LOCUS       NM_019488               2135 bp    mRNA    linear   ROD 18-DEC-2022
DEFINITION  Mus musculus solute carrier family 2, (facilitated glucose
            transporter), member 8 (Slc2a8), transcript variant 1, mRNA.
ACCESSION   NM_019488
VERSION     NM_019488.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2135)
  AUTHORS   Yoo D, Park J, Lee C, Song I, Lee YH, Yun T, Lee H, Heguy A, Han
            JY, Dasen JS, Kim H and Baek M.
  TITLE     Little skate genome provides insights into genetic programs
            essential for limb-based locomotion
  JOURNAL   Elife 11, e78345 (2022)
   PUBMED   36288084
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2135)
  AUTHORS   Kappen C, Kruger C, Jones S and Salbaum JM.
  TITLE     Nutrient Transporter Gene Expression in the Early
            Conceptus-Implications From Two Mouse Models of Diabetic Pregnancy
  JOURNAL   Front Cell Dev Biol 10, 777844 (2022)
   PUBMED   35478964
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2135)
  AUTHORS   Lee H, Kim E, Shin EA, Shon JC, Sun H, Kim JE, Jung JW, Lee H,
            Pinanga Y, Song DG, Liu KH and Lee JW.
  TITLE     Crosstalk between TM4SF5 and GLUT8 regulates fructose metabolism in
            hepatic steatosis
  JOURNAL   Mol Metab 58, 101451 (2022)
   PUBMED   35123128
  REMARK    GeneRIF: Crosstalk between TM4SF5 and GLUT8 regulates fructose
            metabolism in hepatic steatosis.
REFERENCE   4  (bases 1 to 2135)
  AUTHORS   Mardones L, Munoz K and Villagran M.
  TITLE     Cell-specific expression of functional glucose transporter 8 in
            mammary gland
  JOURNAL   Biochem Biophys Res Commun 567, 125-130 (2021)
   PUBMED   34153681
  REMARK    GeneRIF: Cell-specific expression of functional glucose transporter
            8 in mammary gland.
REFERENCE   5  (bases 1 to 2135)
  AUTHORS   Burkus J, Navarrete Santos A, Schindler M, Babelova J, Jung JS,
            Spirkova A, Ksinanova M, Kovarikova V, Fischer B, Koppel J, Fabian
            D and Cikos S.
  TITLE     Adiponectin stimulates glucose uptake in mouse blastocysts and
            embryonic carcinoma cells
  JOURNAL   Reproduction 159 (3), 227-239 (2020)
   PUBMED   32023207
  REMARK    GeneRIF: Adiponectin stimulates glucose uptake in mouse blastocysts
            and embryonic carcinoma cells.
REFERENCE   6  (bases 1 to 2135)
  AUTHORS   Schurmann A, Axer H, Scheepers A, Doege H and Joost HG.
  TITLE     The glucose transport facilitator GLUT8 is predominantly associated
            with the acrosomal region of mature spermatozoa
  JOURNAL   Cell Tissue Res 307 (2), 237-242 (2002)
   PUBMED   11845330
  REMARK    GeneRIF: The mRNA synthesis of this carrier protein during the
            maturation of the mouse testis coincides with the appearance of
            mature spermatozoa.
REFERENCE   7  (bases 1 to 2135)
  AUTHORS   Scheepers A, Doege H, Joost HG and Schurmann A.
  TITLE     Mouse GLUT8: genomic organization and regulation of expression in
            3T3-L1 adipocytes by glucose
  JOURNAL   Biochem Biophys Res Commun 288 (4), 969-974 (2001)
   PUBMED   11689004
  REMARK    GeneRIF: genomic organization, promoter region, and regulation of
            expression in 3T3-L1 cells by glucose
REFERENCE   8  (bases 1 to 2135)
  AUTHORS   Carayannopoulos MO, Chi MM, Cui Y, Pingsterhaus JM, McKnight RA,
            Mueckler M, Devaskar SU and Moley KH.
  TITLE     GLUT8 is a glucose transporter responsible for insulin-stimulated
            glucose uptake in the blastocyst
  JOURNAL   Proc Natl Acad Sci U S A 97 (13), 7313-7318 (2000)
   PUBMED   10860996
REFERENCE   9  (bases 1 to 2135)
  AUTHORS   Doege H, Schurmann A, Bahrenberg G, Brauers A and Joost HG.
