LOCUS       NM_026331               4162 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus solute carrier family 25, member 37 (Slc25a37), mRNA.
ACCESSION   NM_026331
VERSION     NM_026331.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4162)
  AUTHORS   Zhang,T., Sun,L., Hao,Y., Suo,C., Shen,S., Wei,H., Ma,W., Zhang,P.,
            Wang,T., Gu,X., Li,S.T., Chen,Z., Yan,R., Zhang,Y., Cai,Y.,
            Zhou,R., Jia,W., Huang,F., Gao,P. and Zhang,H.
  TITLE     ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of
            iron regulatory protein 1
  JOURNAL   Nat Cancer 3 (1), 75-89 (2022)
   PUBMED   35121990
REFERENCE   2  (bases 1 to 4162)
  AUTHORS   Seguin,A., Jia,X., Earl,A.M., Li,L., Wallace,J., Qiu,A.,
            Bradley,T., Shrestha,R., Troadec,M.B., Hockin,M., Titen,S.,
            Warner,D.E., Dowdle,P.T., Wohlfahrt,M.E., Hillas,E., Firpo,M.A.,
            Phillips,J.D., Kaplan,J., Paw,B.H., Barasch,J. and Ward,D.M.
  TITLE     The mitochondrial metal transporters mitoferrin1 and mitoferrin2
            are required for liver regeneration and cell proliferation in mice
  JOURNAL   J Biol Chem 295 (32), 11002-11020 (2020)
   PUBMED   32518166
  REMARK    GeneRIF: The mitochondrial metal transporters mitoferrin1 and
            mitoferrin2 are required for liver regeneration and cell
            proliferation in mice.
REFERENCE   3  (bases 1 to 4162)
  AUTHORS   Baldauf,L., Endres,T., Scholz,J., Kirches,E., Ward,D.M.,
            Lessmann,V., Borucki,K. and Mawrin,C.
  TITLE     Mitoferrin-1 is required for brain energy metabolism and
            hippocampus-dependent memory
  JOURNAL   Neurosci Lett 713, 134521 (2019)
   PUBMED   31563673
  REMARK    GeneRIF: Mitoferrin-1 is required for brain energy metabolism and
            hippocampus-dependent memory.
REFERENCE   4  (bases 1 to 4162)
  AUTHORS   Pan,J., Mor,G., Ju,W., Zhong,J., Luo,X., Aldo,P.B., Zhong,M.,
            Yu,Y., Jenkins,E.C., Brown,W.T. and Zhong,N.
  TITLE     Viral Infection-Induced Differential Expression of LncRNAs
            Associated with Collagen in Mouse Placentas and Amniotic Sacs
  JOURNAL   Am J Reprod Immunol 74 (3), 237-257 (2015)
   PUBMED   26073538
REFERENCE   5  (bases 1 to 4162)
  AUTHORS   Chung,J., Anderson,S.A., Gwynn,B., Deck,K.M., Chen,M.J.,
            Langer,N.B., Shaw,G.C., Huston,N.C., Boyer,L.F., Datta,S.,
            Paradkar,P.N., Li,L., Wei,Z., Lambert,A.J., Sahr,K., Wittig,J.G.,
            Chen,W., Lu,W., Galy,B., Schlaeger,T.M., Hentze,M.W., Ward,D.M.,
            Kaplan,J., Eisenstein,R.S., Peters,L.L. and Paw,B.H.
  TITLE     Iron regulatory protein-1 protects against mitoferrin-1-deficient
            porphyria
  JOURNAL   J Biol Chem 289 (11), 7835-7843 (2014)
   PUBMED   24509859
  REMARK    GeneRIF: impaired mitochondrial [Fe-S] cluster biogenesis in
            Mfrn1(gt/gt) cells results in elevated IRP1 RNA-binding that
            attenuates ALAS2 mRNA translation and protoporphyrin accumulation
            Erratum:[J Biol Chem. 2014 May 16;289(20):13707]
REFERENCE   6  (bases 1 to 4162)
  AUTHORS   Yoon,D., Pastore,Y.D., Divoky,V., Liu,E., Mlodnicka,A.E.,
            Rainey,K., Ponka,P., Semenza,G.L., Schumacher,A. and Prchal,J.T.
