LOCUS       NM_001033633            6541 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus solute carrier family 2 (facilitated glucose
            transporter), member 13 (Slc2a13), mRNA.
ACCESSION   NM_001033633 XM_139529
VERSION     NM_001033633.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6541)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6541)
  AUTHORS   Kappen,C., Kruger,C., Jones,S. and Salbaum,J.M.
  TITLE     Nutrient Transporter Gene Expression in the Early
            Conceptus-Implications From Two Mouse Models of Diabetic Pregnancy
  JOURNAL   Front Cell Dev Biol 10, 777844 (2022)
   PUBMED   35478964
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6541)
  AUTHORS   Teranishi,Y., Inoue,M., Yamamoto,N.G., Kihara,T., Wiehager,B.,
            Ishikawa,T., Winblad,B., Schedin-Weiss,S., Frykman,S. and
            Tjernberg,L.O.
  TITLE     Proton myo-inositol cotransporter is a novel gamma-secretase
            associated protein that regulates Abeta production without
            affecting Notch cleavage
  JOURNAL   FEBS J 282 (17), 3438-3451 (2015)
   PUBMED   26094765
  REMARK    GeneRIF: SLC2A13 is a novel gamma-secretase associated protein that
            regulates amyloid beta production without affecting Notch cleavage.
            Review article
REFERENCE   4  (bases 1 to 6541)
  AUTHORS   Fu,H., Li,B., Hertz,L. and Peng,L.
  TITLE     Contributions in astrocytes of SMIT1/2 and HMIT to myo-inositol
            uptake at different concentrations and pH
  JOURNAL   Neurochem Int 61 (2), 187-194 (2012)
   PUBMED   22564531
  REMARK    GeneRIF: astrocytes obtained directly from the brain express HMIT
            and is expressed in neurons
REFERENCE   5  (bases 1 to 6541)
  AUTHORS   Di Daniel,E., Mok,M.H., Mead,E., Mutinelli,C., Zambello,E.,
            Caberlotto,L.L., Pell,T.J., Langmead,C.J., Shah,A.J., Duddy,G.,
            Kew,J.N. and Maycox,P.R.
  TITLE     Evaluation of expression and function of the H+/myo-inositol
            transporter HMIT
  JOURNAL   BMC Cell Biol 10, 54 (2009)
   PUBMED   19607714
  REMARK    GeneRIF: Inositol transport and homeostasis were unaffected in
            H+/myo-inositol transporter targeted null-mutant mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6541)
  AUTHORS   Uldry,M., Steiner,P., Zurich,M.G., Beguin,P., Hirling,H., Dolci,W.
            and Thorens,B.
  TITLE     Regulated exocytosis of an H+/myo-inositol symporter at synapses
            and growth cones
  JOURNAL   EMBO J 23 (3), 531-540 (2004)
   PUBMED   14749729
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147341.1, AK039571.1 and BB429800.1.
