LOCUS       NM_001004184            2846 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus solute carrier family 28 (sodium-coupled nucleoside
            transporter), member 1 (Slc28a1), mRNA.
ACCESSION   NM_001004184 XM_485954
VERSION     NM_001004184.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2846)
  AUTHORS   Persaud,A.K., Bernier,M.C., Massey,M.A., Agrawal,S., Kaur,T.,
            Nayak,D., Xie,Z., Weadick,B., Raj,R., Hill,K., Abbott,N., Joshi,A.,
            Anabtawi,N., Bryant,C., Somogyi,A., Cruz-Monserrate,Z., Amari,F.,
            Coppola,V., Sparreboom,A., Baker,S.D., Unadkat,J.D., Phelps,M.A.
            and Govindarajan,R.
  TITLE     Increased renal elimination of endogenous and synthetic pyrimidine
            nucleosides in concentrative nucleoside transporter 1 deficient
            mice
  JOURNAL   Nat Commun 14 (1), 3175 (2023)
   PUBMED   37264059
  REMARK    Erratum:[Nat Commun. 2023 Jun 7;14(1):3335. doi:
            10.1038/s41467-023-39187-w.. PMID: 37286564]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2846)
  AUTHORS   Errasti-Murugarren,E., Fernandez-Calotti,P., Veyhl-Wichmann,M.,
            Diepold,M., Pinilla-Macua,I., Perez-Torras,S., Kipp,H., Koepsell,H.
            and Pastor-Anglada,M.
  TITLE     Role of the transporter regulator protein (RS1) in the modulation
            of concentrative nucleoside transporters (CNTs) in epithelia
  JOURNAL   Mol Pharmacol 82 (1), 59-67 (2012)
   PUBMED   22492015
REFERENCE   3  (bases 1 to 2846)
  AUTHORS   Cheng,X. and Klaassen,C.D.
  TITLE     Tissue distribution, ontogeny, and hormonal regulation of
            xenobiotic transporters in mouse kidneys
  JOURNAL   Drug Metab Dispos 37 (11), 2178-2185 (2009)
   PUBMED   19679677
REFERENCE   4  (bases 1 to 2846)
  AUTHORS   Klein,K., Kullak-Ublick,G.A., Wagner,M., Trauner,M. and
            Eloranta,J.J.
  TITLE     Hepatocyte nuclear factor-4alpha and bile acids regulate human
            concentrative nucleoside transporter-1 gene expression
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 296 (4), G936-G947 (2009)
   PUBMED   19228884
  REMARK    GeneRIF: The concentrative nucleoside transporter-1 (CNT1) promoter
            was characterized with respect to DNA response elements and their
            binding factors are reported.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC061230.1 and AC109220.16.
            
            On Apr 28, 2009 this sequence version replaced NM_001004184.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061230.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-380               BC061230.1         1-380
            381-504             AC109220.16        93000-93123         c
            505-2846            BC061230.1         505-2846
FEATURES             Location/Qualifiers
     source          1..2846
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.71 cM"
     gene            1..2846
                     /gene="Slc28a1"
                     /gene_synonym="CNT 1; Cnt1"
                     /note="solute carrier family 28 (sodium-coupled nucleoside
                     transporter), member 1"
                     /db_xref="GeneID:434203"
                     /db_xref="MGI:MGI:3605073"
     exon            1..79
                     /gene="Slc28a1"
                     /gene_synonym="CNT 1; Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            80..191
                     /gene="Slc28a1"
                     /gene_synonym="CNT 1; Cnt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..2042
                     /gene="Slc28a1"
                     /gene_synonym="CNT 1; Cnt1"
                     /note="Na(+)/nucleoside cotransporter 1; solute carrier
                     family 28 member 1; concentrative nucleoside transporter
