LOCUS       NM_001408387            2660 bp    mRNA    linear   ROD 13-DEC-2024
DEFINITION  Mus musculus solute carrier family 26, member 6 (Slc26a6),
            transcript variant 2, mRNA.
ACCESSION   NM_001408387 XM_036154633
VERSION     NM_001408387.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2660)
  AUTHORS   Anbazhagan,A.N., Ge,Y., Priyamvada,S., Kumar,A., Jayawardena,D.,
            Palani,A.R.V., Husain,N., Kulkarni,N., Kapoor,S., Kaur,P.,
            Majumder,A., Lin,Y.D., Maletta,L., Gill,R.K., Alrefai,W.A.,
            Saksena,S., Zadeh,K., Hong,S., Mohamadzadeh,M. and Dudeja,P.K.
  TITLE     A Direct Link Implicating Loss of SLC26A6 to Gut Microbial
            Dysbiosis, Compromised Barrier Integrity, and Inflammation
  JOURNAL   Gastroenterology 167 (4), 704-717 (2024)
   PUBMED   38735402
  REMARK    GeneRIF: A Direct Link Implicating Loss of SLC26A6 to Gut Microbial
            Dysbiosis, Compromised Barrier Integrity, and Inflammation.
REFERENCE   2  (bases 1 to 2660)
  AUTHORS   Su,S., Wahl,A., Rugis,J., Suresh,V., Yule,D.I. and Sneyd,J.
  TITLE     A mathematical model of ENaC and Slc26a6 regulation by CFTR in
            salivary gland ducts
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 326 (5), G555-G566 (2024)
   PUBMED   38349781
  REMARK    GeneRIF: A mathematical model of ENaC and Slc26a6 regulation by
            CFTR in salivary gland ducts.
REFERENCE   3  (bases 1 to 2660)
  AUTHORS   Shin,S., Awuah Boadi,E. and Bandyopadhyay,B.C.
  TITLE     Ablation of TRPC3 compromises bicarbonate and phosphate transporter
            activity in mice proximal tubular cells
  JOURNAL   Clin Exp Pharmacol Physiol 50 (3), 247-255 (2023)
   PUBMED   36433745
  REMARK    GeneRIF: Ablation of TRPC3 compromises bicarbonate and phosphate
            transporter activity in mice proximal tubular cells.
REFERENCE   4  (bases 1 to 2660)
  AUTHORS   Borgo,G.M., Burke,T.P., Tran,C.J., Lo,N.T.N., Engstrom,P. and
            Welch,M.D.
  TITLE     A patatin-like phospholipase mediates Rickettsia parkeri escape
            from host membranes
  JOURNAL   Nat Commun 13 (1), 3656 (2022)
   PUBMED   35760786
  REMARK    GeneRIF: A patatin-like phospholipase mediates Rickettsia parkeri
            escape from host membranes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2660)
  AUTHORS   Whittamore,J.M. and Hatch,M.
  TITLE     The anion exchanger PAT-1 (Slc26a6) does not participate in oxalate
            or chloride transport by mouse large intestine
  JOURNAL   Pflugers Arch 473 (1), 95-106 (2021)
   PUBMED   33205229
  REMARK    GeneRIF: The anion exchanger PAT-1 (Slc26a6) does not participate
            in oxalate or chloride transport by mouse large intestine.
REFERENCE   6  (bases 1 to 2660)
  AUTHORS   Xie,Q., Welch,R., Mercado,A., Romero,M.F. and Mount,D.B.
  TITLE     Molecular characterization of the murine Slc26a6 anion exchanger:
            functional comparison with Slc26a1
  JOURNAL   Am J Physiol Renal Physiol 283 (4), F826-F838 (2002)
   PUBMED   12217875
  REMARK    GeneRIF: encodes an apical Cl(-)/formate/oxalate and Cl(-)/base
            exchanger and reveals significant mechanistic differences between
            apical and basolateral oxalate exchangers of the proximal tubule
REFERENCE   7  (bases 1 to 2660)
  AUTHORS   Jiang,Z., Grichtchenko,I.I., Boron,W.F. and Aronson,P.S.
