LOCUS       NM_172659               2136 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus solute carrier family 2 (facilitated glucose
            transporter), member 6 (Slc2a6), transcript variant 1, mRNA.
ACCESSION   NM_172659
VERSION     NM_172659.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2136)
  AUTHORS   Chen,S.Y., Olzomer,E.M., Beretta,M., Cantley,J., Nunemaker,C.S.,
            Hoehn,K.L. and Byrne,F.L.
  TITLE     Investigating the Expression and Function of the Glucose
            Transporter GLUT6 in Obesity
  JOURNAL   Int J Mol Sci 23 (17), 9798 (2022)
   PUBMED   36077188
  REMARK    GeneRIF: Investigating the Expression and Function of the Glucose
            Transporter GLUT6 in Obesity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2136)
  AUTHORS   Kappen,C., Kruger,C., Jones,S. and Salbaum,J.M.
  TITLE     Nutrient Transporter Gene Expression in the Early
            Conceptus-Implications From Two Mouse Models of Diabetic Pregnancy
  JOURNAL   Front Cell Dev Biol 10, 777844 (2022)
   PUBMED   35478964
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2136)
  AUTHORS   Caruana,B.T., Byrne,F.L., Knights,A.J., Quinlan,K.G.R. and
            Hoehn,K.L.
  TITLE     Characterization of Glucose Transporter 6 in
            Lipopolysaccharide-Induced Bone Marrow-Derived Macrophage Function
  JOURNAL   J Immunol 202 (6), 1826-1832 (2019)
   PUBMED   30700586
REFERENCE   4  (bases 1 to 2136)
  AUTHORS   Maedera,S., Mizuno,T., Ishiguro,H., Ito,T., Soga,T. and Kusuhara,H.
  TITLE     GLUT6 is a lysosomal transporter that is regulated by inflammatory
            stimuli and modulates glycolysis in macrophages
  JOURNAL   FEBS Lett 593 (2), 195-208 (2019)
   PUBMED   30431159
  REMARK    GeneRIF: Study provides evidence that GLUT6 is a lysosomal
            transporter that is regulated by inflammatory stimuli and modulates
            inflammatory responses by affecting the metabolic shift in
            macrophages.
REFERENCE   5  (bases 1 to 2136)
  AUTHORS   Byrne,F.L., Olzomer,E.M., Brink,R. and Hoehn,K.L.
  TITLE     Knockout of glucose transporter GLUT6 has minimal effects on whole
            body metabolic physiology in mice
  JOURNAL   Am J Physiol Endocrinol Metab 315 (2), E286-E293 (2018)
   PUBMED   29664675
  REMARK    GeneRIF: these data show that GLUT6 is not a major regulator of
            whole body metabolic physiology
REFERENCE   6  (bases 1 to 2136)
  AUTHORS   Bulusu,V., Prior,N., Snaebjornsson,M.T., Kuehne,A., Sonnen,K.F.,
            Kress,J., Stein,F., Schultz,C., Sauer,U. and Aulehla,A.
  TITLE     Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to
            Mouse Embryo Mesoderm Development
  JOURNAL   Dev Cell 40 (4), 331-341 (2017)
   PUBMED   28245920
REFERENCE   7  (bases 1 to 2136)
  AUTHORS   Preitner,F., Pimentel,A., Metref,S., Berthonneche,C., Sarre,A.,
            Moret,C., Rotman,S., Centeno,G., Firsov,D. and Thorens,B.
  TITLE     No development of hypertension in the hyperuricemic liver-Glut9
            knockout mouse
  JOURNAL   Kidney Int 87 (5), 940-947 (2015)
   PUBMED   25565311
  REMARK    GeneRIF: In liver-specific Glut9 knockout mice, inosine-induced
            hyperuricemia was not associated with hypertension despite partial
            renal deficiency.
REFERENCE   8  (bases 1 to 2136)
  AUTHORS   Sun,M., Mondal,K., Patel,V., Horner,V.L., Long,A.B., Cutler,D.J.,
            Caspary,T. and Zwick,M.E.
  TITLE     Multiplex Chromosomal Exome Sequencing Accelerates Identification
            of ENU-Induced Mutations in the Mouse
  JOURNAL   G3 (Bethesda) 2 (1), 143-150 (2012)
   PUBMED   22384391
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY202464.1 and AK150104.1.
