LOCUS       NM_026165               4403 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus solute carrier family 25, member 46 (Slc25a46),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_026165
VERSION     NM_026165.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4403)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4403)
  AUTHORS   Hwang,I., Kim,B.S., Ko,H.R., Cho,S., Lee,H.Y., Cho,S.W., Ryu,D.,
            Shim,S. and Ahn,J.Y.
  TITLE     Cerebellar dysfunction and schizophrenia-like behavior in
            Ebp1-deficient mice
  JOURNAL   Mol Psychiatry 27 (4), 2030-2041 (2022)
   PUBMED   35165395
REFERENCE   3  (bases 1 to 4403)
  AUTHORS   Yang,L., Slone,J., Li,Z., Lou,X., Hu,Y.C., Queme,L.F.,
            Jankowski,M.P. and Huang,T.
  TITLE     Systemic administration of AAV-Slc25a46 mitigates mitochondrial
            neuropathy in Slc25a46-/- mice
  JOURNAL   Hum Mol Genet 29 (4), 649-661 (2020)
   PUBMED   31943007
REFERENCE   4  (bases 1 to 4403)
  AUTHORS   Li,Z., Peng,Y., Hufnagel,R.B., Hu,Y.C., Zhao,C., Queme,L.F.,
            Khuchua,Z., Driver,A.M., Dong,F., Lu,Q.R., Lindquist,D.M.,
            Jankowski,M.P., Stottmann,R.W., Kao,W.W.Y. and Huang,T.
  TITLE     Loss of SLC25A46 causes neurodegeneration by affecting
            mitochondrial dynamics and energy production in mice
  JOURNAL   Hum Mol Genet 26 (19), 3776-3791 (2017)
   PUBMED   28934388
REFERENCE   5  (bases 1 to 4403)
  AUTHORS   Terzenidou,M.E., Segklia,A., Kano,T., Papastefanaki,F.,
            Karakostas,A., Charalambous,M., Ioakeimidis,F., Papadaki,M.,
            Kloukina,I., Chrysanthou-Piterou,M., Samiotaki,M., Panayotou,G.,
            Matsas,R. and Douni,E.
  TITLE     Novel insights into SLC25A46-related pathologies in a genetic mouse
            model
  JOURNAL   PLoS Genet 13 (4), e1006656 (2017)
   PUBMED   28376086
  REMARK    GeneRIF: Our mutant mice provide a valid model for understanding
            the mechanistic basis of the complex SLC25A46-mediated pathologies,
            as well as for screening potential therapeutic interventions.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4403)
  AUTHORS   Duchesne,A., Vaiman,A., Castille,J., Beauvallet,C., Gaignard,P.,
            Floriot,S., Rodriguez,S., Vilotte,M., Boulanger,L., Passet,B.,
            Albaric,O., Guillaume,F., Boukadiri,A., Richard,L., Bertaud,M.,
            Timsit,E., Guatteo,R., Jaffrezic,F., Calvel,P., Helary,L.,
            Mahla,R., Esquerre,D., Pechoux,C., Liuu,S., Vallat,J.M.,
            Boichard,D., Slama,A. and Vilotte,J.L.
  TITLE     Bovine and murine models highlight novel roles for SLC25A46 in
            mitochondrial dynamics and metabolism, with implications for human
            and animal health
  JOURNAL   PLoS Genet 13 (4), e1006597 (2017)
   PUBMED   28376083
  REMARK    GeneRIF: we showed that the Slc25a46 disruption caused a
            fusion/fission imbalance and an abnormal mitochondrial architecture
            that disturbed mitochondrial metabolism. These data extended the
            range of phenotypes associated with Slc25a46 dysfunction. Moreover,
            this Slc25a46 knock-out mouse model should be useful to further
            elucidate the role of SLC25A46 in mitochondrial dynamics
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA319087.1, AK030346.1 and BY669800.1.
