LOCUS       NM_130451               3434 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus solute carrier family 2 (facilitated glucose
            transporter), member 10 (Slc2a10), mRNA.
ACCESSION   NM_130451
VERSION     NM_130451.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3434)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3434)
  AUTHORS   Wu,Q., Hu,Z., Wang,Z., Che,Y., Zhang,M., Zheng,S., Xing,K.,
            Zhong,X., Chen,Y., Shi,F. and Yuan,S.
  TITLE     Glut10 restrains neointima formation by promoting SMCs mtDNA
            demethylation and improving mitochondrial function
  JOURNAL   Transl Res 260, 1-16 (2023)
   PUBMED   37220836
  REMARK    GeneRIF: Glut10 restrains neointima formation by promoting SMCs
            mtDNA demethylation and improving mitochondrial function.
REFERENCE   3  (bases 1 to 3434)
  AUTHORS   Kim,C.J., Singh,C., Lee,C., DiMagno,K., O'Donnell,M., Kaczmarek,M.,
            Ahmed,A., Salvo-Schaich,J., Perez,A., Letsou,W., Sepulveda,M.C.,
            Ramos,R.L. and Hadjiargyrou,M.
  TITLE     Mustn1 ablation in skeletal muscle results in increased glucose
            tolerance concomitant with upregulated GLUT expression in male mice
  JOURNAL   Physiol Rep 11 (9), e15674 (2023)
   PUBMED   37170065
  REMARK    GeneRIF: Mustn1 ablation in skeletal muscle results in increased
            glucose tolerance concomitant with upregulated GLUT expression in
            male mice.
REFERENCE   4  (bases 1 to 3434)
  AUTHORS   Kappen,C., Kruger,C., Jones,S. and Salbaum,J.M.
  TITLE     Nutrient Transporter Gene Expression in the Early
            Conceptus-Implications From Two Mouse Models of Diabetic Pregnancy
  JOURNAL   Front Cell Dev Biol 10, 777844 (2022)
   PUBMED   35478964
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3434)
  AUTHORS   Jiang,C.L., Jen,W.P., Tsao,C.Y., Chang,L.C., Chen,C.H. and Lee,Y.C.
  TITLE     Glucose transporter 10 modulates adipogenesis via an ascorbic
            acid-mediated pathway to protect mice against diet-induced
            metabolic dysregulation
  JOURNAL   PLoS Genet 16 (5), e1008823 (2020)
   PUBMED   32453789
  REMARK    GeneRIF: Data show that GLUT10 regulates adipogenesis via ascorbic
            acid-dependent DNA demethylation to benefit proper white adipose
            tissue development and protect mice against high-fat diet
            (HFD)-induced metabolic dysregulation. These findings suggest that
            SLC2A10 may be an important HFD-associated susceptibility locus for
            type 2 diabetes mellitus.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3434)
  AUTHORS   Lee,Y.C., Huang,H.Y., Chang,C.J., Cheng,C.H. and Chen,Y.T.
  TITLE     Mitochondrial GLUT10 facilitates dehydroascorbic acid import and
            protects cells against oxidative stress: mechanistic insight into
            arterial tortuosity syndrome
  JOURNAL   Hum Mol Genet 19 (19), 3721-3733 (2010)
   PUBMED   20639396
  REMARK    GeneRIF: GLUT10 protects cells from oxidative injury.
REFERENCE   7  (bases 1 to 3434)
  AUTHORS   Cheng,C.H., Kikuchi,T., Chen,Y.H., Sabbagha,N.G., Lee,Y.C.,
            Pan,H.J., Chang,C. and Chen,Y.T.
  TITLE     Mutations in the SLC2A10 gene cause arterial abnormalities in mice
  JOURNAL   Cardiovasc Res 81 (2), 381-388 (2009)
   PUBMED   19028722
REFERENCE   8  (bases 1 to 3434)
  AUTHORS   Callewaert,B.L., Loeys,B.L., Casteleyn,C., Willaert,A., Dewint,P.,
            De Backer,J., Sedlmeier,R., Simoens,P., De Paepe,A.M. and
            Coucke,P.J.
  TITLE     Absence of arterial phenotype in mice with homozygous slc2A10
            missense substitutions
  JOURNAL   Genesis 46 (8), 385-389 (2008)
   PUBMED   18693279
  REMARK    GeneRIF: report that two mouse models, homozygous respectively for
            G128E and S150F missense substitutions in glut10 do not present any
            of the vascular, anatomical, or immunohistological abnormalities as
            encountered in human Arterial tortuosity syndrome patients.
REFERENCE   9  (bases 1 to 3434)
  AUTHORS   Wood,I.S., Hunter,L. and Trayhurn,P.
  TITLE     Expression of Class III facilitative glucose transporter genes
            (GLUT-10 and GLUT-12) in mouse and human adipose tissues
  JOURNAL   Biochem Biophys Res Commun 308 (1), 43-49 (2003)
   PUBMED   12890477
  REMARK    GeneRIF: expression in adipose tissue
REFERENCE   10 (bases 1 to 3434)
  AUTHORS   Dawson,P.A., Mychaleckyj,J.C., Fossey,S.C., Mihic,S.J.,
            Craddock,A.L. and Bowden,D.W.