            
            On Jul 26, 2007 this sequence version replaced NM_172659.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150104.1, AK079650.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                BY202464.1         2-49
            49-2136             AK150104.1         2-2089
FEATURES             Location/Qualifiers
     source          1..2136
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 19.18 cM"
     gene            1..2136
                     /gene="Slc2a6"
                     /gene_synonym="A330096C23; F630103L12Rik; GLUT-6; Glut6;
                     Glut9"
                     /note="solute carrier family 2 (facilitated glucose
                     transporter), member 6"
                     /db_xref="GeneID:227659"
                     /db_xref="MGI:MGI:2443286"
     exon            1..182
                     /gene="Slc2a6"
                     /gene_synonym="A330096C23; F630103L12Rik; GLUT-6; Glut6;
                     Glut9"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1587
                     /gene="Slc2a6"
                     /gene_synonym="A330096C23; F630103L12Rik; GLUT-6; Glut6;
                     Glut9"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glucose transporter type 6; solute carrier family 2,
                     facilitated glucose transporter member 6"
                     /codon_start=1
                     /product="solute carrier family 2, facilitated glucose
                     transporter member 6 isoform 1"
                     /protein_id="NP_766247.2"
                     /db_xref="CCDS:CCDS15822.1"
                     /db_xref="GeneID:227659"
                     /db_xref="MGI:MGI:2443286"
                     /translation="MQEPLLRTEGLDYDTFPEVPATPGERERAGALKNRRVFLATFAA
                     VLGNFSFGYALVYTSPVIPELKLSSDPALHLDKIQASWFGSVFTLGAAAGGLSAMLLN
                     DLLGRKLSIMFSAVPSAIGYAIMAGARGLWMLLLGRMLTGFAGGLTAACIPVYVSEIA
                     PPDVRGALGATPQLMAVFGSLSLYALGLLLPWRWLAVAGEGPVLIMILLLSFMPNSPR
                     FLLSKSRDEEALQALTWLRADSEVHWEFEQIQDNVRRQSSRVSWAEAREPRVYRPVLI
                     AVLMRFLQQLTGITPILVYLQTIFDNTSVVLPSQQDAAIVGAVRLLSVLIAAVTMDLA
                     GRKVLLYVSASVMFAANLTLGLYVQFVPRPLTPNSTVEIVTLGDTAFNYLTLIPLLAT
                     MLFIMGYAMGWGPITWLLMSEVLPLRARGVASGLCVLVSWLTAFVLTNYFLLAVNAFG
                     LQVPFFFFSAICLLSLLFTGCCVPETRGRSLEQIEAFFHTRRMSFRP"
     exon            183..345
                     /gene="Slc2a6"
                     /gene_synonym="A330096C23; F630103L12Rik; GLUT-6; Glut6;
                     Glut9"
                     /inference="alignment:Splign:2.1.0"
     exon            346..552
                     /gene="Slc2a6"
                     /gene_synonym="A330096C23; F630103L12Rik; GLUT-6; Glut6;
                     Glut9"
                     /inference="alignment:Splign:2.1.0"
     exon            553..652
                     /gene="Slc2a6"
                     /gene_synonym="A330096C23; F630103L12Rik; GLUT-6; Glut6;
                     Glut9"
                     /inference="alignment:Splign:2.1.0"
     exon            653..861
                     /gene="Slc2a6"
                     /gene_synonym="A330096C23; F630103L12Rik; GLUT-6; Glut6;
                     Glut9"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1014
                     /gene="Slc2a6"
                     /gene_synonym="A330096C23; F630103L12Rik; GLUT-6; Glut6;
                     Glut9"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1123
