LOCUS       NM_009512               2336 bp    mRNA    linear   ROD 04-SEP-2024
DEFINITION  Mus musculus solute carrier family 27 (fatty acid transporter),
            member 5 (Slc27a5), mRNA.
ACCESSION   NM_009512
VERSION     NM_009512.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2336)
  AUTHORS   Shihadih,D., Wang,X., Zushin,P.H., Khodakivskyi,P., Park,H.M.,
            Tso,E., Shiblak,J., Misic,A., Louie,S.M., Ward,C., Hellerstein,M.,
            Nomura,D.K., Goun,E., Urigo,F., Calvisi,D.F., Chen,X. and Stahl,A.
  TITLE     FATP5 Is Indispensable for the Growth of Intrahepatic
            Cholangiocarcinoma
  JOURNAL   Mol Cancer Res 22 (6), 585-595 (2024)
   PUBMED   38358323
  REMARK    GeneRIF: FATP5 Is Indispensable for the Growth of Intrahepatic
            Cholangiocarcinoma.
REFERENCE   2  (bases 1 to 2336)
  AUTHORS   Nie,D., Tang,X., Deng,H., Yang,X., Tao,J., Xu,F., Liu,Y., Wu,K.,
            Wang,K., Mei,Z., Huang,A. and Tang,N.
  TITLE     Metabolic Enzyme SLC27A5 Regulates PIP4K2A pre-mRNA Splicing as a
            Noncanonical Mechanism to Suppress Hepatocellular Carcinoma
            Metastasis
  JOURNAL   Adv Sci (Weinh) 11 (5), e2305374 (2024)
   PUBMED   38059827
REFERENCE   3  (bases 1 to 2336)
  AUTHORS   Wu,K., Liu,Y., Xia,J., Liu,J., Wang,K., Liang,H., Xu,F., Liu,D.,
            Nie,D., Tang,X., Huang,A., Chen,C. and Tang,N.
  TITLE     Loss of SLC27A5 Activates Hepatic Stellate Cells and Promotes Liver
            Fibrosis via Unconjugated Cholic Acid
  JOURNAL   Adv Sci (Weinh) 11 (2), e2304408 (2024)
   PUBMED   37957540
  REMARK    GeneRIF: Loss of SLC27A5 Activates Hepatic Stellate Cells and
            Promotes Liver Fibrosis via Unconjugated Cholic Acid.
REFERENCE   4  (bases 1 to 2336)
  AUTHORS   Kappen,C., Kruger,C., Jones,S. and Salbaum,J.M.
  TITLE     Nutrient Transporter Gene Expression in the Early
            Conceptus-Implications From Two Mouse Models of Diabetic Pregnancy
  JOURNAL   Front Cell Dev Biol 10, 777844 (2022)
   PUBMED   35478964
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2336)
  AUTHORS   Mishima,T., Miner,J.H., Morizane,M., Stahl,A. and Sadovsky,Y.
  TITLE     The expression and function of fatty acid transport protein-2 and
            -4 in the murine placenta
  JOURNAL   PLoS One 6 (10), e25865 (2011)
   PUBMED   22028793
REFERENCE   6  (bases 1 to 2336)
  AUTHORS   Schmuth,M., Ortegon,A.M., Mao-Qiang,M., Elias,P.M., Feingold,K.R.
            and Stahl,A.
  TITLE     Differential expression of fatty acid transport proteins in
            epidermis and skin appendages
  JOURNAL   J Invest Dermatol 125 (6), 1174-1181 (2005)
   PUBMED   16354187
REFERENCE   7  (bases 1 to 2336)
  AUTHORS   Jia,Z., Pei,Z., Li,Y., Wei,L., Smith,K.D. and Watkins,P.A.
  TITLE     X-linked adrenoleukodystrophy: role of very long-chain acyl-CoA
            synthetases
  JOURNAL   Mol Genet Metab 83 (1-2), 117-127 (2004)
   PUBMED   15464426
REFERENCE   8  (bases 1 to 2336)
  AUTHORS   Mihalik,S.J., Steinberg,S.J., Pei,Z., Park,J., Kim,D.G.,
            Heinzer,A.K., Dacremont,G., Wanders,R.J., Cuebas,D.A., Smith,K.D.
            and Watkins,P.A.
  TITLE     Participation of two members of the very long-chain acyl-CoA
            synthetase family in bile acid synthesis and recycling
  JOURNAL   J Biol Chem 277 (27), 24771-24779 (2002)
   PUBMED   11980911
REFERENCE   9  (bases 1 to 2336)
  AUTHORS   Hirsch,D., Stahl,A. and Lodish,H.F.
  TITLE     A family of fatty acid transporters conserved from mycobacterium to
            man
  JOURNAL   Proc Natl Acad Sci U S A 95 (15), 8625-8629 (1998)
   PUBMED   9671728
REFERENCE   10 (bases 1 to 2336)
  AUTHORS   Berger,J., Truppe,C., Neumann,H. and Forss-Petter,S.
