LOCUS       NM_011400               2573 bp    mRNA    linear   ROD 24-SEP-2023
DEFINITION  Mus musculus solute carrier family 2 (facilitated glucose
            transporter), member 1 (Slc2a1), mRNA.
ACCESSION   NM_011400
VERSION     NM_011400.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2573)
  AUTHORS   Rodriguez-Zabala M, Ramakrishnan R, Reinbach K, Ghosh S, Oburoglu
            L, Falques-Costa A, Bellamkonda K, Ehinger M, Pena-Martinez P,
            Puente-Moncada N, Lilljebjorn H, Cammenga J, Pronk CJ, Lazarevic V,
            Fioretos T, Hagstrom-Andersson AK, Woods NB and Jaras M.
  TITLE     Combined GLUT1 and OXPHOS inhibition eliminates acute myeloid
            leukemia cells by restraining their metabolic plasticity
  JOURNAL   Blood Adv 7 (18), 5382-5395 (2023)
   PUBMED   37505194
  REMARK    GeneRIF: Combined GLUT1 and OXPHOS inhibition eliminates acute
            myeloid leukemia cells by restraining their metabolic plasticity.
REFERENCE   2  (bases 1 to 2573)
  AUTHORS   Aiello JJ, Bogart MC, Chan WT, Holoman NC, Trobenter TD, Relf CE,
            Kleinman DM, De Vivo DC and Samuels IS.
  TITLE     Systemic Reduction of Glut1 Normalizes Retinal Dysfunction,
            Inflammation, and Oxidative Stress in the Retina of Spontaneous
            Type 2 Diabetic Mice
  JOURNAL   Am J Pathol 193 (7), 927-938 (2023)
   PUBMED   37062410
  REMARK    GeneRIF: Systemic Reduction of Glut1 Normalizes Retinal
            Dysfunction, Inflammation, and Oxidative Stress in the Retina of
            Spontaneous Type 2 Diabetic Mice.
REFERENCE   3  (bases 1 to 2573)
  AUTHORS   Zhan Y, Chen C, Wu Z, Zhou F and Yu X.
  TITLE     miR-455-3p ameliorates pancreatic acinar cell injury by targeting
            Slc2a1
  JOURNAL   PeerJ 11, e15612 (2023)
   PUBMED   37404474
  REMARK    GeneRIF: miR-455-3p ameliorates pancreatic acinar cell injury by
            targeting Slc2a1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2573)
  AUTHORS   Kim CJ, Singh C, Lee C, DiMagno K, O'Donnell M, Kaczmarek M, Ahmed
            A, Salvo-Schaich J, Perez A, Letsou W, Sepulveda MC, Ramos RL and
            Hadjiargyrou M.
  TITLE     Mustn1 ablation in skeletal muscle results in increased glucose
            tolerance concomitant with upregulated GLUT expression in male mice
  JOURNAL   Physiol Rep 11 (9), e15674 (2023)
   PUBMED   37170065
  REMARK    GeneRIF: Mustn1 ablation in skeletal muscle results in increased
            glucose tolerance concomitant with upregulated GLUT expression in
            male mice.
REFERENCE   5  (bases 1 to 2573)
  AUTHORS   Tayebi N, Leon-Ricardo B, McCall K, Mehinovic E, Engelstad K, Huynh
            V, Turner TN, Weisenberg J, Thio LL, Hruz P, Williams RSB, De Vivo
            DC, Petit V, Haller G and Gurnett CA.
  TITLE     Quantitative determination of SLC2A1 variant functional effects in
            GLUT1 deficiency syndrome
  JOURNAL   Ann Clin Transl Neurol 10 (5), 787-801 (2023)
   PUBMED   37000947
  REMARK    GeneRIF: Quantitative determination of SLC2A1 variant functional
            effects in GLUT1 deficiency syndrome.
REFERENCE   6  (bases 1 to 2573)
  AUTHORS   Smith DE and Gridley T.
  TITLE     Differential screening of a PCR-generated mouse embryo cDNA
            library: glucose transporters are differentially expressed in early
            postimplantation mouse embryos
  JOURNAL   Development 116 (3), 555-561 (1992)
   PUBMED   1289053
REFERENCE   7  (bases 1 to 2573)
  AUTHORS   Morita Y, Tsutsumi O, Hosoya I, Taketani Y, Oka Y and Kato T.
  TITLE     Expression and possible function of glucose transporter protein
            GLUT1 during preimplantation mouse development from oocytes to
            blastocysts
  JOURNAL   Biochem Biophys Res Commun 188 (1), 8-15 (1992)
   PUBMED   1417871
REFERENCE   8  (bases 1 to 2573)
  AUTHORS   Ortiz PA, Honkanen RA, Klingman DE and Haspel HC.
