LOCUS       NM_019741               3096 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus solute carrier family 2 (facilitated glucose
            transporter), member 5 (Slc2a5), mRNA.
ACCESSION   NM_019741
VERSION     NM_019741.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3096)
  AUTHORS   Yan,H., Wang,Z., Teng,D., Chen,X., Zhu,Z., Chen,H., Wang,W.,
            Wei,Z., Wu,Z., Chai,Q., Zhang,F., Wang,Y., Shu,K., Li,S., Shi,G.,
            Zhu,M., Piao,H.L., Shen,X. and Bu,P.
  TITLE     Hexokinase 2 senses fructose in tumor-associated macrophages to
            promote colorectal cancer growth
  JOURNAL   Cell Metab 36 (11), 2449-2467 (2024)
   PUBMED   39471815
REFERENCE   2  (bases 1 to 3096)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3096)
  AUTHORS   Zhang,Y., Yu,X., Bao,R., Huang,H., Gu,C., Lv,Q., Han,Q., Du,X.,
            Zhao,X.Y., Ye,Y., Zhao,R., Sun,J. and Zou,Q.
  TITLE     Dietary fructose-mediated adipocyte metabolism drives antitumor
            CD8+ T cell responses
  JOURNAL   Cell Metab 35 (12), 2107-2118 (2023)
   PUBMED   37863051
REFERENCE   4  (bases 1 to 3096)
  AUTHORS   Bohuslavova,R., Fabriciova,V., Smolik,O., Lebron-Mora,L.,
            Abaffy,P., Benesova,S., Zucha,D., Valihrach,L., Berkova,Z.,
            Saudek,F. and Pavlinkova,G.
  TITLE     NEUROD1 reinforces endocrine cell fate acquisition in pancreatic
            development
  JOURNAL   Nat Commun 14 (1), 5554 (2023)
   PUBMED   37689751
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3096)
  AUTHORS   Cui,Y., Liu,H., Wang,Z., Zhang,H., Tian,J., Wang,Z., Song,W.,
            Guo,H., Liu,L., Tian,R., Zuo,X., Ren,S., Zhang,F. and Niu,R.
  TITLE     Fructose promotes angiogenesis by improving vascular endothelial
            cell function and upregulating VEGF expression in cancer cells
  JOURNAL   J Exp Clin Cancer Res 42 (1), 184 (2023)
   PUBMED   37507736
  REMARK    GeneRIF: Fructose promotes angiogenesis by improving vascular
            endothelial cell function and upregulating VEGF expression in
            cancer cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3096)
  AUTHORS   Fatima,J., Iqbal,C.W., Houghton,S.G., Kasparek,M.S., Duenes,J.A.,
            Zheng,Y. and Sarr,M.G.
  TITLE     Hexose transporter expression and function in mouse small
            intestine: role of diurnal rhythm
  JOURNAL   J Gastrointest Surg 13 (4), 634-641 (2009)
   PUBMED   19082670
  REMARK    GeneRIF: mRNA expression of GLUT5 varied diurnally in the duodenum,
            jejunum and ileum mucosa.  GLUT5 protein level varied diurnally in
            duodenum and jejunum, but not in the ileum.
REFERENCE   7  (bases 1 to 3096)
  AUTHORS   Sakakura,Y., Shibui,T., Irie,K. and Yajima,T.
  TITLE     Metabolic mode peculiar to Meckel's cartilage: immunohistochemical
            comparisons of hypoxia-inducible factor-1alpha and glucose
            transporters in developing endochondral bones in mice
  JOURNAL   Eur J Oral Sci 116 (4), 341-352 (2008)
   PUBMED   18705802
REFERENCE   8  (bases 1 to 3096)
  AUTHORS   Singh,A.K., Amlal,H., Haas,P.J., Dringenberg,U., Fussell,S.,
            Barone,S.L., Engelhardt,R., Zuo,J., Seidler,U. and Soleimani,M.
  TITLE     Fructose-induced hypertension: essential role of chloride and
            fructose absorbing transporters PAT1 and Glut5
  JOURNAL   Kidney Int 74 (4), 438-447 (2008)
   PUBMED   18496516
  REMARK    GeneRIF: The essential role of chloride and fructose absorbing
            Slc2a5 is reported.
REFERENCE   9  (bases 1 to 3096)
  AUTHORS   Wu,X., Wang,X., Gao,J., Yu,Y., Jia,S., Zheng,J., Dallos,P.,
            He,D.Z., Cheatham,M. and Zuo,J.
  TITLE     Glucose transporter 5 is undetectable in outer hair cells and does
            not contribute to cochlear amplification
  JOURNAL   Brain Res 1210, 20-28 (2008)
   PUBMED   18417103
  REMARK    GeneRIF: We conclude that Glut5 is not required for OHC motility or
            cochlear amplification.
REFERENCE   10 (bases 1 to 3096)
  AUTHORS   Corpe,C.P., Bovelander,F.J., Munoz,C.M., Hoekstra,J.H.,
            Simpson,I.A., Kwon,O., Levine,M. and Burant,C.F.
