LOCUS       NM_007450               1332 bp    mRNA    linear   ROD 20-MAY-2024
DEFINITION  Mus musculus solute carrier family 25 (mitochondrial carrier,
            adenine nucleotide translocator), member 4 (Slc25a4), mRNA.
ACCESSION   NM_007450 XM_906838 XM_920112
VERSION     NM_007450.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1332)
  AUTHORS   Zhou,T., Pan,J., Xu,K., Yan,C., Yuan,J., Song,H. and Han,Y.
  TITLE     Single-cell transcriptomics in MI identify Slc25a4 as a new
            modulator of mitochondrial malfunction and apoptosis-associated
            cardiomyocyte subcluster
  JOURNAL   Sci Rep 14 (1), 9274 (2024)
   PUBMED   38654053
  REMARK    GeneRIF: Single-cell transcriptomics in MI identify Slc25a4 as a
            new modulator of mitochondrial malfunction and apoptosis-associated
            cardiomyocyte subcluster.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1332)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1332)
  AUTHORS   Pharaoh,G., Kamat,V., Kannan,S., Stuppard,R.S., Whitson,J.,
            Martin-Perez,M., Qian,W.J., MacCoss,M.J., Villen,J.,
            Rabinovitch,P., Campbell,M.D., Sweet,I.R. and Marcinek,D.J.
  TITLE     The mitochondrially targeted peptide elamipretide (SS-31) improves
            ADP sensitivity in aged mitochondria by increasing uptake through
            the adenine nucleotide translocator (ANT)
  JOURNAL   Geroscience 45 (6), 3529-3548 (2023)
   PUBMED   37462785
  REMARK    GeneRIF: The mitochondrially targeted peptide elamipretide (SS-31)
            improves ADP sensitivity in aged mitochondria by increasing uptake
            through the adenine nucleotide translocator (ANT).
REFERENCE   4  (bases 1 to 1332)
  AUTHORS   Bround,M.J., Havens,J.R., York,A.J., Sargent,M.A., Karch,J. and
            Molkentin,J.D.
  TITLE     ANT-dependent MPTP underlies necrotic myofiber death in muscular
            dystrophy
  JOURNAL   Sci Adv 9 (34), eadi2767 (2023)
   PUBMED   37624892
REFERENCE   5  (bases 1 to 1332)
  AUTHORS   Tang,X., Zhao,S., Liu,J., Liu,X., Sha,X., Huang,C., Hu,L., Sun,S.,
            Gao,Y., Chen,H., Zhang,Z., Wang,D., Gu,Y., Chen,S., Wang,L., Gu,A.,
            Chen,F., Pu,J., Chen,X., Yu,B., Xie,L., Huang,Z., Han,Y. and Ji,Y.
  TITLE     Mitochondrial GSNOR Alleviates Cardiac Dysfunction via ANT1
            Denitrosylation
  JOURNAL   Circ Res 133 (3), 220-236 (2023)
   PUBMED   37377022
  REMARK    GeneRIF: Mitochondrial GSNOR Alleviates Cardiac Dysfunction via
            ANT1 Denitrosylation.
REFERENCE   6  (bases 1 to 1332)
  AUTHORS   Grewal,P.K., van Deutekom,J.C., Mills,K.A., Lemmers,R.J.,
            Mathews,K.D., Frants,R.R. and Hewitt,J.E.
  TITLE     The mouse homolog of FRG1, a candidate gene for FSHD, maps proximal
            to the myodystrophy mutation on chromosome 8
  JOURNAL   Mamm Genome 8 (6), 394-398 (1997)
   PUBMED   9166581
REFERENCE   7  (bases 1 to 1332)
  AUTHORS   Grewal,P.K. and Hewitt,J.E.
  TITLE     Fath, the murine homolog of the Drosophila fat tumor suppressor
            gene, maps to chromosome 8
  JOURNAL   Mamm Genome 8 (5), 383-384 (1997)
   PUBMED   9107695
REFERENCE   8  (bases 1 to 1332)
  AUTHORS   Mills,K.A., Ellison,J.W. and Mathews,K.D.
  TITLE     The Ant1 gene maps near Klk3 on proximal mouse chromosome 8
  JOURNAL   Mamm Genome 7 (9), 707 (1996)
   PUBMED   8703133
REFERENCE   9  (bases 1 to 1332)
  AUTHORS   Ellison,J.W., Li,X., Francke,U. and Shapiro,L.J.
  TITLE     Rapid evolution of human pseudoautosomal genes and their mouse
            homologs
  JOURNAL   Mamm Genome 7 (1), 25-30 (1996)
   PUBMED   8903724
REFERENCE   10 (bases 1 to 1332)
  AUTHORS   Cozens,A.L., Runswick,M.J. and Walker,J.E.
  TITLE     DNA sequences of two expressed nuclear genes for human
            mitochondrial ADP/ATP translocase
  JOURNAL   J Mol Biol 206 (2), 261-280 (1989)
   PUBMED   2541251
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156551.5.