  TITLE     Regulation of the functional expression of hexose transporter
            GLUT-1 by glucose in murine fibroblasts: role of lysosomal
            degradation
  JOURNAL   Biochemistry 31 (23), 5386-5393 (1992)
   PUBMED   1606164
REFERENCE   9  (bases 1 to 2573)
  AUTHORS   Murakami T, Nishiyama T, Shirotani T, Shinohara Y, Kan M, Ishii K,
            Kanai F, Nakazuru S and Ebina Y.
  TITLE     Identification of two enhancer elements in the gene encoding the
            type 1 glucose transporter from the mouse which are responsive to
            serum, growth factor, and oncogenes
  JOURNAL   J Biol Chem 267 (13), 9300-9306 (1992)
   PUBMED   1339457
REFERENCE   10 (bases 1 to 2573)
  AUTHORS   Haefliger JA, Bruzzone R, Jenkins NA, Gilbert DJ, Copeland NG and
            Paul DL.
  TITLE     Four novel members of the connexin family of gap junction proteins.
            Molecular cloning, expression, and chromosome mapping
  JOURNAL   J Biol Chem 267 (3), 2057-2064 (1992)
   PUBMED   1370487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY233228.1 and BC055340.1.
            
            [WARNING] On Oct 13, 2023 this sequence was replaced by
            NM_011400.4.
            
            On Jan 16, 2008 this sequence version replaced NM_011400.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055340.1, SRR1660817.82565.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                BY233228.1         1-31
            32-2573             BC055340.1         1-2542
FEATURES             Location/Qualifiers
     source          1..2573
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4"
     gene            1..2573
                     /gene="Slc2a1"
                     /gene_synonym="Glut-1; Glut1; M100200; Rgsc200"
                     /note="solute carrier family 2 (facilitated glucose
                     transporter), member 1"
                     /db_xref="GeneID:20525"
                     /db_xref="MGI:MGI:95755"
     exon            1..228
                     /gene="Slc2a1"
                     /gene_synonym="Glut-1; Glut1; M100200; Rgsc200"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..1689
                     /gene="Slc2a1"
                     /gene_synonym="Glut-1; Glut1; M100200; Rgsc200"
                     /note="GT1; glucose transporter type 1, erythrocyte/brain;
                     solute carrier family 2, member 1"
                     /codon_start=1
                     /product="solute carrier family 2, facilitated glucose
                     transporter member 1"
                     /protein_id="NP_035530.2"
                     /db_xref="CCDS:CCDS18569.1"
                     /db_xref="GeneID:20525"
                     /db_xref="MGI:MGI:95755"
                     /translation="MDPSSKKVTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFY
                     NQTWNHRYGEPIPSTTLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLL
                     AFVAAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLH
                     QLGIVVGILIAQVFGLDSIMGNADLWPLLLSVIFIPALLQCILLPFCPESPRFLLINR
                     NEENRAKSVLKKLRGTADVTRDLQEMKEEGRQMMREKKVTILELFRSPAYRQPILIAV
                     VLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRR
                     TLHLIGLAGMAGCAVLMTIALALLERLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVA
                     ELFSQGPRPAAIAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYF
                     KVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADSQV"
     exon            229..324
                     /gene="Slc2a1"
                     /gene_synonym="Glut-1; Glut1; M100200; Rgsc200"
                     /inference="alignment:Splign:2.1.0"
     exon            325..485
                     /gene="Slc2a1"
                     /gene_synonym="Glut-1; Glut1; M100200; Rgsc200"
                     /inference="alignment:Splign:2.1.0"
     exon            486..726
                     /gene="Slc2a1"
                     /gene_synonym="Glut-1; Glut1; M100200; Rgsc200"
                     /inference="alignment:Splign:2.1.0"
     exon            727..889
                     /gene="Slc2a1"
