LOCUS       NM_030727               4616 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus solute carrier family 26, member 5 (Slc26a5),
            transcript variant 1, mRNA.
ACCESSION   NM_030727
VERSION     NM_030727.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4616)
  AUTHORS   Sun,Y., Ren,M., Zhang,Y., Li,S., Luo,Z., Sun,S., He,S., Wang,G.,
            Zhang,D., Mansour,S.L., Song,L. and Liu,Z.
  TITLE     Casz1 is required for both inner hair cell fate stabilization and
            outer hair cell survival
  JOURNAL   Science, eado4930 (2025) In press
   PUBMED   39883789
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 4616)
  AUTHORS   de Haan,S., Corbat,A.A., Cederroth,C.R., Autrum,L.G., Hankeova,S.,
            Driver,E.C., Canlon,B., Kelley,M.W. and Andersson,E.R.
  TITLE     Jag1 represses Notch activation in lateral supporting cells and
            inhibits an outer hair cell fate in the medial cochlea
  JOURNAL   Development 151 (21) (2024)
   PUBMED   39373109
REFERENCE   3  (bases 1 to 4616)
  AUTHORS   Lachgar-Ruiz,M., Ingham,N.J., Martelletti,E., Chen,J., James,E.,
            Panganiban,C., Lewis,M.A. and Steel,K.P.
  TITLE     Two new mouse alleles of Ocm and Slc26a5
  JOURNAL   Hear Res 452, 109109 (2024)
   PUBMED   39241555
REFERENCE   4  (bases 1 to 4616)
  AUTHORS   Zheng,J., Zhou,Y., Fuentes,R.J. and Tan,X.
  TITLE     Verification of Outer Hair Cell Motor Protein, Prestin, as a
            Serological Biomarker for Mouse Cochlear Damage
  JOURNAL   Int J Mol Sci 25 (13), 7285 (2024)
   PUBMED   39000390
  REMARK    GeneRIF: Verification of Outer Hair Cell Motor Protein, Prestin, as
            a Serological Biomarker for Mouse Cochlear Damage.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4616)
  AUTHORS   Bi,Z., Ren,M., Zhang,Y., He,S., Song,L., Li,X. and Liu,Z.
  TITLE     Revisiting the Potency of Tbx2 Expression in Transforming Outer
            Hair Cells into Inner Hair Cells at Multiple Ages In Vivo
  JOURNAL   J Neurosci 44 (23), e1751232024 (2024)
   PUBMED   38688721
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4616)
  AUTHORS   Adler,H.J., Belyantseva,I.A., Merritt,R.C. Jr., Frolenkov,G.I.,
            Dougherty,G.W. and Kachar,B.
  TITLE     Expression of prestin, a membrane motor protein, in the mammalian
            auditory and vestibular periphery
  JOURNAL   Hear Res 184 (1-2), 27-40 (2003)
   PUBMED   14553901
  REMARK    GeneRIF: Although prestin is expressed in vestibular hair cells, it
            is unlikely that it supports the form of somatic motility observed
            in outer hair cells.
REFERENCE   7  (bases 1 to 4616)
  AUTHORS   Zheng,J., Richter,C.P. and Cheatham,M.A.
  TITLE     Prestin expression in the cochlea of the reeler mouse
  JOURNAL   Neurosci Lett 347 (1), 13-16 (2003)
   PUBMED   12865130
REFERENCE   8  (bases 1 to 4616)
  AUTHORS   Zheng,J., Long,K.B., Matsuda,K.B., Madison,L.D., Ryan,A.D. and
            Dallos,P.D.
  TITLE     Genomic characterization and expression of mouse prestin, the motor
            protein of outer hair cells
  JOURNAL   Mamm Genome 14 (2), 87-96 (2003)
   PUBMED   12584604
  REMARK    GeneRIF: Genomic characterization and expression of mouse prestin
REFERENCE   9  (bases 1 to 4616)
  AUTHORS   Liberman,M.C., Gao,J., He,D.Z., Wu,X., Jia,S. and Zuo,J.
