LOCUS       NM_001357182            3317 bp    mRNA    linear   ROD 09-FEB-2024
DEFINITION  Mus musculus solute carrier family 27 (fatty acid transporter),
            member 1 (Slc27a1), transcript variant 4, mRNA.
ACCESSION   NM_001357182
VERSION     NM_001357182.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3317)
  AUTHORS   Munoz-Gallardo,M.D.M., Garcia-Padilla,C., Vicente-Garcia,C.,
            Carvajal,J., Arenega,A. and Franco,D.
  TITLE     miR-195b is required for proper cellular homeostasis in the elderly
  JOURNAL   Sci Rep 14 (1), 810 (2024)
   PUBMED   38191655
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3317)
  AUTHORS   Kappen,C., Kruger,C., Jones,S. and Salbaum,J.M.
  TITLE     Nutrient Transporter Gene Expression in the Early
            Conceptus-Implications From Two Mouse Models of Diabetic Pregnancy
  JOURNAL   Front Cell Dev Biol 10, 777844 (2022)
   PUBMED   35478964
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3317)
  AUTHORS   Nishiyama,K., Fujita,T., Fujimoto,Y., Nakajima,H., Takeuchi,T. and
            Azuma,Y.T.
  TITLE     Fatty acid transport protein 1 enhances the macrophage inflammatory
            response by coupling with ceramide and c-Jun N-terminal kinase
            signaling
  JOURNAL   Int Immunopharmacol 55, 205-215 (2018)
   PUBMED   29272817
  REMARK    GeneRIF: this study shows that FATP1 regulates the production of
            inflammatory cytokines through ceramide and the c-Jun N-terminal
            kinase signaling pathway
REFERENCE   4  (bases 1 to 3317)
  AUTHORS   Zhao,L., Cozzo,A.J., Johnson,A.R., Christensen,T., Freemerman,A.J.,
            Bear,J.E., Rotty,J.D., Bennett,B.J. and Makowski,L.
  TITLE     Lack of myeloid Fatp1 increases atherosclerotic lesion size in
            Ldlr-/- mice
  JOURNAL   Atherosclerosis 266, 182-189 (2017)
   PUBMED   29035781
  REMARK    GeneRIF: Macrophage Fatp1 limits atherogenesis in LDL receptor
            knockout mice.
REFERENCE   5  (bases 1 to 3317)
  AUTHORS   Cubizolle,A., Guillou,L., Mollereau,B., Hamel,C.P. and Brabet,P.
  TITLE     Fatty acid transport protein 1 regulates retinoid metabolism and
            photoreceptor development in mouse retina
  JOURNAL   PLoS One 12 (7), e0180148 (2017)
   PUBMED   28672005
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3317)
  AUTHORS   Stuhlsatz-Krouper,S.M., Bennett,N.E. and Schaffer,J.E.
  TITLE     Substitution of alanine for serine 250 in the murine fatty acid
            transport protein inhibits long chain fatty acid transport
  JOURNAL   J Biol Chem 273 (44), 28642-28650 (1998)
   PUBMED   9786857
REFERENCE   7  (bases 1 to 3317)
  AUTHORS   Hui,T.Y., Frohnert,B.I., Smith,A.J., Schaffer,J.E. and
            Bernlohr,D.A.
  TITLE     Characterization of the murine fatty acid transport protein gene
            and its insulin response sequence
  JOURNAL   J Biol Chem 273 (42), 27420-27429 (1998)
   PUBMED   9765271
REFERENCE   8  (bases 1 to 3317)
  AUTHORS   Hirsch,D., Stahl,A. and Lodish,H.F.
  TITLE     A family of fatty acid transporters conserved from mycobacterium to
            man
  JOURNAL   Proc Natl Acad Sci U S A 95 (15), 8625-8629 (1998)
   PUBMED   9671728
REFERENCE   9  (bases 1 to 3317)
  AUTHORS   Man,M.Z., Hui,T.Y., Schaffer,J.E., Lodish,H.F. and Bernlohr,D.A.
  TITLE     Regulation of the murine adipocyte fatty acid transporter gene by
            insulin
  JOURNAL   Mol Endocrinol 10 (8), 1021-1028 (1996)
   PUBMED   8843418
REFERENCE   10 (bases 1 to 3317)
  AUTHORS   Schaffer,J.E. and Lodish,H.F.
  TITLE     Expression cloning and characterization of a novel adipocyte long
            chain fatty acid transport protein
  JOURNAL   Cell 79 (3), 427-436 (1994)
   PUBMED   7954810
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162033.11.
