LOCUS       NM_007854               2490 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus solute carrier family 29 (nucleoside transporters),
            member 2 (Slc29a2), mRNA.
ACCESSION   NM_007854
VERSION     NM_007854.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2490)
  AUTHORS   Chiang,H.L., Wu,K.C., Chen,Y.Y., Ho,C.J., Wang,H.L., Fu,Y.H.,
            Chen,W.Y. and Lin,C.J.
  TITLE     The Critical Role of Equilibrative Nucleoside Transporter-2 in
            Modulating Cerebral Damage and Vascular Dysfunction in Mice with
            Brain Ischemia-Reperfusion
  JOURNAL   Pharm Res 40 (11), 2541-2554 (2023)
   PUBMED   37498500
  REMARK    GeneRIF: The Critical Role of Equilibrative Nucleoside
            Transporter-2 in Modulating Cerebral Damage and Vascular
            Dysfunction in Mice with Brain Ischemia-Reperfusion.
REFERENCE   2  (bases 1 to 2490)
  AUTHORS   Ruan,W., Li,J., Choi,S., Ma,X., Liang,Y., Nair,R., Yuan,X.,
            Mills,T.W. and Eltzschig,H.K.
  TITLE     Targeting myocardial equilibrative nucleoside transporter ENT1
            provides cardioprotection by enhancing myeloid Adora2b signaling
  JOURNAL   JCI Insight 8 (11), e166011 (2023)
   PUBMED   37288658
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2490)
  AUTHORS   Chen,C.Y., Chou,F.Y., Chang,Y.G., Ho,C.J., Wu,K.C., Hsu,C.L.,
            Chern,Y. and Lin,C.J.
  TITLE     Deletion of equilibrative nucleoside transporter 2 disturbs energy
            metabolism and exacerbates disease progression in an experimental
            model of Huntington's disease
  JOURNAL   Neurobiol Dis 177, 106004 (2023)
   PUBMED   36669543
  REMARK    GeneRIF: Deletion of equilibrative nucleoside transporter 2
            disturbs energy metabolism and exacerbates disease progression in
            an experimental model of Huntington's disease.
REFERENCE   4  (bases 1 to 2490)
  AUTHORS   Wu,K.C., Lee,C.Y., Chern,Y. and Lin,C.J.
  TITLE     Amelioration of lipopolysaccharide-induced memory impairment in
            equilibrative nucleoside transporter-2 knockout mice is accompanied
            by the changes in glutamatergic pathways
  JOURNAL   Brain Behav Immun 96, 187-199 (2021)
   PUBMED   34058310
  REMARK    GeneRIF: Amelioration of lipopolysaccharide-induced memory
            impairment in equilibrative nucleoside transporter-2 knockout mice
            is accompanied by the changes in glutamatergic pathways.
REFERENCE   5  (bases 1 to 2490)
  AUTHORS   Chambers,E.D., White,A., Vang,A., Wang,Z., Ayala,A., Weng,T.,
            Blackburn,M., Choudhary,G., Rounds,S. and Lu,Q.
  TITLE     Blockade of equilibrative nucleoside transporter 1/2 protects
            against Pseudomonas aeruginosa-induced acute lung injury and NLRP3
            inflammasome activation
  JOURNAL   FASEB J 34 (1), 1516-1531 (2020)
   PUBMED   31914698
  REMARK    GeneRIF: ENT1/2 chemical inhibition and ENT1 knockout prevented P.
            aeruginosa-induced lung NLRP3 inflammasome activation.
REFERENCE   6  (bases 1 to 2490)
  AUTHORS   Handa,M., Choi,D.S., Caldeiro,R.M., Messing,R.O., Gordon,A.S. and
            Diamond,I.
  TITLE     Cloning of a novel isoform of the mouse NBMPR-sensitive
            equilibrative nucleoside transporter (ENT1) lacking a putative
            phosphorylation site
  JOURNAL   Gene 262 (1-2), 301-307 (2001)
   PUBMED   11179696
REFERENCE   7  (bases 1 to 2490)
  AUTHORS   Kiss,A., Farah,K., Kim,J., Garriock,R.J., Drysdale,T.A. and
            Hammond,J.R.
  TITLE     Molecular cloning and functional characterization of
            inhibitor-sensitive (mENT1) and inhibitor-resistant (mENT2)
            equilibrative nucleoside transporters from mouse brain
  JOURNAL   Biochem J 352 Pt 2 (Pt 2), 363-372 (2000)
   PUBMED   11085929
REFERENCE   8  (bases 1 to 2490)
  AUTHORS   Griffiths,M., Beaumont,N., Yao,S.Y., Sundaram,M., Boumah,C.E.,
            Davies,A., Kwong,F.Y., Coe,I., Cass,C.E., Young,J.D. and
            Baldwin,S.A.
  TITLE     Cloning of a human nucleoside transporter implicated in the
            cellular uptake of adenosine and chemotherapeutic drugs
  JOURNAL   Nat Med 3 (1), 89-93 (1997)
   PUBMED   8986748
REFERENCE   9  (bases 1 to 2490)
  AUTHORS   Williams,J.B. and Lanahan,A.A.
