LOCUS       NM_023596               5240 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus solute carrier family 29 (nucleoside transporters),
            member 3 (Slc29a3), mRNA.
ACCESSION   NM_023596
VERSION     NM_023596.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5240)
  AUTHORS   Lu,Y.S., Hung,W.C., Hsieh,Y.T., Tsai,P.Y., Tsai,T.H., Fan,H.H.,
            Chang,Y.G., Cheng,H.K., Huang,S.Y., Lin,H.C., Lee,Y.H., Shen,T.H.,
            Hung,B.Y., Tsai,J.W., Dzhagalov,I., Cheng,I.H., Lin,C.J., Chern,Y.
            and Hsu,C.L.
  TITLE     Equilibrative nucleoside transporter 3 supports microglial
            functions and protects against the progression of Huntington's
            disease in the mouse model
  JOURNAL   Brain Behav Immun 120, 413-429 (2024)
   PUBMED   38925413
  REMARK    GeneRIF: Equilibrative nucleoside transporter 3 supports microglial
            functions and protects against the progression of Huntington's
            disease in the mouse model.
            Erratum:[Brain Behav Immun. 2024 Oct;121:403. doi:
            10.1016/j.bbi.2024.08.018.. PMID: 39155153]
REFERENCE   2  (bases 1 to 5240)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5240)
  AUTHORS   Shibata,T., Sato,R., Taoka,M., Saitoh,S.I., Komine,M.,
            Yamaguchi,K., Goyama,S., Motoi,Y., Kitaura,J., Izawa,K.,
            Yamauchi,Y., Tsukamoto,Y., Ichinohe,T., Fujita,E., Hiranuma,R.,
            Fukui,R., Furukawa,Y., Kitamura,T., Takai,T., Tojo,A., Ohtsuki,M.,
            Ohto,U., Shimizu,T., Ozawa,M., Yoshida,N., Isobe,T., Latz,E.,
            Mukai,K., Taguchi,T., Hemmi,H., Akira,S. and Miyake,K.
  TITLE     TLR7/8 stress response drives histiocytosis in SLC29A3 disorders
  JOURNAL   J Exp Med 220 (9) (2023)
   PUBMED   37462944
  REMARK    GeneRIF: TLR7/8 stress response drives histiocytosis in SLC29A3
            disorders.
REFERENCE   4  (bases 1 to 5240)
  AUTHORS   Persaud,A.K., Nair,S., Rahman,M.F., Raj,R., Weadick,B., Nayak,D.,
            McElroy,C., Shanmugam,M., Knoblaugh,S., Cheng,X. and
            Govindarajan,R.
  TITLE     Facilitative lysosomal transport of bile acids alleviates ER stress
            in mouse hematopoietic precursors
  JOURNAL   Nat Commun 12 (1), 1248 (2021)
   PUBMED   33623001
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5240)
  AUTHORS   Nair,S., Strohecker,A.M., Persaud,A.K., Bissa,B., Muruganandan,S.,
            McElroy,C., Pathak,R., Williams,M., Raj,R., Kaddoumi,A.,
            Sparreboom,A., Beedle,A.M. and Govindarajan,R.
  TITLE     Adult stem cell deficits drive Slc29a3 disorders in mice
  JOURNAL   Nat Commun 10 (1), 2943 (2019)
   PUBMED   31270333
  REMARK    GeneRIF: adult stem cell deficits that drive ENT3-related
            abnormalities in mice, were identified.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5240)
  AUTHORS   Morgan,N.V., Morris,M.R., Cangul,H., Gleeson,D.,
            Straatman-Iwanowska,A., Davies,N., Keenan,S., Pasha,S., Rahman,F.,
            Gentle,D., Vreeswijk,M.P., Devilee,P., Knowles,M.A., Ceylaner,S.,
            Trembath,R.C., Dalence,C., Kismet,E., Koseoglu,V., Rossbach,H.C.,
            Gissen,P., Tannahill,D. and Maher,E.R.