  TITLE     Prestin is required for electromotility of the outer hair cell and
            for the cochlear amplifier
  JOURNAL   Nature 419 (6904), 300-304 (2002)
   PUBMED   12239568
  REMARK    GeneRIF: targeted deletion of prestin in mice results in loss of
            outer hair cell electromotility in vitro and a 40-60 dB loss of
            cochlear sensitivity in vivo, without disruption of
            mechano-electrical transduction in outer hair cells
REFERENCE   10 (bases 1 to 4616)
  AUTHORS   Bar,I., Lambert De Rouvroit,C., Royaux,I., Krizman,D.B.,
            Dernoncourt,C., Ruelle,D., Beckers,M.C. and Goffinet,A.M.
  TITLE     A YAC contig containing the reeler locus with preliminary
            characterization of candidate gene fragments
  JOURNAL   Genomics 26 (3), 543-549 (1995)
   PUBMED   7607678
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113028.15, AC125313.2, AY024359.2 and CJ076475.1.
            
            On Jan 31, 2014 this sequence version replaced NM_030727.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF529192.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                AC113028.15        79394-79468         c
            76-184              AC113028.15        75762-75870         c
            185-234             AC125313.2         8577-8626
            235-1639            AY024359.2         1-1405
            1640-1641           CJ076475.1         208-209
            1642-2469           AY024359.2         1408-2235
            2470-4616           AC125313.2         44809-46955
FEATURES             Location/Qualifiers
     source          1..4616
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 9.97 cM"
     gene            1..4616
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /note="solute carrier family 26, member 5"
                     /db_xref="GeneID:80979"
                     /db_xref="MGI:MGI:1933154"
     exon            1..75
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            76..184
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            185..386
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..2469
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /note="isoform 1 is encoded by transcript variant 1; outer
                     hair cell motor protein; prestin (motor protein)"
                     /codon_start=1
                     /product="prestin isoform 1"
                     /protein_id="NP_109652.3"
                     /db_xref="CCDS:CCDS19109.1"
                     /db_xref="GeneID:80979"
                     /db_xref="MGI:MGI:1933154"
                     /translation="MDHAEENEIPAETQRYYVERPIFSHPVLQERLHVKDKVTESIGD
                     KLKQAFTCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFA
                     MLAAVPPVFGLYSSFYPVIMYCFFGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPG
                     GVNATNGTEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAA
                     VHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGK
                     EFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLHESYSVDVVGTLPLGLLPPANPDTS
                     LFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGICNSIGSLFQTFS
                     ISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKG
                     MFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQSPSY
                     KVLGQLPDTDVYIDIDAYEEVKEIPGIKIFQINAPIYYANSDLYSSALKRKTGVNPAL
                     IMGARRKAMRKYAKEVGNANVANATVVKVDAEVDGENATKPEEEDDEVKFPPIVIKTT
