LOCUS       NM_177243               3640 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus solute carrier family 26, member 9 (Slc26a9), mRNA.
ACCESSION   NM_177243 XM_976618
VERSION     NM_177243.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3640)
  AUTHORS   Powers,K.G., Wilkerson,B.A., Beach,K.E., Seo,S.S., Rodriguez,J.S.,
            Baxter,A.N., Hunter,S.E. and Bermingham-McDonogh,O.
  TITLE     Deletion of the Ebf1, a mouse deafness gene, causes a dramatic
            increase in hair cells and support cells of the organ of Corti
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39037017
REFERENCE   2  (bases 1 to 3640)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3640)
  AUTHORS   Liu,X., Li,T., Ma,Z., Riederer,B., Yuan,D., Zhu,J., Li,Y., An,J.,
            Wen,G., Jin,H., Yang,X., Seidler,U. and Tuo,B.
  TITLE     SLC26A9 deficiency causes gastric intraepithelial neoplasia in mice
            and aggressive gastric cancer in humans
  JOURNAL   Cell Oncol (Dordr) 45 (3), 381-398 (2022)
   PUBMED   35426084
  REMARK    GeneRIF: SLC26A9 deficiency causes gastric intraepithelial
            neoplasia in mice and aggressive gastric cancer in humans.
REFERENCE   4  (bases 1 to 3640)
  AUTHORS   Li,T., di Stefano,G., Raza,G.S., Sommerer,I., Riederer,B.,
            Romermann,D., Tan,X., Tan,Q., Pallagi,P., Hollenbach,M.,
            Herzig,K.H. and Seidler,U.
  TITLE     Hydrokinetic pancreatic function and insulin secretion are moduled
            by Cl- uniporter Slc26a9 in mice
  JOURNAL   Acta Physiol (Oxf) 234 (1), e13729 (2022)
   PUBMED   34525257
  REMARK    GeneRIF: Hydrokinetic pancreatic function and insulin secretion are
            moduled by Cl(-) uniporter Slc26a9 in mice.
REFERENCE   5  (bases 1 to 3640)
  AUTHORS   Bi,X., Wang,K., Yang,L., Pan,H., Jiang,H., Wei,Q., Fang,M., Yu,H.,
            Zhu,C., Cai,Y., He,Y., Gan,X., Zeng,H., Yu,D., Zhu,Y., Jiang,H.,
            Qiu,Q., Yang,H., Zhang,Y.E., Wang,W., Zhu,M., He,S. and Zhang,G.
  TITLE     Tracing the genetic footprints of vertebrate landing in non-teleost
            ray-finned fishes
  JOURNAL   Cell 184 (5), 1377-1391 (2021)
   PUBMED   33545088
REFERENCE   6  (bases 1 to 3640)
  AUTHORS   Urness,L.D., Paxton,C.N., Wang,X., Schoenwolf,G.C. and Mansour,S.L.
  TITLE     FGF signaling regulates otic placode induction and refinement by
            controlling both ectodermal target genes and hindbrain Wnt8a
  JOURNAL   Dev Biol 340 (2), 595-604 (2010)
   PUBMED   20171206
REFERENCE   7  (bases 1 to 3640)
  AUTHORS   Chang,M.H., Plata,C., Zandi-Nejad,K., Sindic,A., Sussman,C.R.,
            Mercado,A., Broumand,V., Raghuram,V., Mount,D.B. and Romero,M.F.
  TITLE     Slc26a9--anion exchanger, channel and Na+ transporter
  JOURNAL   J Membr Biol 228 (3), 125-140 (2009)
   PUBMED   19365592
  REMARK    GeneRIF: Slc26a9 has three discrete physiological modes:
            nCl(-)-HCO(3)(-) exchanger, Cl(-) channel, and Na(+)-anion
            cotransporter.
REFERENCE   8  (bases 1 to 3640)
  AUTHORS   Xu,J., Song,P., Miller,M.L., Borgese,F., Barone,S., Riederer,B.,
            Wang,Z., Alper,S.L., Forte,J.G., Shull,G.E., Ehrenfeld,J.,
            Seidler,U. and Soleimani,M.
