LOCUS       NM_174870               3608 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus solute carrier family 26 (sulfate transporter), member
            1 (Slc26a1), transcript variant 2, mRNA.
ACCESSION   NM_174870
VERSION     NM_174870.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3608)
  AUTHORS   Yoshida,Y., Inubushi,T., Yokoyama,M., Nag,P., Sasaki,J.I., Oka,A.,
            Murotani,T., Kani,R., Shiraishi,Y., Kurosaka,H., Takahata,Y.,
            Nishimura,R., Imazato,S., Papagerakis,P. and Yamashiro,T.
  TITLE     Slc26a2-mediated sulfate metabolism is important in tooth
            development
  JOURNAL   Dis Model Mech 17 (12) (2024)
   PUBMED   39508796
REFERENCE   2  (bases 1 to 3608)
  AUTHORS   Meng,Z., Qiao,Y., Xue,J., Wu,T., Gao,W., Huang,X., Lv,J., Liu,M.
            and Shen,C.
  TITLE     Slc26a1 is not essential for spermatogenesis and male fertility in
            mice
  JOURNAL   PeerJ 11, e16558 (2023)
   PUBMED   38111663
  REMARK    GeneRIF: Slc26a1 is not essential for spermatogenesis and male
            fertility in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3608)
  AUTHORS   Whittamore,J.M., Stephens,C.E. and Hatch,M.
  TITLE     Absence of the sulfate transporter SAT-1 has no impact on oxalate
            handling by mouse intestine and does not cause hyperoxaluria or
            hyperoxalemia
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 316 (1), G82-G94 (2019)
   PUBMED   30383413
  REMARK    GeneRIF: that SAT-1 has a major role in oxalate excretion via the
            intestine
REFERENCE   4  (bases 1 to 3608)
  AUTHORS   Yin,K., Guo,J., Lin,W., Robertson,S.Y.T., Soleimani,M. and
            Paine,M.L.
  TITLE     Deletion of Slc26a1 and Slc26a7 Delays Enamel Mineralization in
            Mice
  JOURNAL   Front Physiol 8, 307 (2017)
   PUBMED   28559854
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3608)
  AUTHORS   Hasnain,S.Z., Dawson,P.A., Lourie,R., Hutson,P., Tong,H.,
            Grencis,R.K., McGuckin,M.A. and Thornton,D.J.
  TITLE     Immune-driven alterations in mucin sulphation is an important
            mediator of Trichuris muris helminth expulsion
  JOURNAL   PLoS Pathog 13 (2), e1006218 (2017)
   PUBMED   28192541
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3608)
  AUTHORS   Dawson,P.A., Rakoczy,J. and Simmons,D.G.
  TITLE     Placental, renal, and ileal sulfate transporter gene expression in
            mouse gestation
  JOURNAL   Biol Reprod 87 (2), 43 (2012)
   PUBMED   22674389
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3608)
  AUTHORS   Ko,N., Knauf,F., Jiang,Z., Markovich,D. and Aronson,P.S.
  TITLE     Sat1 is dispensable for active oxalate secretion in mouse duodenum
  JOURNAL   Am J Physiol Cell Physiol 303 (1), C52-C57 (2012)
   PUBMED   22517357
  REMARK    GeneRIF: study concludes that a DIDS-sensitive basolateral
            transporter is involved in mediating oxalate secretion across mouse
            duodenum, but Sat1 itself is dispensable for this process
REFERENCE   8  (bases 1 to 3608)
  AUTHORS   Dawson,P.A., Russell,C.S., Lee,S., McLeay,S.C., van Dongen,J.M.,
            Cowley,D.M., Clarke,L.A. and Markovich,D.
  TITLE     Urolithiasis and hepatotoxicity are linked to the anion transporter
            Sat1 in mice
  JOURNAL   J Clin Invest 120 (3), 706-712 (2010)
   PUBMED   20160351
  REMARK    GeneRIF: Sat1 regulates both oxalate and sulfate homeostasis and
            may be critical to the development of calcium oxalate urolithiasis
            and hepatotoxicity.
REFERENCE   9  (bases 1 to 3608)
  AUTHORS   Lee,A., Beck,L. and Markovich,D.
  TITLE     The mouse sulfate anion transporter gene Sat1 (Slc26a1): cloning,
            tissue distribution, gene structure, functional characterization,
            and transcriptional regulation thyroid hormone
  JOURNAL   DNA Cell Biol 22 (1), 19-31 (2003)
   PUBMED   12590734
  REMARK    GeneRIF: first characterization of the structure and regulation of
            the Sat1 gene encoding a SO(4)(2-)/chloride/oxalate anion
            transporter
REFERENCE   10 (bases 1 to 3608)
  AUTHORS   Xie,Q., Welch,R., Mercado,A., Romero,M.F. and Mount,D.B.
  TITLE     Molecular characterization of the murine Slc26a6 anion exchanger:
            functional comparison with Slc26a1
  JOURNAL   Am J Physiol Renal Physiol 283 (4), F826-F838 (2002)
   PUBMED   12217875
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143528.1 and AC161813.2.