  TITLE     Mutations in SLC29A3, encoding an equilibrative nucleoside
            transporter ENT3, cause a familial histiocytosis syndrome
            (Faisalabad histiocytosis) and familial Rosai-Dorfman disease
  JOURNAL   PLoS Genet 6 (2), e1000833 (2010)
   PUBMED   20140240
  REMARK    GeneRIF: Mutation analysis of candidate genes within the target
            interval identified biallelic germline mutations in SLC29A3 in the
            Faisalabad histiocytosis kindred and in two families reported to
            have familial Rosai-Dorfman disease.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5240)
  AUTHORS   Cheng,X. and Klaassen,C.D.
  TITLE     Tissue distribution, ontogeny, and hormonal regulation of
            xenobiotic transporters in mouse kidneys
  JOURNAL   Drug Metab Dispos 37 (11), 2178-2185 (2009)
   PUBMED   19679677
REFERENCE   8  (bases 1 to 5240)
  AUTHORS   Baldwin,S.A., Yao,S.Y., Hyde,R.J., Ng,A.M., Foppolo,S., Barnes,K.,
            Ritzel,M.W., Cass,C.E. and Young,J.D.
  TITLE     Functional characterization of novel human and mouse equilibrative
            nucleoside transporters (hENT3 and mENT3) located in intracellular
            membranes
  JOURNAL   J Biol Chem 280 (16), 15880-15887 (2005)
   PUBMED   15701636
  REMARK    GeneRIF: broad selectivity, low affinity nucleoside transporter
            that can also transport adenine
REFERENCE   9  (bases 1 to 5240)
  AUTHORS   Acimovic,Y. and Coe,I.R.
  TITLE     Molecular evolution of the equilibrative nucleoside transporter
            family: identification of novel family members in prokaryotes and
            eukaryotes
  JOURNAL   Mol Biol Evol 19 (12), 2199-2210 (2002)
   PUBMED   12446811
REFERENCE   10 (bases 1 to 5240)
  AUTHORS   Hyde,R.J., Cass,C.E., Young,J.D. and Baldwin,S.A.
  TITLE     The ENT family of eukaryote nucleoside and nucleobase transporters:
            recent advances in the investigation of structure/function
            relationships and the identification of novel isoforms
  JOURNAL   Mol Membr Biol 18 (1), 53-63 (2001)
   PUBMED   11396612
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK051317.1, CV557129.1 and AC153517.8.
            
            On Jul 14, 2006 this sequence version replaced NM_023596.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13861890.218470.1, AF326986.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               AK051317.1         3-350
            349-853             CV557129.1         219-723
            854-5240            AC153517.8         158835-163221
FEATURES             Location/Qualifiers
     source          1..5240
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 31.38 cM"
     gene            1..5240
                     /gene="Slc29a3"
                     /gene_synonym="4933435C21Rik; Ent3"
                     /note="solute carrier family 29 (nucleoside transporters),
                     member 3"
                     /db_xref="GeneID:71279"
                     /db_xref="MGI:MGI:1918529"
     exon            1..49
