LOCUS       NM_011867               3103 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus solute carrier family 26, member 4 (Slc26a4), mRNA.
ACCESSION   NM_011867 XM_017315068
VERSION     NM_011867.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3103)
  AUTHORS   Fritzsch,B., Weng,X., Yamoah,E.N., Qin,T., Hui,C.C.,
            Lebron-Mora,L., Pavlinkova,G. and Sham,M.H.
  TITLE     Irx3/5 Null Deletion in Mice Blocks Cochlea-Saccule Segregation and
            Disrupts the Auditory Tonotopic Map
  JOURNAL   J Comp Neurol 532 (12), e70008 (2024)
   PUBMED   39655644
REFERENCE   2  (bases 1 to 3103)
  AUTHORS   Lee,H.J., Fenollar-Ferrer,C., Isgrig,K., Wang,Y.X., Valente,K.,
            Eide,J., Honda,K., Chien,W.W., Petralia,R.S., Dong,L.,
            Friedman,T.B., Bonifacino,J.S., Griffith,A.J. and Roux,I.
  TITLE     SLC26A4-AP-2 mu2 interaction regulates SLC26A4 plasma membrane
            abundance in the endolymphatic sac
  JOURNAL   Sci Adv 10 (41), eadm8663 (2024)
   PUBMED   39383236
REFERENCE   3  (bases 1 to 3103)
  AUTHORS   Brazier,F., Corniere,N., Picard,N., Chambrey,R. and Eladari,D.
  TITLE     Pendrin: linking acid base to blood pressure
  JOURNAL   Pflugers Arch 476 (4), 533-543 (2024)
   PUBMED   38110744
  REMARK    GeneRIF: Pendrin: linking acid base to blood pressure.
            Review article
REFERENCE   4  (bases 1 to 3103)
  AUTHORS   Pham,T.D., Verlander,J.W., Chen,C., Pech,V., Kim,H.I., Kim,Y.H.,
            Weiner,I.D., Milne,G.L., Zent,R., Bock,F., Brown,D., Eaton,A. and
            Wall,S.M.
  TITLE     Angiotensin II acts through Rac1 to upregulate pendrin: role of
            NADPH oxidase
  JOURNAL   Am J Physiol Renal Physiol 326 (2), F202-F218 (2024)
   PUBMED   38059296
  REMARK    GeneRIF: Angiotensin II acts through Rac1 to upregulate pendrin:
            role of NADPH oxidase.
REFERENCE   5  (bases 1 to 3103)
  AUTHORS   Kang,H.S., Grimm,S.A., Liao,X.H. and Jetten,A.M.
  TITLE     GLIS3 expression in the thyroid gland in relation to TSH signaling
            and regulation of gene expression
  JOURNAL   Cell Mol Life Sci 81 (1), 65 (2024)
   PUBMED   38281222
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3103)
  AUTHORS   Knauf,F., Yang,C.L., Thomson,R.B., Mentone,S.A., Giebisch,G. and
            Aronson,P.S.
  TITLE     Identification of a chloride-formate exchanger expressed on the
            brush border membrane of renal proximal tubule cells
  JOURNAL   Proc Natl Acad Sci U S A 98 (16), 9425-9430 (2001)
   PUBMED   11459928
REFERENCE   7  (bases 1 to 3103)
  AUTHORS   Royaux,I.E., Wall,S.M., Karniski,L.P., Everett,L.A., Suzuki,K.,
            Knepper,M.A. and Green,E.D.
  TITLE     Pendrin, encoded by the Pendred syndrome gene, resides in the
            apical region of renal intercalated cells and mediates bicarbonate
            secretion
  JOURNAL   Proc Natl Acad Sci U S A 98 (7), 4221-4226 (2001)
   PUBMED   11274445
REFERENCE   8  (bases 1 to 3103)
  AUTHORS   Everett,L.A., Belyantseva,I.A., Noben-Trauth,K., Cantos,R.,
            Chen,A., Thakkar,S.I., Hoogstraten-Miller,S.L., Kachar,B., Wu,D.K.
            and Green,E.D.