            
            On Sep 17, 2008 this sequence version replaced NM_001033633.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147341.1, SRR10662773.670551.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5893              AK147341.1         2-5894
            5894-6082           AK039571.1         2397-2585
            6083-6535           AK147341.1         6083-6535
            6536-6541           BB429800.1         281-286
FEATURES             Location/Qualifiers
     source          1..6541
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 46.05 cM"
     gene            1..6541
                     /gene="Slc2a13"
                     /gene_synonym="6530403A04; A630029G22Rik; Gm308"
                     /note="solute carrier family 2 (facilitated glucose
                     transporter), member 13"
                     /db_xref="GeneID:239606"
                     /db_xref="MGI:MGI:2146030"
     exon            1..687
                     /gene="Slc2a13"
                     /gene_synonym="6530403A04; A630029G22Rik; Gm308"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..2078
                     /gene="Slc2a13"
                     /gene_synonym="6530403A04; A630029G22Rik; Gm308"
                     /note="hmit; h(+)-myo-inositol symporter;
                     h(+)-myo-inositol cotransporter; solute carrier family 2
                     member 13"
                     /codon_start=1
                     /product="proton myo-inositol cotransporter"
                     /protein_id="NP_001028805.2"
                     /db_xref="CCDS:CCDS27761.2"
                     /db_xref="GeneID:239606"
                     /db_xref="MGI:MGI:2146030"
                     /translation="MSRKASEDVEYTLRSLSSLMGERRRRQPEPGAPGGERSLLAAES
                     AASLQGAELERAARRQFQRDETPAFVYAAAAFSALGGFLFGYDTGVVSGAMLLLRRQM
                     RLGAMWQELLVSGAVGAAAVAALAGGALNGALGRRSAILLASALCTVGSAVLAAAANK
                     ETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGA
                     FSYLQKDGWRYMLGLAAIPAVIQFLGFLFLPESPRWLIQKGQTQKARRILSQMRGNQT
                     IDEEYDSIRNSIEEEEKEATAAGPIICRMLSYPPTRRALVVGCGLQMFQQLSGINTIM
                     YYSATILQMSGVEDDRLAIWLASITAFTNFIFTLVGVWLVEKVGRRKLTFGSLAGTTV
                     ALIILALGFLLSAQVSPRVTFRPTTPSDQNTTCTGYSYCNECMLDPDCGFCYKINGSA
                     VIDSSCVPVNKASTTEAAWGRCDNETKFKAEGAHWAYSFCPTPYSWTALVGLVLYLVF
                     FAPGMGPMPWTVNSEIYPLWARSTGNACSAGINWIFNVLVSLTFLHTAEYLTYYGAFF
                     LYAGFAAVGLLFVYGCLPETKGKKLEEIESLFDHRLCSCGAADSDEGRYIEYIRVKGS
                     NYHLSDNDASDVE"
     exon            688..847
                     /gene="Slc2a13"
                     /gene_synonym="6530403A04; A630029G22Rik; Gm308"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1056
                     /gene="Slc2a13"
                     /gene_synonym="6530403A04; A630029G22Rik; Gm308"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1165
                     /gene="Slc2a13"
                     /gene_synonym="6530403A04; A630029G22Rik; Gm308"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1329
                     /gene="Slc2a13"
                     /gene_synonym="6530403A04; A630029G22Rik; Gm308"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1450
