LOCUS       NM_011989               4054 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus solute carrier family 27 (fatty acid transporter),
            member 4 (Slc27a4), mRNA.
ACCESSION   NM_011989 XM_130079
VERSION     NM_011989.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4054)
  AUTHORS   Li,S. and Jin,M.
  TITLE     Ablation of Fatty Acid Transport Protein-4 Enhances Cone Survival,
            M-cone Vision, and Synthesis of Cone-Tropic 9-cis-Retinal in rd12
            Mouse Model of Leber Congenital Amaurosis
  JOURNAL   J Neurosci 44 (27), e1994232024 (2024)
   PUBMED   38811164
  REMARK    GeneRIF: Ablation of Fatty Acid Transport Protein-4 Enhances Cone
            Survival, M-cone Vision, and Synthesis of Cone-Tropic 9-cis-Retinal
            in rd12 Mouse Model of Leber Congenital Amaurosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4054)
  AUTHORS   Dearden,L., Furigo,I.C., Pantaleao,L.C., Wong,L.W.P.,
            Fernandez-Twinn,D.S., de Almeida-Faria,J., Kentistou,K.A.,
            Carreira,M.V., Bidault,G., Vidal-Puig,A., Ong,K.K., Perry,J.R.B.,
            Donato,J. Jr. and Ozanne,S.E.
  TITLE     Maternal obesity increases hypothalamic miR-505-5p expression in
            mouse offspring leading to altered fatty acid sensing and increased
            intake of high-fat food
  JOURNAL   PLoS Biol 22 (6), e3002641 (2024)
   PUBMED   38833481
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4054)
  AUTHORS   Miner,G.E., So,C.M., Edwards,W., Ragusa,J.V., Wine,J.T., Wong
            Gutierrez,D., Airola,M.V., Herring,L.E., Coleman,R.A., Klett,E.L.
            and Cohen,S.
  TITLE     PLIN5 interacts with FATP4 at membrane contact sites to promote
            lipid droplet-to-mitochondria fatty acid transport
  JOURNAL   Dev Cell 58 (14), 1250-1265 (2023)
   PUBMED   37290445
  REMARK    GeneRIF: PLIN5 interacts with FATP4 at membrane contact sites to
            promote lipid droplet-to-mitochondria fatty acid transport.
REFERENCE   4  (bases 1 to 4054)
  AUTHORS   Gocebe,D., Jansakun,C., Zhang,Y., Staffer,S., Tuma-Kellner,S.,
            Altamura,S., Muckenthaler,M.U., Merle,U., Herrmann,T. and
            Chamulitrat,W.
  TITLE     Myeloid-specific fatty acid transport protein 4 deficiency induces
            a sex-dimorphic susceptibility for nonalcoholic steatohepatitis in
            mice fed a high-fat, high-cholesterol diet
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 324 (5), G389-G403 (2023)
   PUBMED   36881564
  REMARK    GeneRIF: Myeloid-specific fatty acid transport protein 4 deficiency
            induces a sex-dimorphic susceptibility for nonalcoholic
            steatohepatitis in mice fed a high-fat, high-cholesterol diet.
REFERENCE   5  (bases 1 to 4054)
  AUTHORS   Kappen,C., Kruger,C., Jones,S. and Salbaum,J.M.
  TITLE     Nutrient Transporter Gene Expression in the Early
            Conceptus-Implications From Two Mouse Models of Diabetic Pregnancy
  JOURNAL   Front Cell Dev Biol 10, 777844 (2022)
   PUBMED   35478964
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4054)
  AUTHORS   Herrmann,T., van der Hoeven,F., Grone,H.J., Stewart,A.F.,
            Langbein,L., Kaiser,I., Liebisch,G., Gosch,I., Buchkremer,F.,
            Drobnik,W., Schmitz,G. and Stremmel,W.