  TITLE     A mammalian delayed-early response gene encodes HNP36, a novel,
            conserved nucleolar protein
  JOURNAL   Biochem Biophys Res Commun 213 (1), 325-333 (1995)
   PUBMED   7639753
REFERENCE   10 (bases 1 to 2490)
  AUTHORS   Lanahan,A., Williams,J.B., Sanders,L.K. and Nathans,D.
  TITLE     Growth factor-induced delayed early response genes
  JOURNAL   Mol Cell Biol 12 (9), 3919-3929 (1992)
   PUBMED   1508193
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC048958.1 and BF465335.1.
            
            On Jul 15, 2008 this sequence version replaced NM_007854.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048958.1, AK010950.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2466              BC048958.1         147-2612
            2467-2490           BF465335.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..2490
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.23 cM"
     gene            1..2490
                     /gene="Slc29a2"
                     /gene_synonym="Der12; Ent2; Hnp36; mENT2"
                     /note="solute carrier family 29 (nucleoside transporters),
                     member 2"
                     /db_xref="GeneID:13340"
                     /db_xref="MGI:MGI:1345278"
     exon            1..272
                     /gene="Slc29a2"
                     /gene_synonym="Der12; Ent2; Hnp36; mENT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..1614
                     /gene="Slc29a2"
                     /gene_synonym="Der12; Ent2; Hnp36; mENT2"
                     /note="36 kDa nucleolar protein HNP36; nucleoside
                     transporter, ei-type; delayed-early response protein 12;
                     solute carrier family 29 member 2; 36 kDa hydrophobic
                     nucleolar protein; equilibrative NBMPR-insensitive
                     nucleoside transporter; equilibrative
                     nitrobenzylmercaptopurine riboside-insensitive nucleoside
                     transporter; delayed early response gene 12"
                     /codon_start=1
                     /product="equilibrative nucleoside transporter 2"
                     /protein_id="NP_031880.2"
                     /db_xref="CCDS:CCDS50354.1"
                     /db_xref="GeneID:13340"
                     /db_xref="MGI:MGI:1345278"
                     /translation="MARGNAPRDSYHLVGISFFILGLGTLLPWNFFITAIPYFQGRLA
                     GTNSSAETMGTNHTSPTDTFNFNNWVTLLSQLPLLLFTLLNSFLYQCIPESVRILGSL
                     LAILLLFALTAALVKVDLSPGLFFSVTMASVWFINSFCAVLQGSLFGQLGTMPSTYST
                     LFLSGQGLAGIFAALAMLMSLASGVDAQTSALGYFITPCVGILLSIVCYLSLPHLKFA
                     RYYLTEKLSQAPTQELETKAELLQADEKNGVPISPQQASPTLDLDPEKEPEPEEPQKP
                     GKPSVFVVFRKIWLTALCLVLVFTVTLSVFPAITAMVTTSSNSPGKWGLFFNPICCFL
                     LFNVMDWLGRSLTSYFLWPDEDSQQLLPLLVCLRFLFVPLFMLCHVPQHARLPIIFRQ
                     DAYFITFMLLFAVSNGYLVSLTMCLAPRQVLPHEREVAGALMTFFLALGLSCGASLSF
                     LFKALL"
     exon            273..354
                     /gene="Slc29a2"
                     /gene_synonym="Der12; Ent2; Hnp36; mENT2"
                     /inference="alignment:Splign:2.1.0"
     exon            355..515
                     /gene="Slc29a2"
                     /gene_synonym="Der12; Ent2; Hnp36; mENT2"
                     /inference="alignment:Splign:2.1.0"
     exon            516..655
                     /gene="Slc29a2"
                     /gene_synonym="Der12; Ent2; Hnp36; mENT2"
                     /inference="alignment:Splign:2.1.0"
     exon            656..790
                     /gene="Slc29a2"
                     /gene_synonym="Der12; Ent2; Hnp36; mENT2"
                     /inference="alignment:Splign:2.1.0"
     exon            791..888
                     /gene="Slc29a2"
                     /gene_synonym="Der12; Ent2; Hnp36; mENT2"
                     /inference="alignment:Splign:2.1.0"
     exon            889..973
                     /gene="Slc29a2"
                     /gene_synonym="Der12; Ent2; Hnp36; mENT2"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1104
                     /gene="Slc29a2"
