loci DFNA6/14 and vestibular
            system development
  JOURNAL   Genomics 77 (3), 189-199 (2001)
   PUBMED   11597144
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC171271.4 and AK156740.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest protein (isoform 1, also known
            as the long form of mGLUT9a).
            
            Sequence Note: Sequence Note: This RefSeq record was created from
            transcript and genomic sequence data because no single transcript
            from the same strain was available for the full length of the gene.
            The extent of this transcript is supported by transcript
            alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156740.1, AK172234.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AC171271.4         74678-74774
            98-3602             AK156740.1         2-3506
FEATURES             Location/Qualifiers
     source          1..3602
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="NOD"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 20.43 cM"
     gene            1..3602
                     /gene="Slc2a9"
                     /gene_synonym="GLUT-9; Glut9; SLC2a9A; SLC2A9B"
                     /note="solute carrier family 2 (facilitated glucose
                     transporter), member 9"
                     /db_xref="GeneID:117591"
                     /db_xref="MGI:MGI:2152844"
     exon            1..268
                     /gene="Slc2a9"
                     /gene_synonym="GLUT-9; Glut9; SLC2a9A; SLC2A9B"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1792
                     /gene="Slc2a9"
                     /gene_synonym="GLUT-9; Glut9; SLC2a9A; SLC2A9B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     facilitated glucose transporter, type 9; urate
                     transporter; glucose transporter type 9; solute carrier
                     family 2, facilitated glucose transporter member 9"
                     /codon_start=1
                     /product="solute carrier family 2, facilitated glucose
                     transporter member 9 isoform 1"
                     /protein_id="NP_001095884.1"
                     /db_xref="CCDS:CCDS51483.1"
                     /db_xref="GeneID:117591"
                     /db_xref="MGI:MGI:2152844"
                     /translation="MDSRELALASLMCDTGGPGELSVGHQQRRTKKWSFSLVVAALVG
                     AFGSSFLYGYNLSVVNAPTPYIKAFYNGTWYRRHGQPIDPDTLTLLWSVTVSIFAIGG
                     LVGTLMVKMIGKFLGRKSTLLVNNGFAISAALLMACSLRAGTFEMLIVGRFIMGVDGG
                     IALSALPMYLNEISPKEIRGSLGQVTAIFICIGVFSGQLLGLPELLGRESTWPYLFGV
                     IIVPALVQLASLPFLPESPRYLLFEKHDEAGAMKAFQTFLGKADVSQELEEALAESRV
                     QRNLRLVSVLELLRAPFVRWQVITVIITMASYQLCGLNAIWFYTNSIFGKAGIPQDKI
                     PYITLSTGGIETLAAIFSGLVIERLGRRPLLIGGFGLMALFFGTLTATLTLQDQAPWV
                     PYLSIVCILAIIASFCSGPGGIPFILTGEFFQQSERPAAFMIAGTVNWLSNFAVGLLF
                     PFIQKSLDSYCFLVFATICIAGATYFYFVLPETKNRTHAEISQAFAKRNKAQPPEVKA
                     DSAMTEEKANSQTEPDSSSTLDSYGQNKIV"
     exon            269..367
                     /gene="Slc2a9"
                     /gene_synonym="GLUT-9; Glut9; SLC2a9A; SLC2A9B"
                     /inference="alignment:Splign:2.1.0"
     exon            368..528
                     /gene="Slc2a9"
                     /gene_synonym="GLUT-9; Glut9; SLC2a9A; SLC2A9B"
                     /inference="alignment:Splign:2.1.0"
