LOCUS       NM_001410376            4030 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus solute carrier family 2 (facilitated glucose
            transporter), member 3 (Slc2a3), transcript variant 2, mRNA.
ACCESSION   NM_001410376 XM_011241268
VERSION     NM_001410376.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4030)
  AUTHORS   Song,C., Sawall,J.K., Ji,X., Song,F., Liao,X., Peng,R., Ren,H.,
            Koyama,E., Pacifici,M. and Long,F.
  TITLE     Tgfbeta signaling stimulates glycolysis to promote the genesis of
            synovial joint interzone in developing mouse embryonic limbs
  JOURNAL   Sci Adv 11 (2), eadq4991 (2025)
   PUBMED   39772668
REFERENCE   2  (bases 1 to 4030)
  AUTHORS   Huang,Y., Wang,Y., Zhen,Y., Liu,W., Wang,Y., Wang,R., Wang,N.,
            Huang,S., Yan,J. and Sun,Q.
  TITLE     LPCAT1 Facilitates Keratinocyte Hyperproliferation and Skin
            Inflammation in Psoriasis by Regulating GLUT3
  JOURNAL   J Invest Dermatol 144 (7), 1479-1490 (2024)
   PUBMED   38246582
  REMARK    GeneRIF: LPCAT1 Facilitates Keratinocyte Hyperproliferation and
            Skin Inflammation in Psoriasis by Regulating GLUT3.
REFERENCE   3  (bases 1 to 4030)
  AUTHORS   Yu,D.M., Zhao,J., Lee,E.E., Kim,D., Mahapatra,R., Rose,E.K.,
            Zhou,Z., Hosler,C., El Kurdi,A., Choe,J.Y., Abel,E.D., Hoxhaj,G.,
            Westover,K.D., Cho,R.J., Cheng,J.B. and Wang,R.C.
  TITLE     GLUT3 promotes macrophage signaling and function via RAS-mediated
            endocytosis in atopic dermatitis and wound healing
  JOURNAL   J Clin Invest 133 (21), e170706 (2023)
   PUBMED   37721853
  REMARK    GeneRIF: GLUT3 promotes macrophage signaling and function via
            RAS-mediated endocytosis in atopic dermatitis and wound healing.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4030)
  AUTHORS   Johnston,S.N., Silagi,E.S., Madhu,V., Nguyen,D.H., Shapiro,I.M. and
            Risbud,M.V.
  TITLE     GLUT1 is redundant in hypoxic and glycolytic nucleus pulposus cells
            of the intervertebral disc
  JOURNAL   JCI Insight 8 (8), e164883 (2023)
   PUBMED   36917198
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4030)
  AUTHORS   Lopez-Tello,J. and Sferruzzi-Perri,A.N.
  TITLE     Characterization of placental endocrine function and fetal brain
            development in a mouse model of small for gestational age
  JOURNAL   Front Endocrinol (Lausanne) 14, 1116770 (2023)
   PUBMED   36843585
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4030)
  AUTHORS   Yi,T., Gilbert,D.J., Jenkins,N.A., Copeland,N.G. and Ihle,J.N.
  TITLE     Assignment of a novel protein tyrosine phosphatase gene (Hcph) to
            mouse chromosome 6
  JOURNAL   Genomics 14 (3), 793-795 (1992)
   PUBMED   1427910
REFERENCE   7  (bases 1 to 4030)
  AUTHORS   Smith,D.E. and Gridley,T.
  TITLE     Differential screening of a PCR-generated mouse embryo cDNA
            library: glucose transporters are differentially expressed in early
            postimplantation mouse embryos
  JOURNAL   Development 116 (3), 555-561 (1992)
   PUBMED   1289053
REFERENCE   8  (bases 1 to 4030)
  AUTHORS   Foroni,L., Boehm,T., White,L., Forster,A., Sherrington,P.,
            Liao,X.B., Brannan,C.I., Jenkins,N.A., Copeland,N.G. and
            Rabbitts,T.H.
  TITLE     The rhombotin gene family encode related LIM-domain proteins whose
            differing expression suggests multiple roles in mouse development
  JOURNAL   J Mol Biol 226 (3), 747-761 (1992)
   PUBMED   1507224
REFERENCE   9  (bases 1 to 4030)
  AUTHORS   Aghayan,M., Rao,L.V., Smith,R.M., Jarett,L., Charron,M.J.,
            Thorens,B. and Heyner,S.