  TITLE     Mice with targeted disruption of the fatty acid transport protein 4
            (Fatp 4, Slc27a4) gene show features of lethal restrictive
            dermopathy
  JOURNAL   J Cell Biol 161 (6), 1105-1115 (2003)
   PUBMED   12821645
  REMARK    GeneRIF: Fatp4-null mice displayed features of a neonatally lethal
            restrictive dermopathy.  Lipid analysis demonstrated a disturbed
            fatty acid composition of epidermal ceramides.
REFERENCE   7  (bases 1 to 4054)
  AUTHORS   Moulson,C.L., Martin,D.R., Lugus,J.J., Schaffer,J.E., Lind,A.C. and
            Miner,J.H.
  TITLE     Cloning of wrinkle-free, a previously uncharacterized mouse
            mutation, reveals crucial roles for fatty acid transport protein 4
            in skin and hair development
  JOURNAL   Proc Natl Acad Sci U S A 100 (9), 5274-5279 (2003)
   PUBMED   12697906
  REMARK    GeneRIF: identification of critical role in skin and hair
            development
REFERENCE   8  (bases 1 to 4054)
  AUTHORS   Herrmann,T., Buchkremer,F., Gosch,I., Hall,A.M., Bernlohr,D.A. and
            Stremmel,W.
  TITLE     Mouse fatty acid transport protein 4 (FATP4): characterization of
            the gene and functional assessment as a very long chain acyl-CoA
            synthetase
  JOURNAL   Gene 270 (1-2), 31-40 (2001)
   PUBMED   11404000
REFERENCE   9  (bases 1 to 4054)
  AUTHORS   Stahl,A., Hirsch,D.J., Gimeno,R.E., Punreddy,S., Ge,P., Watson,N.,
            Patel,S., Kotler,M., Raimondi,A., Tartaglia,L.A. and Lodish,H.F.
  TITLE     Identification of the major intestinal fatty acid transport protein
  JOURNAL   Mol Cell 4 (3), 299-308 (1999)
   PUBMED   10518211
REFERENCE   10 (bases 1 to 4054)
  AUTHORS   Hirsch,D., Stahl,A. and Lodish,H.F.
  TITLE     A family of fatty acid transporters conserved from mycobacterium to
            man
  JOURNAL   Proc Natl Acad Sci U S A 95 (15), 8625-8629 (1998)
   PUBMED   9671728
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845323.18 and BX294378.5.
            
            On Apr 24, 2018 this sequence version replaced NM_011989.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036919.1, AK155388.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-327               AL845323.18        215756-216082
            328-494             AL845323.18        217282-217448
            495-889             AL845323.18        218738-219132
            890-1048            AL845323.18        220478-220636
            1049-1118           AL845323.18        222784-222853
            1119-1210           AL845323.18        222958-223049
            1211-1320           AL845323.18        223983-224092
            1321-1530           AL845323.18        224308-224517
            1531-1657           AL845323.18        224691-224817
            1658-1795           AL845323.18        225387-225524
            1796-1960           AL845323.18        225674-225838
            1961-2107           AL845323.18        225910-226056
            2108-4054           BX294378.5         2561-4507
FEATURES             Location/Qualifiers
     source          1..4054
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 20.64 cM"
     gene            1..4054
