LOCUS       NM_145156               1569 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Mus musculus solute carrier family 25, member 28 (Slc25a28),
            transcript variant 1, mRNA.
ACCESSION   NM_145156 XM_978453
VERSION     NM_145156.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1569)
  AUTHORS   Klag,K.A., Bell,R., Jia,X., Seguin,A., Maschek,J.A., Bronner,M.,
            Cox,J.E., Round,J.L. and Ward,D.M.
  TITLE     Low-Iron Diet-Induced Fatty Liver Development Is Microbiota
            Dependent and Exacerbated by Loss of the Mitochondrial Iron
            Importer Mitoferrin2
  JOURNAL   Nutrients 16 (12), 1804 (2024)
   PUBMED   38931165
  REMARK    GeneRIF: Low-Iron Diet-Induced Fatty Liver Development Is
            Microbiota Dependent and Exacerbated by Loss of the Mitochondrial
            Iron Importer Mitoferrin2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1569)
  AUTHORS   Guan,H., Xiao,L., Hao,K., Zhang,Q., Wu,D., Geng,Z., Duan,B.,
            Dai,H., Xu,R. and Feng,X.
  TITLE     SLC25A28 Overexpression Promotes Adipogenesis by Reducing ATGL
  JOURNAL   J Diabetes Res 2024, 5511454 (2024)
   PUBMED   38736904
  REMARK    GeneRIF: SLC25A28 Overexpression Promotes Adipogenesis by Reducing
            ATGL.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1569)
  AUTHORS   Han,R., Liu,L., Wang,Y., Wu,R., Yang,Y., Zhao,Y., Jian,L., Yuan,Y.,
            Zhang,L., Gu,Y., Gao,C. and Ye,J.
  TITLE     Microglial SLC25A28 Deficiency Ameliorates the Brain Injury After
            Intracerebral Hemorrhage in Mice by Restricting Aerobic Glycolysis
  JOURNAL   Inflammation 47 (2), 591-608 (2024)
   PUBMED   38085466
  REMARK    GeneRIF: Microglial SLC25A28 Deficiency Ameliorates the Brain
            Injury After Intracerebral Hemorrhage in Mice by Restricting
            Aerobic Glycolysis.
REFERENCE   4  (bases 1 to 1569)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 1569)
  AUTHORS   Wang,D., Ye,P., Kong,C., Chao,Y., Yu,W., Jiang,X., Luo,J., Gu,Y.
            and Chen,S.L.
  TITLE     Mitoferrin 2 deficiency prevents mitochondrial iron
            overload-induced endothelial injury and alleviates atherosclerosis
  JOURNAL   Exp Cell Res 402 (1), 112552 (2021)
   PUBMED   33711329
  REMARK    GeneRIF: Mitoferrin 2 deficiency prevents mitochondrial iron
            overload-induced endothelial injury and alleviates atherosclerosis.
REFERENCE   6  (bases 1 to 1569)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 1569)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 1569)
  AUTHORS   Li,F.Y., Leibiger,B., Leibiger,I. and Larsson,C.
  TITLE     Characterization of a putative murine mitochondrial transporter
            homology of hMRS3/4
  JOURNAL   Mamm Genome 13 (1), 20-23 (2002)
   PUBMED   11773964
REFERENCE   9  (bases 1 to 1569)
  AUTHORS   Li,F.Y., Nikali,K., Gregan,J., Leibiger,I., Leibiger,B.,
            Schweyen,R., Larsson,C. and Suomalainen,A.
  TITLE     Characterization of a novel human putative mitochondrial
            transporter homologous to the yeast mitochondrial RNA splicing
            proteins 3 and 4
  JOURNAL   FEBS Lett 494 (1-2), 79-84 (2001)
   PUBMED   11297739
REFERENCE   10 (bases 1 to 1569)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138790.2, AF377994.1 and BE849400.1.
