LOCUS       NM_001290320            4909 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus solute carrier family 26, member 8 (Slc26a8),
            transcript variant 1, mRNA.
ACCESSION   NM_001290320 XM_006525223 XM_006525224 XM_006536788
VERSION     NM_001290320.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4909)
  AUTHORS   Liu,M., Li,J., Li,Y., Jiang,C., Xu,W., Yang,Y. and Shen,Y.
  TITLE     The heterozygous mutations of SLC26A8 are not the main actors for
            male infertility
  JOURNAL   Hum Mutat 43 (5), 604-612 (2022)
   PUBMED   35181959
  REMARK    GeneRIF: The heterozygous mutations of SLC26A8 are not the main
            actors for male infertility.
REFERENCE   2  (bases 1 to 4909)
  AUTHORS   Rode,B., Dirami,T., Bakouh,N., Rizk-Rabin,M., Norez,C.,
            Lhuillier,P., Lores,P., Jollivet,M., Melin,P., Zvetkova,I.,
            Bienvenu,T., Becq,F., Planelles,G., Edelman,A., Gacon,G. and
            Toure,A.
  TITLE     The testis anion transporter TAT1 (SLC26A8) physically and
            functionally interacts with the cystic fibrosis transmembrane
            conductance regulator channel: a potential role during sperm
            capacitation
  JOURNAL   Hum Mol Genet 21 (6), 1287-1298 (2012)
   PUBMED   22121115
REFERENCE   3  (bases 1 to 4909)
  AUTHORS   Toure,A., Lhuillier,P., Gossen,J.A., Kuil,C.W., Lhote,D., Jegou,B.,
            Escalier,D. and Gacon,G.
  TITLE     The testis anion transporter 1 (Slc26a8) is required for sperm
            terminal differentiation and male fertility in the mouse
  JOURNAL   Hum Mol Genet 16 (15), 1783-1793 (2007)
   PUBMED   17517695
  REMARK    GeneRIF: Tat1 (Slc26A8) is a critical component of the sperm
            annulus that is essential for proper sperm tail differentiation and
            motility
REFERENCE   4  (bases 1 to 4909)
  AUTHORS   Longo-Guess,C.M., Gagnon,L.H., Cook,S.A., Wu,J., Zheng,Q.Y. and
            Johnson,K.R.
  TITLE     A missense mutation in the previously undescribed gene Tmhs
            underlies deafness in hurry-scurry (hscy) mice
  JOURNAL   Proc Natl Acad Sci U S A 102 (22), 7894-7899 (2005)
   PUBMED   15905332
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC170998.2.
            
            On Aug 10, 2022 this sequence version replaced NM_001290320.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The exon combination of the
            transcript is inferred from partial mouse transcript alignments,
            RNAseq data and orthologous alignments.
            
            CCDS Note: The exon combination of this CCDS representation is
            inferred due to a lack of full-length transcript support for this
            gene. It is supported by partial mouse transcript alignments,
            RNA-seq data and orthologous alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219379.8250.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1510              AC170998.2         74294-75803
            1511-1706           AC170998.2         80618-80813
            1707-1846           AC170998.2         89317-89456
            1847-1963           AC170998.2         92669-92785
            1964-2145           AC170998.2         95436-95617
            2146-2310           AC170998.2         101792-101956
            2311-2460           AC170998.2         103506-103655
            2461-2543           AC170998.2         105845-105927
            2544-2691           AC170998.2         110528-110675
            2692-2805           AC170998.2         111575-111688
            2806-2883           AC170998.2         112995-113072
            2884-2979           AC170998.2         115259-115354
            2980-3086           AC170998.2         115983-116089