  TITLE     Cloning and functional characterization of the mouse fructose
            transporter, GLUT5
  JOURNAL   Biochim Biophys Acta 1576 (1-2), 191-197 (2002)
   PUBMED   12031501
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK029720.1.
            
            On Apr 5, 2007 this sequence version replaced NM_019741.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029720.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3096              AK029720.1         2-3097
FEATURES             Location/Qualifiers
     source          1..3096
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 80.97 cM"
     gene            1..3096
                     /gene="Slc2a5"
                     /gene_synonym="Glut5; Slc5a"
                     /note="solute carrier family 2 (facilitated glucose
                     transporter), member 5"
                     /db_xref="GeneID:56485"
                     /db_xref="MGI:MGI:1928369"
     exon            1..207
                     /gene="Slc2a5"
                     /gene_synonym="Glut5; Slc5a"
                     /inference="alignment:Splign:2.1.0"
     exon            208..601
                     /gene="Slc2a5"
                     /gene_synonym="Glut5; Slc5a"
                     /inference="alignment:Splign:2.1.0"
     exon            602..683
                     /gene="Slc2a5"
                     /gene_synonym="Glut5; Slc5a"
                     /inference="alignment:Splign:2.1.0"
     CDS             654..2159
                     /gene="Slc2a5"
                     /gene_synonym="Glut5; Slc5a"
                     /note="fructose transporter; GLUT-5; glucose transporter
                     type 5, small intestine"
                     /codon_start=1
                     /product="solute carrier family 2, facilitated glucose
                     transporter member 5"
                     /protein_id="NP_062715.2"
                     /db_xref="CCDS:CCDS18968.1"
                     /db_xref="GeneID:56485"
                     /db_xref="MGI:MGI:1928369"
                     /translation="MEEKHQEETGELTLVLALATLIAAFGSSFQYGYNVAAVNSPSEF
                     MQQFYNDTYYDRNEENIESFTLTLLWSLTVSMFPFGGFIGSLMVGTLVNKLGRKGALL
                     FNNIFSILPAILMGCSQIAQSFELIIISRLLVGICAGISSNVVPMYLGELAPKNLRGA
                     LGVVPQLFITVGILVAQLFGLRSLLANEDGWPVLLGLTGVPAGLQLLLLPFFPESPRY
                     LLIQKKDEAAAERALQTLRGWKDVHLEMEEIRKEDEAEKAAGFISVWKLFTMQSLRWQ
                     LISMIVLMAGQQLSGVNAIYYYADQIYLSAGVKSDDVQYVTAGTGAVNVFMTILTIFV
                     VELWGRRFLLLVGFSTCLIACLVLTAALALQNTISWMPYISIVCVIVYVIGHALGPSP
                     IPALLITEIFLQSSRPAAYMIGGSVHWLSNFTVGLIFPFIQMGLGPYSFIIFATICFL
                     TTIYIFMVVPETKGRTFIEINQIFTMKNKVSDVYPKKEEELGALPHAILEQ"
     exon            684..782
                     /gene="Slc2a5"
                     /gene_synonym="Glut5; Slc5a"
                     /inference="alignment:Splign:2.1.0"
     exon            783..943
                     /gene="Slc2a5"
                     /gene_synonym="Glut5; Slc5a"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1068
                     /gene="Slc2a5"
                     /gene_synonym="Glut5; Slc5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1221
                     /gene="Slc2a5"
                     /gene_synonym="Glut5; Slc5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1347
                     /gene="Slc2a5"
                     /gene_synonym="Glut5; Slc5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1535
                     /gene="Slc2a5"
                     /gene_synonym="Glut5; Slc5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1646
                     /gene="Slc2a5"
                     /gene_synonym="Glut5; Slc5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1748
                     /gene="Slc2a5"
                     /gene_synonym="Glut5; Slc5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1824
                     /gene="Slc2a5"
                     /gene_synonym="Glut5; Slc5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1952
                     /gene="Slc2a5"
                     /gene_synonym="Glut5; Slc5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..3096
                     /gene="Slc2a5"