  TITLE     Specificity of anion exchange mediated by mouse Slc26a6
  JOURNAL   J Biol Chem 277 (37), 33963-33967 (2002)
   PUBMED   12119287
  REMARK    GeneRIF: mediates specificity of anion exchange
REFERENCE   8  (bases 1 to 2660)
  AUTHORS   Wang,Z., Petrovic,S., Mann,E. and Soleimani,M.
  TITLE     Identification of an apical Cl(-)/HCO3(-) exchanger in the small
            intestine
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 282 (3), G573-G579 (2002)
   PUBMED   11842009
REFERENCE   9  (bases 1 to 2660)
  AUTHORS   Aronson,P.S.
  TITLE     Ion exchangers mediating NaCl transport in the renal proximal
            tubule
  JOURNAL   Cell Biochem Biophys 36 (2-3), 147-153 (2002)
   PUBMED   12139400
  REMARK    GeneRIF: An anion transporter expressed on the apical surface of
            renal proximal tubule cells and capable of mediating Cl(-)-formate
            exchange.
            Review article
REFERENCE   10 (bases 1 to 2660)
  AUTHORS   Knauf,F., Yang,C.L., Thomson,R.B., Mentone,S.A., Giebisch,G. and
            Aronson,P.S.
  TITLE     Identification of a chloride-formate exchanger expressed on the
            brush border membrane of renal proximal tubule cells
  JOURNAL   Proc Natl Acad Sci U S A 98 (16), 9425-9430 (2001)
   PUBMED   11459928
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC168054.4 and AEKQ02060806.1.
            
            On Jun 16, 2022 this sequence version replaced XM_036154633.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY049076.1, SRR13422598.1309213.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               AC168054.4         131540-131683
            145-310             AC168054.4         133274-133439
            311-450             AC168054.4         133520-133659
            451-561             AC168054.4         133829-133939
            562-710             AC168054.4         134173-134321
            711-875             AC168054.4         134438-134602
            876-1028            AC168054.4         134689-134841
            1029-1111           AC168054.4         135163-135245
            1112-1259           AC168054.4         135322-135469
            1260-1373           AC168054.4         135694-135807
            1374-1451           AC168054.4         135928-136005
            1452-1547           AC168054.4         136321-136416
            1548-1654           AC168054.4         136498-136604
            1655-1724           AC168054.4         136784-136853
            1725-1817           AEKQ02060806.1     9890-9982           c
            1818-1922           AEKQ02060806.1     9683-9787           c
            1923-2015           AEKQ02060806.1     9195-9287           c
            2016-2192           AEKQ02060806.1     8327-8503           c
            2193-2247           AEKQ02060806.1     8103-8157           c
            2248-2384           AEKQ02060806.1     6170-6306           c
            2385-2660           AEKQ02060806.1     5672-5947           c
FEATURES             Location/Qualifiers
     source          1..2660
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.63 cM"
     gene            1..2660
                     /gene="Slc26a6"
                     /gene_synonym="B930010B04Rik; CFEX; Pat-1; Pat1"
                     /note="solute carrier family 26, member 6"
                     /db_xref="GeneID:171429"
                     /db_xref="MGI:MGI:2159728"
     exon            1..144
                     /gene="Slc26a6"
                     /gene_synonym="B930010B04Rik; CFEX; Pat-1; Pat1"
                     /inference="alignment:Splign:2.1.0"