                     /gene="Slc27a4"
                     /gene_synonym="ACSVL4; FATP4"
                     /note="solute carrier family 27 (fatty acid transporter),
                     member 4"
                     /db_xref="GeneID:26569"
                     /db_xref="MGI:MGI:1347347"
     exon            1..327
                     /gene="Slc27a4"
                     /gene_synonym="ACSVL4; FATP4"
                     /inference="alignment:Splign:2.1.0"
     exon            328..494
                     /gene="Slc27a4"
                     /gene_synonym="ACSVL4; FATP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..2265
                     /gene="Slc27a4"
                     /gene_synonym="ACSVL4; FATP4"
                     /EC_number="6.2.1.3"
                     /EC_number="6.2.1.15"
                     /note="arachidonate--CoA ligase;
                     long-chain-fatty-acid--CoA ligase; very long-chain
                     acyl-CoA synthetase 4"
                     /codon_start=1
                     /product="long-chain fatty acid transport protein 4"
                     /protein_id="NP_036119.1"
                     /db_xref="CCDS:CCDS15858.1"
                     /db_xref="GeneID:26569"
                     /db_xref="MGI:MGI:1347347"
                     /translation="MLLGASLVGALLFSKLVLKLPWTQVGFSLLLLYLGSGGWRFIRV
                     FIKTVRRDIFGGMVLLKVKTKVRRYLQERKTVPLLFASMVQRHPDKTALIFEGTDTHW
                     TFRQLDEYSSSVANFLQARGLASGNVVALFMENRNEFVGLWLGMAKLGVEAALINTNL
                     RRDALRHCLDTSKARALIFGSEMASAICEIHASLEPTLSLFCSGSWEPSTVPVSTEHL
                     DPLLEDAPKHLPSHPDKGFTDKLFYIYTSGTTGLPKAAIVVHSRYYRMASLVYYGFRM
                     RPDDIVYDCLPLYHSAGNIVGIGQCLLHGMTVVIRKKFSASRFWDDCIKYNCTIVQYI
                     GELCRYLLNQPPREAESRHKVRMALGNGLRQSIWTDFSSRFHIPQVAEFYGATECNCS
                     LGNFDSRVGACGFNSRILSFVYPIRLVRVNEDTMELIRGPDGVCIPCQPGQPGQLVGR
                     IIQQDPLRRFDGYLNQGANNKKIANDVFKKGDQAYLTGDVLVMDELGYLYFRDRTGDT
                     FRWKGENVSTTEVEGTLSRLLHMADVAVYGVEVPGTEGRAGMAAVASPISNCDLESFA
                     QTLKKELPLYARPIFLRFLPELHKTGTFKFQKTELRKEGFDPSVVKDPLFYLDARKGC
                     YVALDQEAYTRIQAGEEKL"
     exon            495..889
                     /gene="Slc27a4"
                     /gene_synonym="ACSVL4; FATP4"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1048
                     /gene="Slc27a4"
                     /gene_synonym="ACSVL4; FATP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1118
                     /gene="Slc27a4"
                     /gene_synonym="ACSVL4; FATP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1210
                     /gene="Slc27a4"
                     /gene_synonym="ACSVL4; FATP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1320
                     /gene="Slc27a4"
                     /gene_synonym="ACSVL4; FATP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1530
                     /gene="Slc27a4"
                     /gene_synonym="ACSVL4; FATP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1657
                     /gene="Slc27a4"
                     /gene_synonym="ACSVL4; FATP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1795
