LOCUS       NM_145947               2371 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus solute carrier family 26, member 7 (Slc26a7), mRNA.
ACCESSION   NM_145947
VERSION     NM_145947.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2371)
  AUTHORS   Yamaguchi,N., Suzuki,A., Yoshida,A., Tanaka,T., Aoyama,K.,
            Oishi,H., Hara,Y., Ogi,T., Amano,I., Kameo,S., Koibuchi,N.,
            Shibata,Y., Ugawa,S., Mizuno,H. and Saitoh,S.
  TITLE     The iodide transporter Slc26a7 impacts thyroid function more
            strongly than Slc26a4 in mice
  JOURNAL   Sci Rep 12 (1), 11259 (2022)
   PUBMED   35788623
  REMARK    GeneRIF: The iodide transporter Slc26a7 impacts thyroid function
            more strongly than Slc26a4 in mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2371)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2371)
  AUTHORS   Cao,X., Soleimani,M. and Hughes,B.A.
  TITLE     SLC26A7 constitutes the thiocyanate-selective anion conductance of
            the basolateral membrane of the retinal pigment epithelium
  JOURNAL   Am J Physiol Cell Physiol 319 (4), C641-C656 (2020)
   PUBMED   32726161
  REMARK    GeneRIF: SLC26A7 constitutes the thiocyanate-selective anion
            conductance of the basolateral membrane of the retinal pigment
            epithelium.
REFERENCE   4  (bases 1 to 2371)
  AUTHORS   Quintana-Urzainqui,I., Kozic,Z., Mitra,S., Tian,T., Manuel,M.,
            Mason,J.O. and Price,D.J.
  TITLE     Tissue-Specific Actions of Pax6 on Proliferation and
            Differentiation Balance in Developing Forebrain Are Foxg1 Dependent
  JOURNAL   iScience 10, 171-191 (2018)
   PUBMED   30529950
REFERENCE   5  (bases 1 to 2371)
  AUTHORS   Cangul,H., Liao,X.H., Schoenmakers,E., Kero,J., Barone,S.,
            Srichomkwun,P., Iwayama,H., Serra,E.G., Saglam,H., Eren,E.,
            Tarim,O., Nicholas,A.K., Zvetkova,I., Anderson,C.A., Frankl,F.E.K.,
            Boelaert,K., Ojaniemi,M., Jaaskelainen,J., Patyra,K., Lof,C.,
            Williams,E.D., Soleimani,M., Barrett,T., Maher,E.R.,
            Chatterjee,V.K., Refetoff,S. and Schoenmakers,N.
  CONSRTM   UK10K Consortium
  TITLE     Homozygous loss-of-function mutations in SLC26A7 cause goitrous
            congenital hypothyroidism
  JOURNAL   JCI Insight 3 (20), 99631 (2018)
   PUBMED   30333321
  REMARK    GeneRIF: Study reports homozygous truncating mutations in SLC26A7
            in 6 unrelated families with goitrous congenital hypothyroidism and
            shows that goitrous hypothyroidism also occurs in Slc26a7-null
            mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2371)
  AUTHORS   Sun,X. and Petrovic,S.
  TITLE     Increased acid load and deletion of AE1 increase Slc26a7 expression
  JOURNAL   Nephron Physiol 109 (3), p29-p35 (2008)
   PUBMED   18663336
  REMARK    GeneRIF: Suggest that the increase in Slc26a7 expression caused by
            deletion of AE1 represents an adaptive response, indicating that
            Slc26a7 contributes to the regulation of acid-base balance by the
            kidney.
REFERENCE   7  (bases 1 to 2371)
  AUTHORS   Sun,X., Soleimani,M. and Petrovic,S.
  TITLE     Decreased expression of Slc26a4 (Pendrin) and Slc26a7 in the
            kidneys of carbonic anhydrase II-deficient mice
  JOURNAL   Cell Physiol Biochem 21 (1-3), 95-108 (2008)
   PUBMED   18209476
  REMARK    GeneRIF: CAII deficiency results in a significant decrease in the
            gene and protein expression of bicarbonate transport proteins from
            Slc26 gene family - Slc26a4 (pendrin) and Slc26a7.
REFERENCE   8  (bases 1 to 2371)
  AUTHORS   Dudas,P.L., Mentone,S., Greineder,C.F., Biemesderfer,D. and
            Aronson,P.S.
