LOCUS       NM_001012310            1609 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus solute carrier family 25, member 47 (Slc25a47), mRNA.
ACCESSION   NM_001012310 XM_127129
VERSION     NM_001012310.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1609)
  AUTHORS   Pontanari,F., Demagny,H., Faure,A., Li,X., Benegiamo,G., Jalil,A.,
            Perino,A., Auwerx,J. and Schoonjans,K.
  TITLE     Wars1 downregulation in hepatocytes induces mitochondrial stress
            and disrupts metabolic homeostasis
  JOURNAL   Metabolism 162, 156061 (2025)
   PUBMED   39515413
REFERENCE   2  (bases 1 to 1609)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1609)
  AUTHORS   Cheng,L., Deepak,R.N.V.K., Wang,G., Meng,Z., Tao,L., Xie,M.,
            Chi,W., Zhang,Y., Yang,M., Liao,Y., Chen,R., Liang,Y., Zhang,J.,
            Huang,Y., Wang,W., Guo,Z., Wang,Y., Lin,J.D., Fan,H. and Chen,L.
  TITLE     Hepatic mitochondrial NAD + transporter SLC25A47 activates
            AMPKalpha mediating lipid metabolism and tumorigenesis
  JOURNAL   Hepatology 78 (6), 1828-1842 (2023)
   PUBMED   36804859
  REMARK    GeneRIF: Hepatic mitochondrial NAD + transporter SLC25A47 activates
            AMPKalpha mediating lipid metabolism and tumorigenesis.
REFERENCE   4  (bases 1 to 1609)
  AUTHORS   Yook,J.S., Taxin,Z.H., Yuan,B., Oikawa,S., Auger,C., Mutlu,B.,
            Puigserver,P., Hui,S. and Kajimura,S.
  TITLE     The SLC25A47 locus controls gluconeogenesis and energy expenditure
  JOURNAL   Proc Natl Acad Sci U S A 120 (9), e2216810120 (2023)
   PUBMED   36812201
REFERENCE   5  (bases 1 to 1609)
  AUTHORS   Bresciani,N., Demagny,H., Lemos,V., Pontanari,F., Li,X., Sun,Y.,
            Li,H., Perino,A., Auwerx,J. and Schoonjans,K.
  TITLE     The Slc25a47 locus is a novel determinant of hepatic mitochondrial
            function implicated in liver fibrosis
  JOURNAL   J Hepatol 77 (4), 1071-1082 (2022)
   PUBMED   35714811
  REMARK    GeneRIF: The Slc25a47 locus is a novel determinant of hepatic
            mitochondrial function implicated in liver fibrosis.
REFERENCE   6  (bases 1 to 1609)
  AUTHORS   Jin,X., Liu,J., Chen,Y.P., Xiang,Z., Ding,J.X. and Li,Y.M.
  TITLE     Effect of miR-146 targeted HDMCP up-regulation in the pathogenesis
            of nonalcoholic steatohepatitis
  JOURNAL   PLoS One 12 (3), e0174218 (2017)
   PUBMED   28346483
  REMARK    GeneRIF: Increased HDMCP expression was identified in nonalcoholic
            steatohepatitis animal model and HFFA-72h cultured L02 cell.
            Moreover, under regulation of miR-146, nonalcoholic steatohepatitis
            alleviation was achieved after HDMCP downregulation in both in vivo
            and in vitro, according to the declination of steatosis and
            inflammation related markers.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1609)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 1609)
  AUTHORS   Tan,M.G., Ooi,L.L., Aw,S.E. and Hui,K.M.
  TITLE     Cloning and identification of hepatocellular carcinoma
            down-regulated mitochondrial carrier protein, a novel
            liver-specific uncoupling protein
  JOURNAL   J Biol Chem 279 (43), 45235-45244 (2004)
   PUBMED   15322095
  REMARK    GeneRIF: hepatocellular carcinoma down-regulated mitochondrial
            carrier protein is a novel liver-specific uncoupling protein
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK149369.1 and AI173533.1.