                     /gene_synonym="Glut5; Slc5a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2659..2664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc2a5"
                     /gene_synonym="Glut5; Slc5a"
                     /note="hexamer: AATAAA"
     polyA_site      2688
                     /gene="Slc2a5"
                     /gene_synonym="Glut5; Slc5a"
                     /note="major polyA site"
ORIGIN      
        1 agacctgcac ccacccaccc acctaccctg ttgagaaagt tgaggcaggg attgaaccct
       61 cagctttcag atctcatttt acagtaaaac aggcagagag aagattaata gttgggggcc
      121 aagaagctgg cctctgttcc ctacgctccc aagattgtaa actcggctcg ttatttctgt
      181 accccacctc tcactcccgc ccccgaattg aagagccacc gtgttggagt gggaagaaaa
      241 caaggaagtt ttcctggaag gagacgcccc cactgtccat tgctacccga gcggatctac
      301 acttctggat gcagagtggg ctcctgataa acggctgaag ggtgaaggac aagaagaaag
      361 acatctgctg actgaactcg agcaacagct aataaatcaa aggagcatgt ctaacaagga
      421 tgaaaatctg cgggcctggt gggactttgc tcaggttttg gctgcctggc ctggtcagtc
      481 cggtagcagt tgaacacgtg ctgagcgccg gagcccgtgg tgaccagctt gtgggcagat
      541 tgctggactc acaccagcct ctggggactt agcctgccct gcaaaggaag agtacaagaa
      601 gcacagctgg cactttgagg aggtgagccg caggctgcac ttgcagagca acgatggagg
      661 aaaaacatca agaggagaca ggggagctga cattggtcct tgctctggca acgctcatcg
      721 ctgcctttgg ctcatccttc caatatgggt acaacgtagc tgccgtcaac tctccctcag
      781 agttcatgca gcagttttac aatgacacct actacgacag aaatgaggag aatattgagt
      841 ccttcacctt gacgctgctg tggtccctga cggtgtccat gttccccttt gggggcttta
      901 taggctctct catggttgga accttggtga ataaactggg cagaaaaggg gccctgctgt
      961 tcaacaacat attctccatc ctgccggcca tcttaatggg ctgcagccaa attgcccaat
     1021 cgtttgagct aataattatt tccagacttc tggttggaat ctgtgcaggt atctcttcca
     1081 acgtggtccc tatgtactta ggggagctgg ccccgaaaaa cctacgaggg gctctgggag
     1141 tggtcccgca actcttcatc actgtcggca tccttgtggc ccagctgttt ggccttcgga
     1201 gtctcttggc aaatgaggat ggctggccag ttctcctggg tctaactgga gtccccgcag
     1261 gccttcagct cctcctcctc ccgttctttc ccgagagccc ccgctacctg ctgatccaga
     1321 agaaagatga agcagctgct gagagagccc tccagaccct ccgaggctgg aaagacgtgc
     1381 acctagagat ggaggagatc cggaaggagg atgaggctga gaaggcggcg ggcttcatct
     1441 ctgtgtggaa gttgttcact atgcagtctc tccgttggca actcatctcc atgattgtcc
     1501 tcatggctgg ccagcagctg tcgggagtga acgcgatcta ctactacgcc gatcagatct
     1561 acctcagcgc aggcgtgaaa agcgacgacg tccagtatgt gacagccggg actggggccg
     1621 tcaatgtgtt catgaccatc ctcacgatct ttgtggtaga gctttgggga cggcgattcc
     1681 tactcctcgt cggcttctcc acctgcctca tagcctgctt agtgctgacg gccgcactgg
     1741 cgctgcagaa caccatctcc tggatgccct atatcagcat tgtctgtgtc attgtctacg
     1801 tcataggaca cgccttagga cccagcccca tccctgccct gctcatcact gagatcttcc
     1861 tgcagtcctc ccggccagcc gcctacatga tcggaggcag tgtccactgg ctctctaact
     1921 tcactgtggg gctcatcttc cccttcattc aaatgggcct cggtccctac agcttcatta
     1981 tctttgcaac catctgtttc ctcaccacca tctacatctt catggtcgtc ccagagacca
     2041 agggcaggac attcattgag atcaaccaga tttttaccat gaagaacaag gtgtcagacg
     2101 tatatccgaa gaaggaggag gagcttggcg ccctcccaca cgccatcttg gagcagtagc
     2161 agagccaggc caccagccag cctggccagt ctgcatggac ctcctgtcta gacgttggtt
     2221 ctggattctt gtctgtgaca ctggaaggga gatgagcctg gtgggaagtg tcagccccgt
     2281 caccggcctc cactcagtgg gaacatctgc ctgcttttgt gctttcctgc tgtctctaac
     2341 tatagaggcc agtcataggc tcttggtctc gtgcaaagcc atcccttgcc tttaccgggt
     2401 tgactctggt gagggtcttg taacatcgct tttctaacaa aaagagttgc tgcaagacca
     2461 gatgtgatga tcatatttta ccagcaaaac tgactcttgt gtgtttcccg tgggcctgga
     2521 gagaactctg gcatctactt gggattgatg ttgtcttctt tccctaccca gccatgtcat
     2581 aaagtggggg aacaggccat ttgcgaagac acactgagcg tggattatta actgtaagcg
     2641 atactacttt gtataaccaa taaaacagat atgatcactt ctcaccaaga catagcagtt
     2701 ctctacgagc agagggtggc tgccccgccc ccccccgccc ccacccagag caggatctgg
     2761 catggaaaga cacacagaca ctccctgctg aagaaagggc tgggggagag ctgcagagct
     2821 gtgaagtgtt gtgtgtaaag ttgggagaga ctctgcgtgt ctgcagttac atggtgagca
     2881 ccaagggagc catcaacaag gcagaactga agtctgagag ggggcagggg gaagagagag
     2941 gttacaaaag tatagagaaa gccttgagat gtgaaaggag gtcctaagtg ggctgcggga
     3001 tgtggtgtct tctacggcag cagtcaggat aacagggaaa gctttggggg tctggagcga
     3061 ttgttacata catagaataa agattctttg gcatcg
//
