LOCUS       NM_178934               3762 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus solute carrier family 2 (facilitated glucose
            transporter), member 12 (Slc2a12), mRNA.
ACCESSION   NM_178934
VERSION     NM_178934.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3762)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3762)
  AUTHORS   Kappen,C., Kruger,C., Jones,S. and Salbaum,J.M.
  TITLE     Nutrient Transporter Gene Expression in the Early
            Conceptus-Implications From Two Mouse Models of Diabetic Pregnancy
  JOURNAL   Front Cell Dev Biol 10, 777844 (2022)
   PUBMED   35478964
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3762)
  AUTHORS   Miyata,H., Toyoda,Y., Takada,T., Hiragi,T., Kubota,Y.,
            Shigesawa,R., Koyama,R., Ikegaya,Y. and Suzuki,H.
  TITLE     Identification of an exporter that regulates vitamin C supply from
            blood to the brain
  JOURNAL   iScience 25 (1), 103642 (2022)
   PUBMED   35106468
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3762)
  AUTHORS   Gil-Iturbe,E., Felix-Soriano,E., Sainz,N., Idoate-Bayon,A.,
            Castilla-Madrigal,R., Moreno-Aliaga,M.J. and Lostao,M.P.
  TITLE     Effect of aging and obesity on GLUT12 expression in small
            intestine, adipose tissue, muscle, and kidney and its regulation by
            docosahexaenoic acid and exercise in mice
  JOURNAL   Appl Physiol Nutr Metab 45 (9), 957-967 (2020)
   PUBMED   32176854
  REMARK    GeneRIF: Effect of aging and obesity on GLUT12 expression in small
            intestine, adipose tissue, muscle, and kidney and its regulation by
            docosahexaenoic acid and exercise in mice.
            Erratum:[Appl Physiol Nutr Metab. 2021 Jul;46(7):846-847. doi:
            10.1139/apnm-2021-0402.. PMID: 34185593]
REFERENCE   5  (bases 1 to 3762)
  AUTHORS   Toyoda,Y., Takada,T., Miyata,H., Matsuo,H., Kassai,H., Nakao,K.,
            Nakatochi,M., Kawamura,Y., Shimizu,S., Shinomiya,N., Ichida,K.,
            Hosoyamada,M., Aiba,A. and Suzuki,H.
  TITLE     Identification of GLUT12/SLC2A12 as a urate transporter that
            regulates the blood urate level in hyperuricemia model mice
  JOURNAL   Proc Natl Acad Sci U S A 117 (31), 18175-18177 (2020)
   PUBMED   32690690
  REMARK    GeneRIF: Identification of GLUT12/SLC2A12 as a urate transporter
            that regulates the blood urate level in hyperuricemia model mice.
REFERENCE   6  (bases 1 to 3762)
  AUTHORS   Aerni-Flessner,L.B., Otu,M.C. and Moley,K.H.
  TITLE     The amino acids upstream of NH(2)-terminal dileucine motif play a
            role in regulating the intracellular sorting of the Class III
            transporters GLUT8 and GLUT12
  JOURNAL   Mol Membr Biol 28 (1), 30-41 (2011)
   PUBMED   21067453
  REMARK    GeneRIF: XXX amino acids, specifically the position of a proline -2
            from the dileucine residues, influence the affinity of APs for
            GLUT8 and GLUT12
REFERENCE   7  (bases 1 to 3762)
  AUTHORS   Flessner,L.B. and Moley,K.H.
  TITLE     Similar [DE]XXXL[LI] motifs differentially target GLUT8 and GLUT12
            in Chinese hamster ovary cells
  JOURNAL   Traffic 10 (3), 324-333 (2009)
   PUBMED   19076329
  REMARK    GeneRIF: GLUT8 and GLUT12 exhibit dramatic differences in
            trafficking from the plasma membrane
REFERENCE   8  (bases 1 to 3762)
  AUTHORS   Willnow,T., Antignac,C., Brandli,A., Christensen,E., Cox,R.,
            Davidson,D., Davies,J., Devuyst,O., Eichele,G., Hastie,N.,
            Verroust,P., Schedl,A. and Meij,I.