            
            On Apr 18, 2009 this sequence version replaced NM_001012310.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089616.1, AK149369.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1577              AK149369.1         7-1583
            1578-1609           AI173533.1         1-32                c
FEATURES             Location/Qualifiers
     source          1..1609
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 59.65 cM"
     gene            1..1609
                     /gene="Slc25a47"
                     /gene_synonym="HDMCP"
                     /note="solute carrier family 25, member 47"
                     /db_xref="GeneID:104910"
                     /db_xref="MGI:MGI:2144766"
     exon            1..79
                     /gene="Slc25a47"
                     /gene_synonym="HDMCP"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..984
                     /gene="Slc25a47"
                     /gene_synonym="HDMCP"
                     /note="mitochondrial hepatocellular
                     carcinoma-downregulated carrier protein; hepatocellular
                     carcinoma down-regulated mitochondrial carrier homolog;
                     mitochondrial NAD(+) transporter SLC25A47"
                     /codon_start=1
                     /product="solute carrier family 25 member 47"
                     /protein_id="NP_001012310.2"
                     /db_xref="CCDS:CCDS26165.1"
                     /db_xref="GeneID:104910"
                     /db_xref="MGI:MGI:2144766"
                     /translation="MDFVAGAIGGVCGVAVGYPLDTVKVRIQTEAKYAGIWHCIRDTY
                     RQERVWGFYRGLSLPVCTVSLVSSVSFGTYHHCLAHICRFRYGSTDAKPTKADITLSG
                     CASGLVRVFLTSPTEVAKVRLQTQTQAQTQQRRSSASWTSGAPALCPTPTACLEPRPK
                     YSGPLHCLVTVAREEGLRGLYKGSSALLLREGHSFATYFLSYAMLCEWLTPAGHSQPD
                     VLGVLVAGGCAGVLAWAVATPMDVIKSRLQADGQGQHRYRGLLHCVVTSVREEGPRVL
                     FKGLALNCCRAFPVNMVVFVAYEAVLRLTQSLLT"
     exon            80..123
                     /gene="Slc25a47"
                     /gene_synonym="HDMCP"
                     /inference="alignment:Splign:2.1.0"
     exon            124..195
                     /gene="Slc25a47"
                     /gene_synonym="HDMCP"
                     /inference="alignment:Splign:2.1.0"
     exon            196..378
                     /gene="Slc25a47"
                     /gene_synonym="HDMCP"
                     /inference="alignment:Splign:2.1.0"
     exon            379..703
                     /gene="Slc25a47"
                     /gene_synonym="HDMCP"
                     /inference="alignment:Splign:2.1.0"
     exon            704..1580
                     /gene="Slc25a47"
                     /gene_synonym="HDMCP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1557..1562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a47"
                     /gene_synonym="HDMCP"
                     /note="hexamer: AATAAA"
     polyA_site      1580
                     /gene="Slc25a47"
                     /gene_synonym="HDMCP"
                     /note="major polyA site"
ORIGIN      
        1 agtgtggcat tggcagtaac accggaaacc ttctcatttt ctgtgctgtc catggatttt
       61 gttgctgggg ccattggagg agtctgcggt gttgctgtgg gctaccctct ggatacagtg
      121 aaggtcagaa tccagacgga ggccaaatac gcaggcatct ggcactgcat ccgggacacg
      181 tatcgtcaag agcgggtgtg gggcttctac aggggcctct cactgcccgt gtgcacagtg
      241 tccctggtgt cgtctgtatc ttttggtacc taccaccact gcctggctca catctgccgc
      301 ttccggtacg gcagcacgga cgccaagccc accaaggctg atatcacact ctcaggatgt
      361 gcctctggtc ttgtccgggt gttcctgacg tcacccactg aggtggccaa agtccgcctg
      421 cagacacaga cccaagctca gacacagcag cggcggtcct cggcctcctg gacatctggg
      481 gctcccgctt tgtgtcccac acccactgct tgcttggagc ccaggcctaa gtacagtggg
      541 ccactgcact gtttagtcac agtggctcga gaggaggggc ttcggggact ctacaagggc
      601 agctcggctc tgctccttcg tgagggtcac tcctttgcca cctactttct ctcctatgct
      661 atgctctgcg agtggctcac ccctgctggc catagtcagc cagatgtctt aggtgtgttg
      721 gtggctggag gctgcgctgg ggtcctggcc tgggccgtgg ccacccccat ggatgtgatc
      781 aagtcacgcc tgcaggcgga tgggcagggc cagcatcgct accggggcct cctgcactgt
      841 gtggtgacca gtgtacggga ggagggtccc agggtgctct tcaagggact ggcactcaac
      901 tgctgtcgtg cctttcctgt taacatggtg gtctttgtgg cgtatgaggc tgtgctgagg
      961 ctcacgcaga gcctgctcac ataggcacca gtcagcaaca tccacgtcac acagcagccg
     1021 gaggcaaagg ggagaacggg taggctcagg agcccacggg gctgtcacca gagcagcaga
     1081 ggaccttctg tgctgtgact gaggggaggc ctgagctcgg acagcccagc tgctgaccac
     1141 aaaatcaggg agttgatctg ccatctgctt gggggtcatg agtcaggatt gtgtgggtct
     1201 gcttgatgag gacatgtgtc acttggagtc attttcaccg aacaaagaac tgttcattcc
     1261 tgcttgtact gccatgccca tttcagagca taccttcacc aacccctctg ggtgctaggc
     1321 caacctcgaa acccagttct actcagcatc caccgattca ctgtcccttt agagacaggc
     1381 tagggaccag acagcaagct ggttacatct gactacaggc tgggctggtt ccctgtccta
     1441 ggctactcag aggaccgagg aatcggtgca gggcatcacc atcgcatacc cacaccacct
     1501 gtaggtgctg tgctggccac atgaagatcc tggaacctgg gtcaggggtg gctgttaata
     1561 aatgtttctg tggttgctca aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
