LOCUS       NM_146257               2942 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus solute carrier family 29 (nucleoside transporters),
            member 4 (Slc29a4), mRNA.
ACCESSION   NM_146257 XM_355728
VERSION     NM_146257.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2942)
  AUTHORS   Beaver JN, Weber BL, Ford MT, Anello AE, Kassis SK and Gilman TL.
  TITLE     Uncovering Functional Contributions of PMAT (Slc29a4) to Monoamine
            Clearance Using Pharmacobehavioral Tools
  JOURNAL   Cells 11 (12), 1874 (2022)
   PUBMED   35741002
  REMARK    GeneRIF: Uncovering Functional Contributions of PMAT (Slc29a4) to
            Monoamine Clearance Using Pharmacobehavioral Tools.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2942)
  AUTHORS   Wei R, Gust SL, Tandio D, Maheux A, Nguyen KH, Wang J, Bourque S,
            Plane F and Hammond JR.
  TITLE     Deletion of murine slc29a4 modifies vascular responses to adenosine
            and 5-hydroxytryptamine in a sexually dimorphic manner
  JOURNAL   Physiol Rep 8 (5), e14395 (2020)
   PUBMED   32170814
  REMARK    GeneRIF: Deletion of murine slc29a4 modifies vascular responses to
            adenosine and 5-hydroxytryptamine in a sexually dimorphic manner.
REFERENCE   3  (bases 1 to 2942)
  AUTHORS   Rezai Amin S, Gruszczynski C, Guiard BP, Callebert J, Launay JM,
            Louis F, Betancur C, Vialou V and Gautron S.
  TITLE     Viral vector-mediated Cre recombinase expression in substantia
            nigra induces lesions of the nigrostriatal pathway associated with
            perturbations of dopamine-related behaviors and hallmarks of
            programmed cell death
  JOURNAL   J Neurochem 150 (3), 330-340 (2019)
   PUBMED   30748001
REFERENCE   4  (bases 1 to 2942)
  AUTHORS   Wu KC, Lu YH, Peng YH, Hsu LC and Lin CJ.
  TITLE     Effects of lipopolysaccharide on the expression of plasma membrane
            monoamine transporter (PMAT) at the blood-brain barrier and its
            implications to the transport of neurotoxins
  JOURNAL   J Neurochem 135 (6), 1178-1188 (2015)
   PUBMED   26376205
REFERENCE   5  (bases 1 to 2942)
  AUTHORS   Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K,
            Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre
            A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt
            AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,
            Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S,
            Wohnoutka P, Hawrylycz MJ, Puelles L and Jones AR.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 2942)
  AUTHORS   Duan H and Wang J.
  TITLE     Selective transport of monoamine neurotransmitters by human plasma
            membrane monoamine transporter and organic cation transporter 3
  JOURNAL   J Pharmacol Exp Ther 335 (3), 743-753 (2010)
   PUBMED   20858707
REFERENCE   7  (bases 1 to 2942)
  AUTHORS   Dahlin A, Xia L, Kong W, Hevner R and Wang J.
  TITLE     Expression and immunolocalization of the plasma membrane monoamine
            transporter in the brain
  JOURNAL   Neuroscience 146 (3), 1193-1211 (2007)
   PUBMED   17408864
REFERENCE   8  (bases 1 to 2942)
  AUTHORS   Barnes K, Dobrzynski H, Foppolo S, Beal PR, Ismat F, Scullion ER,
            Sun L, Tellez J, Ritzel MW, Claycomb WC, Cass CE, Young JD,
            Billeter-Clark R, Boyett MR and Baldwin SA.
  TITLE     Distribution and functional characterization of equilibrative
            nucleoside transporter-4, a novel cardiac adenosine transporter
            activated at acidic pH
  JOURNAL   Circ Res 99 (5), 510-519 (2006)
   PUBMED   16873718
  REMARK    GeneRIF: ENT4, in addition to playing roles in cardiac serotonin
            transport, contributes to the regulation of extracellular adenosine
            concentrations, in particular under the acidotic conditions
            associated with ischemia.
REFERENCE   9  (bases 1 to 2942)
  AUTHORS   Engel K, Zhou M and Wang J.
