LOCUS       NM_031197               2571 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus solute carrier family 2 (facilitated glucose
            transporter), member 2 (Slc2a2), mRNA.
ACCESSION   NM_031197
VERSION     NM_031197.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2571)
  AUTHORS   Kadhim,A.Z., Vanderkruk,B., Mar,S., Dan,M., Zosel,K., Xu,E.E.,
            Spencer,R.J., Sasaki,S., Cheng,X., Sproul,S.L.J., Speckmann,T.,
            Nian,C., Cullen,R., Shi,R., Luciani,D.S., Hoffman,B.G., Taubert,S.
            and Lynn,F.C.
  TITLE     Transcriptional coactivator MED15 is required for beta cell
            maturation
  JOURNAL   Nat Commun 15 (1), 8711 (2024)
   PUBMED   39379383
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2571)
  AUTHORS   Zhang,Y., Jiang,X., Wu,D., Huang,H., Jia,G. and Zhao,G.
  TITLE     Sema4D deficiency enhances glucose tolerance through GLUT2
            retention in hepatocytes
  JOURNAL   J Transl Med 22 (1), 864 (2024)
   PUBMED   39334386
  REMARK    GeneRIF: Sema4D deficiency enhances glucose tolerance through GLUT2
            retention in hepatocytes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2571)
  AUTHORS   Kane,E., Mak,T.C.S. and Latreille,M.
  TITLE     MicroRNA-7 regulates endocrine progenitor delamination and
            endocrine cell mass in developing pancreatic islets
  JOURNAL   iScience 27 (7), 110332 (2024)
   PUBMED   39055950
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2571)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 2571)
  AUTHORS   Fu,H., Vuononvirta,J., Fanti,S., Bonacina,F., D'Amati,A., Wang,G.,
            Poobalasingam,T., Fankhaenel,M., Lucchesi,D., Coleby,R.,
            Tarussio,D., Thorens,B., Hearnden,R.J., Longhi,M.P., Grevitt,P.,
            Sheikh,M.H., Solito,E., Godinho,S.A., Bombardieri,M., Smith,D.M.,
            Cooper,D., Iqbal,A.J., Rathmell,J.C., Schaefer,S., Morales,V.,
            Bianchi,K., Norata,G.D. and Marelli-Berg,F.M.
  TITLE     The glucose transporter 2 regulates CD8+ T cell function via
            environment sensing
  JOURNAL   Nat Metab 5 (11), 1969-1985 (2023)
   PUBMED   37884694
REFERENCE   6  (bases 1 to 2571)
  AUTHORS   Smith,D.E. and Gridley,T.
  TITLE     Differential screening of a PCR-generated mouse embryo cDNA
            library: glucose transporters are differentially expressed in early
            postimplantation mouse embryos
  JOURNAL   Development 116 (3), 555-561 (1992)
   PUBMED   1289053
REFERENCE   7  (bases 1 to 2571)
  AUTHORS   Thorens,B., Wu,Y.J., Leahy,J.L. and Weir,G.C.
  TITLE     The loss of GLUT2 expression by glucose-unresponsive beta cells of
            db/db mice is reversible and is induced by the diabetic environment
  JOURNAL   J Clin Invest 90 (1), 77-85 (1992)
   PUBMED   1634622
REFERENCE   8  (bases 1 to 2571)
  AUTHORS   Aghayan,M., Rao,L.V., Smith,R.M., Jarett,L., Charron,M.J.,
            Thorens,B. and Heyner,S.
  TITLE     Developmental expression and cellular localization of glucose
            transporter molecules during mouse preimplantation development
  JOURNAL   Development 115 (1), 305-312 (1992)
   PUBMED   1638987
REFERENCE   9  (bases 1 to 2571)
  AUTHORS   Tal,M., Thorens,B., Surana,M., Fleischer,N., Lodish,H.F.,
            Hanahan,D. and Efrat,S.
  TITLE     Glucose transporter isotypes switch in T-antigen-transformed
            pancreatic beta cells growing in culture and in mice
  JOURNAL   Mol Cell Biol 12 (1), 422-432 (1992)
   PUBMED   1729614
REFERENCE   10 (bases 1 to 2571)
  AUTHORS   Hogan,A., Heyner,S., Charron,M.J., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Thorens,B. and Schultz,G.A.
  TITLE     Glucose transporter gene expression in early mouse embryos
  JOURNAL   Development 113 (1), 363-372 (1991)
   PUBMED   1765007
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK005068.1, AK165430.1 and AI120520.1.