  TITLE     Immunolocalization of anion transporter Slc26a7 in mouse kidney
  JOURNAL   Am J Physiol Renal Physiol 290 (4), F937-F945 (2006)
   PUBMED   16263805
  REMARK    GeneRIF: Slc26a7 is expressed in the proximal tubule and thick
            ascending limb of the loop of Henle, and it may therefore
            contribute to anion transport in these nephron segments
REFERENCE   9  (bases 1 to 2371)
  AUTHORS   Kim,K.H., Shcheynikov,N., Wang,Y. and Muallem,S.
  TITLE     SLC26A7 is a Cl- channel regulated by intracellular pH
  JOURNAL   J Biol Chem 280 (8), 6463-6470 (2005)
   PUBMED   15591059
  REMARK    GeneRIF: findings reveal that SLC26A7 functions as a unique Cl(-)
            channel that is regulated by intracellular H(+)
REFERENCE   10 (bases 1 to 2371)
  AUTHORS   Petrovic,S., Ju,X., Barone,S., Seidler,U., Alper,S.L., Lohi,H.,
            Kere,J. and Soleimani,M.
  TITLE     Identification of a basolateral Cl-/HCO3- exchanger specific to
            gastric parietal cells
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 284 (6), G1093-G1103 (2003)
   PUBMED   12736153
  REMARK    GeneRIF: SLC26A7 is a basolateral Cl(-)/HCO(3)(-) exchanger in
            gastric parietal cells and possibly plays a major role in gastric
            acid secretion
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK054327.1 and AF345194.1.
            
            On Apr 25, 2009 this sequence version replaced NM_145947.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026928.1, AK054327.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1749              AK054327.1         2-1750
            1750-2045           AF345194.1         1652-1947
            2046-2371           AK054327.1         2054-2379
FEATURES             Location/Qualifiers
     source          1..2371
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 6.24 cM"
     gene            1..2371
                     /gene="Slc26a7"
                     /note="solute carrier family 26, member 7"
                     /db_xref="GeneID:208890"
                     /db_xref="MGI:MGI:2384791"
     exon            1..90
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            91..323
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..2101
                     /gene="Slc26a7"
                     /note="anion exchanger Slc26a7"
                     /codon_start=1
                     /product="anion exchange transporter"
                     /protein_id="NP_666059.2"
                     /db_xref="CCDS:CCDS17979.1"
                     /db_xref="GeneID:208890"
                     /db_xref="MGI:MGI:2384791"
                     /translation="MTGAKRKKRSVLWGKMHTPHREDIKQWCKRRLPILEWAPQYNLK
                     ENLLPDTVSGIMLAVQQVAQGLSFAMLSSVHPVFGLYGSLFPAIIYAIFGMGRHVATG
                     TFALTSLISANAVERLVPQSSRNLTTQSNSSVLGLSEFELQRIGVAAAVSFLGGVIQL
                     VMFVLQLGSATFLLTEPVISAMTTGAATHVVTSQVKYLLGIKMPYISGPLGFFYIYAY
                     VFENIKSVQLEALLFSLLSIIVLVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCT
                     NMENTYGLEVVGHIPNGIPPPRAPPMNILSAVLTEAFGVALVGYVASLALAQGSAKKF
                     KYSVDDNQEFLAHGLSNVIPSFLFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVLI
                     VIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWISTYIFTIC
                     FAANVGLLFGVICTIAIVLGRFPRAKTLSITDMKEMELKVKTEMHDETSQQIKIISIN
                     NPLVFLNAKKFSADLMKIILKESDSNQPLDDVSKCEQNTLLSSLSNGNCNEEASQPCS
                     SEKCSLVLNCSGLTFFDYTGVSTLVELYLDCKSRSVDVFLANCTASLIKAMTYYGDLD
                     TEKPIFFDSVPAAISIIQSNKNLSKASDHSEV"
     exon            324..434
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            435..607
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            608..772
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            773..925
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1008
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1156