                     /gene_synonym="Glut-1; Glut1; M100200; Rgsc200"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1077
                     /gene="Slc2a1"
                     /gene_synonym="Glut-1; Glut1; M100200; Rgsc200"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1182
                     /gene="Slc2a1"
                     /gene_synonym="Glut-1; Glut1; M100200; Rgsc200"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1284
                     /gene="Slc2a1"
                     /gene_synonym="Glut-1; Glut1; M100200; Rgsc200"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1488
                     /gene="Slc2a1"
                     /gene_synonym="Glut-1; Glut1; M100200; Rgsc200"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..2573
                     /gene="Slc2a1"
                     /gene_synonym="Glut-1; Glut1; M100200; Rgsc200"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tacaccccag aaccaatggc ggcggtccta taaaaaggca gctccgcgcg ctctccccca
       61 agagcagagg cttgcttgta gagtgacgat ctgagctacg gggtcttaag tgcgtcaggg
      121 cgtggaggtc tggcgggaga cgcatagtta cagcgcgtcc gttctccgtc tcgcagccgg
      181 cacagctaga gcttcgagcg cagcgcggcc atggatccca gcagcaagaa ggtgacgggc
      241 cgcctcatgt tggctgtggg aggagcagtg ctcggatcac tgcagttcgg ctataacact
      301 ggtgtcatca acgcccccca gaaggttatt gaggagttct acaatcaaac atggaaccac
      361 cgctacggag agcccatccc atccaccaca ctcaccacgc tttggtctct ctccgtggcc
      421 atcttctctg tcgggggcat gattggttcc ttctctgtcg gcctctttgt taatcgcttt
      481 ggcaggcgga actccatgct gatgatgaac ctgttggcct ttgtggctgc tgtgcttatg
      541 ggcttctcca aactgggcaa gtcctttgag atgctgatcc tgggccgctt catcatcggt
      601 gtgtactgcg gcctgactac tggctttgtg cccatgtatg tgggagaggt gtcacctaca
      661 gctctacgtg gagccctagg cacactgcac cagctgggaa tcgtcgttgg catccttatt
      721 gcccaggtgt ttggcttaga ctccatcatg ggcaatgcag acttgtggcc tctgctgctc
      781 agtgtcatct tcatcccagc cctgctacag tgtatcctgt tgcccttctg ccccgagagc
      841 ccccgcttcc tgctcatcaa tcgtaacgag gagaaccggg ccaagagtgt gctgaagaag
      901 cttcgaggga cagccgatgt gacccgagac ctgcaggaga tgaaagaaga gggtcggcag
      961 atgatgcggg agaagaaggt caccatcttg gagctgttcc gctcacccgc ctaccgccag
     1021 cccatcctca tcgctgtggt gctgcagctg tcccagcagc tgtcgggtat caatgctgtg
     1081 ttctactact caacgagcat cttcgagaag gcaggtgtgc agcagcctgt gtacgccacc
     1141 atcggctccg gtatcgtcaa cacggccttc actgtggtgt cgctgtttgt tgtagagcga
     1201 gctggacgac ggaccctgca cctcattggc ctggctggca tggcaggctg tgctgtgctc
     1261 atgaccatcg ccctggcctt gctggaacgg ctgccttgga tgtcctatct gagcatcgtg
     1321 gccatctttg gctttgtggc cttctttgaa gtaggccctg gtcctattcc atggttcatt
     1381 gtggccgagc tgttcagcca ggggccccgt cctgctgcta ttgctgtggc tggcttctcc
     1441 aactggacct caaacttcat tgtgggcatg tgcttccagt atgtggagca actgtgcggc
     1501 ccctacgtct tcatcatctt cacggtgctc ctcgtgctct tcttcatctt cacctacttc
     1561 aaagtccctg agaccaaagg ccgaaccttc gatgagatcg cttccggctt ccggcagggg
     1621 ggtgccagcc aaagtgacaa gacacccgag gagctcttcc accctctggg ggcggactcc
     1681 caagtgtgag gagccccaca cccagcccgg cctgctccct gcagcccaag gatctctctg
     1741 gagcacaggc agctagatga gacctcttcc gaaccgacag atctcgggca agccgggcct
     1801 gggcgccttt cctcagccag cagtgaagtc caggaggata ttcaggactt tgatggctcc
     1861 agaattttta atgaaagcaa gactgctgct cagatctatt cagataagca gcaggtttta
     1921 taattttttt attactgatt ttgttatttt ttttttttat cagccactct cctatctcca
     1981 cactgtagtc ttcaccttga ttggcccagt gcctgagggt ggggaccacg ccctgtccag
     2041 acacttgcct tctttgccaa gctaatctgt agggctggac ctatggccaa ggacacacta
     2101 ataccgaact ctgagctagg aggctttacc gctggaggcg gtagctgcca cccacttccg
     2161 caggcctgga cctcggcacc ataggggtcc ggactccatt ttaggattcg cccattcctg
     2221 tctcttccta cccaaccact caattaatct ttccttgcct gagaccagtt ggaagcactg
     2281 gagtgcaggg aggagaggga agggccaggc tgggctgcca ggttctagtc tcctgtgcac
     2341 tgagggccac acaaacacca tgagaaggac ctcggaggct gagaacttaa ctgctgaaga
     2401 cacggacact cctgccctgc tgtgtataga tggaagatat ttatatattt tttggttgtc
     2461 aatattaaat acagacacta agttatagta tatctggaca aacccacttg taaatacacc
     2521 aacaaactcc tgtaacttta cctaagcaga tataaatggc tggtttttag aaa
//
