LOCUS       NM_027460               1877 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus solute carrier family 25, member 33 (Slc25a33), mRNA.
ACCESSION   NM_027460 XM_003689205 XM_003945705 XM_006536021 XM_011251197
VERSION     NM_027460.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1877)
  AUTHORS   Floyd,S., Favre,C., Lasorsa,F.M., Leahy,M., Trigiante,G.,
            Stroebel,P., Marx,A., Loughran,G., O'Callaghan,K., Marobbio,C.M.,
            Slotboom,D.J., Kunji,E.R., Palmieri,F. and O'Connor,R.
  TITLE     The insulin-like growth factor-I-mTOR signaling pathway induces the
            mitochondrial pyrimidine nucleotide carrier to promote cell growth
  JOURNAL   Mol Biol Cell 18 (9), 3545-3555 (2007)
   PUBMED   17596519
  REMARK    GeneRIF: The data indicate that PNC1 is a target of the IGF-I/mTOR
            pathway that is essential for mitochondrial activity in regulating
            cell growth and proliferation.
REFERENCE   2  (bases 1 to 1877)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK795124.1, BQ950692.1, AW989568.1, BB772382.1 and BG063566.2.
            
            On or before Feb 15, 2015 this sequence version replaced
            XM_011251197.1, XM_006536021.1, XM_003945705.1, XM_003689205.1,
            NM_027460.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157423.1, BC011293.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               CK795124.1         10-167
            159-669             BQ950692.1         94-604
            670-1201            AW989568.1         11-542
            1202-1439           BB772382.1         299-536
            1440-1877           BG063566.2         1-438               c
FEATURES             Location/Qualifiers
     source          1..1877
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 80.15 cM"
     gene            1..1877
                     /gene="Slc25a33"
                     /gene_synonym="5730438N18Rik; Pnc1"
                     /note="solute carrier family 25, member 33"
                     /db_xref="GeneID:70556"
                     /db_xref="MGI:MGI:1917806"
     exon            1..268
                     /gene="Slc25a33"
                     /gene_synonym="5730438N18Rik; Pnc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..1175
                     /gene="Slc25a33"
                     /gene_synonym="5730438N18Rik; Pnc1"
                     /note="novel mitochondrial carrier protein domains
                     containing protein"
                     /codon_start=1
                     /product="solute carrier family 25 member 33"
                     /protein_id="NP_081736.2"
                     /db_xref="CCDS:CCDS38976.1"
                     /db_xref="GeneID:70556"
                     /db_xref="MGI:MGI:1917806"
                     /translation="MATGTQQKENTLLHLFAGGCGGTVGAIFTCPLEVIKTRLQSSRL
                     ALRTVYYPQVHLGTISGAGMVRPTSVTPGLLQVLKSILEKEGPKSLFRGLGPNLVGVA
                     PSRAVYFACYSKAKEQFNGIFVPNSNTVHILSAGSAAFVTNTLMNPIWMVKTRMQLER
                     KVRGCKQMNTLQCARRVYQTEGVRGFYRGLTASYAGISETIICFAIYESLKKCLKDAP
                     IVSSTDGAEKSSSGFFGLMAAAAVSKGCASCIAYPHEVIRTRLREEGSKYRSFVQTAR
                     LVFREEGYLAFYRGLFAQLIRQIPNTAIVLSTYEFIVYLLGERA"
     exon            269..448
                     /gene="Slc25a33"
                     /gene_synonym="5730438N18Rik; Pnc1"
                     /inference="alignment:Splign:2.1.0"
     exon            449..526
                     /gene="Slc25a33"