  TITLE     Hypoxia-inducible factor-1 deficiency results in dysregulated
            erythropoiesis signaling and iron homeostasis in mouse development
  JOURNAL   J Biol Chem 281 (35), 25703-25711 (2006)
   PUBMED   16787915
REFERENCE   7  (bases 1 to 4162)
  AUTHORS   Shaw,G.C., Cope,J.J., Li,L., Corson,K., Hersey,C., Ackermann,G.E.,
            Gwynn,B., Lambert,A.J., Wingert,R.A., Traver,D., Trede,N.S.,
            Barut,B.A., Zhou,Y., Minet,E., Donovan,A., Brownlie,A., Balzan,R.,
            Weiss,M.J., Peters,L.L., Kaplan,J., Zon,L.I. and Paw,B.H.
  TITLE     Mitoferrin is essential for erythroid iron assimilation
  JOURNAL   Nature 440 (7080), 96-100 (2006)
   PUBMED   16511496
  REMARK    GeneRIF: Erythroblasts generated from murine embryonic stem cells
            null for Mfrn (also known as Slc25a37) show maturation arrest with
            severely impaired incorporation of 55Fe into haem [mitoferrin]
REFERENCE   8  (bases 1 to 4162)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 4162)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 4162)
  AUTHORS   Li,Q.Z., Eckenrode,S., Ruan,Q.G., Wang,C.Y., Shi,J.D., McIndoe,R.A.
            and She,J.X.
  TITLE     Rapid decrease of RNA level of a novel mouse mitochondria solute
            carrier protein (Mscp) gene at 4-5 weeks of age
  JOURNAL   Mamm Genome 12 (11), 830-836 (2001)
   PUBMED   11845285
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK006155.1, AF288621.1, AK050414.1 and AK162615.1.
            
            On Feb 24, 2006 this sequence version replaced NM_026331.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF288621.1, AK050414.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AK006155.1         12-62
            52-1558             AF288621.1         5-1511
            1559-2874           AK050414.1         1527-2842
            2875-4162           AK162615.1         2736-4023
FEATURES             Location/Qualifiers
     source          1..4162
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.03 cM"
     gene            1..4162
                     /gene="Slc25a37"
                     /gene_synonym="1700020E22Rik; 4930513O14Rik;
                     4930526G11Rik; C330015G08Rik; frascati; Mfrn; Mfrn1;
                     mitoferrin; Mscp"
                     /note="solute carrier family 25, member 37"
                     /db_xref="GeneID:67712"
                     /db_xref="MGI:MGI:1914962"
     exon            1..372
                     /gene="Slc25a37"
                     /gene_synonym="1700020E22Rik; 4930513O14Rik;
                     4930526G11Rik; C330015G08Rik; frascati; Mfrn; Mfrn1;
                     mitoferrin; Mscp"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..1179
                     /gene="Slc25a37"
                     /gene_synonym="1700020E22Rik; 4930513O14Rik;
                     4930526G11Rik; C330015G08Rik; frascati; Mfrn; Mfrn1;
                     mitoferrin; Mscp"
                     /note="mitochondrial solute carrier protein; mitochondrial
                     iron transporter 1"
                     /codon_start=1
                     /product="mitoferrin-1"
                     /protein_id="NP_080607.2"
                     /db_xref="CCDS:CCDS27238.1"
                     /db_xref="GeneID:67712"
                     /db_xref="MGI:MGI:1914962"
                     /translation="MELRRGGVGNQAAGRRMDGDCRDGGCGSKDAGSEDYENLPTSAS
                     VSTHMTAGAMAGILEHSIMYPVDSVKTRMQSLNPDPKARYTSIYGALKRIMHTEGFWR
