LOCUS       NM_178696               3584 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus solute carrier family 25, member 44 (Slc25a44),
            transcript variant 1, mRNA.
ACCESSION   NM_178696
VERSION     NM_178696.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3584)
  AUTHORS   Verkerke,A.R.P., Wang,D., Yoshida,N., Taxin,Z.H., Shi,X., Zheng,S.,
            Li,Y., Auger,C., Oikawa,S., Yook,J.S., Granath-Panelo,M., He,W.,
            Zhang,G.F., Matsushita,M., Saito,M., Gerszten,R.E., Mills,E.L.,
            Banks,A.S., Ishihama,Y., White,P.J., McGarrah,R.W., Yoneshiro,T.
            and Kajimura,S.
  TITLE     BCAA-nitrogen flux in brown fat controls metabolic health
            independent of thermogenesis
  JOURNAL   Cell 187 (10), 2359-2374 (2024)
   PUBMED   38653240
REFERENCE   2  (bases 1 to 3584)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3584)
  AUTHORS   Yoneshiro,T., Kataoka,N., Walejko,J.M., Ikeda,K., Brown,Z.,
            Yoneshiro,M., Crown,S.B., Osawa,T., Sakai,J., McGarrah,R.W.,
            White,P.J., Nakamura,K. and Kajimura,S.
  TITLE     Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is
            required for optimal fever
  JOURNAL   Elife 10, e66865 (2021)
   PUBMED   33944778
  REMARK    GeneRIF: Metabolic flexibility via mitochondrial BCAA carrier
            SLC25A44 is required for optimal fever.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3584)
  AUTHORS   Yoneshiro,T., Wang,Q., Tajima,K., Matsushita,M., Maki,H.,
            Igarashi,K., Dai,Z., White,P.J., McGarrah,R.W., Ilkayeva,O.R.,
            Deleye,Y., Oguri,Y., Kuroda,M., Ikeda,K., Li,H., Ueno,A.,
            Ohishi,M., Ishikawa,T., Kim,K., Chen,Y., Sponton,C.H.,
            Pradhan,R.N., Majd,H., Greiner,V.J., Yoneshiro,M., Brown,Z.,
            Chondronikola,M., Takahashi,H., Goto,T., Kawada,T., Sidossis,L.,
            Szoka,F.C., McManus,M.T., Saito,M., Soga,T. and Kajimura,S.
  TITLE     BCAA catabolism in brown fat controls energy homeostasis through
            SLC25A44
  JOURNAL   Nature 572 (7771), 614-619 (2019)
   PUBMED   31435015
REFERENCE   5  (bases 1 to 3584)
  AUTHORS   Padilla,J., Jenkins,N.T., Thorne,P.K., Martin,J.S., Rector,R.S.,
            Davis,J.W. and Laughlin,M.H.
  TITLE     Identification of genes whose expression is altered by obesity
            throughout the arterial tree
  JOURNAL   Physiol Genomics 46 (22), 821-832 (2014)
   PUBMED   25271210
REFERENCE   6  (bases 1 to 3584)
  AUTHORS   Gutierrez-Aguilar,M. and Baines,C.P.
  TITLE     Physiological and pathological roles of mitochondrial SLC25
            carriers
  JOURNAL   Biochem J 454 (3), 371-386 (2013)
   PUBMED   23988125
  REMARK    Review article
REFERENCE   7  (bases 1 to 3584)
  AUTHORS   Willnow,T., Antignac,C., Brandli,A., Christensen,E., Cox,R.,
            Davidson,D., Davies,J., Devuyst,O., Eichele,G., Hastie,N.,
            Verroust,P., Schedl,A. and Meij,I.
  TITLE     The European renal genome project: an integrated approach towards
            understanding the genetics of kidney development and disease
  JOURNAL   Organogenesis 2 (2), 42-47 (2005)
   PUBMED   19521566
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY249366.1, AK134914.1 and BY639336.1.
            
            On Aug 7, 2013 this sequence version replaced NM_178696.4.
