LOCUS       NM_007885               3863 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus solute carrier family 26 (sulfate transporter), member
            2 (Slc26a2), mRNA.
ACCESSION   NM_007885
VERSION     NM_007885.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3863)
  AUTHORS   Yoshida,Y., Inubushi,T., Yokoyama,M., Nag,P., Sasaki,J.I., Oka,A.,
            Murotani,T., Kani,R., Shiraishi,Y., Kurosaka,H., Takahata,Y.,
            Nishimura,R., Imazato,S., Papagerakis,P. and Yamashiro,T.
  TITLE     Slc26a2-mediated sulfate metabolism is important in tooth
            development
  JOURNAL   Dis Model Mech 17 (12) (2024)
   PUBMED   39508796
REFERENCE   2  (bases 1 to 3863)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3863)
  AUTHORS   Zheng,C., Liu,H., Zhao,P., Lu,W., Song,S., He,T., Fan,J., Wang,D.,
            Yang,P., Jie,Q., Zheng,H.F., Luo,Z. and Yang,L.
  TITLE     Targeting sulfation-dependent mechanoreciprocity between matrix and
            osteoblasts to mitigate bone loss
  JOURNAL   Sci Transl Med 15 (710), eadg3983 (2023)
   PUBMED   37611084
REFERENCE   4  (bases 1 to 3863)
  AUTHORS   Zheng,C., Lin,X., Liu,H., Lu,W., Xu,X., Wang,D., Gao,B., Wang,C.,
            Zhou,J., Fan,J., Hu,Y., Jie,Q., Chen,D., Yang,L. and Luo,Z.
  TITLE     Phenotypic characterization of Slc26a2 mutant mice reveals a
            multifactorial etiology of spondylolysis
  JOURNAL   FASEB J 34 (1), 720-734 (2020)
   PUBMED   31914611
  REMARK    GeneRIF: support a multifactorial etiology, involving congenitally
            predisposed isthmic conditions, altered biomechanics, and
            age-dependent bone loss, which leads to SLC26A2-related
            spondylolysis
REFERENCE   5  (bases 1 to 3863)
  AUTHORS   Zheng,C., Lin,X., Xu,X., Wang,C., Zhou,J., Gao,B., Fan,J., Lu,W.,
            Hu,Y., Jie,Q., Luo,Z. and Yang,L.
  TITLE     Suppressing UPR-dependent overactivation of FGFR3 signaling
            ameliorates SLC26A2-deficient chondrodysplasias
  JOURNAL   EBioMedicine 40, 695-709 (2019)
   PUBMED   30685387
  REMARK    GeneRIF: the present study has expanded our view of the sulfate
            transporter SLC26A2 to the unexpected field of collagen secretion
            and proteostasis. Our findings will facilitate the understanding of
            genotype-phenotype relationships of SLC26A2-related
            chondrodysplasias and accelerate the development of drug therapy
            against ACG1B and AO2.
REFERENCE   6  (bases 1 to 3863)
  AUTHORS   Kobayashi,T., Sugimoto,T., Saijoh,K., Fukase,M. and Chihara,K.
  TITLE     Cloning of mouse diastrophic dysplasia sulfate transporter gene
            induced during osteoblast differentiation by bone morphogenetic
            protein-2
  JOURNAL   Gene 198 (1-2), 341-349 (1997)
   PUBMED   9370300
REFERENCE   7  (bases 1 to 3863)
  AUTHORS   Kobayashi,T., Sugimoto,T., Saijoh,K., Fujii,M. and Chihara,K.
  TITLE     Cloning and characterization of the 5'-flanking region of the mouse
            diastrophic dysplasia sulfate transporter gene
  JOURNAL   Biochem Biophys Res Commun 238 (3), 738-743 (1997)
   PUBMED   9325159
REFERENCE   8  (bases 1 to 3863)
  AUTHORS   Bassett,D.E. Jr., Boguski,M.S., Spencer,F., Reeves,R., Kim,S.,
            Weaver,T. and Hieter,P.