                     PLRGLNVMMMGAGPAHAMYFACYENMKRTLNDVFSHQGNSHLANGVAGSMATLLHDAV
                     MNPAEVVKQRLQMYNSQHQSAFSCIRTVWRTEGLGAFYRSYTTQLTMNIPFQSIHFIT
                     YEFLQEQVNPRRDYNPQSHIISGGLAGALAAAATTPLDVCKTLLNTQENMALSLANVS
                     GRLSGMANAFRTVYQLNGLAGYFKGIQARVIYQMPSTAISWSVYEFFKYILTKRQLEN
                     RTLY"
     exon            373..601
                     /gene="Slc25a37"
                     /gene_synonym="1700020E22Rik; 4930513O14Rik;
                     4930526G11Rik; C330015G08Rik; frascati; Mfrn; Mfrn1;
                     mitoferrin; Mscp"
                     /inference="alignment:Splign:2.1.0"
     exon            602..658
                     /gene="Slc25a37"
                     /gene_synonym="1700020E22Rik; 4930513O14Rik;
                     4930526G11Rik; C330015G08Rik; frascati; Mfrn; Mfrn1;
                     mitoferrin; Mscp"
                     /inference="alignment:Splign:2.1.0"
     exon            659..4162
                     /gene="Slc25a37"
                     /gene_synonym="1700020E22Rik; 4930513O14Rik;
                     4930526G11Rik; C330015G08Rik; frascati; Mfrn; Mfrn1;
                     mitoferrin; Mscp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4145..4150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a37"
                     /gene_synonym="1700020E22Rik; 4930513O14Rik;
                     4930526G11Rik; C330015G08Rik; frascati; Mfrn; Mfrn1;
                     mitoferrin; Mscp"
                     /note="putative"
     polyA_site      4162
                     /gene="Slc25a37"
                     /gene_synonym="1700020E22Rik; 4930513O14Rik;
                     4930526G11Rik; C330015G08Rik; frascati; Mfrn; Mfrn1;
                     mitoferrin; Mscp"
                     /note="putative"
ORIGIN      
        1 tccagctatt ggtgcttctg gccgctcggc tccaccccag cccgccatgg cgtcagccgc
       61 cgcaacccgg gggaggaggt tcccacttta agaagtgaag ttttcctccc cctccccctc
      121 ctgcccacct cctgccgcct cccgcgcccc gcggggccgc ggatggagct ccgccgtggc
      181 ggcgtgggga accaggctgc gggccggagg atggatgggg actgccgcga tggcggctgc
      241 ggcagcaagg acgccgggtc ggaggactac gagaacctac cgaccagcgc ctcggtgtcc
      301 acccacatga cagcgggagc gatggccggg attctggagc actccatcat gtacccggtg
      361 gactccgtga agacacggat gcagagtttg aatccagatc ccaaagcccg gtatacaagc
      421 atctatggcg ccctcaagag gatcatgcac actgaaggct tctggaggcc cctgcggggc
      481 ctgaacgtga tgatgatggg tgcagggccc gcgcacgcca tgtattttgc ctgctatgaa
      541 aacatgaaaa ggactttaaa tgacgttttc agccaccaag gaaacagcca tctagctaat
      601 ggggtagctg ggagtatggc caccctactc cacgatgcag taatgaatcc agcagaagtg
      661 gtgaaacagc gcttacagat gtacaactcc cagcaccagt cagccttcag ttgtatccgg
      721 acagtgtggc ggaccgaggg gttgggggcc ttctacagga gttacaccac acagctgacc
      781 atgaatatcc ccttccagtc aattcacttc atcacctatg agtttctgca ggagcaagtc
      841 aaccctcgcc gggactacaa cccacagtct cacatcatct caggaggcct ggccggggca
      901 ctggccgcag ctgccaccac cccgctggac gtctgcaaaa ccctcctcaa cacgcaggag
      961 aacatggctc tctccctggc caacgtcagc ggccggctgt cgggcatggc caatgccttc
     1021 cggacggtgt accagctcaa cggccttgcc ggctatttca aaggcatcca ggctcgagtc
     1081 atctaccaga tgccttccac cgccatctcc tggtccgttt atgagttctt caagtacatc
     1141 cttacaaaga ggcagctgga gaatcgaact ctgtactaaa ggaatggggc agtgggaagt
     1201 ggttctgaca tcctttgttc cagcttcatc ctcttgttct cgcacccagg gcttgtcctg
     1261 aagggtgctt gcgccaggcc cttcgttccc tggtgccgta gagagggagg accggcctcc
     1321 actgaccagc atgctgtctg tggggacatc cgaggtggtg gtaggcggga gaaacttggg