            
            On Jan 16, 2008 this sequence version replaced NM_031197.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005068.1, AK165430.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2537              AK005068.1         2-2538
            2538-2566           AK165430.1         2473-2501
            2567-2571           AI120520.1         10-14               c
FEATURES             Location/Qualifiers
     source          1..2571
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 12.19 cM"
     gene            1..2571
                     /gene="Slc2a2"
                     /gene_synonym="Glut-2; Glut2"
                     /note="solute carrier family 2 (facilitated glucose
                     transporter), member 2"
                     /db_xref="GeneID:20526"
                     /db_xref="MGI:MGI:1095438"
     exon            1..129
                     /gene="Slc2a2"
                     /gene_synonym="Glut-2; Glut2"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1686
                     /gene="Slc2a2"
                     /gene_synonym="Glut-2; Glut2"
                     /note="glucose transporter type 2, liver; liver-type
                     glucose transporter"
                     /codon_start=1
                     /product="solute carrier family 2, facilitated glucose
                     transporter member 2"
                     /protein_id="NP_112474.2"
                     /db_xref="CCDS:CCDS50880.1"
                     /db_xref="GeneID:20526"
                     /db_xref="MGI:MGI:1095438"
                     /translation="MSEDKITGTLAFTVFTAVLSSFQFGYDIGVINAPQEVIISHYRH
                     VLGVPLDDRKAAINYDVNGTDTPLTVTPAYTTPAPWDEEETEGSAHIVTMLWSLSVSS
                     FAVGGMVASFFGGWLGDKLGRIKAMLAANSLSLTGALLMGCSKFGPAHALIIAGRSVS
                     GLYCGLISGLVPMYIGEIAPTTLRGALGTLHQLALVTGILISQIAGLSFILGNQDHWH
                     ILLGLSAVPALLQCLLLLFCPESPRYLYIKLEEEVRAKKSLKRLRGTEDVTKDINEMK
                     KEKEEASTEQKVSVIQLFTDANYRQPILVALMLHMAQQFSGINGIFYYSTSIFQTAGI
                     SQPVYATIGVGAINMIFTAVSVLLVEKAGRRTLFLTGMIGMFFCTIFMSVGLVLLDKF
                     AWMSYVSMTAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPTALALAAFSNWVCNFVIA
                     LCFQYIADFLGPYVFFLFAGVVLVFTLFTFFKVPETKGKSFEEIAAEFRKKSGSAPPR
                     KAAVQMEFLASSESV"
     exon            130..222
                     /gene="Slc2a2"
                     /gene_synonym="Glut-2; Glut2"
                     /inference="alignment:Splign:2.1.0"
     exon            223..482
                     /gene="Slc2a2"
                     /gene_synonym="Glut-2; Glut2"
                     /inference="alignment:Splign:2.1.0"
     exon            483..607
                     /gene="Slc2a2"
                     /gene_synonym="Glut-2; Glut2"
                     /inference="alignment:Splign:2.1.0"
     exon            608..723
                     /gene="Slc2a2"
                     /gene_synonym="Glut-2; Glut2"
                     /inference="alignment:Splign:2.1.0"
     exon            724..886
                     /gene="Slc2a2"
                     /gene_synonym="Glut-2; Glut2"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1074
                     /gene="Slc2a2"
                     /gene_synonym="Glut-2; Glut2"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1179
                     /gene="Slc2a2"
                     /gene_synonym="Glut-2; Glut2"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1281
                     /gene="Slc2a2"
                     /gene_synonym="Glut-2; Glut2"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1485
                     /gene="Slc2a2"
                     /gene_synonym="Glut-2; Glut2"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..2571
                     /gene="Slc2a2"
                     /gene_synonym="Glut-2; Glut2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2515..2520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc2a2"