  TITLE     GLUT8, a novel member of the sugar transport facilitator family
            with glucose transport activity
  JOURNAL   J Biol Chem 275 (21), 16275-16280 (2000)
   PUBMED   10821868
REFERENCE   10 (bases 1 to 2135)
  AUTHORS   Ibberson M, Uldry M and Thorens B.
  TITLE     GLUTX1, a novel mammalian glucose transporter expressed in the
            central nervous system and insulin-sensitive tissues
  JOURNAL   J Biol Chem 275 (7), 4607-4612 (2000)
   PUBMED   10671487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY786601.1, AK081806.1 and BF459354.1.
            
            [WARNING] On May 19, 2023 this sequence was replaced by
            NM_019488.6.
            
            On Oct 4, 2017 this sequence version replaced NM_019488.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155792.1, BC090993.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BY786601.1         2-12
            12-2109             AK081806.1         2-2099
            2110-2135           BF459354.1         1-26                c
FEATURES             Location/Qualifiers
     source          1..2135
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 22.09 cM"
     gene            1..2135
                     /gene="Slc2a8"
                     /gene_synonym="D2Ertd44e; GLUT8; GlutX1"
                     /note="solute carrier family 2, (facilitated glucose
                     transporter), member 8"
                     /db_xref="GeneID:56017"
                     /db_xref="MGI:MGI:1860103"
     exon            1..126
                     /gene="Slc2a8"
                     /gene_synonym="D2Ertd44e; GLUT8; GlutX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1504
                     /gene="Slc2a8"
                     /gene_synonym="D2Ertd44e; GLUT8; GlutX1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     intestinal GLUT8 transporter; GLUT-8; glucose transporter
                     type 8; glucose transporter type X1; glucose transporter
                     X1"
                     /codon_start=1
                     /product="solute carrier family 2, facilitated glucose
                     transporter member 8 isoform 1"
                     /protein_id="NP_062361.1"
                     /db_xref="CCDS:CCDS15937.1"
                     /db_xref="GeneID:56017"
                     /db_xref="MGI:MGI:1860103"
                     /translation="MSPEDPQETQPLLRPPEARTPRGRRVFLASFAAALGPLSFGFAL
                     GYSSPAIPSLRRTAPPALRLGDNAASWFGAVVTLGAAAGGILGGWLLDRAGRKLSLLL
                     CTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSC
                     VQLMVVTGILLAYVAGWVLEWRWLAVLGCVPPTLMLLLMCYMPETPRFLLTQHQYQEA
                     MAALRFLWGSEEGWEEPPVGAEHQGFQLALLRRPGIYKPLIIGISLMVFQQLSGVNAI
                     MFYANSIFEEAKFKDSSLASVTVGIIQVLFTAVAALIMDRAGRRLLLALSGVIMVFSM
                     SAFGTYFKLTQSLPSNSSHVGLVPIAAEPVDVQVGLAWLAVGSMCLFIAGFAVGWGPI
                     PWLLMSEIFPLHVKGVATGICVLTNWFMAFLVTKEFSSVMEMLRPYGAFWLTAAFCAL
                     SVLFTLTVVPETKGRTLEQVTAHFEGR"
     exon            127..289
                     /gene="Slc2a8"
                     /gene_synonym="D2Ertd44e; GLUT8; GlutX1"
                     /inference="alignment:Splign:2.1.0"
     exon            290..496
                     /gene="Slc2a8"
                     /gene_synonym="D2Ertd44e; GLUT8; GlutX1"
                     /inference="alignment:Splign:2.1.0"
     exon            497..596
                     /gene="Slc2a8"
                     /gene_synonym="D2Ertd44e; GLUT8; GlutX1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..796
                     /gene="Slc2a8"