  TITLE     A novel relative of the very-long-chain acyl-CoA synthetase and
            fatty acid transporter protein genes with a distinct expression
            pattern
  JOURNAL   Biochem Biophys Res Commun 247 (2), 255-260 (1998)
   PUBMED   9642112
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK144301.1, BC145825.1 and AI173562.1.
            
            On Apr 29, 2009 this sequence version replaced NM_009512.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013272.1, AJ223959.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AK144301.1         2-61
            61-2226             BC145825.1         1-2166
            2227-2336           AI173562.1         1-110               c
FEATURES             Location/Qualifiers
     source          1..2336
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 7.71 cM"
     gene            1..2336
                     /gene="Slc27a5"
                     /gene_synonym="FACVL3; FATP5; Vlacsr; VLCS-H2; VLCSH2"
                     /note="solute carrier family 27 (fatty acid transporter),
                     member 5"
                     /db_xref="GeneID:26459"
                     /db_xref="MGI:MGI:1347100"
     exon            1..815
                     /gene="Slc27a5"
                     /gene_synonym="FACVL3; FATP5; Vlacsr; VLCS-H2; VLCSH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..2200
                     /gene="Slc27a5"
                     /gene_synonym="FACVL3; FATP5; Vlacsr; VLCS-H2; VLCSH2"
                     /EC_number="6.2.1.3"
                     /EC_number="6.2.1.7"
                     /note="bile acyl-CoA synthetase; BAL; BACS; FATP-5; BA-CoA
                     ligase; VLACS-related; cholate--CoA ligase; bile acid-CoA
                     ligase; fatty acid transport protein 5; solute carrier
                     family 27 member 5; very long-chain acyl-CoA
                     synthetase-related protein; very long-chain acyl-Coenzyme
                     A dehydrogenase synthase related;
                     long-chain-fatty-acid--CoA ligase"
                     /codon_start=1
                     /product="long-chain fatty acid transport protein 5"
                     /protein_id="NP_033538.2"
                     /db_xref="CCDS:CCDS20821.1"
                     /db_xref="GeneID:26459"
                     /db_xref="MGI:MGI:1347100"
                     /translation="MGIWKKLTLLLLLLLLVGLGQPPWPAAMALALRWFLGDPTCLVL
                     LGLALLGRPWISSWMPHWLSLVGAALTLFLLPLQPPPGLRWLHKDVAFTFKMLFYGLK
                     FRRRLNKHPPETFVDALERQALAWPDRVALVCTGSEGSSITNSQLDARSCQAAWVLKA
                     KLKDAVIQNTRDAAAILVLPSKTISALSVFLGLAKLGCPVAWINPHSRGMPLLHSVRS
                     SGASVLIVDPDLQENLEEVLPKLLAENIHCFYLGHSSPTPGVEALGASLDAAPSDPVP
                     ASLRATIKWKSPAIFIFTSGTTGLPKPAILSHERVIQVSNVLSFCGCRADDVVYDVLP
                     LYHTIGLVLGFLGCLQVGATCVLAPKFSASRFWAECRQHGVTVILYVGEILRYLCNVP
                     EQPEDKIHTVRLAMGNGLRANVWKNFQQRFGPIRIWEFYGSTEGNVGLMNYVGHCGAV
                     GRTSCILRMLTPFELVQFDIETAEPLRDKQGFCIPVEPGKPGLLLTKVRKNQPFLGYR
                     GSQAESNRKLVANVRRVGDLYFNTGDVLTLDQEGFFYFQDRLGDTFRWKGENVSTGEV
                     ECVLSSLDFLEEVNVYGVPVPGCEGKVGMAAVKLAPGKTFDGQKLYQHVRSWLPAYAT
                     PHFIRIQDSLEITNTYKLVKSRLVREGFDVGIIADPLYILDNKAQTFRSLMPDVYQAV
                     CEGTWNL"
     exon            816..1025
                     /gene="Slc27a5"
                     /gene_synonym="FACVL3; FATP5; Vlacsr; VLCS-H2; VLCSH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1184
                     /gene="Slc27a5"
                     /gene_synonym="FACVL3; FATP5; Vlacsr; VLCS-H2; VLCSH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1309
                     /gene="Slc27a5"
                     /gene_synonym="FACVL3; FATP5; Vlacsr; VLCS-H2; VLCSH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1504
                     /gene="Slc27a5"
                     /gene_synonym="FACVL3; FATP5; Vlacsr; VLCS-H2; VLCSH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1595
                     /gene="Slc27a5"