  TITLE     Genome cross-referencing and XREFdb: implications for the
            identification and analysis of genes mutated in human disease
  JOURNAL   Nat Genet 15 (4), 339-344 (1997)
   PUBMED   9090377
REFERENCE   9  (bases 1 to 3863)
  AUTHORS   Makalowski,W., Zhang,J. and Boguski,M.S.
  TITLE     Comparative analysis of 1196 orthologous mouse and human
            full-length mRNA and protein sequences
  JOURNAL   Genome Res 6 (9), 846-857 (1996)
   PUBMED   8889551
REFERENCE   10 (bases 1 to 3863)
  AUTHORS   Hastbacka,J., de la Chapelle,A., Mahtani,M.M., Clines,G.,
            Reeve-Daly,M.P., Daly,M., Hamilton,B.A., Kusumi,K., Trivedi,B.,
            Weaver,A. et al.
  TITLE     The diastrophic dysplasia gene encodes a novel sulfate transporter:
            positional cloning by fine-structure linkage disequilibrium mapping
  JOURNAL   Cell 78 (6), 1073-1087 (1994)
   PUBMED   7923357
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK052942.1 and AC148012.5.
            
            On Dec 20, 2006 this sequence version replaced NM_007885.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D42049.1, BC028345.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2636              AK052942.1         2-2637
            2637-3863           AC148012.5         55095-56321
FEATURES             Location/Qualifiers
     source          1..3863
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 34.41 cM"
     gene            1..3863
                     /gene="Slc26a2"
                     /gene_synonym="Dtd; ST-OB"
                     /note="solute carrier family 26 (sulfate transporter),
                     member 2"
                     /db_xref="GeneID:13521"
                     /db_xref="MGI:MGI:892977"
     exon            1..199
                     /gene="Slc26a2"
                     /gene_synonym="Dtd; ST-OB"
                     /inference="alignment:Splign:2.1.0"
     exon            200..335
                     /gene="Slc26a2"
                     /gene_synonym="Dtd; ST-OB"
                     /inference="alignment:Splign:2.1.0"
     exon            336..1058
                     /gene="Slc26a2"
                     /gene_synonym="Dtd; ST-OB"
                     /inference="alignment:Splign:2.1.0"
     CDS             360..2579
                     /gene="Slc26a2"
                     /gene_synonym="Dtd; ST-OB"
                     /note="solute carrier family 26 member 2; diastrophic
                     dysplasia protein homolog"
                     /codon_start=1
                     /product="sulfate transporter"
                     /protein_id="NP_031911.1"
                     /db_xref="CCDS:CCDS29282.1"
                     /db_xref="GeneID:13521"
                     /db_xref="MGI:MGI:892977"
                     /translation="MSSENKEQHDLSPRDLPEEAFGFPSELPLETQRRSGTDLRQSET
                     GHGRRAFRRIHMELREKPDTDIKQFVIRELQKSCQCSAAKVRDGAFDFFPVLRWLPKY
                     DLKKNILGDVMSGLIVGILLVPQSIAYSLLAGQEPIYGLYTSFFASIIYFLFGTSRHI
                     SVGIFGILCLMIGEVVDRELHKACPDTDATSSSIAVFSSGCVVVNHTLDGLCDKSCYA
                     IKIGSTVTFMAGVYQVAMGFFQVGFVSVYLSDALLSGFVTGASFTILTSQAKYLLGLS