            
            [WARNING] On Mar 19, 2024 this sequence was replaced by
            NM_001357182.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155185.1, AK164798.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-295               AC162033.11        26197-26491
            296-690             AC162033.11        35007-35401
            691-852             AC162033.11        35510-35671
            853-922             AC162033.11        35748-35817
            923-1014            AC162033.11        36213-36304
            1015-1124           AC162033.11        36370-36479
            1125-1334           AC162033.11        39721-39930
            1335-1461           AC162033.11        40023-40149
            1462-1599           AC162033.11        40236-40373
            1600-1764           AC162033.11        40445-40609
            1765-1911           AC162033.11        40949-41095
            1912-3317           AC162033.11        41505-42910
FEATURES             Location/Qualifiers
     source          1..3317
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.43 cM"
     gene            1..3317
                     /gene="Slc27a1"
                     /gene_synonym="Fatp; FATP1; Vlc27a1"
                     /note="solute carrier family 27 (fatty acid transporter),
                     member 1"
                     /db_xref="GeneID:26457"
                     /db_xref="MGI:MGI:1347098"
     exon            1..295
                     /gene="Slc27a1"
                     /gene_synonym="Fatp; FATP1; Vlc27a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..2069
                     /gene="Slc27a1"
                     /gene_synonym="Fatp; FATP1; Vlc27a1"
                     /EC_number="6.2.1.3"
                     /EC_number="6.2.1.15"
                     /note="fatty acid transport protein 1; arachidonate--CoA
                     ligase; long-chain-fatty-acid--CoA ligase; very long-chain
                     acyl-CoA synthetase"
                     /codon_start=1
                     /product="long-chain fatty acid transport protein 1"
                     /protein_id="NP_001344111.1"
                     /db_xref="CCDS:CCDS40386.1"
                     /db_xref="GeneID:26457"
                     /db_xref="MGI:MGI:1347098"
                     /translation="MRAPGAGTASVASLALLWFLGLPWTWSAAAAFCVYVGGGGWRFL
                     RIVCKTARRDLFGLSVLIRVRLELRRHRRAGDTIPCIFQAVARRQPERLALVDASSGI
                     CWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNV
                     NLRREPLAFCLGTSAAKALIYGGEMAAAVAEVSEQLGKSLLKFCSGDLGPESILPDTQ
                     LLDPMLAEAPTTPLAQAPGKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHS
                     YSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFSASRFWDDCVKYNCTVV
                     QYIGEICRYLLRQPVRDVEQRHRVRLAVGNGLRPAIWEEFTQRFGVPQIGEFYGATEC
                     NCSIANMDGKVGSCGFNSRILTHVYPIRLVKVNEDTMEPLRDSEGLCIPCQPGEPGLL
                     VGQINQQDPLRRFDGYVSDSATNKKIAHSVFRKGDSAYLSGDVLVMDELGYMYFRDRS
                     GDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPGVEGKAGMAAIADPHSQLDPN
                     SMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQTSDRLFFLDLK
                     QGRYVPLDERVHARICAGDFSL"
     exon            296..690
                     /gene="Slc27a1"
                     /gene_synonym="Fatp; FATP1; Vlc27a1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..852
                     /gene="Slc27a1"
                     /gene_synonym="Fatp; FATP1; Vlc27a1"
                     /inference="alignment:Splign:2.1.0"
     exon            853..922
                     /gene="Slc27a1"
                     /gene_synonym="Fatp; FATP1; Vlc27a1"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1014
                     /gene="Slc27a1"
                     /gene_synonym="Fatp; FATP1; Vlc27a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1124
                     /gene="Slc27a1"
                     /gene_synonym="Fatp; FATP1; Vlc27a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1334
                     /gene="Slc27a1"
                     /gene_synonym="Fatp; FATP1; Vlc27a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1461
                     /gene="Slc27a1"
                     /gene_synonym="Fatp; FATP1; Vlc27a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1599
                     /gene="Slc27a1"
                     /gene_synonym="Fatp; FATP1; Vlc27a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1764
                     /gene="Slc27a1"
