LOCUS       NM_021353               2911 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus solute carrier family 26, member 3 (Slc26a3), mRNA.
ACCESSION   NM_021353 XM_913589
VERSION     NM_021353.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2911)
  AUTHORS   Ljungholm,P.L., Ermund,A., Soderlund Garsveden,M.M.,
            Pettersson,V.L. and Gustafsson,J.K.
  TITLE     The anion exchanger slc26a3 regulates colonic mucus expansion
            during steady state and in response to prostaglandin E2, while Cftr
            regulates de novo mucus release in response to carbamylcholine
  JOURNAL   Pflugers Arch 476 (8), 1209-1219 (2024)
   PUBMED   38829391
  REMARK    GeneRIF: The anion exchanger slc26a3 regulates colonic mucus
            expansion during steady state and in response to prostaglandin E2,
            while Cftr regulates de novo mucus release in response to
            carbamylcholine.
REFERENCE   2  (bases 1 to 2911)
  AUTHORS   Oh,Y., Kasu,M., Bottoms,C.J., Douglas,J.C., Sekulovski,N.,
            Hayashi,K. and MacLean Ii,J.A.
  TITLE     Rhox8 homeobox gene ablation leads to rete testis abnormality and
            male subfertility in micedagger
  JOURNAL   Biol Reprod 109 (4), 520-532 (2023)
   PUBMED   37471646
REFERENCE   3  (bases 1 to 2911)
  AUTHORS   Guo,Y., Li,X., Geng,C., Song,S., Xie,X. and Wang,C.
  TITLE     Vitamin D receptor involves in the protection of intestinal
            epithelial barrier function via up-regulating SLC26A3
  JOURNAL   J Steroid Biochem Mol Biol 227, 106231 (2023)
   PUBMED   36462760
  REMARK    GeneRIF: Vitamin D receptor involves in the protection of
            intestinal epithelial barrier function via up-regulating SLC26A3.
REFERENCE   4  (bases 1 to 2911)
  AUTHORS   Peritore-Galve,F.C., Kaji,I., Smith,A., Walker,L.M., Shupe,J.A.,
            Washington,M.K., Algood,H.M.S., Dudeja,P.K., Goldenring,J.R. and
            Lacy,D.B.
  TITLE     Increased intestinal permeability and downregulation of absorptive
            ion transporters Nhe3, Dra, and Sglt1 contribute to diarrhea during
            Clostridioides difficile infection
  JOURNAL   Gut Microbes 15 (1), 2225841 (2023)
   PUBMED   37350393
  REMARK    GeneRIF: Increased intestinal permeability and downregulation of
            absorptive ion transporters Nhe3, Dra, and Sglt1 contribute to
            diarrhea during Clostridioides difficile infection.
REFERENCE   5  (bases 1 to 2911)
  AUTHORS   Jayawardena,D., Priyamvada,S., Kageyama,T., White,Z., Kumar,A.,
            Griggs,T.F., Majumder,A., Akram,R., Anbazhagan,A.N., Sano,T. and
            Dudeja,P.K.
  TITLE     Loss of SLC26A3 Results in Colonic Mucosal Immune Dysregulation via
            Epithelial-Immune Cell Crosstalk
  JOURNAL   Cell Mol Gastroenterol Hepatol 15 (4), 903-919 (2023)
   PUBMED   36535508
  REMARK    GeneRIF: Loss of SLC26A3 Results in Colonic Mucosal Immune
            Dysregulation via Epithelial-Immune Cell Crosstalk.
REFERENCE   6  (bases 1 to 2911)
  AUTHORS   Ishiguro,H., Namkung,W., Yamamoto,A., Wang,Z., Worrell,R.T., Xu,J.,
            Lee,M.G. and Soleimani,M.
  TITLE     Effect of Slc26a6 deletion on apical Cl-/HCO3- exchanger activity
            and cAMP-stimulated bicarbonate secretion in pancreatic duct
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 292 (1), G447-G455 (2007)
   PUBMED   16901991
  REMARK    GeneRIF: In Slc26a6-knockout mice, a robust Slc26a3 compensatory
            upregulation can replace the function of Slc26a6 in pancreatic
            ducts.
