LOCUS       NM_011978               2309 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus solute carrier family 27 (fatty acid transporter),
            member 2 (Slc27a2), mRNA.
ACCESSION   NM_011978
VERSION     NM_011978.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2309)
  AUTHORS   Ghoshal,K., Luther,J.M., Pakala,S.B., Chetyrkin,S., Falck,J.R.,
            Zent,R., Wasserman,D.H. and Pozzi,A.
  TITLE     Epoxygenase Cyp2c44 Regulates Hepatic Lipid Metabolism and Insulin
            Signaling by Controlling FATP2 Localization and Activation of the
            DAG/PKCdelta Axis
  JOURNAL   Diabetes 73 (8), 1229-1243 (2024)
   PUBMED   38743615
  REMARK    GeneRIF: Epoxygenase Cyp2c44 Regulates Hepatic Lipid Metabolism and
            Insulin Signaling by Controlling FATP2 Localization and Activation
            of the DAG/PKCdelta Axis.
REFERENCE   2  (bases 1 to 2309)
  AUTHORS   Shi,X., Pang,S., Zhou,J., Yan,G., Gao,R., Wu,H., Wang,Z., Wei,Y.,
            Liu,X. and Tan,W.
  TITLE     Bladder-cancer-derived exosomal circRNA_0013936 promotes
            suppressive immunity by up-regulating fatty acid transporter
            protein 2 and down-regulating receptor-interacting protein kinase 3
            in PMN-MDSCs
  JOURNAL   Mol Cancer 23 (1), 52 (2024)
   PUBMED   38461272
  REMARK    GeneRIF: Bladder-cancer-derived exosomal circRNA_0013936 promotes
            suppressive immunity by up-regulating fatty acid transporter
            protein 2 and down-regulating receptor-interacting protein kinase 3
            in PMN-MDSCs.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2309)
  AUTHORS   Shi,X., Pang,S., Zhou,J., Yan,G., Sun,J. and Tan,W.
  TITLE     Feedback loop between fatty acid transport protein 2 and receptor
            interacting protein 3 pathways promotes polymorphonuclear
            neutrophil myeloid-derived suppressor cells-potentiated suppressive
            immunity in bladder cancer
  JOURNAL   Mol Biol Rep 49 (12), 11643-11652 (2022)
   PUBMED   36169895
  REMARK    GeneRIF: Feedback loop between fatty acid transport protein 2 and
            receptor interacting protein 3 pathways promotes polymorphonuclear
            neutrophil myeloid-derived suppressor cells-potentiated suppressive
            immunity in bladder cancer.
REFERENCE   4  (bases 1 to 2309)
  AUTHORS   Kappen,C., Kruger,C., Jones,S. and Salbaum,J.M.
  TITLE     Nutrient Transporter Gene Expression in the Early
            Conceptus-Implications From Two Mouse Models of Diabetic Pregnancy
  JOURNAL   Front Cell Dev Biol 10, 777844 (2022)
   PUBMED   35478964
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2309)
  AUTHORS   Kim,J.L., Mestre,B., Malitsky,S., Itkin,M., Kupervaser,M. and
            Futerman,A.H.
  TITLE     Fatty acid transport protein 2 interacts with ceramide synthase 2
            to promote ceramide synthesis
  JOURNAL   J Biol Chem 298 (4), 101735 (2022)
   PUBMED   35181339
  REMARK    GeneRIF: Fatty acid transport protein 2 interacts with ceramide
            synthase 2 to promote ceramide synthesis.
REFERENCE   6  (bases 1 to 2309)
  AUTHORS   Steinberg,S.J., Wang,S.J., Kim,D.G., Mihalik,S.J. and Watkins,P.A.
  TITLE     Human very-long-chain acyl-CoA synthetase: cloning, topography, and
            relevance to branched-chain fatty acid metabolism
  JOURNAL   Biochem Biophys Res Commun 257 (2), 615-621 (1999)
   PUBMED   10198260
REFERENCE   7  (bases 1 to 2309)
  AUTHORS   Hirsch,D., Stahl,A. and Lodish,H.F.
  TITLE     A family of fatty acid transporters conserved from mycobacterium to
            man
  JOURNAL   Proc Natl Acad Sci U S A 95 (15), 8625-8629 (1998)
   PUBMED   9671728
REFERENCE   8  (bases 1 to 2309)
  AUTHORS   Berger,J., Truppe,C., Neumann,H. and Forss-Petter,S.
  TITLE     A novel relative of the very-long-chain acyl-CoA synthetase and
            fatty acid transporter protein genes with a distinct expression
            pattern
  JOURNAL   Biochem Biophys Res Commun 247 (2), 255-260 (1998)
   PUBMED   9642112
REFERENCE   9  (bases 1 to 2309)
  AUTHORS   Berger,J., Truppe,C., Neumann,H. and Forss-Petter,S.