                     /gene_synonym="FACVL3; FATP5; Vlacsr; VLCS-H2; VLCSH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1794
                     /gene="Slc27a5"
                     /gene_synonym="FACVL3; FATP5; Vlacsr; VLCS-H2; VLCSH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1892
                     /gene="Slc27a5"
                     /gene_synonym="FACVL3; FATP5; Vlacsr; VLCS-H2; VLCSH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2023
                     /gene="Slc27a5"
                     /gene_synonym="FACVL3; FATP5; Vlacsr; VLCS-H2; VLCSH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2330
                     /gene="Slc27a5"
                     /gene_synonym="FACVL3; FATP5; Vlacsr; VLCS-H2; VLCSH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2306..2311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc27a5"
                     /gene_synonym="FACVL3; FATP5; Vlacsr; VLCS-H2; VLCSH2"
                     /note="hexamer: AATAAA"
     polyA_site      2330
                     /gene="Slc27a5"
                     /gene_synonym="FACVL3; FATP5; Vlacsr; VLCS-H2; VLCSH2"
                     /note="major polyA site"
ORIGIN      
        1 gatagtactt ggtcatattt gggaagtggg tagacagatt tccttaaagg caggtagtta
       61 gggctttgga gcactcatca gagctaagag agactacacg ctctcatcta cttcagaaag
      121 agccaatgcc atgggtattt ggaagaaact aaccttactg ctgttgctgc ttctgctggt
      181 tggcctgggg cagcccccat ggccagcagc tatggctctg gccctgcgtt ggttcctggg
      241 agaccccaca tgccttgtgc tgcttggctt ggcattgctg ggcagaccct ggatcagctc
      301 ctggatgccc cactggctga gcctggtagg agcagctctt accttattcc tattgcctct
      361 acagccaccc ccagggctac gctggctgca taaagatgtg gctttcacct tcaagatgct
      421 tttctatggc ctaaagttca ggcgacgcct taacaaacat cctccagaga cctttgtgga
      481 tgctttagag cggcaagcac tggcatggcc tgaccgggtg gccttggtgt gtactgggtc
      541 tgagggctcc tcaatcacaa atagccagct ggatgccagg tcctgtcagg cagcatgggt
      601 cctgaaagca aagctgaagg atgccgtaat ccagaacaca agagatgctg ctgctatctt
      661 agttctcccg tccaagacca tttctgcttt gagtgtgttt ctggggttgg ccaagttggg
      721 ctgccctgtg gcctggatca atccacacag ccgagggatg cccttgctac actctgtacg
      781 gagctctggg gccagtgtgc tgattgtgga tccagacctc caggagaacc tggaagaagt
      841 ccttcccaag ctgctagctg agaacattca ctgcttctac cttggccaca gctcacccac
      901 cccgggagta gaggctctgg gagcttccct ggatgctgca ccttctgacc cagtacctgc
      961 cagccttcga gctacgatta agtggaaatc tcctgccata ttcatcttta cttcagggac
     1021 cactggactc ccaaagccag ccatcttatc acatgagcgg gtcatacaag tgagcaacgt
     1081 gctgtccttc tgtggatgca gagctgatga tgtggtctat gacgtcctac ctctgtacca
     1141 tacgataggg cttgtccttg gattccttgg ctgcttacaa gttggagcca cctgtgtcct
     1201 ggcccccaag ttctctgcct cccgattctg ggctgagtgc cggcagcatg gcgtaacagt
     1261 gatcttgtat gtgggtgaaa tcctgcggta cttgtgtaac gtccctgagc aaccagaaga
     1321 caagatacat acagtgcgct tggccatggg caatggactt cgggcaaatg tgtggaaaaa
     1381 cttccagcaa cgctttggtc ccattcggat ctgggaattc tacggatcca cagagggcaa
     1441 tgtgggctta atgaactatg tgggccactg cggggctgtg ggaaggacca gctgcatcct
     1501 tcgaatgctg actccctttg agcttgtaca gttcgacata gagacagcag agcctctgag
     1561 ggacaaacag ggtttttgca ttcctgtgga gccaggaaag ccaggacttc ttttgaccaa
     1621 ggttcgaaag aaccaaccct tcctgggcta ccgtggttcc caggccgagt ccaatcggaa
     1681 acttgttgcg aatgtacgac gcgtaggaga cctgtacttc aacactgggg acgtgctgac
     1741 cttggaccag gaaggcttct tctactttca agaccgcctt ggtgacacct tccggtggaa
     1801 gggcgaaaac gtatctactg gagaggtgga gtgtgttttg tctagcctag acttcctaga
     1861 ggaagtcaat gtctatggtg tgcctgtgcc agggtgtgag ggtaaggttg gcatggctgc
     1921 tgtgaaactg gctcctggga agacttttga tgggcagaag ctataccagc atgtccgctc
     1981 ctggctccct gcctatgcca cacctcattt catccgtatc caggattccc tggagatcac
     2041 aaacacctac aagctggtaa agtcacggct ggtgcgtgag ggttttgatg tggggatcat
     2101 tgctgacccc ctctacatac tggacaacaa ggcccagacc ttccggagtc tgatgccaga
     2161 tgtgtaccag gctgtgtgtg aaggaacctg gaatctctga ccacctagcc aactggaagg
     2221 caatccaaaa gtgtagagat tgacactagt cagcttcaca aagttgtccg ggttccagat
     2281 gcccatggcc cagtagtact tagagaataa acttgaatgt gtatacaaaa aaaaaa
//