                     /gene="Slc2a6"
                     /gene_synonym="A330096C23; F630103L12Rik; GLUT-6; Glut6;
                     Glut9"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1285
                     /gene="Slc2a6"
                     /gene_synonym="A330096C23; F630103L12Rik; GLUT-6; Glut6;
                     Glut9"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1431
                     /gene="Slc2a6"
                     /gene_synonym="A330096C23; F630103L12Rik; GLUT-6; Glut6;
                     Glut9"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..2136
                     /gene="Slc2a6"
                     /gene_synonym="A330096C23; F630103L12Rik; GLUT-6; Glut6;
                     Glut9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtagggcgga gcttcgcctg ctgtgctgag ggctcaggca gatgctttag ctctgcagtg
       61 gagtcccgct gtatctgacc atccgcgctg gccatgcagg aacccctgct aagaaccgag
      121 ggactcgact atgatacctt ccccgaggtg cccgcgactc ctggagagag agaacgagcc
      181 ggggccttga aaaacagaag ggtgttcctg gctaccttcg ccgctgtgct gggcaatttc
      241 agctttgggt atgccttggt ctacacatct ccagtcatcc ctgaactgaa gctctcttct
      301 gacccagcac tacacctgga caaaatccag gcatcctggt ttgggtccgt gttcaccttg
      361 ggtgccgcag cagggggcct cagtgctatg ttactcaatg acctcctggg ccggaagctc
      421 agcatcatgt tctcagctgt cccctcagcc attggctatg caatcatggc cggtgcccgt
      481 ggcctctgga tgcttctgtt ggggaggatg ctgacgggct ttgccggggg actcactgct
      541 gcctgcatcc cggtgtacgt gtctgagatt gcaccccctg atgttcgtgg ggccctgggg
      601 gccacaccgc agctcatggc cgtgtttgga tccctgtctc tctacgccct tggtctgctg
      661 ctaccttggc gatggcttgc tgtggctgga gaggggccgg ttctcatcat gatcctgctg
      721 ctcagcttca tgcccaactc tcctcgcttc ttgctctcaa agagccggga tgaggaggca
      781 ctgcaggcgc tgacctggct gcgagctgac tccgaggtcc attgggagtt tgagcagatc
      841 caggacaacg tgcggagaca gagtagccga gtgtcgtggg cggaagcccg ggaaccccgt
      901 gtgtaccggc ctgttctcat tgcagtactg atgcgctttc tgcagcagct gacaggcatc
      961 acacccatcc tggtgtacct acagaccatc ttcgacaaca catccgtggt gctgccctcc
     1021 cagcaggatg cagcgatagt tggtgctgtg aggctcctat ctgtgctgat tgctgctgtc
     1081 accatggacc tggcgggccg aaaagttctg ctctatgtgt cagcatccgt catgtttgct
     1141 gccaacctga cactggggct ctacgtccag tttgtgccaa ggcctctgac ccccaacagc
     1201 actgtggaga tcgtgaccct gggggacaca gccttcaact atcttaccct gatacccctg
     1261 ctggccacca tgctcttcat tatgggctat gccatgggct ggggtcccat cacctggctc
     1321 ctcatgtctg aggttctgcc cttgcgtgcc cgtggtgtgg cctcagggct ctgcgtgctg
     1381 gtcagctggc tcacagcctt cgtcctcact aactacttcc tgctggcagt gaatgccttc
     1441 ggcctccagg tgcctttctt cttcttctcg gccatctgcc tgctcagctt gctcttcaca
     1501 ggctgctgtg tgcctgagac caggggccgc tcgctggagc agatcgaggc cttcttccac
     1561 actcgcagga tgtccttcag gccctagtca gggtctcacc tgtaaggggc caaaccaccc
     1621 aggccaggcc tatgcactgg ccacagattc acacctgcca ctgggagcag cagcacccct
     1681 gccatcagcc agagcacact tccaccttgg gacaggcagt ttaccaacaa tgggctggtg
     1741 ggctccagca gaagcctgca gtgctgagat ctgcaggggg agcaggcagc cctgccccag
     1801 actgagcaga ggctgtaccc aagaacaagg ctgtcgggac ctccgatctg gttcctcagt
     1861 cctacgagga acacttccca tgtaggcccg tgttgaggac aggaaacaga gatggaggtg
     1921 gcaaagtggc actgtccaag gacattgtca catcattctg atcaactggc caggaggagg
     1981 acagggtcct gcacccagtt gggtctgggt accttgggga acactggact tccaaaggcc
     2041 agagcacagg acccagtcca aaccttggat acctctagtc tgccaactgt tcactgtttt
     2101 tcaaaataaa gagctgggcc tacagcctca gggagg
//