  TITLE     Targeted disruption of mouse Pds provides insight about the
            inner-ear defects encountered in Pendred syndrome
  JOURNAL   Hum Mol Genet 10 (2), 153-161 (2001)
   PUBMED   11152663
REFERENCE   9  (bases 1 to 3103)
  AUTHORS   Hrabe de Angelis,M.H., Flaswinkel,H., Fuchs,H., Rathkolb,B.,
            Soewarto,D., Marschall,S., Heffner,S., Pargent,W., Wuensch,K.,
            Jung,M., Reis,A., Richter,T., Alessandrini,F., Jakob,T., Fuchs,E.,
            Kolb,H., Kremmer,E., Schaeble,K., Rollinski,B., Roscher,A.,
            Peters,C., Meitinger,T., Strom,T., Steckler,T., Holsboer,F.,
            Klopstock,T., Gekeler,F., Schindewolf,C., Jung,T., Avraham,K.,
            Behrendt,H., Ring,J., Zimmer,A., Schughart,K., Pfeffer,K., Wolf,E.
            and Balling,R.
  TITLE     Genome-wide, large-scale production of mutant mice by ENU
            mutagenesis
  JOURNAL   Nat Genet 25 (4), 444-447 (2000)
   PUBMED   10932192
REFERENCE   10 (bases 1 to 3103)
  AUTHORS   Everett,L.A., Morsli,H., Wu,D.K. and Green,E.D.
  TITLE     Expression pattern of the mouse ortholog of the Pendred's syndrome
            gene (Pds) suggests a key role for pendrin in the inner ear
  JOURNAL   Proc Natl Acad Sci U S A 96 (17), 9727-9732 (1999)
   PUBMED   10449762
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123618.26 and CR974423.21.
            
            On or before Jun 24, 2023 this sequence version replaced
            XM_017315068.3, NM_011867.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF167411.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AC123618.26        10266-10299
            35-394              AC123618.26        10731-11090
            395-534             AC123618.26        13071-13210
            535-645             AC123618.26        20227-20337
            646-830             AC123618.26        22220-22404
            831-995             AC123618.26        22984-23148
            996-1148            AC123618.26        25668-25820
            1149-1231           AC123618.26        25942-26024
            1232-1379           AC123618.26        29599-29746
            1380-1493           AC123618.26        30954-31067
            1494-1571           AC123618.26        34337-34414
            1572-1667           AC123618.26        34544-34639
            1668-1774           AC123618.26        34894-35000
            1775-1844           AC123618.26        37036-37105
            1845-1937           AC123618.26        38461-38553
            1938-2033           AC123618.26        40696-40791
            2034-2264           AC123618.26        41401-41631
            2265-2319           AC123618.26        43595-43649
            2320-2465           AC123618.26        44654-44799
            2466-2549           CR974423.21        127-210
            2550-3103           CR974423.21        2285-2838
FEATURES             Location/Qualifiers
     source          1..3103
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 13.53 cM"
     gene            1..3103
                     /gene="Slc26a4"
                     /gene_synonym="Pds; pendrin"
                     /note="solute carrier family 26, member 4"
                     /db_xref="GeneID:23985"
                     /db_xref="MGI:MGI:1346029"
     exon            1..34
                     /gene="Slc26a4"
                     /gene_synonym="Pds; pendrin"
                     /inference="alignment:Splign:2.1.0"
     exon            35..394
                     /gene="Slc26a4"
                     /gene_synonym="Pds; pendrin"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..2573
                     /gene="Slc26a4"
                     /gene_synonym="Pds; pendrin"
                     /note="sodium-independent chloride/iodide transporter"
                     /codon_start=1
                     /product="pendrin"
                     /protein_id="NP_035997.1"
                     /db_xref="CCDS:CCDS36429.1"
                     /db_xref="GeneID:23985"
                     /db_xref="MGI:MGI:1346029"
                     /translation="MAARGGRSEPPQLAEYSCSYTVSRPVYSELAFQQQRERRLPERR