  TITLE     Identification and characterization of a novel monoamine
            transporter in the human brain
  JOURNAL   J Biol Chem 279 (48), 50042-50049 (2004)
   PUBMED   15448143
REFERENCE   10 (bases 1 to 2942)
  AUTHORS   Acimovic Y and Coe IR.
  TITLE     Molecular evolution of the equilibrative nucleoside transporter
            family: identification of novel family members in prokaryotes and
            eukaryotes
  JOURNAL   Mol Biol Evol 19 (12), 2199-2210 (2002)
   PUBMED   12446811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY727407.1 and BC025599.1.
            
            [WARNING] On Oct 5, 2023 this sequence was replaced by NM_146257.3.
            
            On Mar 23, 2007 this sequence version replaced NM_146257.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025599.1, SRR1660817.262474.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                BY727407.1         2-69
            69-2942             BC025599.1         13-2886
FEATURES             Location/Qualifiers
     source          1..2942
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 81.56 cM"
     gene            1..2942
                     /gene="Slc29a4"
                     /gene_synonym="ENT4; mENT4; mPMAT; PMAT"
                     /note="solute carrier family 29 (nucleoside transporters),
                     member 4"
                     /db_xref="GeneID:243328"
                     /db_xref="MGI:MGI:2385330"
     exon            1..191
                     /gene="Slc29a4"
                     /gene_synonym="ENT4; mENT4; mPMAT; PMAT"
                     /inference="alignment:Splign:2.1.0"
     exon            192..371
                     /gene="Slc29a4"
                     /gene_synonym="ENT4; mENT4; mPMAT; PMAT"
                     /inference="alignment:Splign:2.1.0"
     exon            372..503
                     /gene="Slc29a4"
                     /gene_synonym="ENT4; mENT4; mPMAT; PMAT"
                     /inference="alignment:Splign:2.1.0"
     exon            504..617
                     /gene="Slc29a4"
                     /gene_synonym="ENT4; mENT4; mPMAT; PMAT"
                     /inference="alignment:Splign:2.1.0"
     exon            618..746
                     /gene="Slc29a4"
                     /gene_synonym="ENT4; mENT4; mPMAT; PMAT"
                     /inference="alignment:Splign:2.1.0"
     exon            747..821
                     /gene="Slc29a4"
                     /gene_synonym="ENT4; mENT4; mPMAT; PMAT"
                     /inference="alignment:Splign:2.1.0"
     exon            822..1066
                     /gene="Slc29a4"
                     /gene_synonym="ENT4; mENT4; mPMAT; PMAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1208
                     /gene="Slc29a4"
                     /gene_synonym="ENT4; mENT4; mPMAT; PMAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1396
                     /gene="Slc29a4"
                     /gene_synonym="ENT4; mENT4; mPMAT; PMAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1637
                     /gene="Slc29a4"
                     /gene_synonym="ENT4; mENT4; mPMAT; PMAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..2789
                     /gene="Slc29a4"
                     /gene_synonym="ENT4; mENT4; mPMAT; PMAT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgggccggg ctagctcgct gcagctgctg cgcccccagc acgcgctcac ggacccgggc
       61 ccgcggaccg ggacaccgag caggacgccc gccgcgcccg gtcccaagcc tcgagaagcg