     exon            529..653
                     /gene="Slc2a9"
                     /gene_synonym="GLUT-9; Glut9; SLC2a9A; SLC2A9B"
                     /inference="alignment:Splign:2.1.0"
     exon            654..799
                     /gene="Slc2a9"
                     /gene_synonym="GLUT-9; Glut9; SLC2a9A; SLC2A9B"
                     /inference="alignment:Splign:2.1.0"
     exon            800..932
                     /gene="Slc2a9"
                     /gene_synonym="GLUT-9; Glut9; SLC2a9A; SLC2A9B"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1120
                     /gene="Slc2a9"
                     /gene_synonym="GLUT-9; Glut9; SLC2a9A; SLC2A9B"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1231
                     /gene="Slc2a9"
                     /gene_synonym="GLUT-9; Glut9; SLC2a9A; SLC2A9B"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1333
                     /gene="Slc2a9"
                     /gene_synonym="GLUT-9; Glut9; SLC2a9A; SLC2A9B"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1409
                     /gene="Slc2a9"
                     /gene_synonym="GLUT-9; Glut9; SLC2a9A; SLC2A9B"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1537
                     /gene="Slc2a9"
                     /gene_synonym="GLUT-9; Glut9; SLC2a9A; SLC2A9B"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..3602
                     /gene="Slc2a9"
                     /gene_synonym="GLUT-9; Glut9; SLC2a9A; SLC2A9B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3219..3224
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc2a9"
                     /gene_synonym="GLUT-9; Glut9; SLC2a9A; SLC2A9B"
                     /note="hexamer: AATAAA"
     polyA_site      3238
                     /gene="Slc2a9"
                     /gene_synonym="GLUT-9; Glut9; SLC2a9A; SLC2A9B"
                     /note="major polyA site"
     regulatory      3580..3585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc2a9"
                     /gene_synonym="GLUT-9; Glut9; SLC2a9A; SLC2A9B"
                     /note="hexamer: AATAAA"
     polyA_site      3601
                     /gene="Slc2a9"
                     /gene_synonym="GLUT-9; Glut9; SLC2a9A; SLC2A9B"
                     /note="major polyA site"
ORIGIN      
        1 cggggagcga agctgtctca gttgcttggg agcaggggag caatgtcgct cgcttcctgt
       61 tcaggcatga tcacagagcc acgcttcctg ctctgccctc cttcctgtgg actctgcctc
      121 ctcgctgcag agatgccctg gcaagtccag ggtcctggag ccaggaagaa aaaagatgga
      181 ttccagggag cttgctttag cttccctgat gtgtgacacc ggtggccctg gggagctctc
      241 tgtgggtcac cagcagagga ggacaaagaa atggtccttc tcgctcgtcg tggcagctct
      301 cgtgggagcc ttcgggtcct ccttcctcta cgggtacaac ctctccgtgg tgaacgcgcc
      361 cacgccgtat atcaaggcct tttacaatgg aacctggtac aggaggcatg gacagcccat
      421 tgacccggat accctgactc tgctctggtc tgtgactgtg tccatatttg cgattggtgg
      481 cctggtggga acgctgatgg tgaagatgat tggaaagttt cttgggagga agtccacatt
      541 gctggtcaac aatggatttg ccatttccgc agcgttgctg atggcatgct cactccgggc
      601 aggaaccttt gagatgctca ttgtgggacg gttcatcatg ggtgtggatg gaggcattgc
      661 actcagcgcg ctccccatgt atctcaacga gatctcaccc aaggagatcc ggggctctct
      721 gggccaggtg actgccatct tcatctgcat tggcgtgttt tctggacagt tgctgggcct
      781 gccggagctg ctgggaaggg agagcacctg gccatacctg ttcggagtga tcattgtccc
      841 tgccttggtc cagctggcaa gcctgccatt tctccctgag agcccacgct accttctctt