                     TLRDSLARSCSCSRKRAFGVVKTLLPILDWLPKYRVKEWLLSDIISGVSTGLVGTLQG
                     MAYALLAAVPVQFGLYSAFFPILTYFVFGTSRHISVGPFPVVSLMVGSVVLSMAPDDH
                     FLVPSGNGSALNSTTLDTGTRDAARVLLASTLTLLVGIIQLVFGGLQIGFIVRYLADP
                     LVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGILSIIYTLIEIFQNIGDTNIADFIAGL
                     LTIIVCMAVKELNDRFKHRIPVPIPIEVIVTIIATAISYGANLEKNYNAGIVKSIPSG
                     FLPPVLPSVGLFSDMLAASFSIAVVAYAIAVSVGKVYATKHDYVIDGNQEFIAFGISN
                     VFSGFFSCFVATTALSRTAVQESTGGKTQVAGLISAVIVMVAIVALGRLLEPLQKSVL
                     AAVVIANLKGMFMQVCDVPRLWKQNKTDAVIWVFTCIMSIILGLDLGLLAGLLFALLT
                     VVLRVQFPSWNGLGSVPSTDIYKSITHYKNLEEPEGVKILRFSSPIFYGNVDGFKKCI
                     NSTVGFDAIRVYNKRLKALRRIQKLIKKGQLRATKNGIISDIGSSNNAFEPDEDVEEP
                     EELNIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAVSFLDVVGVRSLRMIVKE
                     FQRIDVNVYFALLQDDVLEKMEQCGFFDDNIRKDRFFLTVHDAILHLQNQVKSREGQD
                     SLLETVARIRDCKDPLDLMEAEMNAEELDVQDEAMRRLAS"
     exon            395..534
                     /gene="Slc26a4"
                     /gene_synonym="Pds; pendrin"
                     /inference="alignment:Splign:2.1.0"
     exon            535..645
                     /gene="Slc26a4"
                     /gene_synonym="Pds; pendrin"
                     /inference="alignment:Splign:2.1.0"
     exon            646..830
                     /gene="Slc26a4"
                     /gene_synonym="Pds; pendrin"
                     /inference="alignment:Splign:2.1.0"
     exon            831..995
                     /gene="Slc26a4"
                     /gene_synonym="Pds; pendrin"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1148
                     /gene="Slc26a4"
                     /gene_synonym="Pds; pendrin"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1231
                     /gene="Slc26a4"
                     /gene_synonym="Pds; pendrin"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1379
                     /gene="Slc26a4"
                     /gene_synonym="Pds; pendrin"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1493
                     /gene="Slc26a4"
                     /gene_synonym="Pds; pendrin"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1571
                     /gene="Slc26a4"
                     /gene_synonym="Pds; pendrin"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1667
                     /gene="Slc26a4"
                     /gene_synonym="Pds; pendrin"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1774
                     /gene="Slc26a4"
                     /gene_synonym="Pds; pendrin"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1844
                     /gene="Slc26a4"
                     /gene_synonym="Pds; pendrin"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..1937
                     /gene="Slc26a4"
                     /gene_synonym="Pds; pendrin"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2033
                     /gene="Slc26a4"
                     /gene_synonym="Pds; pendrin"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2264
                     /gene="Slc26a4"
                     /gene_synonym="Pds; pendrin"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2319
                     /gene="Slc26a4"
                     /gene_synonym="Pds; pendrin"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2465
                     /gene="Slc26a4"
                     /gene_synonym="Pds; pendrin"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2549
                     /gene="Slc26a4"
                     /gene_synonym="Pds; pendrin"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..3103
                     /gene="Slc26a4"
                     /gene_synonym="Pds; pendrin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3074..3079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc26a4"
                     /gene_synonym="Pds; pendrin"
                     /note="hexamer: AATAAA"