            
            On Jul 17, 2015 this sequence version replaced NM_174870.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream start codon, compared to variant 1. The encoded isoform
            (2) has a shorter N-terminus than isoform 1. Variants 2 and 3
            encode the same isoform (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY093420.1, AK143528.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2935              AK143528.1         13-2947
            2936-3608           AC161813.2         15930-16602
FEATURES             Location/Qualifiers
     source          1..3608
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 53.24 cM"
     gene            1..3608
                     /gene="Slc26a1"
                     /gene_synonym="Sat1"
                     /note="solute carrier family 26 (sulfate transporter),
                     member 1"
                     /db_xref="GeneID:231583"
                     /db_xref="MGI:MGI:2385894"
     exon            1..127
                     /gene="Slc26a1"
                     /gene_synonym="Sat1"
                     /inference="alignment:Splign:2.1.0"
     exon            128..745
                     /gene="Slc26a1"
                     /gene_synonym="Sat1"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..2269
                     /gene="Slc26a1"
                     /gene_synonym="Sat1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     sulfate anion transporter 1"
                     /codon_start=1
                     /product="sulfate anion transporter 1 isoform 2"
                     /protein_id="NP_777359.3"
                     /db_xref="CCDS:CCDS19517.1"
                     /db_xref="GeneID:231583"
                     /db_xref="MGI:MGI:2385894"
                     /translation="MDASPEPQQKGGTLVLVRRQPPVSQGLLETLKARLKKSCTCSMP
                     CAQALVQGLFPAIHWLPQYRLKEYLAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSL
                     YTSFFANLIYFLMGTSRHVNVGIFSLLCLMVGQVVDRELQLAGFDPSQDSLGPKNNDS
                     TLNNSATTLIIGLQDCRRDCYAIRVATALTLMAGLYQVLMGILRLGFVSTYLSQPLLD
                     GFAMGASVTILTSQAKHMLGVQIPRHQGLGMVVHTWLSLLQNVGQANICDVVTSALCL
                     GVLLAAKELSDRYRHRLKVPIPTELFVIVVATIVSHFGQLHTRFDSRVAGNIPTGFVA
                     PQVPDPKIMWRVALDAMSLALVGSAFSISLAEMFARSHGYSVSANQELLAVGCCNVLP
                     AFFHCFATSAALSKTLVKIATGCQTQLSSVVSAAVVLLVLLVLAPLFHDLQRCVLACI
                     IVVSLRGALRKVKDLPQLWRLSPADALVWVATAATCVLVSTEAGLLAGVFFSLLSLAG
                     RTQRPRAALLARIGDSTFYEDAAEFEGLLPPPEVRVFRFTGPLYYANKDFFLRSLYRL
                     TGLDAGHSATRKDQGPEVGVSNRSLVDGKDLGSVSSGAGLVVPLAFGFHTVVIDCAPL
                     LFLDVAGMATLKDLRRDYRALDITLLLACCSPSVRDTLRKGGFLGEEQGAENELLFPS
                     VHSAVEAACARREELLAADSAL"
     exon            746..3608
                     /gene="Slc26a1"
                     /gene_synonym="Sat1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3493..3498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc26a1"
                     /gene_synonym="Sat1"
                     /note="hexamer: GATAAA"
     polyA_site      3516
                     /gene="Slc26a1"
                     /gene_synonym="Sat1"
                     /note="major polyA site"
ORIGIN      
        1 atcagcctca gaggtgcctg ccaaccagct ctctgtctgt taagccagag tgattggagg
       61 atcagcccac cagcaaactg ctgcccctgg atattgcaaa gccttcagag ccggccaggt
      121 gccccagata agccaaagag cctggtgtga caggatggat gcttctcctg agccccaaca
      181 gaagggtggg acactggtac tggtccgacg gcagccccct gtgtcccagg gcttgctgga
      241 aacactgaag gccaggctga agaagagctg cacctgcagt atgccatgtg ctcaggctct
      301 ggtgcagggt ctgtttcctg ccatacactg gctgccccag taccgcctta aggaatacct
      361 agcaggtgat gtcatgtcag gattggtcat tggcattatc ctggtgccac aggccatagc
      421 ctactcactg ctggctgggt tacaacccat ctatagcctc tacacttcct tctttgccaa
      481 cctgatctac ttcctcatgg gcacctcccg ccatgttaat gtgggcatct tcagcctgct