                     /gene="Slc2a13"
                     /gene_synonym="6530403A04; A630029G22Rik; Gm308"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1576
                     /gene="Slc2a13"
                     /gene_synonym="6530403A04; A630029G22Rik; Gm308"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1698
                     /gene="Slc2a13"
                     /gene_synonym="6530403A04; A630029G22Rik; Gm308"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1851
                     /gene="Slc2a13"
                     /gene_synonym="6530403A04; A630029G22Rik; Gm308"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..6541
                     /gene="Slc2a13"
                     /gene_synonym="6530403A04; A630029G22Rik; Gm308"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6503..6508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc2a13"
                     /gene_synonym="6530403A04; A630029G22Rik; Gm308"
                     /note="hexamer: AAGAAA"
     regulatory      6516..6521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc2a13"
                     /gene_synonym="6530403A04; A630029G22Rik; Gm308"
                     /note="hexamer: AATAAA"
     polyA_site      6527
                     /gene="Slc2a13"
                     /gene_synonym="6530403A04; A630029G22Rik; Gm308"
                     /note="major polyA site"
     polyA_site      6537
                     /gene="Slc2a13"
                     /gene_synonym="6530403A04; A630029G22Rik; Gm308"
                     /note="major polyA site"
ORIGIN      
        1 gacgcacgac cccgcccccg gccgctccgt agcgccagct tagcagaggc tgcgaggcgg
       61 gtggctcggg tggcagaaga gcagcggctc agcagctggc agagagtgcg cggcgcccca
      121 cacgcaactt ccccgcagcc gcctcggcgg cgtccgcctg tcccatgtcc cgcaaggcga
      181 gcgaggacgt ggagtacacg ctgcgcagcc tgagcagcct gatgggcgag aggcgccgcc
      241 ggcagccgga gccgggggcg ccaggcgggg agcgcagcct cctggccgcc gagtcggccg
      301 ccagcctgca gggcgcggag ctggagcgcg cggcgcgcag gcagttccag cgcgacgaga
      361 ccccggcctt cgtgtacgcg gccgccgcct tctcggcgct cggcggcttc ctgttcggct
      421 acgacaccgg cgtggtgtcg ggggccatgc tgctgctgcg gcgccagatg cgcctgggcg
      481 cgatgtggca ggagctgctg gtgtcgggcg cggtgggcgc ggccgccgtc gcggcgctgg
      541 ccggaggggc cctgaacggc gccctcggtc ggcgcagcgc catcctgctg gccagcgccc
      601 tgtgcaccgt gggctccgcc gtgctggccg ccgccgccaa caaggagacg ctgctggccg
      661 gccgcctggt cgtggggctc ggcatcggca tcgcatccat gaccgtgccc gtgtacatcg
      721 cggaggtttc tccacccaac ctgagaggtc gcctggtcac catcaacacc ctcttcatca
      781 caggcggaca gttctttgca agtgttgtcg atggcgcctt cagttacctg cagaaggatg
      841 gatggaggta catgttggga cttgcggcca ttccagctgt tatacagttt cttggattcc
      901 tctttttgcc cgaaagccct cggtggctga ttcagaaggg acagactcag aaggcccgcc
      961 gaattttgtc ccagatgcgt ggcaatcaga ccattgatga ggagtatgac agcatcagga
     1021 acagtatcga ggaggaggaa aaggaagcca ccgcagctgg acctataatc tgcagaatgc
     1081 tgagttaccc cccaactcgc cgagcgttag ttgtgggatg tggcttacag atgttccagc
     1141 aactctcggg catcaacact atcatgtact acagcgcaac catcctccag atgtccggcg
     1201 tggaagatga cagacttgca atatggctgg cttcgatcac agcattcacc aatttcattt
     1261 tcacactagt gggagtctgg ctcgtcgaga aagtgggtcg caggaagctt acctttggta
     1321 gtttggcagg taccacagta gcactgatta tccttgccct gggatttttg ctctcggcac