     exon            145..310
                     /gene="Slc26a6"
                     /gene_synonym="B930010B04Rik; CFEX; Pat-1; Pat1"
                     /inference="alignment:Splign:2.1.0"
     exon            311..450
                     /gene="Slc26a6"
                     /gene_synonym="B930010B04Rik; CFEX; Pat-1; Pat1"
                     /inference="alignment:Splign:2.1.0"
     exon            451..561
                     /gene="Slc26a6"
                     /gene_synonym="B930010B04Rik; CFEX; Pat-1; Pat1"
                     /inference="alignment:Splign:2.1.0"
     exon            562..710
                     /gene="Slc26a6"
                     /gene_synonym="B930010B04Rik; CFEX; Pat-1; Pat1"
                     /inference="alignment:Splign:2.1.0"
     exon            711..875
                     /gene="Slc26a6"
                     /gene_synonym="B930010B04Rik; CFEX; Pat-1; Pat1"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1028
                     /gene="Slc26a6"
                     /gene_synonym="B930010B04Rik; CFEX; Pat-1; Pat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1111
                     /gene="Slc26a6"
                     /gene_synonym="B930010B04Rik; CFEX; Pat-1; Pat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1259
                     /gene="Slc26a6"
                     /gene_synonym="B930010B04Rik; CFEX; Pat-1; Pat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1373
                     /gene="Slc26a6"
                     /gene_synonym="B930010B04Rik; CFEX; Pat-1; Pat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1451
                     /gene="Slc26a6"
                     /gene_synonym="B930010B04Rik; CFEX; Pat-1; Pat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1547
                     /gene="Slc26a6"
                     /gene_synonym="B930010B04Rik; CFEX; Pat-1; Pat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1654
                     /gene="Slc26a6"
                     /gene_synonym="B930010B04Rik; CFEX; Pat-1; Pat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1724
                     /gene="Slc26a6"
                     /gene_synonym="B930010B04Rik; CFEX; Pat-1; Pat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1817
                     /gene="Slc26a6"
                     /gene_synonym="B930010B04Rik; CFEX; Pat-1; Pat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1922
                     /gene="Slc26a6"
                     /gene_synonym="B930010B04Rik; CFEX; Pat-1; Pat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2015
                     /gene="Slc26a6"
                     /gene_synonym="B930010B04Rik; CFEX; Pat-1; Pat1"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2192
                     /gene="Slc26a6"
                     /gene_synonym="B930010B04Rik; CFEX; Pat-1; Pat1"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2247
                     /gene="Slc26a6"
                     /gene_synonym="B930010B04Rik; CFEX; Pat-1; Pat1"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2384
                     /gene="Slc26a6"
                     /gene_synonym="B930010B04Rik; CFEX; Pat-1; Pat1"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2660
                     /gene="Slc26a6"
                     /gene_synonym="B930010B04Rik; CFEX; Pat-1; Pat1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2642..2647
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc26a6"
                     /gene_synonym="B930010B04Rik; CFEX; Pat-1; Pat1"
                     /note="hexamer: AATAAA"