                     /gene_synonym="Der12; Ent2; Hnp36; mENT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1213
                     /gene="Slc29a2"
                     /gene_synonym="Der12; Ent2; Hnp36; mENT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1299
                     /gene="Slc29a2"
                     /gene_synonym="Der12; Ent2; Hnp36; mENT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1502
                     /gene="Slc29a2"
                     /gene_synonym="Der12; Ent2; Hnp36; mENT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..2473
                     /gene="Slc29a2"
                     /gene_synonym="Der12; Ent2; Hnp36; mENT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2447..2452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc29a2"
                     /gene_synonym="Der12; Ent2; Hnp36; mENT2"
                     /note="hexamer: ATTAAA"
     polyA_site      2466
                     /gene="Slc29a2"
                     /gene_synonym="Der12; Ent2; Hnp36; mENT2"
                     /note="major polyA site"
ORIGIN      
        1 tggagagcgg gcgtccgggg gaggggagca atggctcttt gttcccgccc tggaggcgga
       61 gccgaggtcc gagcctgcaa aacgtggtcc gcagtgtaac ccaaccccga ccctccgcta
      121 cggcgctccg accttgggat tcctggacac cgaccagcgt cgctctcctt cggcctccca
      181 gccctgcgta ggcgcaggtg cagccgcctt ctgtgggcct ggtgcaatag gactgcggca
      241 accatggcgc ggggaaacgc ccctcgggac agctaccacc tggttgggat cagcttcttc
      301 attctgggac tgggcaccct tctcccctgg aacttcttca ttaccgccat cccgtacttc
      361 caggggcggt tagcagggac caacagcagt gctgagacca tgggcaccaa ccacaccagt
      421 cccacagaca ctttcaactt caacaactgg gtgacactgc tgtcccagct gcctctactg
      481 ctcttcacgc tcctcaactc cttcctgtat cagtgcatcc ccgagtcggt gcggattctg
      541 ggcagcctgc tggccatact actgctcttt gccctgacag cagcgttggt gaaggtggac
      601 ttgagccctg ggctgttctt ctctgtcacc atggcgtccg tctggttcat caattccttc
      661 tgtgccgtgc ttcaaggcag cctctttggg cagctgggta ccatgccttc tacctacagc
      721 accctcttcc tcagtggcca gggcctggct gggatcttcg ctgcccttgc tatgctcatg
      781 tccttggcca gtggcgtgga tgcccagacc tctgctcttg gatacttcat cacaccctgt
      841 gtgggcatcc tcctctccat cgtatgttac ctcagcctgc ctcatctgaa gtttgcccgt
      901 tactacctga ccgagaagct gtctcaggct ccaactcagg agctggagac taaagctgag
      961 ctcctccaag ctgatgagaa gaatggggtt cccatcagcc cccaacaggc cagcccaact
     1021 ctggatcttg accctgagaa ggagccagag ccggaggagc cacagaagcc aggaaaacct
     1081 tcagtctttg ttgtcttccg gaagatctgg ctgacggcgc tgtgccttgt gttggtcttc
     1141 acagtcaccc tgtcggtctt tcctgccatc acagccatgg tgaccaccag ctccaatagc
     1201 cccgggaagt ggggtctgtt cttcaaccct atctgttgct ttctgctctt caacgtcatg
     1261 gattggctgg gccggagcct gacctcctac ttcctgtggc cagatgagga cagtcagcag
     1321 ctgctgcccc tgctggtgtg cctgcgcttc ctgtttgtcc cactcttcat gctgtgccac
     1381 gtgccccagc acgcccggct gcccatcatc ttcaggcagg atgcctactt catcaccttc
     1441 atgctgctct tcgctgtttc caacggctac ttggtgtctc tcaccatgtg cctggcaccc
     1501 aggcaggtgt tgccacatga gagggaggta gccggagccc tcatgacctt cttcctggcc
     1561 ctgggactct cctgcggagc ctccctctcc ttcctcttca aggctttact ctgaggacca
     1621 ccagtgctcc acacagtcct cccctcagtg cagcttctgg agttgggacg ttcacaggga
     1681 aggacctcca atatacctgg tctcttggtc tgtgggttcg tggctggtag ccacgttgca
     1741 tatggtgagg aagaatccac cactggtcac tctgcctctc agctaggagt aacacgggac
     1801 acagaaacct ggagctcaca gagatgcaca aaagggcaag ttggaaggca gctatggggg
     1861 aagcaggcgc agggcccttc actgccctcc tgactacatt tcttcatcag tccatccact
     1921 gaccccaggg agcaaagcca gctgtaggtc ttgcttagga caccctgacg gtctctacct
     1981 cggctcagag tgggacctgg gaccagctcc agagcgtcag cgtccccttc tcacccacag
     2041 gccctgacag ggcatgaagt gtcatggaaa ctgaggggaa gagaaagctc aaaggacctc
     2101 tgagcctcca acagggtttt ctcgaagcca acacccctag aatccagatg ggcctgtctg
     2161 acagaaaggc agttggcctg catgtgttgt gcactgcact ttacagtttg caaagttttt
     2221 ccagaagcct ctgtgaggcc tttggaacaa gctgggcagg gatcatcccc aggtgggatt
     2281 cgactgtcta tggaagagta aggcgatggc cttcatcgcc ttccttgtag gtgctgcccc
     2341 tgtcccgcca cttgcttctt ttcctcaaag ttctccaggc aggtgccctc ggcacttgct
     2401 actgtgtttt tgccccattt ctcctccgac cctgctcctg catccaatta aaactgttca
     2461 tttctacgac ggaaaaaaaa aaaaaaaaaa
//