                     LPRSHGVGSVITTWIHIFRNIRNTNICDLITSLLCLLVLVPSKELNEHFKDKLKAPIP
                     VELIVVVAATLASHFGKLNGNYNSSIAGHIPTGFMPPKAPDWSLIPNVAVDAIAISII
                     GFAITVSLSEMFAKKHGYTVKANQEMYAIGFCNIIPSFFHCITTSAALAKTLVKESTG
                     CQTQLSAIVTALVLLLVLLVIAPLFYSLQKCVLGVITIVNLRGALLKFRDLPKMWRLS
                     RMDTVIWFVTMLSSALLSTEIGLLVGVCFSMFCVILRTQKPKNSLLGLEEESETFESI
                     STYKNLRSKSGIKVFRFIAPLYYINKECFKSALYKKALNPVLVKAAWKKAAKRKLKEE
                     MVTFRGDPDEVSMQLSHDPLEVHTIVIDCSAIQFLDTAGIHTLKEVRRDYEAVGIQVL
                     LAQCNPSVRDSLARGEYCKKEEETLLFYSLSEAVAFAEDSQNQKGVCVVNGLSLSGD"
     exon            1059..3863
                     /gene="Slc26a2"
                     /gene_synonym="Dtd; ST-OB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2618..2623
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc26a2"
                     /gene_synonym="Dtd; ST-OB"
                     /note="hexamer: AATAAA"
     polyA_site      2636
                     /gene="Slc26a2"
                     /gene_synonym="Dtd; ST-OB"
                     /note="major polyA site"
     regulatory      3231..3236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc26a2"
                     /gene_synonym="Dtd; ST-OB"
                     /note="hexamer: AAGAAA"
     polyA_site      3249
                     /gene="Slc26a2"
                     /gene_synonym="Dtd; ST-OB"
                     /note="major polyA site"
ORIGIN      
        1 cttccgcacc tttactccgg tgactgtggt ccgctgcctc ctcctcgggg ccgggccatg
       61 ggcggggacg gttgccgggt attaaaggga ggctcgcccg cggctggact gcctgtaccc
      121 gtgcggcggc gatcccgcag cccagtcttg cgggaggacg cgccgcggga gcccgtgtac
      181 ggcggcccgg agcgttaagg cgtaaaattt ctgctttaaa gacatcatct tcaggattcc
      241 atcaattcca ggacatgtgc tgtaattcct gtctttgctc ctccgtaagt gatgcgtggc
      301 tgtcttcaga agtgccctct gagcagcagt gattggaagt gaaccatctg tctcctgaaa
      361 tgtcttcaga aaataaagag cagcatgacc tctcaccgag ggacttacct gaagaagcct
      421 ttggtttccc atctgagctc cccctggaga ctcaaagaag gtcaggcact gacttgaggc
      481 agtctgagac cggtcatggc cggagagctt tccgtaggat ccacatggag ctccgtgaga
      541 aaccagacac agacatcaaa cagtttgtca tcagagagct ccagaagagt tgccagtgca
      601 gcgcagccaa agtcagagac ggggcttttg atttctttcc tgttttgcgg tggctcccaa
      661 aatatgacct gaagaaaaac attttaggtg atgtgatgtc tggcctgatt gtgggtatcc
      721 tgttggtgcc ccagtccatt gcttactccc tgctggctgg ccaggagcct atatatggtc
      781 tatatacatc attttttgcc agcattattt atttcctgtt tggtacatcc cgccacatct
      841 ctgtgggcat ttttggaata ctgtgcctta tgattggtga ggttgttgac cgagaactac
      901 ataaagcctg ccctgacact gatgctacgt catcttcgat agcagtgttt tcaagtggat
      961 gtgtggttgt aaaccataca ttagacggac tctgtgataa aagctgctat gcaattaaaa
     1021 ttggcagcac tgtgaccttc atggctggag tttatcaggt agcaatgggc ttctttcaag
     1081 tgggctttgt ctctgtctac ctctccgacg ccttgctgag cgggtttgtc actggcgcct
     1141 ccttcaccat cctcacgtct caggccaagt acctccttgg gctgagcctt cctcggagtc
     1201 atggtgtcgg ctcagtcatt actacctgga tccacatctt cagaaacatc cgtaacacca
     1261 acatctgtga tctcatcacc agccttttat gtcttctggt cctcgtgcca tccaaagaac
     1321 tcaatgagca cttcaaggac aagctcaagg ctccaattcc ggtcgagctc attgtcgttg