                     /gene_synonym="Glut-2; Glut2"
                     /note="hexamer: AATAAA"
     polyA_site      2540
                     /gene="Slc2a2"
                     /gene_synonym="Glut-2; Glut2"
                     /note="major polyA site"
     regulatory      2546..2551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc2a2"
                     /gene_synonym="Glut-2; Glut2"
                     /note="hexamer: AATAAA"
     polyA_site      2571
                     /gene="Slc2a2"
                     /gene_synonym="Glut-2; Glut2"
                     /note="major polyA site"
ORIGIN      
        1 gctcctcctc ctcctacaat gtataaccag gtagagtgag cactctggct ggtcagctat
       61 tcatccacat tcagtacagg acctggatta agaggacaat tccacacaca cacaatgtca
      121 gaagacaaga tcaccggaac cttggctttc actgtcttca ctgctgtact gagttccttc
      181 cagttcggct atgacatcgg tgtgatcaat gcacctcaag aggtaataat atcccattat
      241 cgacatgttt tgggtgttcc actggatgac cggaaagctg ccattaacta tgacgtcaat
      301 ggcacagaca ccccacttac agtcacacca gcatacacaa caccagctcc ctgggatgaa
      361 gaggagactg aaggatctgc tcacatagtc actatgctct ggtctctgtc tgtgtccagc
      421 tttgcagtgg gcggaatggt cgcctcattc tttggtgggt ggctcgggga caaacttgga
      481 aggatcaaag caatgttggc tgcaaacagc ctctcattga ctggagccct cttgatggga
      541 tgttccaaat ttggaccggc acacgccctc atcattgctg gacgaagtgt atcaggactg
      601 tattgtgggc taatttcagg actggttcca atgtacattg gagagatcgc tccaaccaca
      661 ctcaggggtg ccctgggtac tcttcaccaa ctggcccttg tcacaggcat tcttattagt
      721 cagattgctg gcctcagctt tattctgggc aatcaggatc attggcacat cctacttggc
      781 ctatctgctg tgccagctct tctgcagtgt ctgctactgc tcttctgtcc agaaagcccc
      841 agataccttt atataaagtt ggaagaggaa gtcagggcaa agaaaagctt gaagagacta
      901 agaggaactg aggatgtcac caaagatatt aatgagatga agaaagaaaa ggaagaggca
      961 tcgactgagc agaaggtctc cgtgatccag ctcttcacgg atgccaatta ccgacagccc
     1021 atcctcgtgg cgctgatgct gcacatggcc cagcagttct caggaatcaa tgggatattt
     1081 tactattcaa ccagcatttt tcagacagct ggcatcagcc agcctgtgta tgcaaccatt
     1141 ggtgttgggg ccatcaacat gatcttcacg gctgtctctg tgctgcttgt ggagaaggca
     1201 gggcggcgga ccctgttcct aaccgggatg attggcatgt ttttctgcac catcttcatg
     1261 tcggtgggac ttgtgctgct ggataaattc gcctggatga gttacgtgag catgactgcc
     1321 atcttcctct ttgtcagttt ctttgagatt gggccaggtc caatcccttg gttcatggtt
     1381 gctgaatttt tcagccaagg accccgtcct acggctctgg cactggctgc cttcagcaac
     1441 tgggtctgca attttgtcat cgccctctgc ttccagtaca ttgcggactt ccttgggcct
     1501 tacgtgttct tcctcttcgc tggggtggtc ctggtcttca ccctgtttac attctttaaa
     1561 gttccagaaa ccaaaggaaa gtcttttgag gaaatcgctg cagaattccg gaagaagagt
     1621 ggttcggccc caccacgcaa agctgctgta caaatggaat tcctggcgtc ttcagagagt
     1681 gtgtgaggat gacctgccta aaaccgagga accgaccagg aggaaccacg cgctccctct
     1741 taaaccgatt ccttcctcgg tgtgcgacta cacccaggag tatcgtttat tcatttggaa
     1801 gaatttttac agactccgat tagaaatatc aacatatatt attaccaaag aaagtatttt
     1861 tttaacttaa agaatctatt tttgatggta acactcttca gtaaaccaga ggctattttg
     1921 ctactctaca gggaagtgtg taataacctt cctagccctg ttctactgaa attgaagagc
     1981 tttcaacata tcgctgcttt ttaaagcacg tgactaagaa atctgcagct acaactgcta
     2041 tctagatatt taattacacc ggaatgttct tagccccaga tcagaagcta aaggacatac
     2101 ggctggtgtc agcaaggctc acattcaaac tgactttctg ttacctttcc tcggcttctc
     2161 tcacttggat tagacttcgg gttttgcgta cagccatttt ctgcattttt atatagaatt
     2221 cctgagtatg ttaaactgta tttgtaatga gaaactcttt ttttatagct accaaaagct
     2281 tcctacagtg agagaaaaca ttttagtttc tttgatgtat tttgcaaggt taaatgcttg
     2341 agttgttctt agctgtagag ctcagattat cagttagtta tattagcatc caaagcatgt
     2401 tagtttctca ccacttcagt ctttgtgttg tacttatact tgtttttttt aattgcccat
     2461 ggcacacact taaaccatta ggagtcagcc attttgcata ttgcctaaaa atctaataaa
     2521 ctgggtcaat cacagggaaa tctggaataa agagtttttc tatttgttaa a
//