  TITLE     The European renal genome project: an integrated approach towards
            understanding the genetics of kidney development and disease
  JOURNAL   Organogenesis 2 (2), 42-47 (2005)
   PUBMED   19521566
REFERENCE   9  (bases 1 to 3762)
  AUTHORS   Zhou,Y., Kaye,P.L. and Pantaleon,M.
  TITLE     Identification of the facilitative glucose transporter 12 gene
            Glut12 in mouse preimplantation embryos
  JOURNAL   Gene Expr Patterns 4 (6), 621-631 (2004)
   PUBMED   15465484
  REMARK    GeneRIF: analysis of Glut12 expression in mouse preimplantation
            embryos
REFERENCE   10 (bases 1 to 3762)
  AUTHORS   Wood,I.S., Hunter,L. and Trayhurn,P.
  TITLE     Expression of Class III facilitative glucose transporter genes
            (GLUT-10 and GLUT-12) in mouse and human adipose tissues
  JOURNAL   Biochem Biophys Res Commun 308 (1), 43-49 (2003)
   PUBMED   12890477
  REMARK    GeneRIF: expression in adipose tissue
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166256.5, AK028970.1 and AK031659.1.
            
            On Apr 8, 2009 this sequence version replaced NM_178934.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031659.1, AJ549317.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AC166256.5         113476-113502       c
            28-3599             AK028970.1         1-3572
            3600-3762           AK031659.1         3518-3680
FEATURES             Location/Qualifiers
     source          1..3762
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 10.21 cM"
     gene            1..3762
                     /gene="Slc2a12"
                     /gene_synonym="GLUT-12; Glut12"
                     /note="solute carrier family 2 (facilitated glucose
                     transporter), member 12"
                     /db_xref="GeneID:353169"
                     /db_xref="MGI:MGI:3052471"
     exon            1..303
                     /gene="Slc2a12"
                     /gene_synonym="GLUT-12; Glut12"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..2057
                     /gene="Slc2a12"
                     /gene_synonym="GLUT-12; Glut12"
                     /note="facilitated glucose transporter; glucose
                     transporter type 12; solute carrier family 2, member 12"
                     /codon_start=1
                     /product="solute carrier family 2, facilitated glucose
                     transporter member 12"
                     /protein_id="NP_849265.2"
                     /db_xref="CCDS:CCDS23729.1"
                     /db_xref="GeneID:353169"
                     /db_xref="MGI:MGI:3052471"
                     /translation="MVPVENTEGPNLLNQKGREAETEGSCGASGGGHPACAGGPSMFT
                     FLTSVTAAISGLLVGYELGLISGALLQIRTLLALTCHEQEMVVSSLLIGAFLASLTGG
                     VLIDRYGRRLAIILSSCLLGLGSLVLIMSLSYTLLIMGRVAIGVSISLSSIATCVYIA
                     EIAPQHRRGLLVSLNELMIVTGILFAYISNYAFANISNGWKYMFGLVIPLGVLQAIAM
                     YFLPPSPRFLVMKGQEESAGKVLRKLRVISDTTEELTLIKSSLKDEYQYSFWDLFRSK
                     DNMRTRILIGLTLVFFVQTTGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVVS
                     TIPATLLVDHIGSKTFLCIGSSVMSASLLTMGIVNLNINMNFTNICRSHSLLNQSLEE
                     FVFYATGNLSISNSSLREHFKRITPYSKGSFMPMGNGMEPKGEMTFTSSLPNAGLSRT
                     EHQGVTDTAVVPAAYKWLSLASLLVYVAAFSIGLGPMPWLVLSEIFPGGIRGRAMALT
                     SSMNWGVNLLISLTFLTVTDLIGLSWVCFIYTIMSLASLAFVVLFIPETKGCSLEQIS
                     VELAKANYVKNNICFMSHHQEELVPTQLQKRKPQEQLPECNHLCGRGQSQRPSPDT"
     exon            304..1647
                     /gene="Slc2a12"
                     /gene_synonym="GLUT-12; Glut12"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1770
                     /gene="Slc2a12"
                     /gene_synonym="GLUT-12; Glut12"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1903
                     /gene="Slc2a12"
                     /gene_synonym="GLUT-12; Glut12"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..3762
                     /gene="Slc2a12"
                     /gene_synonym="GLUT-12; Glut12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3734..3739
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc2a12"
                     /gene_synonym="GLUT-12; Glut12"
                     /note="hexamer: AATAAA"
     polyA_site      3757
                     /gene="Slc2a12"
                     /gene_synonym="GLUT-12; Glut12"
                     /note="major polyA site"
ORIGIN      
        1 aaagccttcg gaaatagaaa caaagttggt tacaaatcac actggctttg cccgaaggtc
       61 gcccccccac tcaaacccct cccactcttc tttagcatgc tgcccatggg gacagtgacc
      121 actgctgtca gcgcggtagg tctgggtggt ccggtggcga gcgagaagct gtaagtacta
      181 ccgtgaccat ggtacctgtt gaaaacacag agggccccaa tctgctgaac cagaagggga
      241 gagaggcgga gaccgaaggc agctgtggag ccagcggcgg agggcatcct gcctgcgcgg
      301 gaggtcccag catgtttacg ttcctgacat ctgttactgc agccatcagc ggcctcctgg
      361 tgggttatga acttgggctc atctctggag ctcttctgca gatcagaacg ctattagccc
      421 tgacctgcca cgagcaggaa atggttgtga gttccctcct catcggggca ttcctcgcct
      481 ctctcacagg aggcgtgctc atagacaggt acggaagaag gctcgccata atcctgtcat
      541 cctgcctcct aggacttgga agcttggtct tgataatgag tttgtcctac acgctcctta
      601 taatggggag agtggctata ggggtttcca tatccctgtc ttccattgcc acgtgtgtgt
      661 acattgcgga aattgccccc caacacagaa gaggacttct tgtgtcgttg aatgagctga
      721 tgattgtcac tggtattctc tttgcctata tttcaaatta tgcatttgcc aacatctcca
      781 atggttggaa gtatatgttt ggccttgtga tccccctggg agttctgcaa gcaatagcga
      841 tgtactttct tcccccaagt cctcgtttcc tggtgatgaa gggacaagag gagtcggcag
      901 gcaaagtcct caggaagtta agagtgatct cagacaccac tgaagaactc actttgatca
      961 aatcttcctt gaaagatgag tatcagtaca gtttttggga tctgtttcgc tctaaggaca
     1021 acatgaggac cagaatcctg ataggtctga cactggtatt ttttgtccag accactgggc
     1081 agccaaacat actattctac gcatcaactg tcttgaagtc tgttggcttc cagagcaatg
     1141 aggcagctag ccttgcctcc actggggtgg gagtggtcaa ggtggttagc actatcccag
     1201 caaccctcct tgtggaccac attggcagca aaaccttcct ctgtattggc tcctccgtga
     1261 tgtccgcttc actgttgacc atgggcattg tgaacctcaa catcaatatg aacttcacca
