LOCUS       NM_009204               2822 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus solute carrier family 2 (facilitated glucose
            transporter), member 4 (Slc2a4), transcript variant 1, mRNA.
ACCESSION   NM_009204
VERSION     NM_009204.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2822)
  AUTHORS   Kioumourtzoglou,D., Black,H.L., Al Tobi,M., Livingstone,R.,
            Petrie,J.R., Boyle,J.G., Gould,G.W. and Bryant,N.J.
  TITLE     Phosphorylation of Syntaxin 4 by the Insulin Receptor Drives
            Exocytic SNARE Complex Formation to Deliver GLUT4 to the Cell
            Surface
  JOURNAL   Biomolecules 13 (12), 1738 (2023)
   PUBMED   38136609
  REMARK    GeneRIF: Phosphorylation of Syntaxin 4 by the Insulin Receptor
            Drives Exocytic SNARE Complex Formation to Deliver GLUT4 to the
            Cell Surface.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2822)
  AUTHORS   Kawakami,F., Imai,M., Isaka,Y., Cookson,M.R., Maruyama,H., Kubo,M.,
            Farrer,M.J., Kanzaki,M., Kawashima,R., Maekawa,T., Tamaki,S.,
            Kurosaki,Y., Kojima,F., Ohba,K. and Ichikawa,T.
  TITLE     LRRK2 negatively regulates glucose tolerance via regulation of
            membrane translocation of GLUT4 in adipocytes
  JOURNAL   FEBS Open Bio 13 (12), 2200-2214 (2023)
   PUBMED   37845194
  REMARK    GeneRIF: LRRK2 negatively regulates glucose tolerance via
            regulation of membrane translocation of GLUT4 in adipocytes.
REFERENCE   3  (bases 1 to 2822)
  AUTHORS   Shi,H., Hao,X., Sun,Y., Zhang,H., Zhao,Y., Wang,B., Lu,J., Hou,W.,
            Yan,Y., Yu,X., Xue,L., Luo,X. and Wang,H.
  TITLE     Bone marrow mesenchymal stem cell-derived exosomes reduce insulin
            resistance and obesity in mice via the PI3K/AKT signaling pathway
  JOURNAL   FEBS Open Bio 13 (6), 1015-1026 (2023)
   PUBMED   37073893
  REMARK    GeneRIF: Bone marrow mesenchymal stem cell-derived exosomes reduce
            insulin resistance and obesity in mice via the PI3K/AKT signaling
            pathway.
REFERENCE   4  (bases 1 to 2822)
  AUTHORS   Knudsen,J.R., Persson,K.W., Henriquez-Olguin,C., Li,Z., Di Leo,N.,
            Hesselager,S.A., Raun,S.H., Hingst,J.R., Trouillon,R., Wohlwend,M.,
            Wojtaszewski,J.F.P., Gijs,M.A.M. and Jensen,T.E.
  TITLE     Microtubule-mediated GLUT4 trafficking is disrupted in
            insulin-resistant skeletal muscle
  JOURNAL   Elife 12, e83338 (2023)
   PUBMED   37073948
  REMARK    GeneRIF: Microtubule-mediated GLUT4 trafficking is disrupted in
            insulin-resistant skeletal muscle.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2822)
  AUTHORS   Yao,X., Liu,L., Shao,W., Bai,M., Ding,X., Wang,G., Wang,S.,
            Zheng,L., Sun,Y., Wang,G., Huang,Y., Yu,C., Song,Z., Bao,Y.,
            Yang,S. and Sun,L.
  TITLE     Tectorigenin targets PKACalpha to promote GLUT4 expression in
            skeletal muscle and improve insulin resistance in vitro and in vivo
  JOURNAL   Int J Biol Sci 19 (5), 1579-1596 (2023)
   PUBMED   37056927
  REMARK    GeneRIF: Tectorigenin targets PKACalpha to promote GLUT4 expression
            in skeletal muscle and improve insulin resistance in vitro and in
            vivo.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2822)
  AUTHORS   Olichon-Berthe,C., Van Obberghen,E. and Le Marchand-Brustel,Y.
  TITLE     Effect of cold acclimation on the expression of glucose transporter
            Glut 4
  JOURNAL   Mol Cell Endocrinol 89 (1-2), 11-18 (1992)
   PUBMED   1301380
REFERENCE   7  (bases 1 to 2822)
  AUTHORS   Smith,D.E. and Gridley,T.
  TITLE     Differential screening of a PCR-generated mouse embryo cDNA
            library: glucose transporters are differentially expressed in early
            postimplantation mouse embryos
  JOURNAL   Development 116 (3), 555-561 (1992)
   PUBMED   1289053
REFERENCE   8  (bases 1 to 2822)
  AUTHORS   Stephens,J.M. and Pekala,P.H.
  TITLE     Transcriptional repression of the C/EBP-alpha and GLUT4 genes in
            3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is
            coordinate and independent of protein synthesis
  JOURNAL   J Biol Chem 267 (19), 13580-13584 (1992)
   PUBMED   1618860
REFERENCE   9  (bases 1 to 2822)
  AUTHORS   Kotliar,N. and Pilch,P.F.