  TITLE     Deletion of the chloride transporter Slc26a9 causes loss of
            tubulovesicles in parietal cells and impairs acid secretion in the
            stomach
  JOURNAL   Proc Natl Acad Sci U S A 105 (46), 17955-17960 (2008)
   PUBMED   19004773
  REMARK    GeneRIF: Slc26a9 plays an essential role in gastric acid secretion
            via effects on the viability of tubulovesicles/secretory canaliculi
            and by regulating chloride secretion in parietal cells.
REFERENCE   9  (bases 1 to 3640)
  AUTHORS   Romero,M.F., Chang,M.H., Plata,C., Zandi-Nejad,K., Mercado,A.,
            Broumand,V., Sussman,C.R. and Mount,D.B.
  TITLE     Physiology of electrogenic SLC26 paralogues
  JOURNAL   Novartis Found Symp 273, 126-38 (2006)
   PUBMED   17120765
  REMARK    GeneRIF: Slc26a9 functions as an electrogenic nCl-/HCO3- exchanger,
            suggesting a role in pulmonary and gastric HCO3- secretion and/or
            CO2 transport.
REFERENCE   10 (bases 1 to 3640)
  AUTHORS   Xu,J., Henriksnas,J., Barone,S., Witte,D., Shull,G.E., Forte,J.G.,
            Holm,L. and Soleimani,M.
  TITLE     SLC26A9 is expressed in gastric surface epithelial cells, mediates
            Cl-/HCO3- exchange, and is inhibited by NH4+
  JOURNAL   Am J Physiol Cell Physiol 289 (2), C493-C505 (2005)
   PUBMED   15800055
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK078966.1 and AK086815.1.
            
            On Jul 27, 2007 this sequence version replaced NM_177243.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK086815.1, AK078966.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2705              AK078966.1         2-2706
            2706-3640           AK086815.1         2708-3642
FEATURES             Location/Qualifiers
     source          1..3640
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 57.18 cM"
     gene            1..3640
                     /gene="Slc26a9"
                     /gene_synonym="E030002L01Rik"
                     /note="solute carrier family 26, member 9"
                     /db_xref="GeneID:320718"
                     /db_xref="MGI:MGI:2444594"
     exon            1..92
                     /gene="Slc26a9"
                     /gene_synonym="E030002L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            93..235
                     /gene="Slc26a9"
                     /gene_synonym="E030002L01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..2483
                     /gene="Slc26a9"
                     /gene_synonym="E030002L01Rik"
                     /note="SLC26A9 anion transporter/exchanger; anion
                     transporter/exchanger protein 9; anion
                     transporter/exchanger-9"
                     /codon_start=1
                     /product="solute carrier family 26 member 9"
                     /protein_id="NP_796217.2"
                     /db_xref="CCDS:CCDS15273.1"
                     /db_xref="GeneID:320718"
                     /db_xref="MGI:MGI:2444594"
                     /translation="MNQPRPRYVVDRAAYSLSLFDDEFEKKDRAYPVGEKLRNTFRCS
                     SAKFKAFVFGLLPVLSWLPKYKIKDYIIPDLLGGLSGGCIQVPQGMAFALLANLPAVN
                     GLYSSFFPLLTYFFLGGIHQMVPGTFAVISILVGNICLQLAPESKFQIFNNVTNETYV
                     DTAAMEAERLHVSATLACLTAVIQMALGFMQFGFVAIYLSESFIRGFMTAAGLQILIS
                     VLKYIFGLTIPSYTGPGSIVFTFIDICKNLPHTNIASLIFALVSGVFLVLVKELNARY
                     MHKIHFPIPTEMIVVVVATAISGSCKMPKKYHMQIVGEIRQGFPTPVAPMVSQWKDMV
                     GTAFSLAIVGYVINLAMGRTLASKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALS
                     VTLAVDGAGGKSQVASLCVSLVVMITMLVLGSYLYPLPKAVLGALIAVNLKNSLKQLT
                     DPYYLWRKSKLDCCVWVVSFLSSFFLSLPYGVAVGVAFSILVVIFQTQFRNGSTLAQV
                     MDTDIYVNPKTYNRAQEIAGVKIVTYCSPLYFANSEIFRQKVIAKTGMDPQKVLLAKQ
                     KYLRKQEKRTAIPTQQRKSLFMKTKTVSLQELQQDFESAPSTDPNNNQAPAAEAHISY