                     /gene="Slc27a4"
                     /gene_synonym="ACSVL4; FATP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1960
                     /gene="Slc27a4"
                     /gene_synonym="ACSVL4; FATP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2107
                     /gene="Slc27a4"
                     /gene_synonym="ACSVL4; FATP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..4054
                     /gene="Slc27a4"
                     /gene_synonym="ACSVL4; FATP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2963..2968
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc27a4"
                     /gene_synonym="ACSVL4; FATP4"
                     /note="hexamer: AATAAA"
     polyA_site      2988
                     /gene="Slc27a4"
                     /gene_synonym="ACSVL4; FATP4"
                     /note="major polyA site"
     polyA_site      3652
                     /gene="Slc27a4"
                     /gene_synonym="ACSVL4; FATP4"
     regulatory      3995..4000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc27a4"
                     /gene_synonym="ACSVL4; FATP4"
                     /note="hexamer: ATTAAA"
     polyA_site      4015
                     /gene="Slc27a4"
                     /gene_synonym="ACSVL4; FATP4"
ORIGIN      
        1 agtggtgcgc gcagggctgg aggggctggg cggtgtcggg cgcgctgggg ctgggttgcg
       61 ctgaggtgca cggactcaga agctcgccct ctgcggggac ggcacagaag gcggtgctgc
      121 cggctggcac agccggtgcg ggtgcgggag gcgggtgggg gtggagcggg gcagaggtac
      181 agaccctaca aggacgagga gtgggccaga cgcaccgagg ctcggctgtg tgtgccccgg
      241 ggcggccgat gcccccagcg caccgcactc cgctgccgca accgggccgc atcctgacgg
      301 ggcgccgcgc cgcgcagccg cagccgggtc acaatgctac ttggagcatc tctggtgggg
      361 gcgctactgt tctccaagct agtgctgaag ctgccctgga cccaggtggg attctccctg
      421 ttgctcctgt acttggggtc tggtggctgg cgtttcatcc gggtcttcat caagacggtc
      481 aggagagata tctttggtgg catggtgctc ctgaaggtga agaccaaggt gcgacggtac
      541 cttcaggagc ggaagacggt gcccctgctg tttgcttcaa tggtacagcg ccacccggac
      601 aagacagccc tgattttcga gggcacagac actcactgga ccttccgcca gctggatgag
      661 tactccagta gtgtggccaa cttcctgcag gcccggggcc tggcctcagg caatgtagtt
      721 gccctcttta tggaaaaccg caatgagttt gtgggtctgt ggctaggcat ggccaagctg
      781 ggcgtggagg cggctctcat caacaccaac cttaggcggg atgccctgcg ccactgtctt
      841 gacacctcaa aggcacgagc tctcatcttt ggcagtgaga tggcctcagc tatctgtgag
      901 atccatgcta gcctggagcc cacactcagc ctcttctgct ctggatcctg ggagcccagc
      961 acagtgcccg tcagcacaga gcatctggac cctcttctgg aagatgcccc gaagcacctg
     1021 cccagtcacc cagacaaggg ttttacagat aagctcttct acatctacac atcgggcacc
     1081 acggggctac ccaaagctgc cattgtggtg cacagcaggt attatcgtat ggcttccctg
     1141 gtgtactatg gattccgcat gcggcctgat gacattgtct atgactgcct ccccctctac
     1201 cactcagcag gaaacatcgt ggggattggc cagtgcttac tccacggcat gactgtggtg
     1261 atccggaaga agttctcagc ctcccggttc tgggatgatt gtatcaagta caactgcaca
     1321 attgtacagt acattggcga gctctgccgc tacctcctga accagccacc ccgtgaggct
     1381 gagtctcggc acaaggtgcg catggcactg ggcaacggtc tccggcagtc catctggacc
     1441 gacttctcca gccgtttcca catcccccag gtggctgagt tctatggggc cactgaatgc