  TITLE     Expression of the glucose transporter isoform GLUT 4 is
            insufficient to confer insulin-regulatable hexose uptake to
            cultured muscle cells
  JOURNAL   Mol Endocrinol 6 (3), 337-345 (1992)
   PUBMED   1584210
REFERENCE   10 (bases 1 to 2822)
  AUTHORS   Fowlis,G.A., Adelman,S., Knight,A.M. and Simpson,E.
  TITLE     PCR-analyzed microsatellites of the mouse genome--additional
            polymorphisms among ten inbred mouse strains
  JOURNAL   Mamm Genome 3 (4), 192-196 (1992)
   PUBMED   1611214
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596185.12 and AK137607.1.
            
            [WARNING] On May 3, 2024 this sequence was replaced by NM_009204.3.
            
            On Nov 16, 2006 this sequence version replaced NM_009204.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137607.1, AK164310.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AL596185.12        59821-59835         c
            16-2822             AK137607.1         1-2807
FEATURES             Location/Qualifiers
     source          1..2822
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.93 cM"
     gene            1..2822
                     /gene="Slc2a4"
                     /gene_synonym="Glut-4; Glut4; GT2; twgy"
                     /note="solute carrier family 2 (facilitated glucose
                     transporter), member 4"
                     /db_xref="GeneID:20528"
                     /db_xref="MGI:MGI:95758"
     exon            1..242
                     /gene="Slc2a4"
                     /gene_synonym="Glut-4; Glut4; GT2; twgy"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..1739
                     /gene="Slc2a4"
                     /gene_synonym="Glut-4; Glut4; GT2; twgy"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glucose transporter type 4, insulin-responsive"
                     /codon_start=1
                     /product="solute carrier family 2, facilitated glucose
                     transporter member 4 isoform 1"
                     /protein_id="NP_033230.2"
                     /db_xref="CCDS:CCDS36201.1"
                     /db_xref="GeneID:20528"
                     /db_xref="MGI:MGI:95758"
                     /translation="MPSGFQQIGSDDGEPPRQRVTGTLVLAVFSAVLGSLQFGYNIGV
                     INAPQKVIEQSYNATWLGRQGPGGPDSIPQGTLTTLWALSVAIFSVGGMISSFLIGII
                     SQWLGRKRAMLANNVLAVLGGALMGLANAAASYEILILGRFLIGAYSGLTSGLVPMYV
                     GEIAPTHLRGALGTLNQLAIVIGILVAQVLGLESMLGTATLWPLLLALTVLPALLQLI
                     LLPFCPESPRYLYIIRNLEGPARKSLKRLTGWADVSDALAELKDEKRKLERERPMSLL
                     QLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFESAGVGQPAYATIGAGVVNT
                     VFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFV
                     AFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTCNFIVGMGFQYVADAMGPYVF
                     LLFAVLLLGFFIFTFLKVPETRGRTFDQISAAFRRTPSLLEQEVKPSTELEYLGPDEN
                     D"
     exon            243..359
                     /gene="Slc2a4"
                     /gene_synonym="Glut-4; Glut4; GT2; twgy"
                     /inference="alignment:Splign:2.1.0"
     exon            360..532
                     /gene="Slc2a4"
                     /gene_synonym="Glut-4; Glut4; GT2; twgy"
                     /inference="alignment:Splign:2.1.0"
     exon            533..657
                     /gene="Slc2a4"
                     /gene_synonym="Glut-4; Glut4; GT2; twgy"
                     /inference="alignment:Splign:2.1.0"
     exon            658..773
                     /gene="Slc2a4"
                     /gene_synonym="Glut-4; Glut4; GT2; twgy"
                     /inference="alignment:Splign:2.1.0"
     exon            774..936
                     /gene="Slc2a4"
                     /gene_synonym="Glut-4; Glut4; GT2; twgy"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1124
                     /gene="Slc2a4"
                     /gene_synonym="Glut-4; Glut4; GT2; twgy"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1229
                     /gene="Slc2a4"
                     /gene_synonym="Glut-4; Glut4; GT2; twgy"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1331
                     /gene="Slc2a4"