            
            Transcript Variant: This variant (1) represent the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134914.1, AK032960.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BY249366.1         7-8
            3-2423              AK134914.1         2-2422
            2424-3579           AK134914.1         2424-3579
            3580-3584           BY639336.1         412-416
FEATURES             Location/Qualifiers
     source          1..3584
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.82 cM"
     gene            1..3584
                     /gene="Slc25a44"
                     /gene_synonym="6720482A19; B430110G05Rik"
                     /note="solute carrier family 25, member 44"
                     /db_xref="GeneID:229517"
                     /db_xref="MGI:MGI:2444391"
     exon            1..414
                     /gene="Slc25a44"
                     /gene_synonym="6720482A19; B430110G05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             371..1372
                     /gene="Slc25a44"
                     /gene_synonym="6720482A19; B430110G05Rik"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="solute carrier family 25 member 44 isoform a"
                     /protein_id="NP_848811.2"
                     /db_xref="CCDS:CCDS50950.1"
                     /db_xref="GeneID:229517"
                     /db_xref="MGI:MGI:2444391"
                     /translation="MPGDSELAVQEPDRRSPGTMEDKRNIQIIEWEHLDKKKFYVFGV
                     AMTMMIRVSVYPFTLIRTRLQVQKGKSLYHGTFDAFVKILRADGVAGLYRGFLVNTFT
                     LISGQCYVTTYELTRKFVADYSQSNTVKSLVAGGSASLVAQSITVPIDVVSQHLMMQR
                     KGEKMGRFQVHGNLEGQGVIAFGQTKDIIRQILRADGLRGFYRGYVASLLTYIPNSAV
                     WWPFYHFYAEQLSRLCPQECPHIVFQAISGPLAAATASILTNPMDVIRTRVQVEGKSS
                     IVLTFRQLMAEEGPWGLMKGLSARIISATPSTIVIVVGYESLKKLSLRPELVDSRHW"
     exon            415..1052
                     /gene="Slc25a44"
                     /gene_synonym="6720482A19; B430110G05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1180
                     /gene="Slc25a44"
                     /gene_synonym="6720482A19; B430110G05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..3584
                     /gene="Slc25a44"
                     /gene_synonym="6720482A19; B430110G05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3557..3562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a44"
                     /gene_synonym="6720482A19; B430110G05Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3583
                     /gene="Slc25a44"
                     /gene_synonym="6720482A19; B430110G05Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcatctcagt ttccggttcc ggcaataccg ggatcccagt ggagatggag gaagatgcga
       61 accgagtctg gctgtcgctg ggactggagg atagcgcggg ggctgcggtc taggagtccc
      121 agtctcagac gcggctaaag cgctggggtc tgagaaggaa agcgaccacg gtgcttaggt
      181 gtcttgaagg atcagaggta cctaaggttc aacctgtcga ggaggcagtg gatatctgtc
      241 tgttctgcgg ggctgcatcg ccatgggaag ccgctctgca gttttggcaa cgaaaggcaa
      301 gtcccccgag gcatctcgtc ctggccgagg agcatgagag actgacagct agagaagcct
      361 gacgaggggt atgcccgggg actctgaatt ggccgtgcaa gagcctgaca gaaggtctcc
      421 gggcacaatg gaggacaaac ggaacatcca gatcatcgag tgggagcacc tggacaagaa
      481 gaagttctat gtgtttggtg ttgctatgac aatgatgatc agggtcagcg tgtacccgtt
      541 caccctcatc cgcacccgcc tgcaggtcca gaagggcaag agcctctacc acgggacctt
      601 cgatgccttt gtcaagatcc tgcgagcaga tggagtggcg ggcctctacc gggggttcct
      661 ggtcaacacc ttcacactca tctccggcca gtgctatgtc accacttacg agctcacccg