     1381 aggtctcacc acgggtcact tttagaccaa cgactccttc ggatcaaaat accacctgca
     1441 cgggatacag ttactgcaat gagtgtatgc tggatccaga ctgtggtttc tgctacaaga
     1501 tcaacggttc agctgtcatt gattcctcct gtgttccagt taacaaagcc tctacaactg
     1561 aagcagcctg gggcaggtgt gataatgaaa ccaagttcaa agctgaaggt gctcactggg
     1621 cttacagttt ctgccctacc ccctactcct ggacagcact cgtgggcctg gtgttgtacc
     1681 ttgttttctt tgcacctgga atgggaccaa tgccctggac cgtgaactct gaaatctatc
     1741 ctctctgggc aagaagtaca ggaaatgcgt gctcagctgg aataaactgg attttcaacg
     1801 tgctggtttc tttgaccttt ttacacacag cagagtatct tacatactat ggagcattct
     1861 tcctctacgc cggattcgcc gctgtgggac tgctttttgt ctatggctgc ctccctgaaa
     1921 ccaaggggaa aaaattggag gaaatcgaat cgctctttga ccaccggcta tgttcatgtg
     1981 gcgctgccga ctcggatgaa gggaggtaca ttgagtacat ccgcgtgaag ggaagcaact
     2041 atcatctctc cgacaacgac gcttctgacg tggagtaact ctcgaccaat gactttttag
     2101 ttaccgaagt gaacgtggcg ggaaggccag cggttggtca ctgccctgct cgcaagctga
     2161 gtctccccac agtccttaca aacgactcca tattccagaa gacttgatga gcagaaaaat
     2221 ccaaccgtgg tgatgtttat tttcatacac agaaatgttt aaaaaacaaa cagatttttt
     2281 cttaagcaaa tgtgtatacg cccttcctga gacagtctaa acattactgt tgtacccagt
     2341 gacttcactt gggatccctg tctccttaaa ccacatataa ttattagtgg caacacagtc
     2401 agtgataatc taggcagatt atatatgtat atttataaag gattatttaa gatgatctaa
     2461 agatatttaa tgtcaaaaca tggcctattg accctaaatt ttcatatcag gtagtggctt
     2521 ttctctgatc agcacaaagt gaatgccatc taaacttcca tccacaaatt cagaagtcct
     2581 atgaggacac agctgtccct cttgccttcg ggttccagag gttggcttct ccaacacaga
     2641 tatggaaatt ccctcggagg ctgagtatac agcatctttt gaacattatc caaagcaggc
     2701 cttttaaggg ttattttcgt actctttttt gcatcagtga tgagtatatt tgcagagaca
     2761 cgctagcatg ttttgataag tatattttat tgttcaagtg agaaagaaca gatttttaat
     2821 atatcctggt tcgttcgtta cttcagaatg caactgtaaa cgtgacgcag tgccaggcgg
     2881 tcagctgtat cccagggtca gttccacacc agactctctt cgttgtcacg ccctggctcc
     2941 cgctgtcctg tgccttcctt ggtgttgaat gacagctgct ggcagattgt ctggctctct
     3001 ctttctgata cacaggagga aagaagtcag tggcagagat gttattgaca tttcatttaa
     3061 accctaggac ttcttcctcc agatgtctta ttggttagta cgaaggacag gagcacacct
     3121 cacttctaat tacttgcaat ttccccctga ggacgtgagc tactttaacc ccgtgttctc
     3181 ttctcattct tagtaatttg ctacacaagt gaaaattcga agcagtgtct gccactttat
     3241 ctcagacatg gtttggtttc tgtctagaga catggaggtt tctccattgg aaaaagacat
     3301 agagaggttc taatgccacc gtcggtaaaa cgtgttgatt ttctcttgta tctctcaaag
     3361 tattcgatgg tttctctgtt cagtcaaccc tgagttccta agtcttacca ccctactaag
     3421 agctatgtga tacaaacaaa attacttcct cacaaaagtc atttgcctgt tcttctaaag
     3481 ctatggatga gtctaatgac cagttaggaa cacatcactt tgctgctgca caccatggtc
     3541 taaacatcta attaggtaca tgcccaggtg agtgatggct agtgatagat gaagcatctc
     3601 tgccaatttc aaaacgttta ttcttgctgc ttctttctta ctgtaactat caagcagaaa
     3661 ctgaagtaaa ggaagttatc ccctagtcac cagaggtact tacacagtca ctttcctgcc
     3721 ctaccaatct tgcagccaaa agaagagggt cttgattgat tatttaatgt tatttttaga
     3781 aaccaactaa tataatattt ttggaaaagt tttcctcaaa ttaggtgctt tgaaatttat
     3841 ttatagagga tattagtact gtttttttct ctagagcaga agatattatt taacaggatg
     3901 tattattgga tatttctgac ctctgaagat atttcttaac tcaatagcat tttacaagat