                     /gene_synonym="Glut-4; Glut4; GT2; twgy"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1535
                     /gene="Slc2a4"
                     /gene_synonym="Glut-4; Glut4; GT2; twgy"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..2822
                     /gene="Slc2a4"
                     /gene_synonym="Glut-4; Glut4; GT2; twgy"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2800..2805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc2a4"
                     /gene_synonym="Glut-4; Glut4; GT2; twgy"
                     /note="putative"
     polyA_site      2822
                     /gene="Slc2a4"
                     /gene_synonym="Glut-4; Glut4; GT2; twgy"
                     /note="putative"
ORIGIN      
        1 gcatctttcc ccctcaagcg ggtctcacta gatcccggag agccttggtg ctctccggtt
       61 ccgtgggttg tggcagtgag tcccaccaga cccgcccttt gcacacggct tccgaacgcc
      121 ggggtctcgt gccggccagg cccggaccct ataccctatt catttttttc ttattgcagc
      181 gcctgagtct tttcttcttt taaaacaaga tgccgtcggg tttccagcag atcggctctg
      241 acgatgggga accccctcgg cagcgagtga ctggaacact ggtcctagct gtattctcag
      301 ctgtgcttgg ctcccttcag tttggctata acattggggt tatcaatgcc ccacagaagg
      361 tgattgaaca gagctacaat gcaacgtggc tgggtaggca aggtcctggg ggaccggatt
      421 ccatcccaca aggcaccctc actacgctct gggctctctc cgtggccatc ttctctgtgg
      481 gtggcatgat ctcttccttt ctcattggca tcatttctca atggttggga aggaaaaggg
      541 ctatgctggc caacaatgtc ttggccgtgt tggggggcgc cctcatgggc ctagccaatg
      601 ccgcggcctc ctatgagata ctcattcttg gacggttcct cattggcgcc tactcagggc
      661 taacatcagg gctggtgccc atgtatgtgg gagaaatcgc ccccactcat cttcggggtg
      721 ccttgggaac actcaaccaa ctggccatcg tcattggcat tctggttgcc caggtgctgg
      781 gcttggagtc tatgctgggc acagctaccc tgtggccact gcttctggct ctcacagtac
      841 tccctgctct cctgcagctg attctgctgc ccttctgtcc tgagagcccc agatacctct
      901 acatcatccg gaacctggag gggcctgccc gaaagagtct aaagcgcctg accggctggg
      961 ctgatgtgtc tgacgcacta gctgagctga aggatgagaa acggaagttg gagagagagc
     1021 gtccaatgtc cttgctccag ctcctgggca gccgcaccca ccggcagcct ctgatcatcg
     1081 cagtggtgct gcagctgagc caacagctct caggcatcaa tgctgttttc tactattcaa
     1141 ccagcatctt cgagtcggct ggggtgggac agccagccta cgccaccata ggagctggtg
     1201 tggtcaatac ggtcttcacg ttggtctcgg tgctcttagt agaacgagct ggacgacgga
     1261 cactccatct gttgggcctg gccggcatgt gtggctgtgc catcttgatg accgtggctc
     1321 tgctgctgct ggaacgggtt ccagccatga gctatgtctc catcgtggcc atatttggct
     1381 ttgtggcctt ctttgagatt ggccctggcc ccattccctg gttcattgtg gcagagctct
     1441 tcagccaggg cccccgccca gccgccatgg ctgtcgctgg tttctccaac tggacctgta
     1501 acttcattgt cggcatgggt ttccagtatg ttgcggatgc tatgggtcct tacgtcttcc
     1561 ttctatttgc cgtcctcctg cttggcttct tcatcttcac cttcctaaaa gtgcctgaaa
     1621 ccagaggccg gacgtttgac cagatctcag ctgccttccg acggacacct tcccttttag
     1681 agcaggaggt gaaacccagt acagaacttg aatacttagg gccagatgag aatgactgag
     1741 gggcaaaaca gggtgggaga gccaccctct ccacccagac tccctccttt cctctacagc
     1801 actttagccc tctcttccct gttacctcca ggttgaagga acagcagcct ggggaactgg
     1861 gaagctgaag ggaggggtgg tccatgtacc cctcattccc cctgtgtgat tcttttggat
     1921 tatttatgtg tgtggctagg ctgtggccac ctagatgggc tttctccgtc ctgccttcct
     1981 cctgccccta cccagactca gctctagact actttcctcc cctttcgaga aggggtctgc
     2041 aggagggtgg ggtggccctg aattcatcag gataaacagc aggggtgggt gtgtgagcga
     2101 gtgctttcct cccacaaact ggcacttcca ctgaactctt gccacacagg ctctgggtga
     2161 agggggttgt cttgacccct ccagggcaaa ggatacaccc tcccaaaatc tagccctgcc
     2221 tccccacagg ctccaccctc ccgggcaaag gaacacaata gtacatacct gacagggcaa
     2281 ggacggttag agcgcatcag tctccatttg gggccctagg ttgttcccag ggctgcaaag
     2341 cgtaggtacc aacactttct tgttcccctc caggaagggt gctaaacccg aaagcttctg
     2401 accaactaag ggcgggaggg gatttgaaag gctgcctata aacactggtt gggagggagc
     2461 ctttggtatt tttgtatgtt ttgaagaacg gatagggagc agaaacccaa gggctgctgt
     2521 attaaatgtg tatatagaga ttcgtccata aagtcactgt ttgaagatga gtgtcctgtg
     2581 ctggaggaac tggagggtgt gcaaaaagaa aatgcctcac tcaccctttg cacttcatcc
     2641 ttcctgggct cagggcaccg aggcctctag attctgtcac ctttttttta ggggggggcg
     2701 ggtttcgaga cagggtttct ctgtcctgga actcactttg tagaccaggc tggccttgaa
     2761 ctcaagaaat ccgcctgcct ctgcctcccg attgctggga ttaaaggtgt gcgtgtgcca
     2821 cc
//