            
            On Oct 28, 2017 this sequence version replaced NM_026165.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA319087.1, AK030346.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                CA319087.1         1-28
            29-4399             AK030346.1         2-4372
            4400-4403           BY669800.1         410-413
FEATURES             Location/Qualifiers
     source          1..4403
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 17.79 cM"
     gene            1..4403
                     /gene="Slc25a46"
                     /gene_synonym="1200007B05Rik"
                     /note="solute carrier family 25, member 46"
                     /db_xref="GeneID:67453"
                     /db_xref="MGI:MGI:1914703"
     exon            1..402
                     /gene="Slc25a46"
                     /gene_synonym="1200007B05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1376
                     /gene="Slc25a46"
                     /gene_synonym="1200007B05Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mitochondrial outer membrane protein SLC25A46"
                     /codon_start=1
                     /product="mitochondrial outer membrane protein SLC25A46
                     isoform 1"
                     /protein_id="NP_080441.1"
                     /db_xref="CCDS:CCDS29110.1"
                     /db_xref="GeneID:67453"
                     /db_xref="MGI:MGI:1914703"
                     /translation="MHPRRPEGFDGLGYRGGVRDDPAFGGPFHARSFGSGTELGHWVT
                     TPPDIPGSRNLHWGEKSPSYGVPSAPPTLEGSAEEPFPGGGEGPRPGPSSEQLNRFAG
                     FGIGLASLFTENVLAHPCIVLRRQCQVNYHARHYHLTPFSIINIMYSFNKTQGPRALW
                     KGMGSTFIVQGVTLGAEGIISEFTPLPREVSHKLNPKQIGEHLLLKCLTYMVAMPFYS
                     ASLIETVQSEIIRDNTGILECVKEGIGRVIGLGVPHSKRLLPLFSLIFPTVLHGVLHY
                     IISSIIQKIVLLILKRKTYNSHLAESTSPMQNMLDAYFPELIANFAASLCSDVILYPL
                     ETVLHRLHIQGTRTIIDNTDLGYEVLPINTQYEGMRDCINTIKQEEGVFGFYKGFGAV
                     IIQYTLHATILQITKMIYSTLLQNSI"
     exon            403..445
                     /gene="Slc25a46"
                     /gene_synonym="1200007B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            446..503
                     /gene="Slc25a46"
                     /gene_synonym="1200007B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            504..581
                     /gene="Slc25a46"
                     /gene_synonym="1200007B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            582..682
                     /gene="Slc25a46"
                     /gene_synonym="1200007B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            683..739
                     /gene="Slc25a46"
                     /gene_synonym="1200007B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            740..797
                     /gene="Slc25a46"
                     /gene_synonym="1200007B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            798..4403
                     /gene="Slc25a46"
                     /gene_synonym="1200007B05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2959..2964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a46"
                     /gene_synonym="1200007B05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2978