  TITLE     Developmental expression and cellular localization of glucose
            transporter molecules during mouse preimplantation development
  JOURNAL   Development 115 (1), 305-312 (1992)
   PUBMED   1638987
REFERENCE   10 (bases 1 to 4030)
  AUTHORS   Gould,G.W., Brant,A.M., Kahn,B.B., Shepherd,P.R., McCoid,S.C. and
            Gibbs,E.M.
  TITLE     Expression of the brain-type glucose transporter is restricted to
            brain and neuronal cells in mice
  JOURNAL   Diabetologia 35 (4), 304-309 (1992)
   PUBMED   1516757
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163108.5 and AC131715.3.
            
            On Aug 6, 2022 this sequence version replaced XM_011241268.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.219356.1,
                                           SRR17784647.330331.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-378               AC163108.5         64340-64717
            379-456             AC163108.5         68651-68728
            457-549             AC131715.3         11243-11335
            550-710             AC131715.3         11730-11890
            711-951             AC131715.3         14425-14665
            952-1114            AC131715.3         14982-15144
            1115-1302           AC131715.3         16113-16300
            1303-1407           AC131715.3         18849-18953
            1408-1509           AC131715.3         19251-19352
            1510-1713           AC131715.3         20127-20330
            1714-4030           AC131715.3         21583-23899
FEATURES             Location/Qualifiers
     source          1..4030
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 57.82 cM"
     gene            1..4030
                     /gene="Slc2a3"
                     /gene_synonym="Glut-3; Glut3"
                     /note="solute carrier family 2 (facilitated glucose
                     transporter), member 3"
                     /db_xref="GeneID:20527"
                     /db_xref="MGI:MGI:95757"
     exon            1..378
                     /gene="Slc2a3"
                     /gene_synonym="Glut-3; Glut3"
                     /inference="alignment:Splign:2.1.0"
     exon            379..456
                     /gene="Slc2a3"
                     /gene_synonym="Glut-3; Glut3"
                     /inference="alignment:Splign:2.1.0"
     CDS             436..1923
                     /gene="Slc2a3"
                     /gene_synonym="Glut-3; Glut3"
                     /note="isoform a is encoded by transcript variant 2;
                     glucose transporter type 3, brain"
                     /codon_start=1
                     /product="solute carrier family 2, facilitated glucose
                     transporter member 3 isoform a"
                     /protein_id="NP_001397305.1"
                     /db_xref="GeneID:20527"
                     /db_xref="MGI:MGI:95757"
                     /translation="MESSKHNVTPSLVFAVTVATIGSFQFGYNTGVINAPETILKDFL
                     NYTLEERLEDLPSEGLLTALWSLCVAIFSVGGMIGSFSVGLFVNRFGRRNSMLLVNLL
                     AIIAGCLMGFAKIAESVEMLILGRLLIGIFCGLCTGFVPMYIGEVSPTALRGAFGTLN
                     QLGIVVGILVAQIFGLDFILGSEELWPGLLGLTIIPAILQSAALPFCPESPRFLLINK
                     KEEDQATEILQRLWGTSDVVQEIQEMKDESVRMSQEKQVTVLELFRSPNYVQPLLISI
                     VLQLSQQLSGINAVFYYSTGIFKDAGVQEPIYATIGAGVVNTIFTVVSLFLVERAGRR
                     TLHMIGLGGMAVCSVFMTISLLLKDDYEAMSFVCIVAILIYVAFFEIGPGPIPWFIVA