                     /gene_synonym="D2Ertd44e; GLUT8; GlutX1"
                     /inference="alignment:Splign:2.1.0"
     exon            797..940
                     /gene="Slc2a8"
                     /gene_synonym="D2Ertd44e; GLUT8; GlutX1"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1049
                     /gene="Slc2a8"
                     /gene_synonym="D2Ertd44e; GLUT8; GlutX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1220
                     /gene="Slc2a8"
                     /gene_synonym="D2Ertd44e; GLUT8; GlutX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1366
                     /gene="Slc2a8"
                     /gene_synonym="D2Ertd44e; GLUT8; GlutX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..2118
                     /gene="Slc2a8"
                     /gene_synonym="D2Ertd44e; GLUT8; GlutX1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attggtcact cctgcagcgg aggccgcgct cgcccgagcg gcgacagttc gcgggtcagg
       61 tcctgctgac atgtctcccg aggaccccca ggagacgcag ccgctattgc ggccaccgga
      121 agccaggact ccccgcggcc gccgggtctt cctcgcttcc ttcgccgccg ctctgggacc
      181 cctcagcttc ggcttcgcgc tcggctacag ctcccccgcc atccccagcc tgcggcgcac
      241 cgcacccccg gccctgcgcc tcggagacaa tgcggcctcc tggttcgggg ccgtcgtgac
      301 cctgggcgct gctgcagggg gcatactggg cggctggctc ctggaccgtg cagggcgcaa
      361 gctgagcctc ttgctctgca ccgtgccctt cgtgactggc tttgctgtca tcaccgcggc
      421 ccgggatgtg tggatgctgc tcggaggccg cctcctcacc ggccttgcct gcggagtcgc
      481 ctcactagtg gcaccggttt acatctcgga aatcgcctac ccagctgtcc gaggactgct
      541 cggctcctgt gtgcagctga tggttgtcac tggcatcctc ctggcctatg tggcaggctg
      601 ggtcctagag tggcgctggc tggccgtgct gggctgtgtg ccccccaccc tcatgctgct
      661 gctcatgtgc tacatgcccg agaccccacg ttttctcctc actcaacacc agtaccagga
      721 ggccatggct gccttgcgct tcctgtgggg ctctgaggag ggctgggaag agccccctgt
      781 tggggctgag caccagggct tccagctggc cctgctgagg cgccctggca tctacaagcc
      841 cctcatcatc ggcatttccc tcatggtctt ccagcagctg tcaggggtca atgctatcat
      901 gttctatgcc aacagcatct tcgaggaggc caagttcaag gacagcagcc tggcctcggt
      961 cactgtgggc ataatccagg tcctgttcac tgctgtggcg gccctcatca tggacagagc
     1021 agggcgaagg ctgctcctgg ccttgtcggg tgtgatcatg gtgttcagta tgagtgcctt
     1081 tggtacctac ttcaaactga cccagagcct ccccagcaac tcctcccacg taggcctggt
     1141 gcccatcgcg gcggagcctg tggatgtcca agtgggactg gcctggctgg ctgtaggcag
     1201 catgtgcctc ttcattgctg gctttgcggt gggctgggga cccatcccct ggctcctcat
     1261 gtcagagatc ttccctctgc atgtcaaggg tgtggctacc ggcatctgtg tcctcaccaa
     1321 ctggttcatg gcctttctag tgaccaaaga gttcagcagc gtcatggaga tgctcagacc
     1381 ctacggtgcc ttctggctca ccgctgcctt ctgcgctctc agtgtcctat tcacactgac
     1441 cgttgtccct gagactaaag gcaggactct ggaacaagtc acagcccatt tcgagggacg
     1501 atgacagacc ctttctgtgc ctgggagccc cgagctgagc tgcctttggg tttcagaagg
     1561 agtggagtgg cctgtaacta agccacacct cagtttgagc ctggaggccc cctgactcct
     1621 cacctcaggg ccctctttgc ccagatctca acccagattc ccaccgtgag gcccaccaga
     1681 ctctgagtgc ggtctctgca gcctgcttca cacacaggac atctgaggag ctgtgcatcc
     1741 tcacctgacc caggtgtctc cttcttaaga ctgaggcagc tgaagggacc tgagggctcc
     1801 tggctcccgt ttcctggctg gggtgcccgg tcctaagcag ccgcctgtac ctcacttgac
     1861 tgggagatca gaaagggact tagccatatg ggctcagaaa caaggtcagg tgagcccagg
     1921 tagaagagag aatgttcttg ccaaccaagc cctcctcaga gctgcgcaga gactctccgg
     1981 ggtcaccctg gggccagcca gcttacccat cacttacagg ttctttctgg ctctttcctg
     2041 ggctccgtgt cctgggtcat tagccaccat atcttgttga gtttcaggaa ataaaaagcc
     2101 tcttactgtt caacttcaaa aaaaaaaaaa aaaaa
//