  TITLE     cDNA cloning and mRNA distribution of a mouse very long-chain
            acyl-CoA synthetase
  JOURNAL   FEBS Lett 425 (2), 305-309 (1998)
   PUBMED   9559670
REFERENCE   10 (bases 1 to 2309)
  AUTHORS   Pirard,M., Collet,J.F., Matthijs,G. and Van Schaftingen,E.
  TITLE     Comparison of PMM1 with the phosphomannomutases expressed in rat
            liver and in human cells
  JOURNAL   FEBS Lett 411 (2-3), 251-254 (1997)
   PUBMED   9271215
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK165446.1, AF033031.1 and AI326155.1.
            
            On Aug 29, 2006 this sequence version replaced NM_011978.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013442.1, AJ223958.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1461              AK165446.1         2-1462
            1462-2054           AF033031.1         1343-1935
            2055-2309           AI326155.1         1-255               c
FEATURES             Location/Qualifiers
     source          1..2309
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 61.76 cM"
     gene            1..2309
                     /gene="Slc27a2"
                     /gene_synonym="ACSVL1; FATP2; Vlac; Vlacs; VLCS"
                     /note="solute carrier family 27 (fatty acid transporter),
                     member 2"
                     /db_xref="GeneID:26458"
                     /db_xref="MGI:MGI:1347099"
     exon            1..609
                     /gene="Slc27a2"
                     /gene_synonym="ACSVL1; FATP2; Vlac; Vlacs; VLCS"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1994
                     /gene="Slc27a2"
                     /gene_synonym="ACSVL1; FATP2; Vlac; Vlacs; VLCS"
                     /EC_number="6.2.1.3"
                     /EC_number="6.2.1.7"
                     /EC_number="6.2.1.15"
                     /EC_number="6.2.1.24"
                     /note="very long-chain acyl-CoA synthetase; FATP-2;
                     THCA-CoA ligase; fatty acid transport protein 2;
                     long-chain-fatty-acid--CoA ligase; solute carrier family
                     27 member 2; very long-chain-fatty-acid-CoA ligase;
                     fatty-acid-coenzyme A ligase, very long-chain 1; very
                     long-chain acyl-Coenzyme A dehydrogenase synthase;
                     phytanate--CoA ligase; arachidonate--CoA ligase"
                     /codon_start=1
                     /product="long-chain fatty acid transport protein 2"
                     /protein_id="NP_036108.2"
                     /db_xref="CCDS:CCDS16683.1"
                     /db_xref="GeneID:26458"
                     /db_xref="MGI:MGI:1347099"
                     /translation="MLPVLYTGLAGLLLLPLLLTCCCPYLLQDVRYFLRLANMARRVR
                     SYRQRRPVRTILRAFLEQARKTPHKPFLLFRDETLTYAQVDRRSNQVARALHDQLGLR
                     QGDCVALFMGNEPAYVWIWLGLLKLGCPMACLNYNIRAKSLLHCFQCCGAKVLLASPD
                     LQEAVEEVLPTLKKDAVSVFYVSRTSNTNGVDTILDKVDGVSAEPTPESWRSEVTFTT
                     PAVYIYTSGTTGLPKAATINHHRLWYGTGLAMSSGITAQDVIYTTMPLYHSAALMIGL
                     HGCIVVGATLALRSKFSASQFWDDCRKYNVTVIQYIGELLRYLCNTPQKPNDRDHKVK
                     KALGNGLRGDVWREFIKRFGDIHVYEFYASTEGNIGFVNYPRKIGAVGRANYLQRKVA
                     RYELIKYDVEKDEPVRDANGYCIKVPKGEVGLLVCKITQLTPFIGYAGGKTQTEKKKL
                     RDVFKKGDIYFNSGDLLMIDRENFVYFHDRVGDTFRWKGENVATTEVADIVGLVDFVE
                     EVNVYGVPVPGHEGRIGMASLKIKENYEFNGKKLFQHIAEYLPSYARPRFLRIQDTIE
                     ITGTFKHRKVTLMEEGFNPTVIKDTLYFMDDAEKTFVPMTENIYNAIIDKTLKL"
     exon            610..819
                     /gene="Slc27a2"
                     /gene_synonym="ACSVL1; FATP2; Vlac; Vlacs; VLCS"
                     /inference="alignment:Splign:2.1.0"
     exon            820..978
                     /gene="Slc27a2"
                     /gene_synonym="ACSVL1; FATP2; Vlac; Vlacs; VLCS"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1103
                     /gene="Slc27a2"
                     /gene_synonym="ACSVL1; FATP2; Vlac; Vlacs; VLCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1298
                     /gene="Slc27a2"