                     ELFSQGPRPAAIAVAGCCNWTSNFLVGMLFPSAAAYLGAYVFIIFAAFLIFFLIFTFF
                     KVPETKGRTFEDIARAFEGQAHSGKGPAGVELNSMQPVKETPGNA"
     exon            457..549
                     /gene="Slc2a3"
                     /gene_synonym="Glut-3; Glut3"
                     /inference="alignment:Splign:2.1.0"
     exon            550..710
                     /gene="Slc2a3"
                     /gene_synonym="Glut-3; Glut3"
                     /inference="alignment:Splign:2.1.0"
     exon            711..951
                     /gene="Slc2a3"
                     /gene_synonym="Glut-3; Glut3"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1114
                     /gene="Slc2a3"
                     /gene_synonym="Glut-3; Glut3"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1302
                     /gene="Slc2a3"
                     /gene_synonym="Glut-3; Glut3"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1407
                     /gene="Slc2a3"
                     /gene_synonym="Glut-3; Glut3"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1509
                     /gene="Slc2a3"
                     /gene_synonym="Glut-3; Glut3"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1713
                     /gene="Slc2a3"
                     /gene_synonym="Glut-3; Glut3"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..4030
                     /gene="Slc2a3"
                     /gene_synonym="Glut-3; Glut3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4012..4017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc2a3"
                     /gene_synonym="Glut-3; Glut3"
                     /note="hexamer: AATAAA"
     polyA_site      4030
                     /gene="Slc2a3"
                     /gene_synonym="Glut-3; Glut3"
                     /note="major polyA site"
ORIGIN      
        1 aaacctagcc gtgttgtctg cttgacaaga caccagcggg gtagcagacc tttatgatac
       61 caaagcgcca aacccgcacc ggagtccttt tgaagacgaa ggggaacaca tgggctgtga
      121 aggggctcac cagctccttc cacggaaccc gctctgcgcc ctcctggggg agtagaggcg
      181 cgagggggtt ccgtatctct taaagcagca atgtcaactc cctcttaagg gaggcacgga
      241 ggatggcggg gcccaggacg tgaagcctca gggcgctgac acgttcgggg accccagact
      301 acgcctgatc ggttggtggc caggtgagga gcaggacgca ggcgacaggc cgccctggaa
      361 gggacccttg ctttcgccga agctgtgcct tgaagagaaa tttgaagaag gatcaagtct
      421 tgctacaata gagagatgga gagcagcaaa cataatgtga ccccatctct ggtgttcgcc
      481 gtgactgttg ccacgatcgg ctctttccag tttggctaca acactggagt catcaatgca
      541 cctgagacaa tcctaaagga ctttcttaac tacactttgg aagagcggtt agaagaccta
      601 ccaagtgagg gactgctgac tgccctctgg tccttatgtg tggccatctt ctctgttggt
      661 ggcatgattg gctctttttc tgttggactc tttgtcaacc gctttggcag acgcaactct
      721 atgcttctag tcaacttgct ggccatcatt gcgggctgcc ttatgggatt cgccaagata
      781 gcggagtctg ttgaaatgct gatcctgggc cgcttactca ttggcatttt ctgtggcctg
      841 tgcacgggct ttgtgcctat gtacattgga gaggtgtctc ccactgccct tcggggtgca
      901 tttggcacac taaaccagct gggcatcgtt gttgggattc tggtagctca gatctttggt
      961 ttggacttta ttctgggctc tgaagaactg tggcctgggc tccttggctt aaccatcatt
     1021 ccagctatcc tgcaaagcgc agcccttcca ttttgccctg agagtccaag attcttgctc
     1081 attaacaaaa aggaggaaga ccaagctaca gagatcctgc agcgcttgtg gggcacctcg
     1141 gacgtggtcc aggagatcca ggagatgaag gatgagagtg ttcggatgtc acaggagaag
     1201 caggtgactg tgctggagct cttcaggtca cccaactacg tccagccgct tctcatctcc