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1270
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1348
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1444
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1551
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1618
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1756
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1805
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1906
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..1961
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2065
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2371
                     /gene="Slc26a7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2282..2287
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc26a7"
                     /note="hexamer: AATAAA"
     polyA_site      2308
                     /gene="Slc26a7"
                     /note="major polyA site"
ORIGIN      
        1 aactatctca ccaccgaacc tattactttt ccaagttcag aaaagtatta catgaacaga
       61 aaccattcct tattcagata agaatttaag aagttgacta ctacaggagg gaatctgaaa
      121 atctgaaaaa atgacgggag caaagaggaa aaagagaagc gtgctgtggg gcaagatgca
      181 caccccccac cgagaagaca ttaagcagtg gtgtaagagg cgcctaccta tcttggaatg
      241 ggcaccgcag tacaatctga aggaaaacct gcttccagac actgtgtctg ggataatgtt
      301 ggcagttcaa caggtggcac aagggctgtc cttcgctatg ctttcatctg tacacccagt
      361 ttttggttta tatggatctc tgtttccagc catcatttat gctatatttg gaatgggacg
      421 ccatgttgcc acaggcacct ttgccttgac atccttgata tcagccaacg ctgtggaacg
      481 actggtccct cagagcagca ggaacctcac cacacagagc aactcaagtg tgttgggctt
      541 atccgagttt gagctgcaga gaatcggggt tgcagcagct gtttctttct tgggtggagt
      601 gattcagctg gtcatgtttg tgctgcagct gggcagtgcc acattcctgc ttacagagcc
      661 tgtgatcagc gccatgacca caggggccgc cacccatgtc gtgacatcac aagtcaagta
      721 tctcttggga atcaaaatgc catatatatc cggaccactg ggattctttt atatttatgc
      781 gtatgtcttt gagaacatca agtctgtcca gctggaagca ctgctctttt ctttgctgag
      841 catcattgtc cttgttctcg ttaaagagct gaatgaacag tttaaaagaa aaattaaagt
      901 tgttcttcct gtcgacttag ttttgatcat tgccgcctca tttgcttgct attgtaccaa
      961 catggaaaac acatacggat tagaagtagt tgggcacatt ccaaacggga ttcctcctcc
     1021 ccgtgctccc ccaatgaaca tcctctctgc agtgctcact gaagctttcg gagttgcact
     1081 tgtaggctat gtggcctcgc tggctctcgc acaaggatct gccaagaagt tcaaatattc
     1141 agttgatgac aaccaggaat ttttggccca tggcctcagc aacgtgatcc cttcatttct
     1201 cttctgcatc ccaagcgctg ccgccatggg aaggacggct ggtttgtaca gcaccggcgc
     1261 aaagacgcag gtggcttgtc taatatcttg cattttcgtc cttattgtca tctatgcaat
     1321 aggacctctg ctgtactggc tgcccatgtg cgttcttgca agtattattg ttgtgggcct
     1381 gaagggaatg ttaatacagt tccgggattt aaaaaaatac tggaatgtgg ataaaatcga
     1441 ttggggcata tggatcagta cttacatttt tacaatatgc tttgctgcca atgtgggatt
     1501 gttgtttggt gttatctgca ccatagctat cgtgttagga cgtttcccaa gggcaaagac
     1561 tttaagcata acagacatga aagaaatgga attgaaggtg aagacagaaa tgcatgatga
     1621 aacctcgcaa cagataaaaa tcatctcaat aaacaaccca cttgttttcc tgaatgcaaa
     1681 gaaatttagt gctgatttga tgaaaataat cctaaaggaa agtgacagca accaaccact
     1741 tgatgatgtc agcaagtgtg aacagaacac cttgctcagt tccctgtcca acggcaactg
     1801 caatgaagag gcttcccagc cctgctccag cgagaagtgt tctttggtcc tgaattgcag
     1861 tggcttgacc ttttttgact acacaggagt ctccacgctt gttgagctct accttgattg
     1921 caagagcagg agtgtggatg tgttcttagc caactgtact gcatccttga taaaagcaat
     1981 gacatactat ggagacctag acaccgaaaa accaattttt tttgactcgg tacctgctgc
     2041 gataagtatc atccaatcaa ataagaattt gagcaaggcc agtgaccaca gtgaagtctg
     2101 agacccatgt gttgaagtgc acgcctcatc tttagcagct gccccaaaga ggccagatcc
     2161 tggcattttg cacacatttt ggtgtatata cagtgtatca ctcagtaaga atgatatgac
     2221 ttggcaactg catagccact ggccaagact tgctgacctt ctattttttc taattttcct
     2281 taataaacag attcatttag ttatttcata taggcatcaa tatgcattta gctttagttt
     2341 actgaacagt aaacatgctt ttatttcttg c
//