                     /gene="Slc29a3"
                     /gene_synonym="4933435C21Rik; Ent3"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1476
                     /gene="Slc29a3"
                     /gene_synonym="4933435C21Rik; Ent3"
                     /note="mENT3; solute carrier family 29 member 3"
                     /codon_start=1
                     /product="equilibrative nucleoside transporter 3"
                     /protein_id="NP_076085.1"
                     /db_xref="CCDS:CCDS48571.1"
                     /db_xref="GeneID:71279"
                     /db_xref="MGI:MGI:1918529"
                     /translation="MAFASEDNVYHSSNAVYRAPSNHQEADQEALLGKLLDYPAPGLQ
                     RPEDRFNGAYIIFFCLGIGGLLPWNFFVTAKEYWAYKLRNCSSPASGEDPEDMDILNY
                     FESYLAVASTVPSLLFLVANFLLVNRVQVHVRVLASLSVSLAIFVVMIVLVKVDTSSW
                     TRGFFSLTIACMAIISSSSTIFNSSVYGLTGSFPMRNAQALISGGAMGGTVSAVALLV
                     DLAASSDVRDSTLAFFLMAAVFLGLCMGLYLLLSQLEYARYYMRPVAPVRVFSGEDNP
                     SQDAPSASSVAPASRVMHTPPLGPILKKTASLGFCAVSLYFVTAFIIPAISTNIQSMH
                     KGTGSPWTSKFFVPLTVFLLFNFADLCGRQVTAWIQVPGPRSKLLPGLVVSRFCLVPL
                     FLLCNYQPRSHLTKVLFQSDIYPVLFTCLLGLSNGYLSTLVLIYGPKIVPRELAEATS
                     VVMLFYMSVGLMLGSACAALLEHFI"
     exon            50..348
                     /gene="Slc29a3"
                     /gene_synonym="4933435C21Rik; Ent3"
                     /inference="alignment:Splign:2.1.0"
     exon            349..431
                     /gene="Slc29a3"
                     /gene_synonym="4933435C21Rik; Ent3"
                     /inference="alignment:Splign:2.1.0"
     exon            432..658
                     /gene="Slc29a3"
                     /gene_synonym="4933435C21Rik; Ent3"
                     /inference="alignment:Splign:2.1.0"
     exon            659..821
                     /gene="Slc29a3"
                     /gene_synonym="4933435C21Rik; Ent3"
                     /inference="alignment:Splign:2.1.0"
     exon            822..5240
                     /gene="Slc29a3"
                     /gene_synonym="4933435C21Rik; Ent3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5215..5220
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc29a3"
                     /gene_synonym="4933435C21Rik; Ent3"
                     /note="hexamer: AATAAA"
     polyA_site      5240
                     /gene="Slc29a3"
                     /gene_synonym="4933435C21Rik; Ent3"
                     /note="major polyA site"
ORIGIN      
        1 acagtggccc agcgccttgg acctggtgga ggtagcagcg gcagcgacat ggcctttgcc
       61 tctgaggaca atgtatacca cagctccaat gctgtctaca gagccccgag taaccatcaa
      121 gaagctgacc aggaagccct gctggggaaa ctactagact acccagcccc gggcctgcag
      181 aggccagagg atcgcttcaa tggtgcctac atcatcttct tctgcctggg aattgggggc
      241 ctactgccct ggaacttctt tgtcactgct aaggagtact gggcatataa actccgaaac
      301 tgctccagcc cagcgtccgg ggaggaccct gaggacatgg acatcctgaa ctactttgag
      361 agctacctgg cagttgcctc cactgtgccc tccctgctgt tcctggtggc taacttcctg
