LOCUS       NM_178766               2838 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus solute carrier family 25, member 40 (Slc25a40),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_178766
VERSION     NM_178766.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2838)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2838)
  AUTHORS   Wang,Y., Yen,F.S., Zhu,X.G., Timson,R.C., Weber,R., Xing,C.,
            Liu,Y., Allwein,B., Luo,H., Yeh,H.W., Heissel,S., Unlu,G.,
            Gamazon,E.R., Kharas,M.G., Hite,R. and Birsoy,K.
  TITLE     SLC25A39 is necessary for mitochondrial glutathione import in
            mammalian cells
  JOURNAL   Nature 599 (7883), 136-140 (2021)
   PUBMED   34707288
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044260.1, AK045863.1, AK079538.1 and BY368313.1.
            
            On Jan 24, 2014 this sequence version replaced NM_178766.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088444.1, AK045863.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AK044260.1         2-13
            13-2012             AK045863.1         1-2000
            2013-2836           AK079538.1         1943-2766
            2837-2838           BY368313.1         372-373
FEATURES             Location/Qualifiers
     source          1..2838
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 3.43 cM"
     gene            1..2838
                     /gene="Slc25a40"
                     /gene_synonym="B230315F11Rik"
                     /note="solute carrier family 25, member 40"
                     /db_xref="GeneID:319653"
                     /db_xref="MGI:MGI:2442486"
     exon            1..202
                     /gene="Slc25a40"
                     /gene_synonym="B230315F11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            203..274
                     /gene="Slc25a40"
                     /gene_synonym="B230315F11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            275..383
                     /gene="Slc25a40"
                     /gene_synonym="B230315F11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..1297
                     /gene="Slc25a40"
                     /gene_synonym="B230315F11Rik"
                     /note="isoform a is encoded by transcript variant 1;
                     probable mitochondrial glutathione transporter SLC25A40"
                     /codon_start=1
                     /product="mitochondrial glutathione transporter SLC25A40
                     isoform a"
                     /protein_id="NP_848881.2"
                     /db_xref="CCDS:CCDS39010.1"
                     /db_xref="GeneID:319653"
                     /db_xref="MGI:MGI:2442486"
                     /translation="MEPETEGPPPTIPVTPLQQMIASCTGAVLTSLMVTPLDVVKIRL
                     QAQNNPFPKGKCFLYSNGLMDHMCVCEEESKKAWYKKPGNFRGTLDAFLKILRNEGIK
                     SLWSGLPPTLVMAIPATVIYFTCYEQLSAFLKTKLGENETRIPIVAGVVARFGAVTVI
                     SPLELIRTKVQSKKFSYKELYQFVSMRVSEDGWISLWKGWAPTILRDVPFSAMYWYNY
                     ENLKRWLCEKSGLYEPTFMINFTSGALSGSFAAVATLPFDVVKTQKQTQLWTNEYCKF
                     PAPLDMSTWTIMKNIVADKGFSGLFTGLIPRLVKIVPACAIMISSYELGKSFFQKQNV
                     ESR"
     exon            384..443
                     /gene="Slc25a40"
                     /gene_synonym="B230315F11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            444..550
                     /gene="Slc25a40"
                     /gene_synonym="B230315F11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            551..618
                     /gene="Slc25a40"
                     /gene_synonym="B230315F11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            619..743
                     /gene="Slc25a40"
                     /gene_synonym="B230315F11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            744..917
                     /gene="Slc25a40"
                     /gene_synonym="B230315F11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1027
                     /gene="Slc25a40"
                     /gene_synonym="B230315F11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1109
                     /gene="Slc25a40"
                     /gene_synonym="B230315F11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1190