            3087-3156           AC170998.2         116169-116238
            3157-3249           AC170998.2         117307-117399
            3250-3381           AC170998.2         117492-117623
            3382-3759           AC170998.2         120594-120971
            3760-3814           AC170998.2         122950-123004
            3815-3999           AC170998.2         123102-123286
            4000-4909           AC170998.2         126828-127737
FEATURES             Location/Qualifiers
     source          1..4909
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 14.82 cM"
     gene            1..4909
                     /gene="Slc26a8"
                     /note="solute carrier family 26, member 8"
                     /db_xref="GeneID:224661"
                     /db_xref="MGI:MGI:2385046"
     exon            1..1510
                     /gene="Slc26a8"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1706
                     /gene="Slc26a8"
                     /inference="alignment:Splign:2.1.0"
     CDS             1525..4524
                     /gene="Slc26a8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     testis anion transporter 1; anion exchange transporter"
                     /codon_start=1
                     /product="testis anion transporter 1 isoform 1"
                     /protein_id="NP_001277249.1"
                     /db_xref="CCDS:CCDS70779.1"
                     /db_xref="GeneID:224661"
                     /db_xref="MGI:MGI:2385046"
                     /translation="MQTERSLQSFSNRYTQIPFVYDVKRSVYNEENFQQEHRKKGPTS
                     GNVDIDITTFKHHVQCGCSWHKFLRCMLTVFPFLEWICLYRFKDWLLGDLLAGLSVGL
                     VQVPQGLILSLLTRQLIPPLNVTYAAFCSSVIYVIFGSCHQMSIGPFFLVSALMINVL
                     KDRPFNNGHLILGTFVKDDFSVPTFYLSYNRSLSMVASTTFLTGIIQLSMGMLGMGFM
                     ATYLPEAATSAYLAAVALHIILAQMTCILGIMVSFHAGPISFIYNIINYCIALPKANS
                     TSILLFITSVVALRINKCIRITFNRYPIEFPMELLLILGFSLLTSKITMATENSKMLM
                     NMIPYSFVFPENPEFGILSRVVLQALSLSFVSSFLLISLGKKIANFHNYRTNSNQDLI
                     AIGLCNLLSSFFKCCVFTGSLSRTTIQDKSGGRQQFASLVGAGVMLLLMVKMESFFHN
                     LPNAVLAGIILSNVVPYLEAIYNLPSLWRQDQYECIIWMVTFSSAILLGLDVGLLISL
                     AFTFFVITIRSHRTKILVLGQIPNTNIYRNVNDYREVILIPGVKIFQCCSSITFVNVY
                     HLKQKVLKEVNMVKLPLKEEEIYTLFHESETSIAENKLCRCFCDCEELEPEIRVVYTE
                     RYENRQEQDSSINLIRCSYLGSGDSSQVTSEEQIPYTVSSTSQRNIVQSYEDTEKAWL
                     PNSPPRNSPLPPPEASESLAQSRSRSIIMPYSDTSVQNNTHTIILDFSMVHYVDNRAL
                     VILRQMCNAFYNANILVLISGCHTSVVKSFEKNDFFDEGITKAQLFLSLHDAVLFALS
                     RKFSEPSDLSMDETETVIQETYSESDKNGNLSNLRLKTGKAIIEGSQHASPGFTKNLK
                     PGKDDLEFDLELDPMLSFEQSSGMDLNLDLDLDLDQSELDPGSELDSEIQAKPELELE
                     SELETDAQTEPETEEEPELEPEPEPEPETEPEPEPERERKTRTRSQSPWRNYFTAYRF
                     GSSNSQSRAPPQTRPEKRKPHNYPNSP"
     exon            1707..1846
                     /gene="Slc26a8"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1963
                     /gene="Slc26a8"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2145
                     /gene="Slc26a8"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2310
                     /gene="Slc26a8"
                     /inference="alignment:Splign:2.1.0"
     exon            2311..2460
                     /gene="Slc26a8"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..2543
                     /gene="Slc26a8"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..2691
                     /gene="Slc26a8"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2805
                     /gene="Slc26a8"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..2883
                     /gene="Slc26a8"
                     /inference="alignment:Splign:2.1.0"