                     1; sodium-coupled nucleoside transporter 1"
                     /codon_start=1
                     /product="sodium/nucleoside cotransporter 1"
                     /protein_id="NP_001004184.2"
                     /db_xref="CCDS:CCDS21402.1"
                     /db_xref="GeneID:434203"
                     /db_xref="MGI:MGI:3605073"
                     /translation="MADDTPRQRESISLTPVAHGLENMGAEFLEIMEEGQLPHRHSSL
                     PEGGGSRSKAVWKPFSRWRSLQPTVQARSLCREHWQLFEWISKGLLSTAYIGFLIVAC
                     LLDFPRALALFVITCVVLVFLAYNLLKRLLGSKLKKCVKFQGHSCLSLWLKRGLALAA
                     GLGVILWLSLDTAQRPEQLVSFAGICVFLVLLFAGSKHHRAVSWRAVSWGLGLQFVLG
                     LFVIRTEPGFVAFQWLGDQIRVFLSYTEAGSSFVFGEALVKDVFAFQVLPIIVFFSCV
                     MSVLYYLGLMQWVILKIAWLMQVTMGTSATETLSVAGNIFVSQTEAPLLIRPYLADMT
                     LSEVHVVMTGGYATIAGSLLGAYISFGIDASSLIAASVMAAPCALALSKLVYPEVEES
                     KFRSEEGVKLTYGDAQNLVEAASAGAAISVKVVANIAANLIAFLAVLAFINAALSWLG
                     DMVDIQGLSFQLICSYVLRPVAFLMGVAWEDCPVVAELLGIKLFLNEFVAYQELSQYK
                     QRRLAGAEEWLGDKKQWISVRAEILTTYALCGFANFSSIGIMLGGLTSMVPQRRSDFS
                     QIVLRALITGAFVSLVNACVAGILYVPRGVEVDCMSLLNQTVSSSSFEVYLCCRQVFQ
                     NTSLEFGQEALHNCCRFYNHTVCT"
     exon            192..280
                     /gene="Slc28a1"
                     /gene_synonym="CNT 1; Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            281..372
                     /gene="Slc28a1"
                     /gene_synonym="CNT 1; Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            373..556
                     /gene="Slc28a1"
                     /gene_synonym="CNT 1; Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            557..698
                     /gene="Slc28a1"
                     /gene_synonym="CNT 1; Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            699..812
                     /gene="Slc28a1"
                     /gene_synonym="CNT 1; Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            813..890
                     /gene="Slc28a1"
                     /gene_synonym="CNT 1; Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..971
                     /gene="Slc28a1"
                     /gene_synonym="CNT 1; Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1052
                     /gene="Slc28a1"
                     /gene_synonym="CNT 1; Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1178
                     /gene="Slc28a1"
                     /gene_synonym="CNT 1; Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1309
                     /gene="Slc28a1"
                     /gene_synonym="CNT 1; Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1478
                     /gene="Slc28a1"
                     /gene_synonym="CNT 1; Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1676
                     /gene="Slc28a1"
                     /gene_synonym="CNT 1; Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1758
                     /gene="Slc28a1"
                     /gene_synonym="CNT 1; Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1857
                     /gene="Slc28a1"
                     /gene_synonym="CNT 1; Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..1969
                     /gene="Slc28a1"
                     /gene_synonym="CNT 1; Cnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2846
                     /gene="Slc28a1"
                     /gene_synonym="CNT 1; Cnt1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2822..2827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc28a1"
                     /gene_synonym="CNT 1; Cnt1"
                     /note="hexamer: AATAAA"