                     ITFSPDASTAAACELPASTRSPQEASDTLASVPPFVTFHTLILDMSGVSFVDLMGIKA
                     LAKLSSTYEKIGVQIFLVNIHAQVYNDISHGGVFEDGCVQRSHVFPSIHDAVLFAQAN
                     AREAPDRNFHGAPGDTEFSLYDSEEEGPSYWDLEQEMFGTMFHTETLTAL"
     exon            236..375
                     /gene="Slc26a9"
                     /gene_synonym="E030002L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            376..486
                     /gene="Slc26a9"
                     /gene_synonym="E030002L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            487..662
                     /gene="Slc26a9"
                     /gene_synonym="E030002L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            663..827
                     /gene="Slc26a9"
                     /gene_synonym="E030002L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            828..980
                     /gene="Slc26a9"
                     /gene_synonym="E030002L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1063
                     /gene="Slc26a9"
                     /gene_synonym="E030002L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1211
                     /gene="Slc26a9"
                     /gene_synonym="E030002L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1325
                     /gene="Slc26a9"
                     /gene_synonym="E030002L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1403
                     /gene="Slc26a9"
                     /gene_synonym="E030002L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1499
                     /gene="Slc26a9"
                     /gene_synonym="E030002L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1606
                     /gene="Slc26a9"
                     /gene_synonym="E030002L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1676
                     /gene="Slc26a9"
                     /gene_synonym="E030002L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1769
                     /gene="Slc26a9"
                     /gene_synonym="E030002L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1883
                     /gene="Slc26a9"
                     /gene_synonym="E030002L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2165
                     /gene="Slc26a9"
                     /gene_synonym="E030002L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2220
                     /gene="Slc26a9"
                     /gene_synonym="E030002L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2363
                     /gene="Slc26a9"
                     /gene_synonym="E030002L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2435
                     /gene="Slc26a9"
                     /gene_synonym="E030002L01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..3640
                     /gene="Slc26a9"
                     /gene_synonym="E030002L01Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3035
                     /gene="Slc26a9"
                     /gene_synonym="E030002L01Rik"
                     /note="major polyA site"
ORIGIN      
        1 agagcccttt cacacacctc aggaacacct ctctgctgcc cgctgcccag acacacctgc
       61 agccctgccc agccggctct gctcacccag agcttgtcaa tgtcccagac atgaaccagc
      121 ccaggccccg ctacgtggta gacagagctg cgtactccct ctccctcttc gatgatgagt
      181 ttgagaagaa ggaccgtgcc tacccggtgg gagagaagct tcgcaacact ttcaggtgct
      241 cctcagccaa gttcaaagcc tttgtgtttg ggctgttgcc tgtgctctcc tggctcccta
      301 aatacaagat caaagactac atcatccctg acttgctggg tggactcagt ggagggtgta
      361 tccaggtgcc acaaggcatg gcatttgcat tgctggccaa ccttcctgct gtcaacggtc
      421 tctactcctc cttcttcccc ctcctgacct atttcttctt agggggtatt caccagatgg
      481 tgccaggtac ctttgccgtt atcagcatcc tggtgggtaa catctgtctg cagctggccc
      541 cagagtcgaa attccagatc ttcaacaatg tcaccaatga gacctacgtg gacacagcag