     3961 caaatgtggt acagttagca tattatggga aggaaaaaaa tgagtaaagt actcctttta
     4021 aaatagagtt ttctgagttg cccaacccgc tgcctcagtt cttccctttg aggtccacat
     4081 agccttaagc acacaggtat ctcaacagag ctggcacagg gtaccttttt ttaaaggggc
     4141 agctagaatc cttagtcctg aaagctaggt gtgacctgtt ctcgctgaca taaaaacaag
     4201 tacattctca gctttatgtc cctaaattaa cataatattg ggaaatcatc cccatccttc
     4261 ctgccctgtt cccttcatca tttctaaaaa ttatttatta tctatatagt aacggtaact
     4321 catacctcta acatacaaga cagagaggca catatgagac ttattcatat cttgtaaaaa
     4381 agcaactcaa tacttgaaaa ggaaccttct ataatccaga tatgactttt agatttgctg
     4441 aacatttata atacattaaa ttttcagatt tttattctat caaacacctc ttctattaaa
     4501 ccatcaaatg tatattttgt gggacaattt ctatatgata tgacttgacc tgatgtgtta
     4561 aaatagacat attaaataag tgtacttgcc actgcagtaa taggcttctt tcgaaacgtg
     4621 tcccaaatcc aatccaggtg tctttccttt gggaacattg ggtgaagaag atcctgaaca
     4681 ggcctgcagt ctggcagggt ggctaatgtg caggagaatg aagaatgcat aattttgtat
     4741 gcatgtaagc acatacggct ggaaatgatg tcaaaaagac ttgatgttgt gatcttggga
     4801 gacagttcag tgttacagcg ctggcctgta aagattgggc cttaatattt ttcttccata
     4861 tagacatctg taataatttt gctggctaca cctatattgg tcagcatcca aaacatggct
     4921 ttgaatatac ctggagaaga tctaaataaa tagtaattac aggagtaaaa ccaccagaat
     4981 cttttcaaca gttttatcaa tgaaacacac tttaggtcca gtcttaacaa ctgccactca
     5041 ctctaatgtg ggagaccagt gaaagcacag aatttatgga tctttgctgt aactccagtg
     5101 tccactaaac agagagaaag actggggagg aactgacacc tgacccattt agtttttaag
     5161 agcaaagtaa aactgtaatg cattgttaat aatcatacct ctcggggcat gggtgaggtg
     5221 gtgttttaga cagcgcgacc catgtcttct gtaataaccg tgtgtgaaaa tgtttcaatt
     5281 atcaagtttg gaccatttcc ctaactagaa acaaaaggat tagaaggtaa aaaccaggcc
     5341 aagggtagag agttcctggc agctgctctc tagcaaacag ttctacattc taccttaaac
     5401 tgcaaagtta gagatgaaat tcacaggtca aaagtagcga ctgcctataa aaggactcag
     5461 aattattctc tgggttaatt tttaacatcc ttcagcctag aaatctctac caatcctggc
     5521 ctcgtgcaca gccagggtca ttcagttctc caagtagtgc tgcctccttg ggaaaccaca
     5581 accagctgca aatgccaaca gctagctacc tgctcaactc ttccttgtat gcagtttaga
     5641 gaagacagtg cgtatgtgcc aatcatcttc agagagttgc tttatggata ctcatgttcg
     5701 gatgtaccag gaagtatttt atcattatcc taatgggctt gtgtgttcag aacagtatac
     5761 ttctctaaat cttcatatgt gtacagtaca atctagaaca ctttagtaac ctggtcaacg
     5821 gccttcattg acatggttta caggtaatat tcgcatttta gaccaattaa gctcatagga
     5881 ttgatttttt ttttgtcgtg tccatataaa taagaaatgg actgcgcaga taataagtac
     5941 tcaaacttat gaatcagtcc tttagaaagt tctaagattt tgctaaattc aacctcccat
     6001 atcacttaaa gtttagacaa gatgatctta actctagcca aagtagaaat ctaagaccta
     6061 tatacatatc cagattctcg ggtggctccc tgtgctgtgt ctcccttgat gttacagtac
     6121 tgtttgtgac aaatgttcta atttctatct agaaactcta agcatacatc tctatccagt
     6181 caggagtctc ttgctgtcag aggtgtatgt attttgaact gtatttcatt ttctagtgca
     6241 tgttatctgc ggtttaatac ttgacaaacc ttggcaagtt tagtctttcc attcccacct
     6301 gtgaagacgg actatctctc ggaaactgcc actgtcccat tctatcaaat catgctagcc
     6361 tctgctgtat ctaaagtatg gtctattttc tggagattta gtgatataca tgtaaatgtt
     6421 ttttaagtta ttttattgaa cctcaatatt tacatggagt tataatcttt ttttaaagaa
     6481 agtgccagtg ccagaactgt ataagaaaac agtcaaataa aagcaaagat aattcactgt
     6541 c
//