                     /gene_synonym="Fatp; FATP1; Vlc27a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1911
                     /gene="Slc27a1"
                     /gene_synonym="Fatp; FATP1; Vlc27a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..3317
                     /gene="Slc27a1"
                     /gene_synonym="Fatp; FATP1; Vlc27a1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tagtaaaagc gtttgggttt aggctacagt gtggaaaaag aacgcggcca gggtctgtga
       61 cgtgacctgg gcgggatcag gactaggtgg gaggcggtac ctgcggtctc agctgtgtgc
      121 tccgcaggat gcgggctcct ggagcaggaa cagcctctgt ggcctcactg gcgctgcttt
      181 ggtttctggg acttccgtgg acctggagcg cggcggcggc gttctgtgtg tacgtgggtg
      241 gcggcggctg gcgctttctg cgtatcgtct gcaagacggc gaggcgagac ctctttggcc
      301 tctctgttct gattcgtgtt cggctagagc tgcgacgaca ccggcgagca ggagacacga
      361 tcccgtgcat cttccaggct gtggcccggc gacaaccaga gcgcctggca ctggtggacg
      421 ccagtagtgg tatatgctgg accttcgcac agctggacac ctactccaat gctgtagcca
      481 acctgttccg ccagctgggc tttgcaccag gcgatgtggt ggctgtgttc ctggagggcc
      541 ggccggagtt cgtgggactg tggctgggcc tggccaaggc cggtgtggtg gctgctcttc
      601 tcaatgtcaa cctgaggcgg gagcccctgg ccttctgcct gggcacatca gctgccaagg
      661 ccctcattta tggcggggag atggcagcgg cggtggcgga ggtgagcgag cagctgggga
      721 agagcctcct caagttctgc tctggagatc tggggcctga gagcatcctg cctgacacgc
      781 agctcctgga ccccatgctt gctgaggcgc ccaccacacc cctggcacaa gccccaggca
      841 agggcatgga tgatcggctg ttttacatct atacttctgg gaccaccggg cttcctaagg
      901 ctgccattgt ggtgcacagc aggtactacc gcattgctgc ctttggccac cattcctaca
      961 gcatgcgtgc cgccgatgtg ctctatgact gcctgccact ctaccactct gcagggaaca
     1021 tcatgggtgt ggggcagtgc gtcatctacg ggttgacggt ggtactgcgc aagaagttct
     1081 ccgccagccg cttctgggat gactgtgtca agtacaattg cacggtagtg cagtacatag
     1141 gtgaaatctg ccgctacctg ctgaggcagc cggttcgcga cgtggagcag cgacaccgcg
     1201 tgcgcctggc cgtgggtaat gggctgcggc cagccatctg ggaggagttc acgcagcgct
     1261 tcggtgtgcc acagatcggc gagttctacg gcgctaccga gtgcaactgc agcattgcca
     1321 acatggacgg caaggtcggc tcctgcggct tcaacagccg tatcctcacg catgtgtacc
     1381 ccatccgtct ggtcaaggtc aatgaggaca cgatggagcc actgcgggac tccgagggcc
     1441 tctgcatccc gtgccagccc ggggaacccg gccttctcgt gggccagatc aaccagcagg
     1501 accctctgcg gcgtttcgat ggttatgtta gtgacagtgc caccaacaag aagattgccc
     1561 acagcgtttt ccgaaagggc gatagcgcct acctctcagg tgacgtgcta gtgatggacg
     1621 agctgggcta catgtatttc cgtgaccgca gcggggacac cttccgctgg cgcggggaga
     1681 acgtgtccac cacggaggtg gaagccgtgc tgagccgcct actgggccag acggacgtgg
     1741 ctgtgtatgg ggtggctgtg ccaggagtgg aggggaaagc tggcatggca gccatcgcag
     1801 atccccacag ccagttggac cctaactcaa tgtaccagga attacagaag gttcttgcat
     1861 cctatgctcg gcccatcttc ctgcgtcttc tgccccaggt ggataccaca ggcaccttca
     1921 agatccagaa gacccggctg cagcgtgaag gctttgaccc ccgtcagacc tcagacaggc
     1981 tcttctttct agacctgaag cagggacgct atgtacccct ggatgagaga gtccatgccc
     2041 gcatttgtgc aggcgacttc tcactctgag cctggagagt gggctgggcc tggactcctg
     2101 agacctggga gcctgacacc cctcttcggg tgcttctcct gcctggccac atggacagca
     2161 gcacctgtga gagtaggaaa atggaacctg agtggctggg acccctctcc tacttcccac
     2221 tatgcatcca ttttgcctct gccttgatct ttttctccat ctcttttctc cctacccagc
     2281 aggagcccca caaacacatg ttggctgctg tgtcctgcag ttggaccagt gtccaggggt
     2341 acaggcttca ggctgtgacc cacactggta cccacctccc tttcctattg tgccttaggt
     2401 tcatccacgg ttcccctgtg gagcaagtgg gggcccacat agctgctgtc cctgctgagg
     2461 gttggtagca atcacaccct catgtcagct gggagacacg cgcagtctcc cactgacccc
     2521 caatcaactg aaaatattgt tttgactact ttttgttttt ttgttttttt gttttttttt
     2581 ttggtttttc gagacagagt ttctctgtat agccctggct gtcctggaac tcactttgta
     2641 gaccaggctg gcctcgaaat cagaaatcca cctgcctctg cctccctagt gctgggatta
     2701 aagacatgcg ccaccaccgc ctggctgttt tgtatttttg ttttgttttg agatagggtc
     2761 tcactgtgga ggccaagctg gcctcagact ccccacccca ttgcctctgg gcaccattct
     2821 atattctcag actgatgaca atgcactagt gtccctagga gttttctgag tctccacttc
     2881 cctcatagcc tcaagcttcc agaactgact ctgatcactt ggatgtggct agtgttggct
     2941 ctacccacat gtgtcaattc aggggtcccc aggcatagtc tctggaagcc ctcaccctga
     3001 aaaagcttgg agagactcag gaaggttgtt gtgttctctt gggcaccccc tggtggcagt
     3061 cctgggcatg cttccgcact gtactagtgc atatagccca gacctatgac atttgaggtc
     3121 tacccttctg gctcctgtgg tccccattga gatccttggt gactcacctc agtcaccaag
     3181 cagagcctct gcctgccttc atcttcgagg tcatgaagga tgtggacaga gcagctacag
     3241 gctgccagca gtcaaccaca tgagagtgtt acttccttgt tggtttttaa aaaataaatg
     3301 tgctgagcct cgacgcc
//