                     /gene_synonym="ACSVL1; FATP2; Vlac; Vlacs; VLCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1389
                     /gene="Slc27a2"
                     /gene_synonym="ACSVL1; FATP2; Vlac; Vlacs; VLCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1588
                     /gene="Slc27a2"
                     /gene_synonym="ACSVL1; FATP2; Vlac; Vlacs; VLCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1686
                     /gene="Slc27a2"
                     /gene_synonym="ACSVL1; FATP2; Vlac; Vlacs; VLCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1817
                     /gene="Slc27a2"
                     /gene_synonym="ACSVL1; FATP2; Vlac; Vlacs; VLCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..2301
                     /gene="Slc27a2"
                     /gene_synonym="ACSVL1; FATP2; Vlac; Vlacs; VLCS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2281..2286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc27a2"
                     /gene_synonym="ACSVL1; FATP2; Vlac; Vlacs; VLCS"
                     /note="hexamer: AATAAA"
     polyA_site      2301
                     /gene="Slc27a2"
                     /gene_synonym="ACSVL1; FATP2; Vlac; Vlacs; VLCS"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcagcg cgtccggagg ccgagcccag tcgccagctc ctgctctgct cctctcccgc
       61 ctgccgccgc gctgcacgcc tcgagcactc cctcggcccc ggcggggacc ggggaccccg
      121 cagctaccgc catgctgcca gtgctctaca ccggcctggc ggggctgctg ctgctgcctc
      181 tgctgctcac ctgctgctgc ccctacctcc tccaagatgt gcggtacttc ctgcggctgg
      241 ccaacatggc ccggcgggtg cgcagctacc ggcagcggcg acccgtgcgt accatcctgc
      301 gggccttcct ggaacaagcg cgcaagaccc cacacaagcc cttcctgctg ttccgagacg
      361 agacgctcac ctacgcccag gtggaccggc gcagcaacca agtggcgcgg gcgctgcacg
      421 atcaactggg cctacgacag ggggattgcg tagccctctt catgggcaat gagccggcct
      481 acgtgtggat ctggctggga ctgctcaaac tgggctgtcc catggcgtgc ctcaactaca
      541 acattcgtgc caagtctctg ctgcactgct ttcaatgctg cggggcgaag gtgctgctgg
      601 cctccccaga tctacaagaa gctgtggagg aggttcttcc aaccctgaaa aaggatgccg
      661 tgtccgtctt ttacgtaagc agaacttcta acacaaatgg tgtggacaca atactggaca
      721 aagtagacgg agtgtcggcg gaacccaccc cggagtcgtg gaggtctgaa gtcactttta
      781 ccacgccagc agtatacatt tatacttcgg gaaccacagg tcttccaaaa gcggcaacca
      841 tcaatcatca tcgcctatgg tatgggacag gccttgctat gtcgagtgga atcacggccc
      901 aggatgtcat ctataccaca atgcccctgt accacagtgc agcgctcatg atcggccttc
      961 acggatgcat cgtggttggg gctactttag ctttgcggag caaattctca gccagccagt
     1021 tttgggacga ctgcaggaaa tacaacgtca cggtcattca gtacattggt gaactgcttc
     1081 ggtacctgtg caacacaccg cagaaaccaa atgaccggga ccacaaagtg aaaaaagccc
     1141 tgggaaatgg cttacgagga gatgtgtgga gagagttcat caagagattt ggggacatcc
     1201 acgtgtatga gttctacgca tccactgaag gcaacattgg atttgtgaac tatccaagga
     1261 aaatcggtgc tgtcgggaga gcaaactacc tacaaagaaa agttgcaagg tatgagctga
     1321 tcaagtatga cgtggagaag gacgagccgg tccgtgacgc aaatggatat tgcatcaaag
     1381 tccccaaagg tgaggttgga ctcttggttt gcaaaatcac acagctcaca ccatttattg
     1441 gctatgctgg aggaaagacc cagacagaga agaaaaaact cagagatgtc tttaagaaag
     1501 gcgacatcta cttcaacagc ggagacctcc tgatgatcga ccgtgagaac ttcgtctact
     1561 ttcacgacag ggttggagat actttccggt ggaaaggaga gaacgtagct accacagaag
     1621 tcgctgacat cgtgggactg gtagattttg ttgaagaagt gaatgtgtat ggcgtgcctg
     1681 tgccaggtca tgagggtcga attgggatgg cctccctcaa gatcaaagaa aactacgagt
     1741 tcaatggaaa gaaactcttt caacacatcg cggagtacct gcccagttac gcgaggcctc
     1801 ggttcctgag gatacaagat accattgaga tcactgggac ttttaaacac cgcaaagtga
     1861 ccctgatgga agagggcttc aatcccacag tcatcaaaga taccttgtat ttcatggatg
     1921 atgcagagaa aacatttgtg cccatgactg agaacattta taatgccata attgataaaa
     1981 ctctgaagct ctgaatattc cctggtggtt tagctcatga catttccaga aagaaactcg
     2041 atagacctcg cagagccact tcatacgtag aatccaactt taacttgatt gaagactata
     2101 aggtgcgatt ttatttttag gaaattattc attaaaagga tagttttttt ttttttttta
     2161 attacacctg aacctttgca agtaaaaaga tttagagaca attatttttc aatgtgcacc
     2221 tgccatttgt ccttgcaaac taagcttctt ggagagaggg ccttattttt ttaaagacat
     2281 aataaactat attaacacta aaaaaaaaa
//