REFERENCE   7  (bases 1 to 2911)
  AUTHORS   Jacob,P., Rossmann,H., Lamprecht,G., Kretz,A., Neff,C., Lin-Wu,E.,
            Gregor,M., Groneberg,D.A., Kere,J. and Seidler,U.
  TITLE     Down-regulated in adenoma mediates apical Cl-/HCO3- exchange in
            rabbit, rat, and human duodenum
  JOURNAL   Gastroenterology 122 (3), 709-724 (2002)
   PUBMED   11875004
REFERENCE   8  (bases 1 to 2911)
  AUTHORS   Kunieda,T., Takahashi,K., Shinkai,Y., Tsuji,T., Schweinfest,C.W.
            and Katoh,H.
  TITLE     The down-regulated in adenoma (Dra) gene encoding
            intestine-specific anion transporter maps to mouse chromosome 12
  JOURNAL   Exp Anim 49 (1), 67-68 (2000)
   PUBMED   10803366
REFERENCE   9  (bases 1 to 2911)
  AUTHORS   Melvin,J.E., Park,K., Richardson,L., Schultheis,P.J. and Shull,G.E.
  TITLE     Mouse down-regulated in adenoma (DRA) is an intestinal
            Cl(-)/HCO(3)(-) exchanger and is up-regulated in colon of mice
            lacking the NHE3 Na(+)/H(+) exchanger
  JOURNAL   J Biol Chem 274 (32), 22855-22861 (1999)
   PUBMED   10428871
REFERENCE   10 (bases 1 to 2911)
  AUTHORS   Silberg,D.G., Wang,W., Moseley,R.H. and Traber,P.G.
  TITLE     The Down regulated in Adenoma (dra) gene encodes an
            intestine-specific membrane sulfate transport protein
  JOURNAL   J Biol Chem 270 (20), 11897-11902 (1995)
   PUBMED   7744840
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK018566.1, BC139271.1 and
            CR974423.21.
            
            On Dec 16, 2012 this sequence version replaced NM_021353.2.
            
            Summary: This gene encodes a member of the solute carrier/sulfate
            transporter family. The encoded protein is predominantly expressed
            in the intestine where it is essential for chloride absorption.
            Disruption of this gene results in chloride-rich diarrhea and
            compensatory up-regulation of ion-absorbing transporters. [provided
            by RefSeq, Dec 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments and
            orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF136751.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               AK018566.1         2-166
            166-2520            BC139271.1         1-2355
            2521-2911           CR974423.21        48732-49122         c
FEATURES             Location/Qualifiers
     source          1..2911
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 13.45 cM"
     gene            1..2911
                     /gene="Slc26a3"
                     /gene_synonym="9030623B18Rik; 9130013M11Rik; Dra"
                     /note="solute carrier family 26, member 3"
                     /db_xref="GeneID:13487"
                     /db_xref="MGI:MGI:107181"
     exon            1..123
                     /gene="Slc26a3"
                     /gene_synonym="9030623B18Rik; 9130013M11Rik; Dra"
                     /inference="alignment:Splign:2.1.0"
     exon            124..343
                     /gene="Slc26a3"
                     /gene_synonym="9030623B18Rik; 9130013M11Rik; Dra"
                     /inference="alignment:Splign:2.1.0"
     exon            344..483
                     /gene="Slc26a3"
                     /gene_synonym="9030623B18Rik; 9130013M11Rik; Dra"
                     /inference="alignment:Splign:2.1.0"
     exon            484..594
                     /gene="Slc26a3"
                     /gene_synonym="9030623B18Rik; 9130013M11Rik; Dra"