      121 gggcacagcg caaagggtcc gggcgcgggc ggcaggcagg cagcgaggat cccagcctgg
      181 ggccgcccga gtgtgaactg ccatgggctc tatcggaagc cagcgcctca aggagccctg
      241 cgtggcagcc acatctgacc agagtgtggt gacaagcttt agctttgaca acttccagct
      301 ggagacgaca gcagaggggg ctcaggatcc aggcatcaga gtcaggggtg tccccacttt
      361 cacagactct gcggtagagg agcctgtgcc agatgaccgc taccatgcca tctactttgc
      421 catgctgctg gctggcgtgg gcttcctact gccatacaac agctttatca ccgatgtcga
      481 ctatcttcac cacaagtacc cagggacctc catcgtattt gacatgagcc tcacctatat
      541 cctggtggca ttggcggctg tgctcctaaa caacgttgtg gtggagaggt tgaacctgca
      601 caccaggatc accacaggct acctcctcgc cttgggtccc ttgctcttta tcagcatatg
      661 cgatgtgtgg ctgcagctct tctctcacga ccaggcttac gccatcaacc tggccgccgt
      721 gggcactgtg gcctttggtt gcacagtgca gcaatctagc ttctatggct acacgggatt
      781 actgcccaag aggtacacgc agggtgtgat gactggagag agcacggcag gggtgatgat
      841 ctctctgagt cgaatcctca ctaagctgct gctcccggac gagcgggcca gcaccatcat
      901 cttcttcctg gtgtctgccg gcttggagct cctgtgcttc ctgctgcatc tgctggtgcg
      961 gcgcagccgt tttgtgctct actataccac tcggccccgt gacagccgcc ccgtccaggc
     1021 aggctaccga gtgcaccacg atgtcgcatc cggagacatc cactttgagc accaaactcc
     1081 agccctatcc agcagcaggt ccccgaagga gagcccggcc catgaggtga cgcacagcaa
     1141 cagtggggtc tacatgcgtt ttgatgtgcc ccggccacga gtcaaacgaa gctggcccac
     1201 cttcagagcc ctgctgttgc accgatacgt cgtggcgcgg gtcatctggg ccgacatgct
     1261 gtccattgcg gtaacctact tcattacact gtgcctgttt ccgggcctgg agtccgagat
     1321 ccgccactgc gtgctggggg agtggctgcc catcctggtg atggccgtgt tcaacctgtc
     1381 agactttgtg ggcaagatcc tggcagccct gcccgtggag tggcggggca ctcacctgct
     1441 cgcctgctct tgcctgcgtg tggtcttcat ccccctcttc atcctgtgtg tgtaccccag
     1501 tggcatgcct gccctccgcc accctgcctg gccctgtgtc ttctcgctgc taatgggcat
     1561 cagcaatggc tactttggca gtgtgcccat gatcctggca gctggaaaag tgagccccaa
     1621 gcagcgggaa ctggcaggaa acaccatgac tgtgtcctac atgtcggggc tgaccctggg
     1681 ctctgctgtg gcctactgca cctacagcct cacccgagat gcccacggca gctgctttca
     1741 aacagccacc gccgccgccg ccaacgactc catccctgtc ggtccctgag ccgggcccac
     1801 ccaatcctgc cccctgccca ggaagagctg cctgggccag ttaccccaag gcctgaggac
     1861 cctcccaccc ctgcctcagt gcctgcgggg tcctggccac ctcctaagcc actaacgcca
     1921 ccttgccacc ttgtcccagt tgtccaaaac agctggaact tgtcttcacc gcccagggca
     1981 ccgcctcccc gtgtcctgtg tttggtcaga cacctgccct tcaccctctg tgtccagagg
     2041 cccagcatct gtcacacatc aagggggcgt ttattcagtc ttagagccac tcggaatggc
     2101 tggccacagt ctgagctgac tcccttcagt gtgaccccac tgtgtggttc catggtcttc
     2161 gatgtggttt tcatttactg gtcagggggc acctccctgt attagaaatc ttggaggaaa
     2221 gtccccaact ccgttctgtc cctttcttgt tcttagacac ttcttcacag ccctacccct
     2281 gcacccgcac acataaagcg tcaagtctgg aaaactcatt cctcatacac aggcctcctg
     2341 tagtcatagc aacagagatg acctaggtgc acccacctta ggtggaggac ttccccatgc
     2401 acaccaccac ccctcttaga gcacaggcta agggccacgg ctaacaggga cgtcccattt
     2461 ctttcctgtt ccatccaact tacccatcat gcagggacag ctgaggtcca ctcgtgacct
     2521 aggccgcccc actcccatcc accgagagtc aagtgatgac acgacacact tgaaaccctg
     2581 gcaagtggct gcaaggtgag gattggactc gtgggtgcca ggatcggctg gaggacctcc
     2641 tgccaaagag agcttttgct gagccgggac acttgcctct ccacacagtg gccccagccg
     2701 tgaccaccct gtaccagtcc ctgctgtgtc ctgtctacct gtgtgttctc tgactaccgc
     2761 actggccatt aaatatggca gagactgcca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2821 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2881 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2941 aa
//