                     /gene="Slc25a46"
                     /gene_synonym="1200007B05Rik"
                     /note="major polyA site"
     regulatory      3379..3384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a46"
                     /gene_synonym="1200007B05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3408
                     /gene="Slc25a46"
                     /gene_synonym="1200007B05Rik"
     regulatory      3984..3989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a46"
                     /gene_synonym="1200007B05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4008
                     /gene="Slc25a46"
                     /gene_synonym="1200007B05Rik"
     regulatory      4295..4300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a46"
                     /gene_synonym="1200007B05Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      4325
                     /gene="Slc25a46"
                     /gene_synonym="1200007B05Rik"
ORIGIN      
        1 cgggttctag ccgtgacttc cggttgtcag tctccggacg cgcagcggct gcggcgggga
       61 cgcggtggag gcctgggctc cgtgggccgg cctctctcgt cctcgtccgc ctgtccgaga
      121 tgcatccgcg gcgccctgag ggcttcgatg gcctgggcta ccggggaggc gttcgggatg
      181 atccggcttt cggcggccct ttccatgcgc gctccttcgg ttcagggacg gaactgggcc
      241 actgggtgac gacgcccccg gacatcccgg gcagccgcaa cctgcactgg ggcgaaaaga
      301 gcccttccta cggcgtgccg tccgcgcccc cgacgctcga gggttccgcg gaggagccct
      361 ttcccggcgg cggcgagggc ccgcggccgg gaccgagcag cgaacagttg aatagatttg
      421 ctggatttgg tattggactt gcaagtctct ttacagaaaa tgtgctggcc catccttgca
      481 ttgttttacg ccgccagtgt caggtcaatt accatgctcg gcattaccat ctcactccat
      541 tttcaattat caacattatg tatagcttca acaaaactca gggaccaaga gccctatgga
      601 aagggatggg aagcacattt attgttcagg gagtcacact tggagcagaa ggcataataa
      661 gtgaatttac acctttaccg agggaggttt cacacaaatt gaaccctaaa caaataggtg
      721 aacaccttct cctgaaatgc ctaacataca tggtggccat gcctttttat tctgcaagtc
      781 tgatcgaaac agtacagagt gagataatcc gagataacac tggcattctg gaatgtgtta
      841 aagaaggaat tggacgagtg ataggcttgg gagtgcctca cagcaaacgc cttcttccac
      901 tgttttcatt gatcttccca acagtgctgc atggagttct tcattacatt atcagctcca
      961 tcattcagaa gattgtcctt ctaattctga agagaaagac ctataacagc cacctagctg
     1021 agagcactag ccccatgcag aatatgttgg atgcctattt tccagaactt attgcgaact
     1081 ttgctgccag cctttgttct gacgttatac tttacccact ggaaacagtt ctgcatcgtc
     1141 ttcatattca aggaacacgc acaattattg acaacacaga ccttggctac gaagtacttc
     1201 caattaatac gcagtatgag ggaatgagag actgtataaa taccataaag caggaggaag
     1261 gagtgtttgg tttctataaa gggtttggtg ctgttataat acagtataca ctgcatgcaa
     1321 ccatcttaca gattaccaaa atgatttact ccacacttct tcagaatagc atttgagatt
     1381 taggttctat gattggctga accaaaagat gttggataat ttgctatgac atttcaagta
     1441 ataaaagtaa aaatactgcg cggaaagaaa taggctggga attaccactg gtggaaaacc
     1501 tcatgctaat tattctgact ttttattttt cttaaggcat agatatatag atatatagat
     1561 atataatact gggtcaaacc tttccaaaat tgaaaactca ataaaggtaa tactttaaat
     1621 ttaaaatgta aagttacatt ttagtataac actcatgctg aagtaaaatt gatcctgggg
     1681 agaaacaaaa aatgtatcaa gtataaaatg aaattgcaat gacttgaatc tgttttactg
     1741 accttactat ttgttatgtt tgtttaactt ggattcaggt cactgtgtta attattaaag