     1501 aactgtagcc tgggcaactt tgacagccgg gtgggggcct gtggcttcaa tagccgcatc
     1561 ctgtcctttg tgtaccctat ccgtttggta cgtgtcaatg aggataccat ggaactgatc
     1621 cggggacccg atggagtctg cattccctgt caaccaggtc agccaggcca gctggtgggt
     1681 cgcatcatcc agcaggaccc tctgcgccgt ttcgacgggt acctcaacca gggtgccaac
     1741 aacaagaaga ttgctaatga tgtcttcaag aagggggacc aagcctacct cactggtgac
     1801 gtcctggtga tggatgagct gggttacctg tacttccgag atcgcactgg ggacacgttc
     1861 cgctggaaag gggagaatgt atctaccact gaggtggagg gcacactcag ccgcctgctt
     1921 catatggcag atgtggcagt ttatggtgtt gaggtgccag gaactgaagg ccgagcagga
     1981 atggctgccg ttgcaagtcc catcagcaac tgtgacctgg agagctttgc acagaccttg
     2041 aaaaaggagc tgcctctgta tgcccgcccc atcttcctgc gcttcttgcc tgagctgcac
     2101 aagacaggga ccttcaagtt ccagaagaca gagttgcgga aggagggctt tgacccatct
     2161 gttgtgaaag acccgctgtt ctatctggat gctcggaagg gctgctacgt tgcactggac
     2221 caggaggcct atacccgcat ccaggcaggc gaggagaagc tgtgatttcc ccctacatcc
     2281 ctctgagggc cagaagatgc tggattcaga gccctagcgt ccaccccaga ggggtcctgg
     2341 gcaatgccag accaaagcta gcagggcccg cacctccgcc cctaggtgct gatctcccct
     2401 ctcccaaact gccaagtgac tcactgccgc ttccccgacc ctccagaggc tttctgtgaa
     2461 agtctcatcc aagctgtgtc ttctggtcca ggcgtggccc ctggccccag ggtttctgat
     2521 aggctccttt aggatggtat cttgggtcca gcgggccagg gtgtgggaga ggagtcacta
     2581 agatccctcc aatcagaagg gagcttacaa aggaaccaag gcaaagcctg tagactcagg
     2641 aagctaagtg gccagagact atagtggcca gtcatcccat gtccacagag gatcttggtc
     2701 cagagctgcc aaagtgtcac ctctccctgc ctgcacctct ggggaaaaga ggacagcatg
     2761 tggccactgg gcacctgtct caagaagtca ggatcacaca ctcagtcctt gtttctccag
     2821 gttcccttgt tcttgtctcg gggagggagg gacgagtgtc ctgtctgtcc ttcctgcctg
     2881 tctgtgagtc tgtgttgctt ctccatctgt cctagcctga gtgtgggtgg aacaggcatg
     2941 aggagagtgt ggctcagggg ccaataaact ctgccttgac tcctcttagc ctgacagcct
     3001 ggctccttgc ctacctcctt cccctctagc ccctttcgct tagcccttgg gataagccct
     3061 tagccagtcc tcttttccaa agctctgcct tcctataact ccttaggaga gactcccacc
     3121 agatctgaca ggatgttaaa ctttggaact taacctttaa agtaagcatg tggctttggg
     3181 caagtgtctc ctgaattatg ggggtaatta agggattcag aaactacaca aagccattag
     3241 gagtgggagg atacttggcg tctttgaggg aaagccctcc cctgcacaga actgtccatg
     3301 gacccatgcg ctgttgctcc atcttctgcc aaatgaccca ttggagcctc cccagccctc
     3361 tgaggctttc tatgaaagtt tcatgtctaa gctctgtctt cttggccagg aggcctctgc
     3421 acccgggctg agactgacag gcacctttag gatgatgcat ctgatccaga cagactgcct
     3481 gacctcctca ggcaacccta gccagtcagc agcacattgg tccagagtcc tccagcctgg
     3541 gagtccctgg gaagtacaga gggtcctaac agcccagggt ggactgctca agggccctcc
     3601 tccactgttg gaccttctcc tgtatctgtg aggtcaattt cttgagttct gagatggttt
     3661 tgtgtggtcc tgattgccat tttacttggg tacgatgtgg agaatggctt tgacctcagg
     3721 atctttctgc ttcctcccag gtgctgggat gaaagacatc tggcttgagt ggttttgttg
     3781 tggttatgtg cgcatgactc aggtttctgc aaacatgagt ccagaggcct cagaatcccc
     3841 tggagctgga attaaagggg gggggggttc taggagctaa cctgggtctc aaagcacatt
     3901 tttttggggg ggggtgttga ttggtgttca agacacagtt tctctatgta acagctctga
     3961 acttacaaag atccgcctgc tccagagtgc agagattaaa tgtgtaccac caccaccctg
     4021 gcttgaagca ggtcttataa atggactatt caag
//