            
            On May 4, 2006 this sequence version replaced XM_978453.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025908.1, AF377994.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               AC138790.2         187066-187247       c
            183-1531            AF377994.1         1-1349
            1532-1569           BE849400.1         344-381
FEATURES             Location/Qualifiers
     source          1..1569
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 36.67 cM"
     gene            1..1569
                     /gene="Slc25a28"
                     /gene_synonym="Mfrn2; Mrs3/4"
                     /note="solute carrier family 25, member 28"
                     /db_xref="GeneID:246696"
                     /db_xref="MGI:MGI:2180509"
     exon            1..406
                     /gene="Slc25a28"
                     /gene_synonym="Mfrn2; Mrs3/4"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1210
                     /gene="Slc25a28"
                     /gene_synonym="Mfrn2; Mrs3/4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mitoferrin-2; mitochondrial iron transporter 2;
                     mitochondrial RNA-splicing protein 3/4 homolog"
                     /codon_start=1
                     /product="mitoferrin-2 isoform 1"
                     /protein_id="NP_660138.1"
                     /db_xref="CCDS:CCDS29834.1"
                     /db_xref="GeneID:246696"
                     /db_xref="MGI:MGI:2180509"
                     /translation="MELEGRSAGGVAGGPAAGPGRSPGESALLDGWLQRGVGRGAGGG
                     EAGAYQPPVRLDPESGPEYEALPAGATVTTHMVAGAVAGILEHCVMYPIDCVKTRMQS
                     LQPDPAARYRNVLEALWRIMRTEGLWRPMRGLNVTATGAGPAHALYFACYEKLKKTLS
                     DVIHPGGNSHIANGAAGCVATLLHDAAMNPAEVVKQRMQMYNSPYHRVTDCVRAVWQN
                     EGAGAFYRSYTTQLTMNVPFQAIHFMTYEFLQEHFNPQRRYNPSSHVLCGACAGAVAA
                     AATTPLDVCKTLLNTQESLALNSNITGHITGMASAFRTVYQVGGVTAYFRGVQARVIY
                     QIPSTAIAWSVYEFFKYLITKRQEEWRAGK"
     exon            407..635
                     /gene="Slc25a28"
                     /gene_synonym="Mfrn2; Mrs3/4"
                     /inference="alignment:Splign:2.1.0"
     exon            636..692
                     /gene="Slc25a28"
                     /gene_synonym="Mfrn2; Mrs3/4"
                     /inference="alignment:Splign:2.1.0"
     exon            693..1535
                     /gene="Slc25a28"
                     /gene_synonym="Mfrn2; Mrs3/4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1518..1523
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a28"
                     /gene_synonym="Mfrn2; Mrs3/4"
                     /note="hexamer: AAGAAA"
     polyA_site      1535
                     /gene="Slc25a28"
                     /gene_synonym="Mfrn2; Mrs3/4"
                     /note="major polyA site"
ORIGIN      
        1 ccggaggccc cgggctctct gggccgcgcc tgaggcggac gcaacggggc cggggggcgg
       61 cggcagtggt ggcggcagcg gcggcgcgtg tgggcgccgc ggctggccga agtggatgga
      121 gttggagggg cggagtgcag gcggcgtggc gggaggacca gctgctgggc ccgggcggag
      181 ccccggggag tcggcgctgc tggacgggtg gctgcagcgg ggcgtgggcc ggggggccgg
      241 cggcggggag gcgggggcct atcagccccc tgtacggctg gatccggagt ccggcccgga
      301 atacgaagcg ctgccggctg gagccactgt caccacgcac atggtggcgg gcgccgtggc
      361 agggatcctg gagcattgcg tgatgtaccc gatcgactgc gtcaagaccc ggatgcagag
      421 cctacagcct gacccagccg cccgctatcg gaacgtgttg gaggctctct ggagaatcat
      481 gaggacagag ggcctgtgga ggcccatgcg ggggctgaac gtcacagcaa caggcgcggg
      541 gcctgcccac gccctctatt ttgcctgcta cgaaaagtta aaaaagacat tgagtgacgt
      601 aatccaccca gggggcaata gccatattgc caatggtgca gccggatgtg tggcgacatt
      661 acttcatgat gcagccatga atccagcgga agtcgtcaag cagaggatgc agatgtacaa
      721 ctcgccgtac caccgcgtga cagactgtgt tcgggcagtg tggcaaaatg aaggggccgg
      781 ggccttttac cgcagctaca cgacccagct gaccatgaat gtccccttcc aagccattca
      841 cttcatgacc tatgagttcc tgcaagagca ctttaacccc cagagacggt acaaccccag
      901 ctcccatgtg ctctgtgggg cctgcgcagg agcagtagct gccgccgcca caaccccact
      961 ggacgtttgt aaaacactgc tcaacaccca ggaatccctg gctttgaact caaacattac
     1021 tggacacatc acaggcatgg ctagtgcctt caggacggtc tatcaagtag gcggggtgac
     1081 tgcttacttc cgaggggtgc aggccagagt catttaccag atcccctcca cagccatcgc
     1141 atggtctgtg tatgaatttt tcaaatacct aatcacaaag cggcaagagg aatggagggc
     1201 aggcaagtga agggatgctg agtggaccag ggtccgaccg cacggctgca tcctgccctt
     1261 ccagcacatt ctctggctgc tggcacactc cagtctcaag aggagttgga aggagggaga
     1321 gagcttgctc caggctgtag ttggctaaca ctagttcttg ccaacatctg tcgccactgt
     1381 tgtctttctt cctgggctct ctgcaagttg agcaaagccc accgcagtac ctctgccacc
     1441 gtctccaccc tgggcctggc gacctgctct agactgatgc agaggataag cagcgcatcc
     1501 cctggttcct aattaaaaag aaaaaagcct ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1561 aaaaaaaaa
//