                     FPEELQRFLPQGENVHTVILDFTQVNFVDSVGVKTLAGIVKEYGDVGIYVYLAGCSPQ
                     VVNDLTRNNFFENPALKELLFHSIHDAVLGSQVREAMAEQEATASLPQEDMEPNATPT
                     TPEA"
     exon            387..526
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            527..637
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            638..804
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            805..969
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1122
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1205
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1353
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1467
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1545
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1641
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1748
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1818
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1911
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2019
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2220
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2275
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..4616
                     /gene="Slc26a5"
                     /gene_synonym="Pres; prestin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacctggac agtgaagtgg agttcactgc agcggcggct ccgcccagcg cagccccggg
       61 cagcgctggt ggccgggaag ggctcatcgt cccttttcca gccctcggca gtttactgcg
      121 gccctgtacc tggagctctg gctgggtggt catctcctgc ccttgtgctg tacgttggat
      181 ctagtggcca tccagaaatg cttgtctcct gctgttggtg aataactgca gaccatggat
      241 catgctgaag aaaatgaaat ccctgcagag acccagaggt actacgtgga aaggcccatc
      301 ttcagtcatc ctgtcctcca agagaggctg cacgtcaagg acaaagtcac agagtccatt
      361 ggagataagc tgaagcaggc attcacgtgt actcctaaaa aaataagaaa catcatttac
      421 atgttcctgc ctatcactaa gtggctgcca gcatataaat tcaaggagta tgtgttaggt
      481 gacttggtct cgggcataag cactggggta ctccagcttc cccaaggctt agccttcgcc
      541 atgctggcag ccgtgcctcc ggtgtttggc ctgtactcat cgttttaccc cgttatcatg
      601 tactgtttct ttggaacctc aagacacata tctataggtc cttttgctgt tattagcttg
      661 atgattggag gtgtggccgt ccggttagta ccagatgata ttgtcatccc aggaggagta
      721 aatgcaacca acgggacaga agccagagat gcactaagag tgaaagtcgc catgtctgtt
      781 accttacttt caggaatcat tcagttttgc ctaggtgtct gtaggtttgg atttgtggcc
      841 atatacctca cggagccatt ggtgcgaggc tttaccactg cggctgctgt ccacgtgttc
      901 acgtccatgt taaaatacct gtttggggtc aaaacaaagc ggtacagtgg aatcttttca
      961 gtggtgtata gtacagttgc tgtgttgcag aatgttaaaa acctcaacgt gtgttcccta
     1021 ggcgtcggcc tgatggtttt tggtttgctg ttgggtggca aggaatttaa tgagagattt
     1081 aaagagaaat tgccagcacc cattcctcta gagttctttg ctgtggtgat ggggactggc
     1141 atttctgcag gatttaacct acatgagtcc tacagtgtgg atgtcgttgg aacacttcct
     1201 ctggggctac ttcctccggc caacccagac accagcctgt tccacctggt gtatgtggac
     1261 gccattgcca tcgccatcgt tggattttca gtgacgatct ccatggccaa aaccttggca
     1321 aataagcatg gctaccaggt tgatggcaat caggagctca ttgccttggg gatatgcaac
     1381 tccattggat ctctcttcca aaccttctcg atttcctgct ccttgtctcg aagccttgtt
     1441 caggaaggaa ctggagggaa aacacagctt gcaggttgtt tggcctcgtt gatgattctg
     1501 ttggtcatat tagccaccgg attcctcttt gagtcgttac cccaggctgt cctttccgcc
     1561 attgtgatcg tcaacctgaa aggaatgttc atgcagttct cagacctgcc ttttttctgg
     1621 agaaccagca aaatagagct gaccatctgg ctgaccacct ttgtgtcctc cctgttcctc
     1681 ggcttggact acggactgat taccgccgtg atcattgctc tgctcacagt gatttataga
     1741 acacagagtc caagctacaa agtcctgggg cagctccctg acacggatgt gtacattgac