     1321 acatctgcag aagccatagt cttcttaacc agtccctgga ggagtttgtg ttctatgcaa
     1381 caggaaacct gtcaattagc aatagcagtc tcagggagca ctttaaaaga atcactccct
     1441 acagcaaggg ctcgtttatg cccatgggga atggcatgga gccgaaaggg gagatgacct
     1501 tcacgtcgtc tttaccaaat gctggactga gccgaactga acaccaggga gtcacagaca
     1561 ctgcagtcgt cccagctgct tacaaatggc tgtccctggc cagcttgctt gtttatgtgg
     1621 ctgcattttc aattggtctg ggacccatgc cttggttggt gcttagtgag atctttcccg
     1681 gtggaattag aggccgcgcc atggccctga catctagcat gaactggggt gtcaaccttc
     1741 tcatctcttt gacatttctg acagtgactg atcttattgg tttgtcatgg gtatgcttca
     1801 tatacacaat catgagtctg gcatcgctgg cttttgttgt tctgtttata cctgagacta
     1861 agggatgctc tttggaacaa atatcagtgg agctagcaaa ggcgaactat gtgaaaaaca
     1921 acatttgttt tatgagtcat caccaggaag aattagtgcc aacacagctt caaaaacgaa
     1981 agccccaaga gcagctccca gagtgtaacc acctgtgtgg aaggggacag tcacaacggc
     2041 cctcgccaga cacctaacgg gctccaatcc ctacgtgtgg cacagtggca ggacttacag
     2101 ggtctctgcc atgttctctc ctcactgtca tggagaagtt agaaagacca ccattaattc
     2161 ctcttcccaa aacagacttt tgccaaaagg tacaagaggc accaatgtcc tgatgtatca
     2221 ggtcaagcaa acaatactgg caggttcaat gccttcaact ttttctctag ttcagctttt
     2281 gaaaagacta catacattct agtgatgagg cctggctctg ccttaagctg tctgtgtagg
     2341 atgccactta cagcttggta ctcaagacac agtggtgttc tgggcaggca cttaccacgt
     2401 gtgcctctga agacactgtg tggatgattt cattgcatct acgttgtagt ttaggatggt
     2461 gtcttgaata agactttagt tggcattcaa gtccaccagt acaaagatta tgcagcttat
     2521 acatcacaca tgagacactt gttaatcaaa gtactctttt gtaagtttta tgtcaatttt
     2581 taaaactcta agataaacca ttttccattt ctttttaaaa attgagtaga aagattaatt
     2641 taaaattcct gggaccatat ttatttagaa atagctgtta gtaaatatta gacaaggagt
     2701 ccggacataa tatttatcca gatctctaag cagttagctt taaattatac agtaaaaatc
     2761 tctaagagtt gtctcctggg aaggctttcg tggtaacctg tcacagccca ccttcctgca
     2821 cttcttccct gccctcagga atcactctac ctcaggctac agacagaggg atggccctga
     2881 cctcaggcca ggtaccttcc tttctgtgat gagcagtgat ggagagccac gccagcaagg
     2941 tggcttttac ccacgggatg cgcttctctg gcctgctttt tccatttgag ttttaagatt
     3001 tgacaaagca tttcaccgag agaatttgca tgtgatagaa aaataaatct gtgatttaaa
     3061 aaaaagagac cagaccccct ccctaatttg ggtttttctt cctttcacca ccaaatggtc
     3121 ccagtctgac gaggtgtgtg cccgccacat gccctggtag ccaagaggat gaggatgggc
     3181 agcagcagga gccagcgtag agcctgggcc tcaggcgcac agcaggaggc ctgcttctca
     3241 agtgcagcct ctgaggaagg gagatttaaa ccctgatccc atcacagtgt gtttccaact
     3301 cgggaagaac tgtgctggtt cctttcttga gggaagaggg ggtgaggtgt gttttgtgaa
     3361 gctgcacttc aaatttacca ggagtctctg cagtcatagg ccacccttta aaaagactca
     3421 aggcaggtta tcaatgtaag cttttttttt cccctccaag ttctcagatt aagatctttt
     3481 aaaaactgtt aaatgattcg attttgcacg tacatggaca cacacacact tggctatttt
     3541 gtttgtgtat tccttgtgaa tgggcaaaaa taagcaaatg tagcttatta ctaatgactt
     3601 caatgaagcg ttggaacctt ctattgttct cttatcacca agtatggaac gagacatttg
     3661 tgttttcaat ataacctttt acccagtatt agccccatgc cactccgagc acatgaagcc
     3721 tgtggttttc aaaaataaaa agggggaata cttaaaactt gg
//