      901 tgaaaagcac gatgaagcag gagccatgaa agccttccaa acatttctgg ggaaagcaga
      961 tgtctcccaa gagctggagg aggccctggc cgagagccgc gtgcaaagga acctccgcct
     1021 ggtgtctgtg ctggagcttc tgagggcacc ctttgtccgc tggcaggtca tcacggtcat
     1081 tatcaccatg gccagctacc aactatgtgg actcaatgcg atctggttct acaccaacag
     1141 catctttggg aaagctggga tccctcagga caagatccca tacatcaccc tgagcacggg
     1201 aggaattgaa acactggctg ctatcttctc tggcttggtc attgagcgct taggaaggag
     1261 acctctcctc attggtggct tcgggctgat ggccctcttc tttgggaccc tcaccgcgac
     1321 actgaccctg caggaccaag ctccctgggt cccttacctc agcattgtgt gcatcttggc
     1381 catcattgcc tcgttctgca gcggtccagg tgggatccca ttcatcctga ccggagagtt
     1441 cttccaacag tcagagcgac cggcagcctt catgatcgca ggcacagtca actggctctc
     1501 aaacttcgcc gtagggctcc ttttcccttt catccagaaa agcctggact cctactgctt
     1561 cctcgtcttc gccacaatat gtatcgcagg tgctacctac ttctattttg tcctcccgga
     1621 gaccaagaac agaacccatg cagaaatcag ccaggcattt gccaagagga acaaggctca
     1681 gcccccagag gtgaaggctg attcagccat gactgaggag aaggccaaca gccagactga
     1741 gcccgattca tcctccacgc tggacagcta tggccaaaac aaaattgtct aaatgtgtgt
     1801 tcttgctata gtaacctaag actttccaaa acacttagaa ggtttcagga gaccaaagcc
     1861 atgtgagact cttatactgg ggagttagga agaaacctgt gggaatcgaa cctcccaggt
     1921 gcacgtccaa actgccctgg aagcatcccc taggtttcct acactcacca tactatatac
     1981 accgagggct gccctcctca tgactgaacc catagttttg aaataaagtt gggggaaagg
     2041 gaacaggttg ccttctcata ggaaaaccat ctggtctgat ggacacttac ttgttgtact
     2101 gggaatggca gcctggggct tgtcccagct gtgctgttgc taagcaaccc tgaccttccc
     2161 tcagcctcta gcctccaggc ccccagacct tggaagactt tccgactttc tctttcacgg
     2221 gaagattctt tgtcccacta acaaatgcct gttgttaatc tttggctctg ccctatggac
     2281 ctgaggctta ggaacacttc ataccaaccc accacgctgc tgatcttacc aaggcaggct
     2341 ctgcccccca gcactcaagg cctcgagacc tgaggctgtc tttagttcag actgttacag
     2401 agagcacaca gagaatcaac caatcatatg aaaaagaact ttgtggtacc tagaggggca
     2461 gagcctgcaa ggtgggccct gaacactgag aatgactcag actacatcta gatttgatgg
     2521 gaaagaacac tgggattgat tgatgatgtc tgtcctggat gtaggaacga cagcctcagt
     2581 tcccgagcct tgtgtttgca atgtgaaggt aacaaactgt ctggaaagac acccgacatc
     2641 actcctagtg ctcaggtaaa ggctggggtg gcaggggtca cctgtctcaa ccgttgttta
     2701 ggaagtcaaa gaggcggttc tagagaaggg tgtttgagtg ggtgtctggt tggggcaatt
     2761 tgcatcttgc tgtcgtcatg tttggctgaa tcccttcttc tgcctccaaa acaaagtacg
     2821 tgtgacaaat gtcataagca aatggcaggc acatgaactg gcattggcgt gtttaagttt
     2881 aggatgcctt agagggtatg tggttccagg aagggaagtc tccacaccag gcaacactgc
     2941 tgttttcctg accgttctgg atgaacatgg ccttaaccaa aacctgtgtt ctgacttttc
     3001 cctccccgtt gaacactctt catcttgggc ctctccttgg tgcattcccg gctcagggaa
     3061 ccataccatc cagccctggt ttgaacactg tgcgttagta tacagaatgc aacatataga
     3121 tttgacaagg gcttgtcaca aagggaacca agtaattgta aaacagaaat cataacattt
     3181 gaaagctggc attctcttgg agatttaagg attgtgtcaa taaatattta ttagcctatc
     3241 attattctgc cttggctggg tactgcagac agagccatgg gcaaggaaac acactgccct
     3301 ggccttcgca ctctcatgtc tgaccgagaa acaccgtcaa agcactaatg gtgggatgca
     3361 gtgccttcac tgggggtggg ggggtgggca ttggtagcgg gaatagatgg gatcttagct
     3421 gagaaagagg aaagccttct cagacaaggg atgaacagag ccagggccag tgaccatgag
     3481 gccggaggcc agcaattatt attgttatgt tcttgtattt gaaattgtag tgaagccaca
     3541 ctaagggcat tttgaaaaaa aaaaaaaaaa gaatctcata ataaaactga tcatctccct
     3601 cg
//