      721 gaagtttgtg gcagactaca gccagagtaa cacagtcaaa tcactcgtag ccgggggctc
      781 ggcctccctt gtggcccaga gcatcacggt gccgatcgat gttgtctccc aacatctgat
      841 gatgcagcgg aagggtgaga aaatgggtcg cttccaagtg cacgggaacc tagagggaca
      901 aggggtgatt gcctttggcc agactaagga catcatcagg cagatccttc gggctgacgg
      961 tctccgaggc ttctaccggg gctatgtggc ctcgctgcta acgtacatcc caaacagtgc
     1021 tgtctggtgg cccttctacc acttctatgc agagcagctg tcgcgcctgt gccctcagga
     1081 gtgccctcac attgtctttc aagccatctc tgggcccctg gctgcagcca ctgcctccat
     1141 cctcaccaat cccatggatg tcatcagaac ccgtgtgcag gttgaaggca agagctccat
     1201 cgtcctgacc ttcaggcagc tgatggcaga ggaggggcct tggggcctca tgaagggcct
     1261 ctcggcaaga atcatctcgg ctacaccctc caccatcgtc atcgtggtgg gctacgagag
     1321 cctcaagaag ctcagcctgc gacctgagct ggtggactcg agacactggt agagagcggt
     1381 ggatggagag gctgtggttt cacacattac tctgggccag ggcagagcag agaggataac
     1441 tgaccctgtg aataccacca ccacacaccc atcctgctcc aggttgtctg tcagggataa
     1501 gagaggagac tttggactgc tccttctgca gaggttctgt gcctggcttc cctcatcccc
     1561 atcatttgat ttcccctgca gatctgggcc cctcactcgg tccttatact cagtcatggc
     1621 cacaggaccc cgttagcccc tctggcaccc ctctctgacc ttccctcagg cctggagaag
     1681 agctgctcct cgtttgcttg tcccctgctt cttctcgagc ctcaggccaa ggctctgagt
     1741 agctgcctgg ggtctattta tttttttatg cctgcttatt ttaaatttgg gacctgagtt
     1801 gttcactgct ttgtcctgcc tttgggggga caaatcggag cagcacacac tctgcagggc
     1861 gttcatcttc taggggagtt actaggaggg aggaatgcta aggcttccta tgtgtagctg
     1921 aacatctgtg aatgagccaa ctcaccctca tagctcagtc tgctgtcaga ccccactcct
     1981 tggagaagtg gaaaactgtg acacagatcc caattcttta tcccccttcc ctgtccctca
     2041 ggcccgggaa ccgcatgagc tgctggcctt cattggccca ggtgactaca gtagaggggc
     2101 atagttataa gtgggtcaga cttactagag aacactgtcc ttggaacttt gccctgaagc
     2161 caggttggga aagagccact ggcttggatg tgtgttcctc actcttatct cctcaggcca
     2221 gctgagccaa gccctggagg tacaacggag gttctgagcc cgaggcagca gtgccacagg
     2281 cacacctgcc acccagatga atagcaacag gtgtctcaca gtgggactct ggaatatgaa
     2341 ctatcctttt ttttcttgtc cttggttgtg aagtatcatc ccagtcatgg taccctgtgc
     2401 tggcaacaga aaaaaaaaaa aaatacagtc aggaaggcac ccaaggccag gtccacctgg
     2461 ttaccagcct cttactgcca aaaccattga tgctttcctc aggagcgtcc ctcttccctg
     2521 cctctactga gcctgtgttg gtggcagaga ggcacatcca ggaatgggag ggaagaaagc
     2581 aggcagatct tgctcttcag cctgggagat gcttgggaaa tgccatggtg ccaaattgga
     2641 aggtgctaac tgaagccttc atgtttctca cggctgctcc acattcttcc atcctgactt
     2701 gacccagtct ccacacacac acctcctact actcgctgta gtctgtattt gtttccttct
     2761 gagccctcta ctaatgtctc agcattttgg tttgtttttt gagacagggt ctcatatatc
     2821 ccaggctggg tttgaattca ttatgtagca gagggtagcc tagaactctt catcttcctc
     2881 cacctcctaa gttccaggtt tacaggacgc cgccaggccc cacttcctgc actttattga
     2941 gagagccctt caatcttgcc catagtcatc tgaagggtga agcccacaga tcattttaaa
     3001 tcctttcgct cctcacctct accttaagac ctatcaatac agtggagcaa gggcccctct
     3061 caggctttca ctatcaagac ctttgtgatt ggacagctct gctctttggt ctttcctaac
     3121 ggggcagagt gtggacatag gttcctccca cctttcatac cttaggttac tccttcccga
     3181 cttttcttgt ccggtgttta agcctctccc tttcttgtcc tatctccctt tccttctttc
     3241 cccttgtgtt tgaaaggacc ttggatataa aggtaaaagg cacccccgtg tcggaactcc
     3301 tactctccca aggtcagggt ctgggattgg ccttggtgaa gatgagccag tgggcggcca
     3361 tttttccaaa actggagacc aaaacagcta gaaatgttga cccattggtc aacacacaaa
     3421 ttagaaactc ggcaagacag gagggctgga tagaggcaca tgggaaagaa tgcacattca
     3481 gcattagcta gaaatggact cgaggagatt agctgcgaat attcactgtt gcactgtatg
     3541 agatctttga aatgtaatta aaagttttta ttgagcccct aaac
//