     1381 gagagggaga agttgctttt ctcctccttc ctccagagga atgtagcttt tctgcctcac
     1441 tgtggccttc tccctagatc tttagatcac accgcagagg caaacagtga cacagcaaag
     1501 aaaaagttta tgtacataaa agtaccatta ccccagtctg aaataggtgg ataatgttta
     1561 tcctttattt ttctacatag agatttttga aattgtgtgt gcttgtgtgt gtctataaat
     1621 aatattagag ttgggaatga tggacctgtt ttgttttttt gttttttaaa taagagagtt
     1681 ccattcttcc atcatgagaa gtaaaacaaa caacaacaac aacaaacaag gggaaaaagg
     1741 caccaaagta ataaatggct ttatgtggcc tgaaattgtg tgtagcgccc ctcccatggg
     1801 agtttaactt gaatgtaaaa taataaatat aaagtttata ttttgaattt ctcttttcat
     1861 ggggaaaaag gtacgttgaa aacaaatcaa aatagtctat cacttggagc ttttttttgt
     1921 tttgttttta attttaattt taaatacagt taccctgcgt gcctttctgt cttttctaag
     1981 acttccagga ccaaaattag ggtcctggag cattttctcc ctctgtagac acccccgtac
     2041 agtcctcagc accatggctg tctcagtaga ataagaatgg ctggccttaa ccttccgtgt
     2101 gagtgatgtg agcgtgtgcc tccctgttca gctcttagca ctgggaatgc cactgtatgc
     2161 ctagccaatt gatgagacag ttcctgcctt tgtcttagga gtaatctcca tagcaacctc
     2221 ctccttgggc acttctgcta acctggtcta taaggtttgt tagtagtctc ctgttgaccc
     2281 atttccccgg cagtctaggg attttgagta tttctggtac tcatctgtca cctaccctgt
     2341 tcagctccac gacttaaaca tcagagcctc ttcactgcac tgaggccagc cctccagccg
     2401 ggactgaagc ctgccacgat cctccgcccc tcccgagctg ctcagcagcc ttgtctcacc
     2461 ctgtgtcact tgagaacctc cgtcctttcc gctttgtttt ctgaagtgga gtcagatcat
     2521 ctcagagaaa gcacaagcct gtgttgtcca gtctcccatc ctcatggaga tgacaggata
     2581 ggctcagttt ccttcttcca gttgtcaacg agtaagctgg gaagacgctc atgttttcgt
     2641 gtccattgcc ctggtctcat ttggaagcca cgactagcat gctccctcac tggggaggct
     2701 tagaccttga gttcccacgg atggtcatgc tgctgcctgg gaagaaattg agcttgtact
     2761 tggagaattt catcttggac ccacgtacca cttggtgcca gtagatgcag ctttttggtt
     2821 ttgtccagca gctatgagaa gttacacact ggtcagctga cttttttttt ttttccccag
     2881 agagaaccac ctctctcaag tactcctatg tattccagga gggcttcctg gctggctgca
     2941 gtttgtctta ctagtgtcct gggctggctg gtgtcctatt atcactgaca atgtttctat
     3001 tcttaccctg ctagcattga gtagagttaa attctataaa tggagaggga agtcaaattg
     3061 tagagtctaa agtcaaattt aaatcaaacc ccaaactatt cctataccac gcttagatac
     3121 attgttgact aatcctgctg caagaccaat attttccctt ggattttctt tacagttatc
     3181 taatactagg atagcccctt tggtcatggc cttataaggt aggaccagga cttcaggact
     3241 ctgtgagctt gaagtccagg ggtcccatcc tggctatcct ctcctcatga ttggtgggtc
     3301 tgcaggaaga tagctttttt aacctgccca tccaattcag tcaccctaag gttgagcgag
     3361 tgatatgtct gcaaaaaagt tgttaaaggt tgggatacat tcaacgtaag ttctgtgcca
     3421 gtcagtcccc cctcccttag ctccaacatt gaaattgtcc ttgaccctca cgcacatgat
     3481 agccagtgtg ttgattgtca tttttgacgt tgcaaatttc aagataggaa aaggctcagt
     3541 gaccagttta ggatagccat aacctatctc ggtcattggc atctttggag tgacatccaa
     3601 ggatggacca tcccacctgt gtacaatgat aatactttag ctgtgtgtgt gtgtgtgtgt
     3661 gtgtgtgttc aggccatgtg acagtcaacc atttaataga tgagtgttaa tttattatag
     3721 ataaatattg atctttaaaa atgggatgct cttaattcat gactttttaa agaattggat
     3781 taaatatagc tacttttatg tgagctttcc cctctgtccc cctgcccctt ctctctgtct
     3841 catttctcac aaccatcacc ctccagtgtc acccccaagg ctatatctcc aacatactgc
     3901 tatgccatta aggttttatt taactttatt tatggataat tatgtctatg aacaacaaat
     3961 gtgccgttac cggtcacaca gtgtgtggga taagagtggc ctagtgttgc tttccgaatg
     4021 tcttaaaata cctgtggtca agattgtttt tgcctttgtg gcctttgggt ttggagagca
     4081 gcattgtgtt cacatgtgtg gatgtctgtc gtgctgctac agttgtaaca ctggagctgg
     4141 aaaaaataaa gcattgatct tg
//