      541 gtgtctcatg gtgggtcagg tggtggacag agaactccag ttggctggct ttgacccttc
      601 ccaggattct ctagggccca agaacaatga cagcaccctc aacaactcag ctacaacact
      661 gatcattggg ctacaggact gcagacggga ctgctatgcc attcgggttg ccactgccct
      721 tactctgatg gccgggcttt atcaggtcct catgggtatc ctccggctgg gcttcgtgtc
      781 tacctatctc tcacaaccac tgctcgatgg ctttgctatg ggagcttctg tgaccatctt
      841 gacttctcag gcaaaacaca tgctgggtgt gcagatccct cggcaccagg gcctaggcat
      901 ggtggtccac acatggttga gcttgctgca gaatgtggga caggccaaca tatgtgatgt
      961 ggtcaccagt gccctgtgcc taggagtgct gctggcagct aaggaactct cagatcgcta
     1021 ccgacaccgt ctgaaggtgc caatacccac agagttattt gttattgtgg tggccacaat
     1081 tgtgtcccat tttggacagc tccatacacg gtttgactcg agggtggctg gcaacattcc
     1141 cactggtttt gtggccccac aggtaccaga ccctaagata atgtggcgtg tggccctgga
     1201 tgccatgtcc ctggccctcg tgggctcagc cttctccatc tccttggcag aaatgtttgc
     1261 ccgtagtcat ggctactctg tcagtgccaa ccaagagctg ctagctgtgg gctgctgcaa
     1321 tgtgctgcct gccttcttcc actgttttgc cactagtgct gctctgtcca aaactctggt
     1381 gaagatagcc actggctgcc agacccagtt gtccagtgtg gtcagtgccg ctgtggtgtt
     1441 gctggtgctg ctggtgctgg ctccactgtt tcatgatctg cagcgatgtg tgctagcttg
     1501 tatcattgtt gtcagcctgc ggggggcgct gcgcaaggtg aaggatctcc cacaactttg
     1561 gcggctaagc cctgccgatg cactggtctg ggtggctact gcagctacct gtgtgctagt
     1621 cagcaccgag gctggactat tagctggagt gttcttctcc ctgcttagcc tggcaggccg
     1681 tacacagcgt ccacgggctg cccttcttgc ccgaattgga gactccacct tctatgagga
     1741 tgctgctgaa tttgagggcc tcctgccccc acctgaggtg cgagtgttcc gtttcacagg
     1801 tccactttac tacgccaaca aggacttctt ccttcggtct ctctacagac tcacagggtt
     1861 ggatgcaggg cactcagcca ccaggaagga tcagggcccg gaggtaggtg tcagtaacag
     1921 gagtcttgtc gatggcaagg atctgggttc agtgagcagt ggggctgggc tggtggtacc
     1981 cctggcattt ggtttccaca cagtggtcat tgactgtgca ccactgctgt tcctggatgt
     2041 ggctggcatg gccacattga aagacctccg cagagactac agggccttgg acatcaccct
     2101 gcttctggct tgctgcagtc cctcggtgag agacacgttg agaaaagggg gcttccttgg
     2161 ggaagaacag ggagctgaaa atgagctgct attccccagt gtgcacagtg ctgtggaggc
     2221 tgcatgtgcc cgccgtgagg agctgctggc tgctgactct gccctctagc agggccctca
     2281 agagcccaca cctgtgttca caagccagtg ctctgtagga gtggtgtgaa tgataaagtc
     2341 attagagata tacccttgga ccacctttgc cctggagaag ccagggaact ccaactaagg
     2401 aaaggaaagt gcagcaccct taatacattc aaggattcca aaccaagggt tcagtgatct
     2461 agactctcta cctctgagtc cactgctgcc ccctggtgcc tgttcaacca gggtagctgt
     2521 acccacacac atgatccctc agcccacaca gtgcccagtt tgatatacta tgttgtcatc
     2581 ttatctgaaa cagaatcctg caaattatat gacctccaag atgccaaaag gacactttcc
     2641 cattccctgt accaccaggt accagatatg agctggatat atggccaagc ctcaagggtc
     2701 tgaatttctg aaaggcctcc tcatgccagg tgctcatctt gactggaccc ttgcaaaggc
     2761 agccacctgc tccagagcca cagtccagtg tcactttcta aggcaatgtg acttatataa
     2821 cctcaacctg accttggggc acaatgtctc tatacagctt atactggtaa ccacaatgtg
     2881 gtatatgtat ggtacaaagc cagacacagt agaccctaac cccattcagt acttctaaaa
     2941 aaaaacaaaa aacaaaacat caggaggaaa ccacctgtgc tccatccagg gtctgccttt
     3001 ggcatagcca agcagacatt ctcctcttct gcccaacagg atgctctaac aggaagcaca
     3061 gccccagccc tatgccctac catgaccccc cccacccccg cgacccccac agcccagcac
     3121 tgtgtcccac agctggcccc gacaaggtca gatccaccac ctcagcatct ctgtaaaaca
     3181 agctctgacc agcaactccc agggtaccca cttccgcatc acccacctgg ctgtgatgag
     3241 atccagcagc cagtgtatcc ggacctgctc aatgccactg tgaggtacgg cacctatgta
     3301 ggcaaggttc agttgctggt cccaactaag gtcgtactgg tcagcctggt cgtgaggcag
     3361 tggggggcta gggacaggac aaagaagtga agtgtttgtc ctaaacaggg gcctgcagca
     3421 tacccgattt tgtacatgta ttacctaact gcctagaccc ttgtggatga attatgtgtc
     3481 tccagagtgt acgataaaat agcccattca ccagaatgtt ctacagtctt gcttgggggc
     3541 agggtgaggg gagctcccac aggacacaga accgtattct aaatagagca tctgcctgcc
     3601 ataaaaaa
//
