LOCUS       NM_144793               1783 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Mus musculus solute carrier family 25, member 38 (Slc25a38),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_144793 XM_993613 XM_993631 XM_993653 XM_993672
VERSION     NM_144793.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1783)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1783)
  AUTHORS   Wang,T., Wei,W., Mansai,H.A.A., Huang,C., Li,L., Ye,Q., Yin,H.,
            Yang,C., Li,X., Liu,S. and Yang,S.
  TITLE     Overexpression of appoptosin promotes mitochondrial damage in MIN6
            cells
  JOURNAL   Mol Med Rep 17 (5), 7149-7155 (2018)
   PUBMED   29568862
  REMARK    GeneRIF: Silencing of appoptosin using short hairpin RNA
            significantly reduced CoCl2induced apoptosis in MIN6 cells. In
            conclusion, CoCl2 increased the expression of appoptosin, which
            aggravated mitochondrial damage in MIN6 cells.
REFERENCE   3  (bases 1 to 1783)
  AUTHORS   Zhao,Y., Tseng,I.C., Heyser,C.J., Rockenstein,E., Mante,M.,
            Adame,A., Zheng,Q., Huang,T., Wang,X., Arslan,P.E., Chakrabarty,P.,
            Wu,C., Bu,G., Mobley,W.C., Zhang,Y.W., St George-Hyslop,P.,
            Masliah,E., Fraser,P. and Xu,H.
  TITLE     Appoptosin-Mediated Caspase Cleavage of Tau Contributes to
            Progressive Supranuclear Palsy Pathogenesis
  JOURNAL   Neuron 87 (5), 963-975 (2015)
   PUBMED   26335643
  REMARK    Erratum:[Neuron. 2024 Dec 4;112(23):3984-3985. doi:
            10.1016/j.neuron.2024.11.001. PMID: 39520984]
REFERENCE   4  (bases 1 to 1783)
  AUTHORS   Zhang,H., Zhang,Y.W., Chen,Y., Huang,X., Zhou,F., Wang,W., Xian,B.,
            Zhang,X., Masliah,E., Chen,Q., Han,J.D., Bu,G., Reed,J.C.,
            Liao,F.F., Chen,Y.G. and Xu,H.
  TITLE     Appoptosin is a novel pro-apoptotic protein and mediates cell death
            in neurodegeneration
  JOURNAL   J Neurosci 32 (44), 15565-15576 (2012)
   PUBMED   23115192
REFERENCE   5  (bases 1 to 1783)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ159224.1, AK078385.1, BM115906.2 and AC110091.4.
            
            On Jun 21, 2018 this sequence version replaced NM_144793.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010801.1, AK078385.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 CJ159224.1         62-63
            3-1601              AK078385.1         2-1600
            1602-1782           BM115906.2         1-181               c
            1783-1783           AC110091.4         59688-59688
FEATURES             Location/Qualifiers
     source          1..1783
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 71.4 cM"
     gene            1..1783
                     /gene="Slc25a38"
                     /gene_synonym="appoptosin"
                     /note="solute carrier family 25, member 38"
                     /db_xref="GeneID:208638"
                     /db_xref="MGI:MGI:2384782"
     exon            1..191
                     /gene="Slc25a38"
                     /gene_synonym="appoptosin"
                     /inference="alignment:Splign:2.1.0"
     exon            192..313
                     /gene="Slc25a38"
                     /gene_synonym="appoptosin"
                     /inference="alignment:Splign:2.1.0"
     exon            314..398
                     /gene="Slc25a38"
                     /gene_synonym="appoptosin"
                     /inference="alignment:Splign:2.1.0"
     exon            399..578