  TITLE     Sequence and functional analysis of GLUT10: a glucose transporter
            in the Type 2 diabetes-linked region of chromosome 20q12-13.1
  JOURNAL   Mol Genet Metab 74 (1-2), 186-199 (2001)
   PUBMED   11592815
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY230011.1, AK052156.1 and
            BB732254.1.
            
            On Dec 19, 2013 this sequence version replaced NM_130451.2.
            
            Summary: This gene encodes a class III facilitative glucose
            transporter. Mutations in the related gene in human are associated
            with arterial tortuosity syndrome. [provided by RefSeq, Dec 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052156.1, AY029579.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                BY230011.1         2-34
            34-3426             AK052156.1         1-3393
            3427-3434           BB732254.1         430-437
FEATURES             Location/Qualifiers
     source          1..3434
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 85.66 cM"
     gene            1..3434
                     /gene="Slc2a10"
                     /gene_synonym="Glut10"
                     /note="solute carrier family 2 (facilitated glucose
                     transporter), member 10"
                     /db_xref="GeneID:170441"
                     /db_xref="MGI:MGI:2156687"
     exon            1..152
                     /gene="Slc2a10"
                     /gene_synonym="Glut10"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1759
                     /gene="Slc2a10"
                     /gene_synonym="Glut10"
                     /note="glucose transporter type 10"
                     /codon_start=1
                     /product="solute carrier family 2, facilitated glucose
                     transporter member 10"
                     /protein_id="NP_569718.1"
                     /db_xref="CCDS:CCDS17083.1"
                     /db_xref="GeneID:170441"
                     /db_xref="MGI:MGI:2156687"
                     /translation="MGLRPAVLLLCASVSLLGGLTFGYELAVISGALLPLQLNFGLSC
                     LEQELLVGSLLLGALLASLVGGFLIDCYGRRRAILGSNAVLLAGSLILGLASSLPWLL
                     LGRLSVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEVGITVGILFSYGLNYVLAGS
                     PWGWRHMFGWAAAPALLQSLSLFLLPAGAEGTAAPKDLIPLQGRETSKPGLVKPQYSF
                     LDLFRAQDGMWSRTVVGLGLVLFQQLTGQPNVLYYASTIFRSVGFHGGSSAVLASVGL
                     GTVKVAATLVATGLVDRAGRRVLLLFGCALMALSVSGIGLVSFAVSLDSGPSCLATSN
                     ASQQVDLPGSSGLLVRSSLPPVLHTNGDQGQLVLSVTERPIHPVITASLGPVLNTASP
                     VPTSPILEHTLLCWSALVCMMVYVSAFSVGFGPVTWLVLSEIYPAEIRGRAFAFCSSF
                     NWAANLFISLSFLDLIGAIGLAWTFLLYGLTAVLGLAFIYLLVPETKGQSLAEIEQQF
                     QTSRFPLNFGHRQRIGIQYHRLDVSSAS"
     exon            153..1424
                     /gene="Slc2a10"
                     /gene_synonym="Glut10"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1547
                     /gene="Slc2a10"
                     /gene_synonym="Glut10"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1683
                     /gene="Slc2a10"
                     /gene_synonym="Glut10"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..3434
                     /gene="Slc2a10"
                     /gene_synonym="Glut10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3410..3415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc2a10"
                     /gene_synonym="Glut10"
                     /note="hexamer: AATAAA"
     polyA_site      3431
                     /gene="Slc2a10"
                     /gene_synonym="Glut10"
                     /note="major polyA site"
ORIGIN      
        1 aggctcagac cgggctggcc aacgtggcgg agggagagcg caggccccag ctctggggaa
       61 agtttgtccg ccactgctac agcggggatt tgaccaggac acgcgggacc cagagcccag
      121 ccctgccgcc cagcgctact cgctagctat gggccttcgc ccagctgtcc tcctgctctg
      181 tgcctctgtg tctttgctgg ggggcctgac cttcggatat gagctggccg tcatatctgg