     exon            2884..2979
                     /gene="Slc26a8"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3086
                     /gene="Slc26a8"
                     /inference="alignment:Splign:2.1.0"
     exon            3087..3156
                     /gene="Slc26a8"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..3249
                     /gene="Slc26a8"
                     /inference="alignment:Splign:2.1.0"
     exon            3250..3381
                     /gene="Slc26a8"
                     /inference="alignment:Splign:2.1.0"
     exon            3382..3759
                     /gene="Slc26a8"
                     /inference="alignment:Splign:2.1.0"
     exon            3760..3814
                     /gene="Slc26a8"
                     /inference="alignment:Splign:2.1.0"
     exon            3815..3999
                     /gene="Slc26a8"
                     /inference="alignment:Splign:2.1.0"
     exon            4000..4909
                     /gene="Slc26a8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4886..4891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc26a8"
                     /note="hexamer: AATAAA"
     polyA_site      4909
                     /gene="Slc26a8"
                     /note="major polyA site"
ORIGIN      
        1 gactgggctc cccggggcgc caagggtgga ggccgcagcg cggggcgcgc gcgcctctct
       61 gtggtcgcac gggcgaatgc ctggcgccat ggcggaaagc cgctgtgaca gcgtcgggga
      121 agagagccaa atgatctttg aactccgagc aacctgctca ctagagtcgt caatttccaa
      181 gaacaacttg aaagaacaga caggccctgt ccagaaagct gtcgcattcc ggtctgctca
      241 aggacaagtg gctcacctcg ggatgctggt gaaacctgcc ccctaggcaa atattagtct
      301 tgcctcaaag cccaggctct ccctccaggc gctcctacat gttttcaggc agaagtggca
      361 gaaggaggtt ccagggaccc acagggagtt ccaatgcacg aggtcagagg tagacatcat
      421 gaatggccac ttccaggctg gggaccagca tttgcaaggc cctgggttca atacccacta
      481 ctggaagggg aaggtacaca cacacactgc aagtaggtca ttccatttca ggaaggtctt
      541 ctcatttatt tatttatatt tacaccacct gcaattccgg catttggaaa gaccagaaaa
      601 cccttcatat acatgcatac atatatatct atttacacag cctgtaattc cagcatttag
      661 aaagaccagg agaccctttc atactattta tttatatgta cagaacctgt aattccagca
      721 tttgaaaaga ccaagagacc tttctcttat ttatttattt atacacaacc tgtaattcca
      781 gcatttggaa agaccagggg acccttctta tttatttatt tgtttattta tttatttgtt
      841 tatttgtatt tacaaatcct gtaattctag catttggaaa aaccaggaga ccaagcctct
      901 gctgtgtagt gatgagaccg tatgtgcaac accccaaaaa ccatcactcg ggtttgagac
      961 cgactcttgc cctttagagc catccaaagt ttagaaattt aaaagaaaat tggggggtgg
     1021 gtattaaaga cttaattcat gcctctgaga gtatggagaa ctactagggc gagcattctg
     1081 accgcatctc atttaggtaa gtctgttgag ctttcttagg ccctggttct agtctctaca
     1141 agatcaatgc gaccctgcat tcccacctag tggaatcttc cgtagaagcc gagaaagcta
     1201 ataaaagtga atggggaaag ttagacccgt aagaacccac atccacccat gcctacaccg
     1261 agcaggagaa aggggaaatc ttattctcgt ggctatttct agaagatccg ggtatgtgga
     1321 gggcagcagg gaccccttct cctcggccca gatgccatcc tcgcccgtca cccgcacagc
     1381 cggaacgccc gcgggttctg cagcaacggc tccggaactg ccggcctccg cgtccgcagc
     1441 gctgccgcca gccaggctgg agccgagtct gtccccagcg tctgcgctcc tgcgggccac
     1501 cggaaaccag ctaatccagg aacaatgcaa acagagagga gcctccagag tttcagcaac
     1561 agatacacac aaatcccttt tgtgtacgat gttaagcgga gcgtgtacaa cgaggagaat
     1621 ttccagcagg agcacaggaa gaagggcccc acctctggga acgtggacat cgatatcacc
     1681 actttcaagc accacgtcca gtgcggctgc tcctggcaca agttcctgag atgcatgctc
     1741 acagtcttcc ccttcctgga gtggatatgt ttgtatcgat tcaaggactg gcttcttgga
     1801 gacttacttg ctggtttaag tgttggtctt gttcaagttc cccaaggcct gatacttagt
     1861 ttactgacaa ggcagctgat tcctcccctc aacgtcactt acgccgcctt ctgctcttca