     1801 atagatgcat atgaggaggt gaaagaaatt cctggaataa aaatattcca aataaatgcc
     1861 ccaatttact atgcaaatag cgacttgtat agcagcgctt taaaaagaaa gactggagta
     1921 aacccagcac tcattatggg agcgagaaga aaggccatga ggaagtacgc caaggaagtt
     1981 ggaaatgcca acgtggccaa tgctactgtt gtcaaagtgg atgcagaagt agacggagaa
     2041 aatgctacaa aacctgaaga agaggatgat gaagtcaaat ttcccccaat agtcatcaaa
     2101 acaacatttc ctgaagagct gcagagattt ttgccccagg gggaaaatgt ccacactgtc
     2161 attctagact ttacgcaggt caattttgtg gattctgttg gagtgaaaac tctggccggg
     2221 attgtgaaag aatatggaga tgttggaatt tatgtatatt tagcaggatg cagcccacaa
     2281 gttgtgaatg acctcacccg caacaacttt tttgaaaatc ctgccttgaa agagcttctg
     2341 ttccacagta tccacgatgc agtcctgggc agccaagttc gggaggcaat ggctgaacaa
     2401 gaagccacag cgtcacttcc ccaggaggat atggagccca atgccacacc caccaccccc
     2461 gaggcataaa ggccctgtat ggggttgtgc accgctcctg aattctggac ttaaacactt
     2521 taaatccaag gtcataggtt tttttttcaa gccctaaggg aaatgctagc agttacggct
     2581 cgatttggag ggtgaacgag gcatagcacg atgcactgca ttgtttagat tgaaatattt
     2641 caaagattaa caggcctctt gcacttatac agttacattt ccatcatacc ttaatgttat
     2701 ctctgttttg tggggttttt tttactcctg atttctttat tatctgaaat ctttggaaac
     2761 taatcacata aaactacaaa attagcaaat gtcttaaaat cggcatgtaa aacataaatt
     2821 acctctaatt ttaaaccttc gtttattaat gtactactca aacctaaaaa agagagacag
     2881 aggaaaagaa aagcagtcgc tctaaagcta atctcacatc atttttttac aaaaagaaac
     2941 tgttccttct aactgcaccc gcacacaccc tgatcacaaa acagttcgtc taattgtctt
     3001 ggctgagcgc atttccaaga tggaattttc tatgtcactc ccattgtccc tggttatgga
     3061 gaaagccatg ttttccttta ttaatggctt ttggtccggc caatgttagc ttccctcccg
     3121 atagtctcca ttctcgtctt tacttctgga gacacttctg gctcactctg tcttcattga
     3181 aagctgctgc tgccggaaga gttttgaagc agagctggag cagtgcccct gtggttactt
     3241 gtgtggggtc tggtggagat ggcagatgtg ttccttgccg tttgactacc tatggcaaac
     3301 gcaggcttgg ccatctttgt tgggaggcct gcgattcttc agcggatcgt tttgcagtgc
     3361 tgcaaccaga acttcccctc catttctgga agaaacagtc ttagttttcc cagttttttc
     3421 tgctacttct tcatgttgtt cggaggctcc agcttgctgc gtcttcccag gctgctctcc
     3481 caccctcccg tctcccacct tcccggctcc caccttcccg gctcccacct cccgtctccc
     3541 accttcccgg ctcccacctt cccggctccc acctacccgg ctcccaccta cccggctccc
     3601 acttcctggc tcccaccttc ctgtctccac ttagtgttat ctttgtagga tgagttaaac
     3661 tcttacaact taagtaggta acttagagca tgctgttgcc aggtggctag tggctcctga
     3721 attttgcact tgtttgagaa cagactgtaa tcaatttcct aacagaagag gagatctaca
     3781 atgcgctaga catgctggct ttaaaataat tttttactat tacagaatga tgtaaatgca
     3841 ttatggatgt tgagaactaa atggacaaag gagaataaga acgcactcag aggtgactat
     3901 cacaggcacc ttaatgaggc tccctccagg tcttttcctg tatatacata ttccctaaca
     3961 aaaataagca caggtctgca tagtgttcta tagtcgatct ttttagttga caacctccgc
     4021 tttgttattc caaagtattc ccccatacag tattcaggtt tcctattgtc ctcaaatttg
     4081 ctgttgattt gtctagactt gtattaattc tatgatttta cattgtaatt ggtcatgtgc
     4141 cttaagtcta tttcaatcta tacagttctt tttgtctctt aaaaatacgt agatgactaa
     4201 gatagttgta ttgaagaatc ccatcttgtg actgtgtcta gttccttctc cagtgttact
     4261 ggacttgctc agctagtcct catgttacct gtcatccaga cgtcattatt caagacacat
     4321 ggacatgagt taagtaattt atgctagtct ggaccctaga taaaacatgc ttcatattgt
     4381 accactcaga aaaacacagg ccatctagct tgcctacctt ttagagtgtg cagataaact
     4441 actggatcaa catggcagtc taacccttca gctggttttt atagtatata ttattatcca
     4501 tatgatgttc ctttggcatt aaataaatgt catttctcat taagccagaa attataacac
     4561 tgggtgacag tccttgccga agtgaactat tttattaaag tttgtccatt tctttc
//