      241 tgccctccta ccactccagc tgaacttcgg gctgagttgc ctcgaacagg agctcctggt
      301 gggcagtctg ctcttgggtg ctctcctcgc ctcccttgtc gggggcttcc tcattgactg
      361 ctatggcagg agacgagcca tcctagggag caatgcggtg ctgctggctg gcagcctgat
      421 tctgggtctg gccagctccc tgccctggct gctcctgggc cgtttatctg ttggctttgc
      481 catctctctg tcttccatgg cttgctgtat ctacgtgtca gaattggtgg ggccgcggca
      541 gaggggtgtg ctggtgtccc tctacgaggt gggcatcact gtgggcattc tgttctctta
      601 cggcctcaac tacgtcctgg ctggcagccc ttggggctgg aggcacatgt ttggctgggc
      661 agctgcacct gctctcctac agtcactcag cctctttctt ctccctgctg gtgcagaggg
      721 cacagcagcc cccaaagacc ttatcccact ccagggaagg gagacaagca aaccgggcct
      781 ggtgaagcca cagtacagct ttctggacct cttcagggcc caggacggca tgtggagccg
      841 gactgtagtg gggctggggc tggtgctgtt tcagcagctc acaggacagc ccaatgtgct
      901 gtattacgcc tctaccatct ttcgctccgt tggcttccac gggggctcct cagctgtgct
      961 ggcttctgtg gggcttggca cggtgaaggt ggctgccacc ttggtcgcca cggggctggt
     1021 ggaccgtgca ggccgcagag tcctcctgct ctttggatgc gctctcatgg ccttatcggt
     1081 cagcggcata ggcctggtca gctttgctgt gtccctggac tctggaccca gctgcctggc
     1141 cacatccaat gccagccagc aggtggatct gcctggaagc tcgggtttgc ttgtgcgttc
     1201 atctctgccg ccagtgctac acaccaatgg ggaccaagga cagctggtcc tgtcagtcac
     1261 tgagagaccc atccatccag tcatcacagc atccctggga ccagttctga acactgcctc
     1321 cccagttccc accagtccca tccttgagca taccctgctg tgctggtctg cgctggtttg
     1381 catgatggtc tacgtgagcg ccttctcggt tggctttgga ccagtaacct ggttggtcct
     1441 cagtgagatc tacccagcgg agatccgagg gagagccttc gccttctgca gcagcttcaa
     1501 ctgggcagct aacctcttta tcagcctctc cttcctcgac ctgatcggtg ccatcggctt
     1561 ggcttggacc ttcctgctct atgggctgac cgctgtcctt ggcctggctt tcatctacct
     1621 acttgttcct gaaaccaaag gacagtcttt agctgaaata gagcagcagt ttcagacaag
     1681 caggttccct ctaaactttg gccataggca gcgcatcggt attcagtacc atcgcctgga
     1741 tgtctcctca gcctcctgag gcatccgtct gcttggaaga tgctgggaca ttggttcctg
     1801 cagcccatct cctgctccct gcctgctggg gtctgaaact cctgatacag atttccttct
     1861 gtagtgacct ctgctcccag aggctgcctc ttgccggtgt gagagataac tgccaaactc
     1921 ttcattttga gtgtgagact ctgagggctc tctggaagat ttagctccat gcctcagttt
     1981 ccccagggag ttgacttgtc tgccatgttt ataatgacat cctctgtggc gttcatcaag
     2041 tgcttctcag aggacctggg aaggaagtgt ctcttaccac catccccaac cagcagaggc
     2101 tgtgagtctc cgccttcctc gtccccttgc tggggtctta gtgatccaga gcctgtattc
     2161 atcagcccct cccacttgcc caagatgttt atcaggtgct gggactctga ctggggacag
     2221 caggctgtaa cggagatggt cttatgaccc tggcctcagt ttccccatgt gtctcacaga
     2281 aactggacta ggctactcct aagatccctt ctcactccac aaggaccgaa gtctcagagc
     2341 agggatataa taagcactca atgaaggggc cctgtcgagt ggctctgggg acagaagctt
     2401 tgttagttag cagagagtgc acctctgttc cagagtctag cattctggaa tgtaagagca
     2461 ggactccaac gtgtgacaag tgctaggacc ccaatagttt ccagggttcg gcagaaggct
     2521 ttgaatgaag gaagggatta gagggactca tccgtgtgtt ggtgattgtg gcttctactt
     2581 cagttgctac tgacttccta aagccctggt ttattcatct gcagaatggg cacagttgtg
     2641 tgcctcagga tatattgacg tacgccatct ctctcaggag agtcttccgt gagccctggg
     2701 ggcttctgct caccgtgtta catagagctc ttctttgggg gcgttgtaaa ggtcagtcaa
     2761 ctggagacaa gcaagagcct caggtcagag gtcacataag gaggacatca ataaaacaga
     2821 gttagttcct agacactggg tagctggcct caccagcact gtcagctgtc ataccctcct
     2881 ggttcccaag cctggcctgg tgaccatgct ctctgtttct agatacgtca ttcataacca
     2941 gtggtgtgct ggattaagct tgtgctggct ccccagagct gactgccacg cagttgggac
     3001 ttctacagac tggttgctaa gcactggcat catctagaaa gtgttttcat ggataataaa
     3061 caatcagtgt aattataata gtcaatactc aaacctcatc accgcctatg tgctggtgca
     3121 tgcctgtaat cccagcactc aggaggctaa aggattgagt gttctaggcc agtctggctt
     3181 caaactgaaa tcttatccaa ccaaatcaat agacgaatac aaaaaaacca aaccttatca
     3241 ctgcctccta acatctctgc tgcccttctc cctcctccac gctgctggga tgccctctgt
     3301 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gcttacagag tgctcttcag
     3361 gtggaacgtt ttctcacaca aagacgtgta atttaaaagt gtattttgaa ataaattatt
     3421 ttgagcacaa acgc
//