                     /inference="alignment:Splign:2.1.0"
     exon            595..761
                     /gene="Slc26a3"
                     /gene_synonym="9030623B18Rik; 9130013M11Rik; Dra"
                     /inference="alignment:Splign:2.1.0"
     exon            762..926
                     /gene="Slc26a3"
                     /gene_synonym="9030623B18Rik; 9130013M11Rik; Dra"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1079
                     /gene="Slc26a3"
                     /gene_synonym="9030623B18Rik; 9130013M11Rik; Dra"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1162
                     /gene="Slc26a3"
                     /gene_synonym="9030623B18Rik; 9130013M11Rik; Dra"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1310
                     /gene="Slc26a3"
                     /gene_synonym="9030623B18Rik; 9130013M11Rik; Dra"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1424
                     /gene="Slc26a3"
                     /gene_synonym="9030623B18Rik; 9130013M11Rik; Dra"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1502
                     /gene="Slc26a3"
                     /gene_synonym="9030623B18Rik; 9130013M11Rik; Dra"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1598
                     /gene="Slc26a3"
                     /gene_synonym="9030623B18Rik; 9130013M11Rik; Dra"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1705
                     /gene="Slc26a3"
                     /gene_synonym="9030623B18Rik; 9130013M11Rik; Dra"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1775
                     /gene="Slc26a3"
                     /gene_synonym="9030623B18Rik; 9130013M11Rik; Dra"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1868
                     /gene="Slc26a3"
                     /gene_synonym="9030623B18Rik; 9130013M11Rik; Dra"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..1964
                     /gene="Slc26a3"
                     /gene_synonym="9030623B18Rik; 9130013M11Rik; Dra"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2198
                     /gene="Slc26a3"
                     /gene_synonym="9030623B18Rik; 9130013M11Rik; Dra"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2253
                     /gene="Slc26a3"
                     /gene_synonym="9030623B18Rik; 9130013M11Rik; Dra"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2396
                     /gene="Slc26a3"
                     /gene_synonym="9030623B18Rik; 9130013M11Rik; Dra"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2462
                     /gene="Slc26a3"
                     /gene_synonym="9030623B18Rik; 9130013M11Rik; Dra"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..2911
                     /gene="Slc26a3"
                     /gene_synonym="9030623B18Rik; 9130013M11Rik; Dra"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2888..2893
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc26a3"
                     /gene_synonym="9030623B18Rik; 9130013M11Rik; Dra"
                     /note="hexamer: ATTAAA"
     polyA_site      2911
                     /gene="Slc26a3"
                     /gene_synonym="9030623B18Rik; 9130013M11Rik; Dra"
                     /note="major polyA site"
ORIGIN      
        1 atgcagaatc tatagaccca agtagatgca tactgtctcc tagaacagga ctgctttatc
       61 tcaaaaaaaa aaaaaaaaaa aaccttccca ctgttgctga agcgccacac tgaatatatt
      121 aaggcatttt aacctgctaa cagcaagaag agctcaccac atagtttcaa agggcttcct