      421 cttgtcaaca gggtccaggt gcacgtccgt gttctggcct cactgtccgt gtccctggcc
      481 atcttcgtgg ttatgattgt gctggtgaag gtggatactt cctcctggac ccgaggcttc
      541 ttcagcctca ccatcgcgtg catggccatc attagcagct cctccaccat cttcaatagc
      601 agcgtttacg gcctcacagg ctccttcccc atgaggaatg cccaggcact gatatcagga
      661 ggagccatgg gagggacagt cagtgccgtg gccttgctgg tggacctggc agcatccagt
      721 gatgtgcggg acagcacgct agccttcttc ctcatggcag cagtcttcct tgggctctgt
      781 atgggactct atctattgct gtcccaactg gagtatgcca ggtactacat gaggccagtt
      841 gccccagttc gagtgttttc tggtgaagac aacccatccc aggatgctcc cagcgcctcc
      901 tctgtggccc ctgcatccag agtgatgcac acaccgcccc ttggacccat cctgaagaag
      961 acggctagcc tcgggttctg cgcagtttcc ctctactttg tcacggcctt catcatcccc
     1021 gccatctcca ccaatatcca gtccatgcac aaaggcaccg gctctccatg gacctccaag
     1081 ttcttcgtgc ccctcaccgt cttcctcctc ttcaactttg ctgacctctg cggccgacag
     1141 gtcacagcct ggatccaggt gccaggtcct aggagcaagc tgctccccgg actggtggtc
     1201 tctcggttct gccttgtgcc tctcttcttg ctctgtaact accagccgcg ctcacacttg
     1261 accaaggtgc ttttccagtc ggacatctac ccagtgcttt tcacctgcct cctggggctc
     1321 agcaacggct acctcagcac gctggtgctc atctatgggc ccaagattgt gccccgggag
     1381 ctggctgagg ccaccagtgt tgtgatgttg ttctatatgt ctgtgggctt gatgctgggc
     1441 tcagcctgcg cggccctgct tgaacacttt atctaggagg gggcggcaag gatgtgggta
     1501 ctgtgtgagt gtgtgaggct tgggtcctta ggagatggac agggtaagcc aaggtctcga
     1561 ggtgttaagc aaggggttga cattttgttt gatgcagagc agagcccact cagactgcct
     1621 ttctctcaga ctgcttgtga gccacatcct tgcacatctt gggcaaggag acattccaaa
     1681 cacagcccag cctggctcat acctgtaatc tcagcattca agagaatgaa gctggaggcc
     1741 cactgtgagt tcaaggccag cctggttaca tagtgaaacc ttttctcaaa aaataagcta
     1801 aaaacaaaaa ccctgagaca ttccaaacac ttccagagaa cactccagag ccgactgaag
     1861 ggcagggtga ggttgtagcc aggatctagc ccagttggta ggatgcttgt ttagcctcca
     1921 tagagcccca gctcctatcc ccagccccga ataagctggg catgttagtg aaagcctgta
     1981 atcctagctc ttgaaaggtg gaagcagcag ggtcagaagt tcaggtcatc ctcagctatt
     2041 tagggagttt gaggctaacc tgggctacag gagacactgt ctcaaaaaaa aaaagacgca
     2101 attgtaaaga gtggggtatg ttacagtcat agctcataag tagcccatct ctaatttgta
     2161 ttgtcacaag gccagaagcc agcctcactc tttccagctg acattgaggt gggagagaat
     2221 ctcagggctc cctgttctaa gagaggctcc tggatttgag gtcccctctg caatggccag
     2281 tactcagact tagggccctg tcgttgtcct actctggcca gcgacaggaa cgacacagac
     2341 accaagttgg gttcacgcag caactttact tcaggctttt tcttttacag ctctcttccc
     2401 cagcagcttc ttcttagggc aagggctaag ctactcttat tctacttctg gcttctacct
     2461 agggcaaggg ctaaacaaac tctcttcact actactggct tcttttacaa cagctaactt
     2521 ctaccactta caacagcagc ttttactact ccatccttct cgcagcaagg gctaaacttt
     2581 tctctctact cgcaccgact cacttccttc tagctccacc cccacctcat ccaatcagaa
     2641 ttcacatatg ctccaggaat gagcttaggt cgttcacaga taggctgaca ggtctggatc
     2701 acgaggaact gtccagcctg gcaggcagcc tacacatgca gcctcactgt gcatgctcgg
     2761 gcaaggcagt aaacaagtgg gtttcacggg gcctgaggct gcacctgctt cccgaatctc