      601 ccatggaggc agaaagactg catgtgtctg cgacacttgc ctgcctgact gctgtcatcc
      661 agatggcctt gggcttcatg cagtttggct ttgttgccat ctacctctct gagtccttta
      721 tccggggctt catgacagcc gctggcctgc agattctcat ctctgtgctc aagtacatct
      781 ttggtctgac cattccctcc tatacaggcc ctggctccat cgtctttacc ttcattgaca
      841 tttgcaaaaa cctcccccac accaacatcg cctcgctcat ctttgccctg gtcagcggtg
      901 tcttcctggt gctggtgaag gaactcaacg ctcggtacat gcacaagatc cacttcccca
      961 tccctacaga gatgattgtg gtggtagttg caaccgctat ctctgggagc tgcaagatgc
     1021 caaaaaaata ccacatgcag attgtggggg agatccgaca agggtttccc actccggtgg
     1081 caccgatggt ttcgcagtgg aaggacatgg tgggcacagc cttctccctg gcaattgtgg
     1141 gctatgtcat caatctggct atgggccgca ccctggccag caagcatggc tatgatgtgg
     1201 attctaacca ggagatgatt gccctgggct gtagcaactt cttcggctcc tttttcaaga
     1261 tccacgtcat ttgctgcgct ctctcagtca cactggctgt ggatggggct ggagggaaat
     1321 cccaggtggc cagcttgtgt gtgtctctgg tggtgatgat caccatgctg gtcctgggat
     1381 cctatctgta ccctctcccc aaggctgtgc taggtgccct gatcgctgtc aatctcaaga
     1441 actccctgaa gcagctcact gacccctact acctctggag gaagagtaag ctagactgtt
     1501 gtgtctgggt ggtgagcttc ctctcctcgt tcttcctgag cctgccctac ggtgtcgcag
     1561 tgggtgtagc cttctccatc ctggttgtga tcttccagac ccagtttcga aatggctcca
     1621 cactggccca ggtcatggac acggacatct atgtgaaccc caagacctac aacagggccc
     1681 aggaaattgc gggagttaag attgtcactt actgctcccc tctctacttt gccaactcag
     1741 agatcttcag gcaaaaagtc attgccaaga caggtatgga cccccagaaa gtattactcg
     1801 ccaagcagaa atatctccgg aagcaggaga agaggacggc gatacccaca cagcagagaa
     1861 agtccctctt catgaaaacc aagacggtct ctctacagga actccaacag gactttgaaa
     1921 gtgctccctc tactgacccc aacaacaacc aagctcctgc ggctgaggct cacatatcct
     1981 acatcacctt cagtccagac gcctccacag ctgctgcatg tgagctgccc gcctccactc
     2041 ggtcccccca ggaggctagt gacactctag ccagtgtgcc gccctttgtc accttccaca
     2101 ctctcatcct tgacatgagt ggagtcagct ttgtggattt gatgggcatc aaagctctcg
     2161 ccaagctaag ctccacctat gagaagatcg gagtccagat ctttctggta aacatccacg
     2221 cccaggtgta taatgacatc agccacggag gtgtctttga agatgggtgt gtacagcgca
     2281 gtcacgtgtt ccccagcatc cacgatgcag tcctctttgc ccaagcaaat gctagagaag
     2341 ccccagaccg caacttccat ggggctccag gggatactga gttctccttg tatgactcag
     2401 aagaggaagg tcccagctat tgggacttag aacaggagat gttcgggacc atgtttcaca
     2461 cagagaccct gactgccctg tgaggaccca tttggttccc atatttcctc ctgagggcct
     2521 ggcatctgga atttccatgg atgatacact cgggattgca ggagtgactg agagaagagt
     2581 atgtctgcca agatgctaga gcctctctca actctttgtt ttctcttcca cctttccctc
     2641 tctccctgtc tccccgggag agagccatct cagcctctgc agctggatga gcaagctctg
     2701 acaaggatga gactctggtg aacccatctc atcacctccc ccttcccact caagcctggg
     2761 ccaactataa gctcatacct cccatcaacg caagccccac cccatggcag ctgacttcca
     2821 gcctttagag tgagctaaga acagaatgat aagagcacct gtgctaagct ggactgcagt
     2881 tcaaatgtat ctgtgtcctg agtgattctg ccttggaagg tttcaggctg tggtggaaca
     2941 cagagatgaa tggggttaca atggtgaagc ttgtccctcc ggttgctcct tctagttgtt
     3001 agctttgtgc ctcaaagaca ctgtactact cacaacccag gagtctctgt ctttgtgccc
     3061 atttccctct cattttccta agactgccca ggcccccact gctgtccagc acttcagact
     3121 ctagtgtgga cagtgggcag gaccctcaag attatcagca ctacctctcc agggacagca
     3181 cacaaaggga cctgattcca ccttatgaat cttccccgcc tggaggccac cccatcctgg
     3241 ggaacaggtg actggcagaa tcctgataca gcagcagcta ttctgcacaa aatcttctaa
     3301 ggaaccctct ttactggatg aatggaagga gtaatatgtt gctaatgtaa actcgggcaa
     3361 actggtggat cctaggccct gacagtccac ctgacctcgg agcccgtatt gcctcacttg
     3421 ggaaatctgt cctgtccatt ttcacttgaa aggacagctc agttgcaccc acccctatca
     3481 gcctgtacca tccagagctg tgatggtagg tcccaacagg caggggagga acttctgagg
     3541 taccaacttc atagccctac tgtgtataga tttgaaggat tgttccagac tggatctccc
     3601 tctacgtgga actcttaaca atctccagac atttttaccc
//