     1801 cagtggatag tgctgggatt ttacctttaa gcaaatagag tatgtcaccg ttgaaaagaa
     1861 ctggtgatta gctttggcac tgtgtaagca gtggctgaag ggtttaaatt gtatttaacc
     1921 attttaattg ctgtatatat ttattatatg gagccatttg tgtctgtgtg tacatgtaac
     1981 ttggaatttc cttcttccct gccagttttc atagaccagc ttattgcatc aaatgaaggt
     2041 agacactttc tgctggaaca tcaagtataa gacatcaaaa tgccagaaaa tagctttttt
     2101 acctgcatcc tgtccagcat tgcagtgtca gaaacttgaa atttgtcctt tgcttgtgat
     2161 gtttggatca tcagatgatt ttagctactt ttaaagagcc taacaatcat ggcagccatg
     2221 accgtttcca cacttacgtt aaggagcccc acctgtcttt catttctcaa agaacttatc
     2281 tgagagggaa caaaatgaaa gttctgggga tttgtgcctc ttgctcacca taaataatca
     2341 ctgcaatctt tcttttttct ttcctttttt tgtatgtgtg cgtgtgtgtg tgtgtgtgtg
     2401 tgtgtgtgtg tgtgtgtgta tgtaaagttt tattctccaa ataagctacc ctgaagataa
     2461 aaatgagaca ttcttggtac tctttattta aacttgcttg gataagtact gaattaaagt
     2521 acaaacctca taggaaattt gcccttatgt gttacgaagg aggaggagga gacactatat
     2581 ttcaacaaat gaaacttgtt aatcagctta ataaaatgaa gttgatgtgt tcccatggtg
     2641 gattagactc tgtaataaag tgatgtatag ttcactggtc actcatgcag cagttagcat
     2701 tttatttctt catggctatg ctcaagttta caaacactga agtgcagtgc ctgcaggtgt
     2761 tgcccaacct agaatgcatg caaactaaca ctgatgttac atgttaaatg ttgcagaggg
     2821 tgtttggact gtgactgatc agagtggaag cttaatatgg tcgtggaaaa gcatgaagta
     2881 aggtgtcagt agcagctgtc cctaccagtc tgtgtctttg gagtaatgct gtcaactctt
     2941 cagttcctca aaagggaaaa taaatgctgt tgatcacatt ctgtatttta tggttaatct
     3001 cttaacgtgt ttttctctgt gtaaaaatgg ggttaacatt ttttactgac ttttagctgc
     3061 taaattttta ggtgtttata gtcaccttcc tcagaatttc attttgtaag tcaaggtagt
     3121 ttcagagaag aaaccagaaa attttggttt cagaaaatgt ttagaacagt ctaaatggaa
     3181 tcaaatattt actgggtaaa ttttgtggaa ttttccatgt gcctgaagat tagatattca
     3241 aggattattt attgacagat accatgaatt tagtaatata aatttattgc atctgaagtc
     3301 aaaatgctgc tgctgaacta aatacatgat tagtctcatt tcctgtttcc ttgcagaaat
     3361 ccacgcaaat taccttaaaa taaagatgga gagagttttt ttttctaact gctttttttt
     3421 ttaaatttgt taaaatgtaa cctttgaaag tcaaacacat tttagttggc cagtgtttct
     3481 cagtgaattg atacctttta cactcagtat gacaaatagc cccgtagatg tgattctgtt
     3541 aagtagaatg caacaaagca ctcactcgct gattgtgcaa aaaaacgcta cagtgctttt
     3601 attcgagaat ctcataatct gagaagcaga agacgctgcc ttgacagctg tactgttgtt
     3661 ggtcgaggtc atggaggatg tgtgctgtct atgtgggtgt ggatgctgta gaacagaaaa
     3721 gacatttcca gctcctgcaa aaactaccta tgtggagagc cgtgaacaat cgccattaca
     3781 agatggcgct ggcttctgca gtgcctaact agtaaacaag caatgtgcac gggtgctgga
     3841 gtaaattcgt gccaagtcac tgcccatctc ggggtgtagc agtggggtga tgagtgagca
     3901 gctaatcagg agctgacgcg tcacacggag gggtatttaa gcagctccat tttccgggtt
     3961 cagggtcttc ctgagaagta agcaataaaa agctttgccg tagaaggacc cggttgtccg
     4021 agtgtgtttt gctggcgaga tgttacaagg acacacctag gttaagtgac ttagaaaact
     4081 tatttaaggg ttcacatcac actgaagtta gagtactact tactgctggc atttctgcgt
     4141 tctcttcaag tatttggcat aatacatatc acttccctgc ccctgaatag gtaccatctt
     4201 atttttatta atagagtact agtttgtata gcagagtaac aataatctgt ggtttgactc
     4261 ttgtgtcttg ttattttatt tatttctaaa atttattaaa ggtttatttt ctttattttt
     4321 taaaattttg tcacagtacc attttaaatg tcttaggtaa taagttgtaa tgtaaaaggt
     4381 ttgataaaat gttgaattca agc
//