      181 tcccactagc cactgtcacc agggaaggca aaatgatcga agccataggg aatcagtatg
      241 tggtggccag accggtgtac tccacaaaga cttttggaga ggagtttaag aagacgcaca
      301 gacatcacaa gacattcctg gaccatctca aagggtgttg tagctgctcc tcacagaagg
      361 ccaagaaaat cgccctgtct ttgttcccca tagcatcttg gttgccagcc tacaagataa
      421 aggaatggct tctcagtgac atcgtctctg gcatcagcac cgggctggtg gctgtactgc
      481 aaggtttagc atttgctctg ctggtcaaca tccctccagc ctacgggttg tacgcagcct
      541 ttttcccagt cataacctac tttttcttgg gcacatctag acacatatct gtgggtccat
      601 ttccagttct gagtatgatg gtgggagttg tcgttacaag agtggtctcg gaccccaatg
      661 cttcttcaga gttgtcctca agctccacag aaaatgactc gttcatagag gagaaagtaa
      721 tggtggctgc atcagtaact gttctttctg gaatcattca gttgctcctg ggggttctgc
      781 aggtcggctt tgtggtgata tacctatccg agtccctaat cagtggcttc accacggctg
      841 ctgccattca cgttctggtt tctcaactga aattcatgct acagctgcca gtcccagcat
      901 acagcgaccc attctctata ttcaaagtcc tggagtcggt cttcacacaa attcagaaga
      961 cgaacatcgc agaccttgtg acatctgtga ttattctagt ggtcgtgttt gtctttaaag
     1021 aaatcaatca gcgttacaga agcaaacttc cggtgcccat ccccatcgaa ctcatcatga
     1081 ctgtaattgc cacaggtgtg tcctatggct gtaactttga agacaggttt ggcgtggccg
     1141 tggttgggaa catgagtctt ggatttcaac cccctattac acccagcgtg gaagttttcc
     1201 aagacaccat aggagacagc ttcggcatcg cgatcgtcgg ctttgccgtg gccttttccg
     1261 ttgccagcgt gtactccctc aaatacgatt atccgattga tggcaatcag gagttaattg
     1321 ccttgggagt gagcaacata ttcactggag cattcaaagg atttgcaggg agcacagccc
     1381 tttccagatc aggggttcag gagagcacgg gaggcaaaac acaggttgcg gggcttctct
     1441 cagctgtcat cgtgttgatc gtcatagttg ccattgggtt tcttctgcag ccgctacaaa
     1501 agtctgtcct ggcagcgcta gcactcggaa acttaaaggg aatgctgatg cagtttgctg
     1561 aaataggcag attgtggaaa aaggataaat atgattgttt aatttggatc atgaccttca
     1621 tcttcgccat tgtccttgga ctcggattag gcctggcggc aagtgtagca tttcaactcc
     1681 taactattgt gttcaggacc caatttccaa agtgcagcac attggctaat gttggaagga
     1741 gcaacatcta caagaataaa aagaattatg ccgaagtgta tgagcctgaa ggagtgaaaa
     1801 tttttagatg tccatctcca atctacttcg caaacattgg tttctttaag cagaaactta
     1861 ttgatgctgt tggctttagc ccacttcgaa ttctacggaa gcgcaacaaa gctttgaaga
     1921 aaatccgaaa actgcagaaa cgaggtctga tacagatgac acctaaaggg tttatatgca
     1981 cctctgacgg tttcaaagac tccgacgaag aattggacaa caaccagata gaagaacttg
     2041 atcagccgat caataccaca gatctgccct ttgacataga ctggaacggg gatcttcccc
     2101 tcaacatcac catccccaaa atcagcctcc acagcctcat cctcgatttt tcagcagtgt
     2161 ctttccttga cgtctcctca atgaggggcc tcagaacgat tttacaagaa tttattagga
     2221 tcaaggtgga cgtatatatt gtgggaaccg atgatgattt cattgacaaa cttgctcggt
     2281 gtgaattctt cgatgatgaa gtcacagact caatattttt cttaacaatc catgatgcta
     2341 ttttgcatat tttgatgaag aaggactaca gcacttcaaa gtttaattcc agccaggaaa
     2401 aagaaaggaa atttgacttt accataaata caaatggagg actacgtaat cgggaatgtc
     2461 aggtaccagt tgaaacgaaa ttctaatcaa gatacaattc ggaaggattc tcatctgtca
     2521 taacaaaaac aaccttatac ctagaaagtt attgctaagt tcatacattg tatgaacgat
     2581 atttttattt gacagaatta tgtttcaaac tttggaacga gattgttcta gcatggtata
     2641 tttttcacat atctagttat gaaattatgt acatattcct aattttctac cttgtagact
     2701 tatcaagggt agaaaagtat tttgtttatt gtatttttgt agcgcagacc gattcctttc
     2761 caagtcatta tcttcttgct caacatttta tggtgtattt acaccactgc tttgactcca
     2821 atttttacag gtcatgctaa tatgtctcta ttttaaacaa ttaagctgta cgggtgtgtg
     2881 ctattttatt aaatgtgtca gttttctgaa a
//