            
            On Mar 28, 2018 this sequence version replaced NM_007450.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078077.1, U27315.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               AC156551.5         166881-167131
            252-738             AC156551.5         168435-168921
            739-879             AC156551.5         169405-169545
            880-1332            AC156551.5         170323-170775
FEATURES             Location/Qualifiers
     source          1..1332
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 26.22 cM"
     gene            1..1332
                     /gene="Slc25a4"
                     /gene_synonym="Ant1; mANC1"
                     /note="solute carrier family 25 (mitochondrial carrier,
                     adenine nucleotide translocator), member 4"
                     /db_xref="GeneID:11739"
                     /db_xref="MGI:MGI:1353495"
     exon            1..251
                     /gene="Slc25a4"
                     /gene_synonym="Ant1; mANC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1037
                     /gene="Slc25a4"
                     /gene_synonym="Ant1; mANC1"
                     /note="ANT 1; ADP,ATP carrier protein 1; solute carrier
                     family 25 member 4; ADP,ATP carrier protein,
                     heart/skeletal muscle; adenine nucleotide translocator 1,
                     skeletal muscle; adenine nucleotide translocase-1"
                     /codon_start=1
                     /product="ADP/ATP translocase 1"
                     /protein_id="NP_031476.3"
                     /db_xref="CCDS:CCDS40333.1"
                     /db_xref="GeneID:11739"
                     /db_xref="MGI:MGI:1353495"
                     /translation="MGDQALSFLKDFLAGGIAAAVSKTAVAPIERVKLLLQVQHASKQ
                     ISAEKQYKGIIDCVVRIPKEQGFLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGG
                     VDRHKQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKGSSQREFNGLGDC
                     LTKIFKSDGLKGLYQGFSVSVQGIIIYRAAYFGVYDTAKGMLPDPKNVHIIVSWMIAQ
                     SVTAVAGLVSYPFDTVRRRMMMQSGRKGADIMYTGTLDCWRKIAKDEGANAFFKGAWS
                     NVLRGMGGAFVLVLYDEIKKYV"
     exon            252..738
                     /gene="Slc25a4"
                     /gene_synonym="Ant1; mANC1"
                     /inference="alignment:Splign:2.1.0"
     exon            739..879
                     /gene="Slc25a4"
                     /gene_synonym="Ant1; mANC1"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1332
                     /gene="Slc25a4"
                     /gene_synonym="Ant1; mANC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1125..1130
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a4"
                     /gene_synonym="Ant1; mANC1"
                     /note="hexamer: GATAAA"
     polyA_site      1161
                     /gene="Slc25a4"
                     /gene_synonym="Ant1; mANC1"
                     /note="major polyA site"
     regulatory      1308..1313
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a4"
                     /gene_synonym="Ant1; mANC1"
                     /note="hexamer: AATAAA"
     polyA_site      1332
                     /gene="Slc25a4"
                     /gene_synonym="Ant1; mANC1"
                     /note="major polyA site"
ORIGIN      
        1 ggggatataa ggagggctgc ggtcaggcgg gcggtccctt cgcgtcgtgc agggacggat
       61 tcggggtggc ggtgcctggc cgggcgtagg caagagcaaa cgagcggctc cttgcaggct
      121 gtgtgcgccc ggctttcagc atgggggatc aggctttgag ctttcttaag gacttcctgg
      181 caggtggcat cgccgccgcc gtctccaaga cggcggtcgc cccgatcgag agggtcaaac
      241 tgctgctgca ggtccagcat gccagcaaac agatcagtgc agagaagcag tacaaaggca
      301 tcattgattg tgtcgtgaga atccccaagg agcagggctt tctctctttc tggaggggta
      361 acctggccaa cgtgatccgg tacttcccca ctcaagccct gaacttcgcc ttcaaagaca
      421 agtacaagca gatcttcctg ggaggcgtgg atcgccataa gcagttctgg cgctactttg
      481 ctggtaacct ggcctctggt ggggcagctg gggccacctc cctctgcttc gtctacccgc
      541 tggactttgc taggaccagg ctggctgccg acgtgggcaa gggatcttcc cagcgagaat
      601 tcaatgggct gggcgactgt ctcaccaaga tcttcaagtc ggacggcctg aagggtctct
      661 accagggttt cagtgtctct gtccagggca tcatcatcta cagagctgcc tacttcggag
      721 tctatgacac tgccaagggg atgctgccag accccaagaa tgtgcacatt atcgtgagct
      781 ggatgattgc ccagagtgtg acagcggtgg cggggctggt gtcctatccg tttgacactg
      841 ttcgtcgtag gatgatgatg cagtctggcc ggaaaggggc tgatattatg tacacgggga
      901 cacttgactg ctggaggaag attgcaaaag atgaaggagc caacgctttc ttcaaaggtg
      961 cttggtccaa tgtactgaga ggcatgggtg gtgcttttgt attggtattg tatgatgaga
     1021 tcaaaaaata tgtgtaatac ccaagctcac aagttcacag atccattgtg tggtttaaca
     1081 gactattctt gaggaaataa aacaaaaaaa agagacagat cttggataaa accagaccgt
     1141 aaggaatacc tcagaaaaaa atgcttcatt gagtattcat taaaccacag aagtattttg
     1201 tatttatttt acatttagat tcccacagaa aacaggctag cttatcatac ttgttcacct
     1261 gattaactga agaactgatg ctgaaaagta actcagtgtg actcattaat aaagactact
     1321 caatacactt ta
//