                     /gene_synonym="5730438N18Rik; Pnc1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..627
                     /gene="Slc25a33"
                     /gene_synonym="5730438N18Rik; Pnc1"
                     /inference="alignment:Splign:2.1.0"
     exon            628..694
                     /gene="Slc25a33"
                     /gene_synonym="5730438N18Rik; Pnc1"
                     /inference="alignment:Splign:2.1.0"
     exon            695..975
                     /gene="Slc25a33"
                     /gene_synonym="5730438N18Rik; Pnc1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1877
                     /gene="Slc25a33"
                     /gene_synonym="5730438N18Rik; Pnc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1418..1423
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a33"
                     /gene_synonym="5730438N18Rik; Pnc1"
                     /note="hexamer: ATTAAA"
     polyA_site      1441
                     /gene="Slc25a33"
                     /gene_synonym="5730438N18Rik; Pnc1"
                     /note="major polyA site"
ORIGIN      
        1 ggccgcgcgc taggctctct gcctagcggc tggaaagcgc cgcagaggcc gctgactggc
       61 cgggcgcgac gccgcggagg gagccgggcg cctgggcctc ccgcgcgcat gggcgcgtcg
      121 gcggctgcct gaggaaggca gcgaagccag cggagctcaa gacctcgcgc gtcccacgag
      181 cggctgcggc gggccgcgga gccggcgcgg ccatggcgac gggcactcag cagaaagaga
      241 acacgctgct tcatctcttc gccggcgggt gcgggggcac agttggtgct attttcacat
      301 gtccactaga agtcattaag acgcgactgc agtcttcgag actagctctt cggacggtgt
      361 attaccctca ggttcatctg gggaccatta gtggagctgg aatggtgaga ccaacgtctg
      421 tgacgcctgg actcctacag gttctgaaat caatcctgga aaaggaggga ccaaagtcac
      481 tctttagagg cctgggtcca aatttggttg gagttgcacc atcaagggct gtgtactttg
      541 catgttattc caaagccaaa gagcaattca atggcatctt cgtgcctaat agcaatactg
      601 tgcacattct ctcagctggc tctgcagctt ttgtcacaaa taccttaatg aatcctattt
      661 ggatggttaa aacgaggatg cagctagaac gcaaggtgag gggctgcaag cagatgaaca
      721 cactccagtg tgctcggcgt gtctaccaga cagaaggcgt ccgcggcttc tatagagggc
      781 tgaccgcctc ctacgctggg atctcggaga caatcatctg ctttgctatt tatgagagct
      841 taaagaagtg tttgaaagac gctccgatcg tctcctccac agatggagct gagaaaagtt
      901 cctctggctt ctttggactc atggcagctg ctgctgtttc taagggatgt gcctcctgca
      961 tcgcttaccc acacgaggtc atcaggacgc ggctccgcga ggaaggcagc aagtacaggt
     1021 cgttcgtgca gaccgcgcgc ctggtgttcc gggaggaagg ctacctcgcc ttctaccgag
     1081 gactgtttgc tcagctcatc cggcagatcc ccaacactgc cattgtcctg tccacctacg
     1141 agttcatcgt gtacctgctg ggagagcgtg cttagtgaca gggccacatg gttgtgctct
     1201 agaagaataa aactgaaaac cctagagatt ttcttttccg ttgatgttta gtgttcaaaa
     1261 ctgaaacagc gaaggccata gaatacctgg ctcatgtcac ctgttggaca tttccttttg
     1321 gattcttgtt tctggaaggt tgaaattcat taacgttaat agttaattat aactttcttt
     1381 tttaacttaa gaggactgag gattgaggag caagtaaatt aaatcatgct atttaatgta
     1441 agttcgtgct gggctgtgtt ctcctttgtg cttactgggc tgccctaagc cggccacggg
     1501 gtctggctgg gcgtggggaa gtgagaagcg tgacttgtgg ggactgagtg gtggacagga
     1561 aagagcggtc acgcttggtg acaactgtga gcaaatggtc cacagctttc cctctgtaca
     1621 tctccatctc ccccctccat ggtggtaggt ttatctgtaa tctgtttcca gacactgaat
     1681 gggggtgggg gtgggggtgg agtgtaactt ccttaaccac cccacccccc accctttctg
     1741 agtcagggtc ttggtgctgt agcccagact gatcttcacc tttaaatctc ctgcctcagc
     1801 ctcccaaggg ctgaaaatgc agatgtacac cctgggcctg acctagctgg acaataaaaa
     1861 ctgcttttag ctacatt
//