     1381 tggcggccac attggcttct cattttggaa aactaaatgg gaattacaat tccagtattg
     1441 ctggacacat tcccactggg tttatgccac ccaaagcacc agactggagc ctcattccta
     1501 atgtggctgt agatgcaata gctatttcta tcattggttt tgctatcact gtatcacttt
     1561 ctgagatgtt tgccaagaaa catggctaca cggtcaaagc aaaccaagaa atgtatgcca
     1621 ttggcttttg caatatcata ccttccttct tccactgcat aactactagt gcagctcttg
     1681 caaagacatt ggttaaagag tcaacaggct gccagacgca gctgtcagct atagtgacag
     1741 cccttgtcct tttgttggtc cttctggtaa tagctccttt attctattcc cttcaaaaat
     1801 gtgtccttgg tgtgatcact attgtaaatc tccggggcgc acttctgaaa tttagagacc
     1861 tgccaaagat gtggaggcta agcagaatgg atacagttat ctggtttgtg actatgctgt
     1921 cctccgctct gttaagcact gaaataggcc tgctggttgg ggtttgtttt tcaatgttct
     1981 gtgtgatcct ccgtactcag aagccaaaga attcactgct tggtttagaa gaagaatctg
     2041 aaacctttga atccatttcc acttacaaga accttcggag caagtccggc atcaaggttt
     2101 tccgcttcat agcccctctc tactacataa acaaagagtg ctttaaatca gctttgtaca
     2161 agaaagctct taacccagtc ttggtaaagg cagcttggaa aaaggcagca aagagaaaac
     2221 tcaaagaaga aatggtgacc tttcgtgggg acccggatga agtttcaatg cagctttccc
     2281 atgatccctt ggaggtgcac actatcgtga tcgactgtag tgccatacag tttttagaca
     2341 cagcaggaat ccacacactg aaagaagttc gccgggatta tgaagccgtt gggatccagg
     2401 ttttactggc gcagtgcaat ccttctgtga gggattcctt ggccagagga gaatattgca
     2461 aaaaggaaga ggaaaccctt ctcttctaca gtctgtctga agcagtagcc tttgcagaag
     2521 actctcagaa tcagaaaggg gtgtgtgttg tcaacggtct gagtctctct ggtgactgag
     2581 aaagttaatc tgcatcttcc tggtaactgg gcaagttaat aaaaggaaga atagtgtctt
     2641 gcctgtttca atgtggaacg ttttctactg tgaaaggaga aagccatgca cacttgaaat
     2701 agttctttga agctagcctt tcgatagtct catgagcttt tggttgggta gaatcaaaaa
     2761 gaagtaaatg ttatggcttc cggcttatgc agatagcatt cttggggtac agtataaatg
     2821 gaatggaact gtaaagcagc ccccaactta agtgccttac tttaggaact atatatctga
     2881 actctgtcct tcaggatgca gagcgaggta acgccgggct ttgcctgaca cacactgcag
     2941 ctctagagag gggacgaaga aaggaggcag cgctgctggt acagaggctg gaaaagcaca
     3001 agggcctacg gaccctgctg ctgtgtctct gttaggattt tgctccccaa acagtaagat
     3061 ctcttgctga tagttagaaa tcatcatttt tcctttcctt catgcaagaa ccgtgccata
     3121 gtctcataag agaatctgac ctcacaacca gcctgatact attgtataga acccatattg
     3181 taaatatcta atgtcttaag tcttcccttt ttatttagaa taagtgggta aagaaagagt
     3241 ttaaaaccag aatggcagtg gaagtctttg tctctcttca tctctgtctt tgtctttgag
     3301 aacttgtctg ctgttacgcc ctgtctcacc tttgacttat tcttgtcccc cccccccccc
     3361 cccccccggg aatccttgct gagttggcat ctctgaacac cagtggcaga gttgtcagag
     3421 aaagcagagt attggctcag cagcttccta acagcactgt gaatgggctt gtggtgcaca
     3481 ttcaaggaga gatcgtaaaa aaaaaaaaaa gaatgaacga cagttcccct taagaaatgc
     3541 caccctccca ccactggggc atcttaggca gtctttcttt atagaagtgg ctgtttatgg
     3601 atgagtacag aggtgatggg gtgcttccaa aaggacatcc atcattactt tgcagatggg
     3661 aaagcagtgt tgatgcttat ggccacgcat cctgttggca tatgataaat attgatgcca
     3721 gtgaccactt ttaatgcagg acttggagcc ttcacagggc cctagatgta ctggggtgtc
     3781 attctcagga gctggctgca ggttaggagt tgagtagttt cttcagaaaa ggacttcaac
     3841 aggtaagaaa agttctccca agt
//