                     /gene="Slc25a38"
                     /gene_synonym="appoptosin"
                     /inference="alignment:Splign:2.1.0"
     exon            579..753
                     /gene="Slc25a38"
                     /gene_synonym="appoptosin"
                     /inference="alignment:Splign:2.1.0"
     exon            754..920
                     /gene="Slc25a38"
                     /gene_synonym="appoptosin"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1783
                     /gene="Slc25a38"
                     /gene_synonym="appoptosin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1578..1583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a38"
                     /gene_synonym="appoptosin"
                     /note="hexamer: AATAAA"
     polyA_site      1604
                     /gene="Slc25a38"
                     /gene_synonym="appoptosin"
                     /note="major polyA site"
     regulatory      1763..1768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a38"
                     /gene_synonym="appoptosin"
                     /note="hexamer: ATTAAA"
     polyA_site      1783
                     /gene="Slc25a38"
                     /gene_synonym="appoptosin"
ORIGIN      
        1 gaaacatcga gccgcttgtc tcgggtaatg agacctgagg ccgggcgggc aggcggggag
       61 ggatgggcgt gagcgcggag ccccggagcc tctcagtcgc cggggccggg ctcgcgtccc
      121 cagtgatcga gaaggcacgc tcggcgctgc tgcagtcgca ggatgtagag gacacggtgg
      181 agacgctcat gttacaccca gtgattaagg ctttcctctg cggctccatc agcgggacct
      241 gttccacgct cctcttccag cctttggatc tcctcaaaac ccgtctgcag gccctgcagc
      301 cctcagacct agggcccaga cgtgttggga tgttggctgt gttcttgaag gtggttcgca
      361 cagaaagtct cctgggcctt tggaaaggga tgtctccttc cattgtgaga tgtgtccctg
      421 gagtggggat ctactttggc accctgtatt cttcgaagca gtatttcttg cgaggccatc
      481 ctcccaccgc cctggagtcg gtcatcctgg gcatgggctc ccgctctgtg gcaggagtct
      541 gcatgtcacc catcacagtg atcaagacac gctatgagag tgggacttac agctatgaga
      601 gcatctatgc agccctgagg agcatctact gcagcgaggg ccaccgtggc ctcttcaggg
      661 gcctgacagc aactctcctc cgtgatgccc ccttctcagg gctctacctg atgttttaca
      721 gtcagaccag gaccgcagtg ctgcacggca cagcccagct ggatgctgct ctgatacccc
      781 ttattaattt ctcctgtggg atatttgctg gcgttctggc ttcactggtg actcaacctg
      841 cagacgtgat caaaactcac atgcagctct ccccagtgaa gtttcagtgg attggccaag
      901 cagccactct catcttcaag aaccatgggc tgcgtggctt ctttcatggc agtgttcccc
      961 gagccctccg aagaacgctg atggctgcca tggcgtggac cgtctatgaa gagatgatgg
     1021 ccaggatggg cctgaagtcc tgacgagaga gagctggttc ctgccatgag ctgctgcagc
     1081 tcactcccgg agtcaggtga agactgcgct gtctgaagag ccaggcacaa gtgccgtcac
     1141 cttttttcca gaattcagag agagtggctg ggtggctgga gccataggca tggagttgcc
     1201 agtacctacc gctctgtgca cacttcccgt cagtgccgcg gggctggatc gagcttggct
     1261 gcccacaagg ctacttgaga ggaggcctct gcaaggtcgc tgcttcagcc acctgcctac
     1321 tctacagggc gccttagaat attggtaatg aaggaatccc ccagtagaga aggtgtgggc
     1381 ctcctgccat gtctgagggc aagaggctca agttagggaa gactggacct aagagagctg
     1441 aggtgggcca gtgagatgcc tcagcaagga aaggtgctta acagaggcct gcgttggctc
     1501 ccaggaccca tatggtggag gagagaattg ctgcaagttg tcctgatttc ctcacatgca
     1561 cccagaccca ataaacaaat aaatgtatta ctttttaaaa taaagacatc accagggtgg
     1621 agactgtctg tgacagaacc aaaacagaac aaaaaaccaa gataggcatt agttttgttc
     1681 ctaggctgcc tcctgtaggc cccgagaacg aatgggacag tctttcccag gcttcatctc
     1741 tgctgttctc acactttcca taattaaagt tcaaacaaac aca
//