     1921 gtcatttatg tcatttttgg atcatgtcat caaatgtcca tcggcccctt cttccttgtg
     1981 agtgctctga tgatcaatgt cctgaaggat agacccttca acaatggtca cctgatcttg
     2041 ggaacttttg tcaaagatga cttctctgtc cccacattct acttgagcta caacagatcc
     2101 ttaagtatgg tggcatctac aactttcctg actgggatta ttcagctgtc aatgggtatg
     2161 ttgggcatgg gcttcatggc cacatatctt ccagaggctg caaccagcgc ttatctagca
     2221 gctgtggccc tgcacatcat actggcccag atgacatgca tcttggggat tatggtcagt
     2281 ttccatgctg ggcccatctc cttcatctac aacataatta actactgcat agctctcccc
     2341 aaagcgaact ctaccagcat cctgctgttc atcacctctg tggtggctct gagaatcaac
     2401 aagtgcatcc gcattacctt caaccgctac cctatcgagt tccccatgga gctgctgctg
     2461 attcttggct tcagcttact tacaagcaag ataaccatgg ccacagaaaa cagcaagatg
     2521 ctgatgaaca tgattccata cagcttcgtg ttccctgaga atccagagtt cggcattctt
     2581 agcagagttg ttttacaagc cttgtcttta tcttttgtga gctcctttct gcttatatct
     2641 ctgggcaaga agattgccaa cttccataac tacagaacca attccaacca ggatttaata
     2701 gccatcggtc tttgcaactt gctcagctcc tttttcaaat gctgtgtgtt caccggtagt
     2761 ttgtccagga cgactatcca ggacaaatct ggaggaagac agcagtttgc ctctctggta
     2821 ggcgcaggtg tgatgctgct gctgatggtg aagatggaaa gcttcttcca caatctgcct
     2881 aacgctgtgc tggctgggat catcttaagc aatgtggtgc cctaccttga agccatttac
     2941 aacttaccca gtttgtggag gcaggaccag tacgaatgta tcatttggat ggtgacattc
     3001 tcctctgcga ttctcctggg actcgacgtt ggactgctca tctcactggc cttcactttc
     3061 tttgtcatca ctattcgctc gcacagaacc aagatcctcg tcttgggtca gatccccaat
     3121 accaacattt acagaaatgt taatgactac cgggaggtga ttctcatccc tggggtgaaa
     3181 atctttcagt gttgcagctc catcacgttt gttaacgtgt accatctaaa gcaaaaggtg
     3241 ttaaaagagg tcaatatggt gaagttgccc cttaaagaag aagaaattta tactctgttt
     3301 catgaaagtg agaccagtat agcagaaaac aaactttgta ggtgtttctg tgactgtgaa
     3361 gaactggagc cagagatcag ggttgtctac acagagcgat atgaaaacag acaggagcag
     3421 gactcatcca tcaacctgat ccgctgctcc tacctgggca gcggggacag cagccaagtc
     3481 acttctgagg aacagattcc ctacacagtg tcttccacat cacagagaaa tatagtgcag
     3541 agctacgagg acacagagaa agcctggcta cccaacagcc ccccaagaaa cagtccactg
     3601 ccaccgcccg aggcctcaga aagcttagca cagagccgat ccagatccat tatcatgcct
     3661 tactcggata cgagtgtgca gaacaacacc cataccatca ttctggactt ttccatggtg
     3721 cactatgtgg ataatcgggc tttggttata ctaaggcaga tgtgcaatgc tttctacaat
     3781 gccaacattt tggtcctcat ttcagggtgt cacacctctg tggtcaagtc gtttgagaag
     3841 aatgatttct ttgatgaagg catcacgaag gcccagctct tcctcagcct ccatgacgcc
     3901 gtgctgtttg ccttgtccag gaagttctct gagccttcag acttaagtat ggatgagacc
     3961 gagacagtga tacaggaaac ctactcagag tcagacaaga atggcaatct gagcaaccta
     4021 agactcaaaa cggggaaggc catcatagaa ggctcccagc atgcaagtcc aggcttcacc
     4081 aagaacctga agcctggtaa ggatgacttg gagtttgacc tggaactgga tcccatgctg
     4141 tcttttgaac agagcagtgg gatggacctc aatctggacc tagacttgga cttggaccag
     4201 tcagagctgg accctggatc tgagctggat tctgagatcc aagccaaacc tgagctggaa
     4261 ctagagtcgg agcttgagac agatgcccag acagagccag agacagagga agagccagag
     4321 ctggagccag agccagagcc agagccagag acagagccag agccagagcc agagagagag
     4381 aggaagacca ggacaaggtc tcagagcccc tggcggaact acttcactgc ttatcgcttt
     4441 ggttcttcaa actcccagtc tagagctcca cctcagacac gcccagaaaa gagaaagcca
     4501 cataattacc ccaattctcc ctaaaacaat aaggatcctt ggtaggtgac tgcaaaatgc
     4561 aggctgagta tcttggcaaa tccctcctgc cctacttggc atgacatcta gactgggtac
     4621 aagccaccgg tcctggctct gtgacccctc cacttgctga cttccttctt attggattct
     4681 gggatcacat gcccatcata tgcccaggct atgtgactca aggttggcag ttgtctctgg
     4741 gttctgtctt caggctttgc agattgcatc ttcaacagat ttccagtgaa ggcctccctg
     4801 cacgtactct ctgggaactg tgccagcttg tctctgagtt cctcctctca gctctgcctc
     4861 cctttctcca gagacatgag acttgaataa aatatgggac tgtacttaa
//