                     /gene="Slc25a40"
                     /gene_synonym="B230315F11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..2838
                     /gene="Slc25a40"
                     /gene_synonym="B230315F11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2774..2779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a40"
                     /gene_synonym="B230315F11Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2792
                     /gene="Slc25a40"
                     /gene_synonym="B230315F11Rik"
                     /note="major polyA site"
ORIGIN      
        1 gaccacgccc ccggcgcgcc agcccgcggg gcctcagacc cggctctccc gcgtcctcct
       61 cgagttccgg ctccgctctg catacttgga gtgtggggca gccagggcgg tggacgcggt
      121 tagcctcgga ggcttcacct cgtggtcgac atcacctgct aggctggctg agacccgggc
      181 cttgcagtcg cctcgccacc agtgctgagg atcaaaccca aatgttgggc atgttaggca
      241 agcactcctg attattgttc ttataactta acagttaaaa agtatggagc ctgaaactga
      301 agggccgcca ccaacaatcc cagtgactcc tcttcagcaa atgattgcct cctgtactgg
      361 agctgtactg acatcactaa tggtgactcc cctggatgtt gttaaaattc gactccaggc
      421 ccagaacaac ccattcccca aaggaaagtg ttttttatac agtaatggac tcatggatca
      481 catgtgtgtc tgtgaagagg agagcaagaa agcatggtat aagaagccag gaaacttccg
      541 tgggacattg gatgcctttt taaaaattct tcgaaatgag ggcataaaat ccctgtggag
      601 cggcctccct cctactctag tgatggcaat tcctgccaca gttatttatt ttacctgcta
      661 tgaacagtta agtgcttttc tgaaaaccaa attaggagaa aatgaaaccc gaataccaat
      721 agttgctggg gttgtcgcca gatttggtgc ggtaacagtg atcagtccat tagaattgat
      781 cagaactaag gtgcagtcta agaagttttc ttacaaggaa ttatatcaat ttgtgagcat
      841 gagagtgtct gaagatggtt ggatttccct ttggaagggc tgggctccta cgattcttag
      901 agatgtgcct ttctcagcaa tgtactggta taattatgaa aatttaaaga ggtggctttg
      961 tgagaaatct ggtttatatg aaccaacatt tatgatcaac tttacttcag gagcattgtc
     1021 tggttctttt gcagctgttg caactttacc atttgatgta gtaaaaacac agaaacagac
     1081 gcaactgtgg acgaatgaat attgtaaatt tcctgcacct ttggatatgt caacctggac
     1141 tataatgaag aacattgttg ctgacaaagg attttctggg ttatttacag gtctaattcc
     1201 tcgattagtt aaaattgttc ctgcttgtgc cattatgatc agttcatatg aattaggaaa
     1261 gtcgttcttc cagaagcaaa atgttgaaag tcggtaattc ttatgatgga catttgacat
     1321 gaaataacaa ccagagccaa ataagatgaa aatttgtagg caagatggtt ttttaacatt
     1381 attatcttac agtatgactt tatgtgtttc cctataattt aaatgaataa taatttctca
     1441 tccacctcta gatcataatt tgaattattt aattttttga aatattaaaa acataatcca
     1501 gaaactgcag ccacttagta ctcttgcaaa gaaagttgct ccttaacagg acaagttttc
     1561 tgagtgcaaa tatcattaca ggcttccttt taaattaatg ctataagtgt ggggcacatc
     1621 agaacttttt ggattgtgta ctaagcactg cagtgtagag agctaagtgc agttccacgc
     1681 aaatttcaat cataagtctc agcatttcag taaagagtgg aagagctatc atgtggcatt
     1741 gttcacattc cccagatggt gcctgttaac gtctttaatt cagggacatt gtgttccctc
     1801 actcctgtta ctgatttaag gtggcctgta gtggcctgta gtgtagaagt ccctaatgaa
     1861 aagtgcagcc actttatctg tgtgaaccaa agtataatca tttacatgat gcaaatgtac
     1921 aagcaggaat gggctgctgg taactagctt gccttccaag tgtcattgtt tgtagaggtc
     1981 tttaggtcag ttctacaact ttttctacta caatcaatat tccctagtct aaaaggccaa
     2041 attataaaat gctccaaaaa tttcaactct atttgatgtc ccaaaatgat gttgttataa
     2101 tcccacacct tcactcaggt gacagcatac agaacgcagg cacatagaaa catttaaatt
     2161 gcctttaggc tatttgtatt aattgtatat gatacacatg aatatattta tcactttaag
     2221 taggaatgag gtttttaaaa atgacctttg tttatttttt gtatatgtct acatatacat
     2281 gaaggtgaga ggaaaccttg aagagttagt tctcccattc caccttgtgg actttgggat
     2341 ttgaactcag gtggtcaggc ttagcagcac gtgccctttc ccacactgag ctcaggaatg
     2401 agattttaag tatgatgaga atgcaggggt agaaaacggt ggctttggaa tgtgtaactc
     2461 ggagtctgat ctctggcaca gatgataaat aatttaaaag taagtaagat gccaatgcaa
     2521 gaaatgctat ttattattat ttacttatct ctataaagca aaaagcactt tatcacgttt
     2581 tatgtgtatt ctatgaaata tgacgtatac cctccctgcc taatgtattt cggtgacaat
     2641 gatctctagg gttggtaggt gaacaaatgc attttgtatc atagtggaaa gtgtttgtat
     2701 gtttcatcag aaataaatga tacatggttt attgtaccat gttgttttac attacaatcc
     2761 tgtgttggtt tacattaaaa tattaatata tacagatgtg tatttgtgat ttgtagtagt
     2821 aaaaatttta aaatcctg
//