     polyA_site      2846
                     /gene="Slc28a1"
                     /gene_synonym="CNT 1; Cnt1"
                     /note="major polyA site"
ORIGIN      
        1 ctcccacagc aacctgtgct tcagtcagtc agttcttaac agtcaatccc tcctgacgct
       61 gccttctcac tacaaatctc tgaagagcct agcacatggc agacgacaca ccgaggcaac
      121 gagagtccat ttccctcaca cctgtggccc atggcctgga gaacatgggg gccgagttcc
      181 tggaaataat ggaggaaggc cagctcccac acaggcactc aagcctgcca gagggtggag
      241 gcagcaggag caaagcagtg tggaaaccct tctcccgatg gaggagtctg cagccgactg
      301 tgcaagcgag aagcctctgc agggagcact ggcagctgtt tgagtggatc agcaaaggcc
      361 tgctctctac tgcatacatc ggcttcttga tcgtcgcctg cctcctggac ttcccgaggg
      421 cgctggcgct gttcgtcatc acctgtgtgg ttctcgtctt tctggcctac aatctgctaa
      481 agaggcttct ggggtccaag ctgaagaagt gtgtgaagtt tcagggccac tcttgcctga
      541 gcctctggct gaagagaggt ctagcccttg ctgctggcct gggtgtgatc ttgtggctat
      601 ctctggacac cgcccagcgg ccggaacagc tggtgtcctt tgcagggatc tgtgtgttcc
      661 ttgtccttct cttcgctggc tcaaagcatc accgtgctgt gtcatggagg gctgtctcct
      721 ggggccttgg gctgcagttt gtgcttggac tcttcgtcat cagaacagag ccaggattcg
      781 ttgcgttcca gtggctaggt gaccagatcc gggtcttcct gagttacacc gaggccggct
      841 ccagcttcgt cttcggggag gctctggtca aggatgtctt tgcctttcag gttttgccca
      901 tcatcgtctt tttcagctgc gtcatgtcag ttctgtacta tctgggcctc atgcagtggg
      961 tgatcctgaa gattgcctgg ttgatgcagg tcaccatggg cacctcagcc actgaaaccc
     1021 taagtgtggc aggaaacatc tttgtgagcc agactgaagc tccactgctg atccggccct
     1081 atctggcaga tatgacactc tctgaagttc acgttgtcat gactggaggc tatgctacta
     1141 ttgctggcag cctcctgggc gcctacatct cctttgggat tgacgcttcc tccttaattg
     1201 ctgcctcagt catggcggcc ccttgtgctt tggccctctc caagctggtc tacccagagg
     1261 tggaggagtc caagttccgg agtgaggaag gcgtgaagct gacgtatgga gatgcccaga
     1321 acctcgtgga agcagccagc gctggggctg ccatctcagt gaaggtcgtt gccaacattg
     1381 ctgccaatct gatcgccttc ctggctgtac tggccttcat caacgctgcc ctctcctggc
     1441 tgggggacat ggtggacatc cagggactca gcttccagct catctgctcc tacgtcctgc
     1501 ggcctgtggc cttcttgatg ggcgtggcct gggaggactg tccagtagtg gctgagctgc
     1561 tgggcatcaa gctgtttctc aatgagtttg tggcctatca agagctttcc cagtacaagc
     1621 agcgacgcct ggcaggggct gaggagtggc ttggtgacaa gaaacagtgg atctctgtca
     1681 gagcagagat cctgacgacg tatgccctct gtggattcgc caacttcagc tccattggca
     1741 tcatgctggg gggtctgacc tccatggtcc cccagcggag gagtgacttc tcccagattg
     1801 tgctacgggc actgatcaca ggggccttcg tgtccctggt aaacgcctgt gtggcaggga
     1861 tcctctatgt gccccggggg gtcgaggtgg actgcatgtc tcttctgaac caaactgtca
     1921 gcagcagcag ctttgaggtt tacctgtgct gtcgccaagt cttccaaaac accagcttgg
     1981 agtttggcca agaggcactg cacaactgct gtcgatttta caatcacaca gtctgcacgt
     2041 agctgggacc aaatatcttc ctaacctcaa ggctcatcca tcctggataa ggccatggga
     2101 ctcaccacga cttccatccc acagctggga aaaggcgctg cagtgaatga cagacgcctc
     2161 acaccctggt cccgttgctg ctccccatgt cctacctctc caagtgtggg ttcccagtgt
     2221 ctagtcggcc ccctcgccct ctgagagcag acattctggt cctctctatt cctctttctt
     2281 tgggaccctc atgtgcacct gcccaaagcc tcctccctgc tcccttccaa gcaccggact
     2341 tgctgggtgc ccccagaagc tgtctctaga gaccttcttc cgcccagtct ccaagagtgc
     2401 tttccacccc agtgtcctgt ggggcaccat ctcattaggt gtgatgtcag agtggcccag
     2461 gctccactct gactcggtaa agtttgatgc gagcttggtg ggtttgttga tgttctagat
     2521 gggtctcatg tagctccttc tagcattgac cttactctgt agctgaggtc accctattcc
     2581 tctgtcctcc cgccgtcacc cctgagtgtc aggagtacag gtgcgcacta tcacactgcg
     2641 gccataagga cttcttgttt gggctgttga gagatctcag tgggtaaagg catctgctgc
     2701 taacttgatg aactgactct gatgcctgga cccccaaggt gaaagaggga agccatctct
     2761 gcatgctgtc ctctgacctc tacatatgtg cgtggcacat gctctgcccc tcccaactaa
     2821 aaataaagta taacttaaaa ccttta
//