     2821 cccctttttg tttaattagt agctctggga tcagcatctg tcttaggttg cccccattcg
     2881 tgccacatcc ttacccatca tcggagtgac gaactcactt tcgccatcct gtcttaggtt
     2941 ggtatgcgca cgtgagggtc ttacccgtca ttgattactg atccagcatg ttgagccaat
     3001 attaggggaa tgttcctgct tccaaggcta ccatagcctt gtttatcagc cctgtgccgc
     3061 cttcgcatat gtgctatcca ccaaagcatt cctccataca caacagtcag caggagcgct
     3121 caaaaggcca tccctcccca attttttaaa gagtcccaca gtttcctgga tgatctccat
     3181 ccattgcttt gcagttgcaa tctccacatg ggtgttgttc acggcaacaa tcgatgcccg
     3241 taattccttc atctttgtgt caagatcatg agtctaattt cctagcatca tcacaccaat
     3301 tgcacaagac agatttgcag ctctggaaaa attctgatac tgaacagagg ttacacatat
     3361 tcctgacata tgagccaagc tctggctaag ggtgttaatt ggagaagaga ttgtaaatcg
     3421 gaatctcctt ttaaaatatc gaataacggg cataactctg cattgggaaa attacaatag
     3481 ggccgaatcc aattgatatc tcctaacaat ttctgaaaat cattcaaggt atgcatttta
     3541 tcccatctct caatttagta cctaaatagt gttttacttc tgtcttttga accttttctg
     3601 gggctatcac caaattccac ttctccaact atttagttag agtcccaaat acttcttcca
     3661 cttccacatt agaggatcca caaatcaaaa tatcatccat actacgcttt ccctttttgt
     3721 ctccctcatc tttaaagggg ggaggagatg gcaacagagg ggctgacagt tcgggcggcc
     3781 tacagcgcct caacctccag cggaacatcc aactacagat gtcactgttg ctattggtcc
     3841 catcgctgtc actagtagac ccttcagagc tagattcctt cttctctttt tttatctttg
     3901 gtttgttgtc taagctgttt agattttcgg cggctagcct gagaagcaat ctcagcattg
     3961 ttctttccgc tagcgtccct caagcatgcc ctgaccaaga tccaaatggc taacattttt
     4021 actgtcattt tagtcgcagt tgaacccata tcgtttaaat tcccttcgtc tctattcctg
     4081 agaaccttag tgctctgtcc ccttttttct gggaaaccta tcaggcctat gctttcttta
     4141 cttgctgaaa ttcctttcgt ctctattcct gagatcctta atgcttcgtc ccttttttcc
     4201 cgggaacctt accgtcatct ctatacctga gaaccttaat gcttcgcccc ttttttcctg
     4261 ggaacctcac aggcctgtgc tttctttaaa tacggttgct taccaaaatt tccttacctc
     4321 cgtttactaa aatttcctac tgctgtttat cactgcttac caaaaatttt ttacttacct
     4381 ttgccgacct acgcgatgag ttccccgttc cccgtatggg ctaccatttg tcgtcgtcct
     4441 actctggcca gcgacaggaa cgacagggac acaggtcggg ttcatgcagc aactttactt
     4501 caggcttttt cttttacagc tctcttcccc agcagcttct tcttagggca agggctaagc
     4561 tactcttatt ctacttctgg cttctaccta gggcaagggc taaacaaact ctcttcacta
     4621 ctactggctt cttttacaac agctaacttc taccacttac aacagcagct tttactactc
     4681 catccttctc gcagcaaggg ctaaactttt ctctctactc gcaccgactc acttccttct
     4741 agctccaccc ccacctcatc caatcagaat tcacacatgc tccaggaatg agcttaggtc
     4801 gttcacagat aggctgacag gtctggatca cgaggaactg tccagcctgg caggcagcct
     4861 acacatgcag cctcactgtg catgctcggg caaggcagta aacaagtggg tttcacgggg
     4921 cctgcggcca cacctgcttc ttgcagggcc ccagcacatg ctggttcctg ggctctgtgc
     4981 ctgagggcag gctaactagc tggaaagaaa gcccgcacaa ggcaggcctt ctaagccttc
     5041 ctctctgagg cctgggctcc tgaggctccc tttgtcaggg actgagcctg gtaggcctgg
     5101 tctccagatg aggactgtat ggtccagtgg tctacctaca gcctatttag ggcatgggga
     5161 aatcttttta acagtcatgt ttacgggttg ttggggtcct tggttcgagg gcataataaa
     5221 tcctgggatt ctcaatgtga
//