     1261 attgtcctcc agctgtctca gcagctctct gggatcaatg ctgtgttcta ttactcaaca
     1321 ggaatcttca aggacgcggg tgtccaggaa ccgatctatg ccacgattgg agcaggcgtg
     1381 gtcaatacta tcttcactgt agtttctctg ttcctggtgg agagggcagg gaggagaacc
     1441 ctgcatatga taggcctggg aggcatggct gtttgctccg ttttcatgac gatttcgctg
     1501 ttactaaagg atgactatga agccatgagc tttgtctgta ttgtggctat cttgatctac
     1561 gtagccttct ttgagattgg acctggcccc attccctggt ttattgtggc tgagctcttc
     1621 agccagggcc cccgcccagc tgccattgcg gtggctggct gttgtaactg gacctccaac
     1681 tttctggtcg gaatgctctt cccctcagct gcagcctact taggagccta cgtttttatc
     1741 atcttcgctg ccttcctcat cttcttccta atcttcacct tcttcaaagt cccggagacc
     1801 aaaggcagga ctttcgagga cattgcccgg gccttcgagg ggcaggcgca ctctggaaaa
     1861 ggccctgccg gtgtggagtt gaacagcatg cagccggtca aggagacccc tggcaacgcc
     1921 tgagccggga gcacctcctt cacctccctc cactgtggaa agccacctcc ccttaagtgg
     1981 ggagacctca tcaggatgaa ccaggactgc ttctgagtgc tgctattctc accccacaca
     2041 ctccatgaaa actcagctgc acccaatgct ggggttgacc agatcgccaa tggcttttaa
     2101 gtgtttgatt tgggggatac ttcccttgta atcaggaaag accaaggaag cctaccttta
     2161 tattgggagg gaaggggccg cagctcccct taggttctaa aacccgctaa ctaggacaac
     2221 tagggagtag gagtagggtg cagcaccgcc cccaccacca ccttagtttg ccaggaaaca
     2281 gatcttcata cccagtgtgg agggccctgg gggattgaac aaaagacccc ctcctcactt
     2341 gatacagctc tgcacagcaa agtaacttga gttttattta ttttatcttc aggttgaatt
     2401 gcataaatat ttattttttt aattgtaatt ttaccaaata atgagacagt aacgaaattg
     2461 aggttggagg gaggtgttta aagagaggtt caggaggaaa gaaagtttgg tgctggagag
     2521 aggttacaac agggaggatg gatgttactg gtggcctgtg agtcacttcc tttgtagatg
     2581 aagggacact atcccttgtt atttctcaga agagcgagtg cctgtactaa aaggctcatg
     2641 gctttctgtg ggccttttct tttaagatta tagtttttat gtagtgttac taaaatctag
     2701 gcttgttact aaagtggtct ttgtagttag tgatattgat ggatttttat gttgcatgga
     2761 gtccagacaa gggaggggtc accgcaagcc tctcctttcc ctggaccaac accctctctg
     2821 tcctgtgagc tcgctttttc ttttctgatg gtcaagccca ttaccaaacg ggcgggcgag
     2881 cgagcgagcc gtgtggatga gacacaaaga cagtagttgt tgagaggcat tagtttcttc
     2941 aacttagttt ttttttaaga gattttaggt gttggtttgt ttcattttgg tttaaaggga
     3001 ttcatagcta acttggattt tgttacctca gctctgggag aggattttcg ctggatgact
     3061 attaatgact tgttttgagg gagtacattt gttgctctag agttgtggca tgctagccta
     3121 tgtctgttac agtctcaggc tgcccttgtt tccaggttcc tgtgctattg tgctacatgc
     3181 ccaaggggcc ttggctctgc tacacacatt agagacagtg actgaatgtg cagtgtggtc
     3241 cacgcatgag ggcacaaatg tctgtgcatt gtcactttgc tctgggcatg aagtccctgg
     3301 tcccttggct cctgtagctt tttattgatc gactattaga actcaaccct gtgtacagaa
     3361 gcagcactgc ctctgctagg tggagcttgc acccaggatt agatgccacc cattgggttc
     3421 cctgtccctg ttggagagag gtgcttcctt gaggtctgag gttggaaggc tctacctcac
     3481 tacagctagg aggcgcaatg gaaaggtgtg aggtcagggc tgtggctcct gaagacccag
     3541 ttgtgggcca agggtggctt tatttaaagg gagttaagaa acatggcata ttggtatgtt
     3601 gatatcacca agattccctt ctgccatagg tcacagacac cttcccaact gtcccctcct
     3661 ccacttccat aaatggagac aaccctgatg gacctcaccc cttttccaca ggtcactgga
     3721 tcccactgtc accctcggtg cttacacatt tcagaccctt taggcaaacc cttgcataga
     3781 gtggtagagc catatctcag tgctcggttt cagtattcaa ctctccactc cctgtggcca
     3841 gttgggattt aaaaactcag attgctatgg aaaggggctt tgctgggaaa ggcgactcct
     3901 ctaacttcac ctcttcagtt cctccagtgg agtttttaca tttgccaatg gccatcttgt
     3961 gaatatcttc atacatactt tctattaatg ttactgtagt ttctgttttg aaataaaact
     4021 tctgaatgta
//