     polyA_site      3098
                     /gene="Slc26a4"
                     /gene_synonym="Pds; pendrin"
                     /note="major polyA site"
ORIGIN      
        1 attctggtcg ggcagaactc cggagcccaa acaggtggcc ggccgcaggg acagtttgtt
       61 gccagcgccg aggactgcgg gacgcggacc ggctttccga agtcgctgcc acaggtggca
      121 cccgaggctg ctcccaggtg cccgccgcgg gccgtttgct cgctccgcgt ttccgaacgt
      181 catccctcgt cgcatcccct ccaggccggc ggtcctcggg tacgcaggcc atggcagcgc
      241 ggggcggcag gtcggagccg ccgcagctcg ccgagtacag ctgcagttac acggtgtcgc
      301 ggccggtgta cagcgagctc gccttccagc agcagcgcga gcggcgcctg cctgagcgca
      361 ggacgctgcg ggacagcctg gcgcggagct gcagttgctc aagaaagaga gcctttggtg
      421 tggtaaagac tctcctgccc attctggact ggctcccaaa ataccgagtc aaggaatggc
      481 tcctcagtga catcatctcc ggagttagca ctgggctggt gggtaccctg caagggatgg
      541 cttatgccct gctggcagca gtacctgttc agttcggtct ctactctgcc tttttcccta
      601 tcctgacgta ttttgtgttc ggaacatcaa gacacatctc agttggccct ttccccgtgg
      661 tcagtttaat ggtgggatct gttgttctga gcatggctcc agatgaccac tttcttgtgc
      721 ccagcggtaa cggaagtgca ttgaactcga ccacgttaga cactggaacc agagatgcgg
      781 cccgagtgtt gcttgcaagc acactcactc ttctagttgg aatcatacag ctggtgtttg
      841 gaggtttgca gattggattc atagtgaggt acttggcaga ccccttggtt ggcggattca
      901 caaccgctgc agccttccaa gtactggtct cacagctaaa gatcgtgctc aatgtttcaa
      961 ccaaaaacta caacggcatc ctctccatta tctacacact aattgagatt tttcaaaata
     1021 tcggtgacac caatattgcc gatttcatcg ctgggctgct gaccatcatc gtctgtatgg
     1081 ctgttaagga actaaatgat cgatttaaac acagaatccc ggtgcccatt cctatagaag
     1141 tgattgtgac aataattgct actgccattt cctatggggc caacttggaa aagaactaca
     1201 atgctggcat tgttaagtcc atcccaagtg ggttcttgcc tcctgtcctg ccatctgtgg
     1261 gcctgttttc ggacatgttg gctgcatcct tttccattgc tgtggtggct tacgctattg
     1321 cagtgtctgt aggaaaagtc tacgccacca agcatgacta tgtcatcgat gggaaccagg
     1381 aattcattgc ctttgggata agcaacgtct tctctggatt tttctcctgt tttgtggcta
     1441 ccactgctct gtctcgaacg gctgtccagg agagcaccgg ggggaagaca caggtggctg
     1501 gcctcatctc agctgtgatt gtgatggttg ccatcgttgc cttggggagg cttctggaac
     1561 ccttgcagaa gtcagtcttg gcggccgttg tcattgccaa cctgaaaggg atgtttatgc
     1621 aggtgtgtga cgttcctcgt ctgtggaagc agaataagac tgatgctgtt atctgggtgt
     1681 ttacatgcat aatgtccatc attctggggc tggacctcgg cttgctagct ggccttttat
     1741 ttgcactact gactgtggtc ctgagagttc agttcccttc atggaatggc cttggaagtg
     1801 tccccagcac agacatctac aaaagcatca cacattataa aaaccttgaa gagcctgaag
     1861 gggtgaagat cctgagattt tccagtccca ttttttacgg caatgtcgat ggttttaaaa
     1921 aatgtatcaa ttcaacggtt ggatttgatg ccattagagt atataataag aggctgaaag
     1981 cactgagaag aatacagaaa ctcatcaaaa aaggacaact cagggcaacc aagaacggga
     2041 tcataagtga tattggctca tcaaataatg ccttcgagcc tgatgaagat gtggaagagc
     2101 cagaggaact taatatccca accaaagaaa ttgagattca agtggactgg aactccgaac
     2161 tcccggtgaa agtgaatgtc ccaaaggtgc caatccacag cctggtgctg gattgcggag
     2221 ctgtatcctt cctggatgtg gtaggagtga ggtcattgcg aatgattgtc aaagaatttc
     2281 agagaattga tgtgaatgtg tactttgctc tgcttcaaga tgatgtgtta gaaaagatgg
     2341 agcagtgtgg gttctttgat gacaacatta gaaaggacag attctttctg acggttcatg
     2401 atgcaatcct ccatctgcag aaccaggtca aatccagaga aggccaggat tccctgctag
     2461 agacggtcgc tcgcattcgg gactgtaaag accctcttga tctgatggag gcagagatga
     2521 atgcagaaga gctcgatgtt caggatgagg ccatgcgtag acttgcttcc tgagagagga
     2581 ctgctagaca gaacctggct gtcagcccag tctctgcaag tgttttctgc actgactgtt
     2641 tctttgcact tcagcagcca tccgcttact gttacgttga aatataatac agtctgaagc
     2701 ttcttaggca ccacacaaga aacacttgtt gtttctgatg ctttaatgca gaaacaagca
     2761 gcttagctgc aaaatatcca aaaccaggag aattagccct gagaattagc aatgttcgga
     2821 tgtgctgcag tgactcacta tgtgctgctg tgacacactg tgtgctggat gccaaagcag
     2881 gtttgctgtc tgagcccata agggttccat ctgtctctgt taggctggcc caacagcttc
     2941 tatgggcagg tgagttagga aggactaatc acagagattc ctgactgact ctgaaatcca
     3001 tgtgttgtgt tgaccacagt gagaagaagg ataaggtaga attactgtgt actcattaat
     3061 gaactttaaa gaaaataaaa ccaatctttt aaaaatgatt tta
//