     polyA_site      2660
                     /gene="Slc26a6"
                     /gene_synonym="B930010B04Rik; CFEX; Pat-1; Pat1"
                     /note="major polyA site"
ORIGIN      
        1 gcacatccta gcggtggagc ttgcggccgg ccaagttctg ggcctggcgc caccttctag
       61 ccggtagtgg cctcctgggg gagctgtttg aaaagcggta cacgagttac cctctgaggg
      121 ccatgggact tcccgatggg tccgaccaag ggacacatca gacgcaggca ctcctgtctg
      181 cagcccaaga aatggagctg cagaggagag actaccatgt ggaaaggcca ttgctgaacc
      241 aggagcagct agaagatctg gggcattggg gcccagcggc gaagacccac cagtggcgaa
      301 cttggttccg atgctcccgt gctcgggccc attctcttct gctccagcac gttccagtcc
      361 tgggctggtt accccggtat cctgtgcgtg aatggctcct gggtgatctg ttatctggcc
      421 tgagtgtggc catcatgcag cttcctcagg gcttggccta tgcccttctg gcgggattgc
      481 ctcctatgtt tggtctgtac agttctttct accccgtctt catctacttc ctgtttggta
      541 cctccagaca catctctgtg gggacctttg ctgtaatgtc tgtgatggtg ggcagtgtga
      601 cagaatctct gacagcagat aaggccttcg tgcaaggctt gaatgccaca gctgatgatg
      661 cacgcgtgca ggtggcctac acactcagct tcctggtcgg cctcttccag gtggggctgg
      721 gcctggtaca cttcggcttc gttgtcacct acctgtcaga gcctctggtc cgcagctata
      781 ccacggctgc atctgtgcaa gtcctcgtct ctcagctcaa gtatgtgttt ggcatcaaac
      841 tcagcagtca ctctgggcca ctgtccgtta tctatacagt gctggaggtc tgtgcccagc
      901 tccctgagac tgtgcccggc accgtggtca cggcgattgt ggcaggagtg gccttggtac
      961 tggtgaagct acttaatgag aagctgcatc ggcgtctgcc cctgcccatc cctggggaac
     1021 tactcacgct cattggggcc actggtattt cctatggtgt gaagctgaat gacagattca
     1081 aggtcgatgt ggtgggcaac atcaccacag ggctcatacc cccggtggca cccaagacag
     1141 agctgtttgc aacgcttgtg ggaaatgcct ttgccattgc tgtggtgggc ttcgccattg
     1201 ccatctcact ggggaagatc tttgccctga ggcatggcta ccgtgtggac agtaaccagg
     1261 agctggtagc ccttggcctc agtaacctca ttggaggctt cttccagtgc ttccccgtga
     1321 gctgctccat gtctcggagc ttggtacagg agagcacggg aggcaacaca caggttgctg
     1381 gagctgtatc ttcccttttt atccttctta ttatcgtcaa acttggggaa ctcttccgag
     1441 acctgcccaa ggccgtcctg gctgctgtca ttattgtgaa cctaaagggc atgatgaagc
     1501 agttctcaga catctgctct ctttggaagg caaacagagt ggacctgcta atctggctgg
     1561 tgacctttgt ggccacaatc ctgctgaacc tggacattgg cctggcagtt tccatagtct
     1621 tctccttgct gctcgtggtc gtccgaatgc agctgcccca ttactccgtc ctggggcagg
     1681 tgccagatac ggatatttat agagacgtgg cagaatactc tggggccaag gaggtcccgg
     1741 gtgtgaaagt cttccgttcc tcagccacgc tgtacttcgc caatgctgag ctctacagcg
     1801 actctctgaa agagaagtgc ggtgtagatg ttgaccgcct catcacccag aagaagaaac
     1861 gaatcaaaaa gcaggagatg aagttaaagc gaatgaagaa agccaagaag tcccagaaac
     1921 aggatgcttc ttccaagatc tcctcagttt ccgtcaacgt caacaccaac ttggaagacg
     1981 tcaaaagcaa tgacgtcgag ggctctgagg ccaaggtgca ccaaggggag gagcttcagg
     2041 atgtagtctc cagcaatcaa gaagatgcca aggccccaac catgacctca ctgaagtccc
     2101 tgggcctgcc tcagccaggc ttccatagcc tcatcctgga cctgagcacc ctctcctttg
     2161 tggacactgt gtgcattaag agcctgaaga atattttccg tgacttccgg gagattgaag
     2221 tggaagtgta catcgcagcc tgttacagtc ctgtggtcgc ccagcttgaa gctggacact
     2281 tctttgatga atctatcact aagcagcatg tctttgcctc tgtccatgac gctgtgacct
     2341 ttgccctcag ccaccggaag tctgtcccta agagccctgt tttggccacc aaactctgac
     2401 tttgctgcag gagactgcct acctctggag gttgtgacag gtcaccctca tgaaaccccc
     2461 tgcctctggg ccacctccag gtgccacctg ggactccatt ccatgtacct gcacatacaa
     2521 ttcatggatg gatgccctgg gactcccaag ttcagtgcta caggcctggg gcagggtatt
     2581 gcagtcaggc tggccttggc tgggtgctga aaaggagctg atgtgggaat acagctttgg
     2641 gaataaattt gtctgtccaa
//
