LOCUS       NM_028711               7047 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus solute carrier family 25, member 27 (Slc25a27),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_028711
VERSION     NM_028711.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7047)
  AUTHORS   Wang,Y.Y., Liu,H., Li,S.J., Feng,B., Huang,Y.Q., Liu,S.B. and
            Yang,Y.L.
  TITLE     Ucp4 Knockdown of Cerebellar Purkinje Cells Induces Bradykinesia
  JOURNAL   Mol Neurobiol 61 (2), 1119-1139 (2024)
   PUBMED   37688710
  REMARK    GeneRIF: Ucp4 Knockdown of Cerebellar Purkinje Cells Induces
            Bradykinesia.
REFERENCE   2  (bases 1 to 7047)
  AUTHORS   Rosenberg,N., Reva,M., Binda,F., Restivo,L., Depierre,P., Puyal,J.,
            Briquet,M., Bernardinelli,Y., Rocher,A.B., Markram,H. and
            Chatton,J.Y.
  TITLE     Overexpression of UCP4 in astrocytic mitochondria prevents
            multilevel dysfunctions in a mouse model of Alzheimer's disease
  JOURNAL   Glia 71 (4), 957-973 (2023)
   PUBMED   36537556
  REMARK    GeneRIF: Overexpression of UCP4 in astrocytic mitochondria prevents
            multilevel dysfunctions in a mouse model of Alzheimer's disease.
REFERENCE   3  (bases 1 to 7047)
  AUTHORS   Xu,S., Yang,X., Qian,Y. and Xiao,Q.
  TITLE     Parkinson's disease-related DJ-1 modulates the expression of
            uncoupling protein 4 against oxidative stress
  JOURNAL   J Neurochem 145 (4), 312-322 (2018)
   PUBMED   29315581
  REMARK    GeneRIF: our results suggested DJ-1 might regulate the expression
            of UCP4 by oxidation of DJ-1 and partially via NF-kappaB pathway in
            its protective response to oxidative stress
REFERENCE   4  (bases 1 to 7047)
  AUTHORS   Ji,F., Shen,T., Zou,W. and Jiao,J.
  TITLE     UCP2 Regulates Embryonic Neurogenesis via ROS-Mediated Yap
            Alternation in the Developing Neocortex
  JOURNAL   Stem Cells 35 (6), 1479-1492 (2017)
   PUBMED   28276603
REFERENCE   5  (bases 1 to 7047)
  AUTHORS   Klotzsch,E., Smorodchenko,A., Lofler,L., Moldzio,R., Parkinson,E.,
            Schutz,G.J. and Pohl,E.E.
  TITLE     Superresolution microscopy reveals spatial separation of UCP4 and
            F0F1-ATP synthase in neuronal mitochondria
  JOURNAL   Proc Natl Acad Sci U S A 112 (1), 130-135 (2015)
   PUBMED   25535394
  REMARK    GeneRIF: UCP4 may dissipate the excessive proton gradient, which is
            usually associated with reactive oxygen species production.
REFERENCE   6  (bases 1 to 7047)
  AUTHORS   Smorodchenko,A., Rupprecht,A., Sarilova,I., Ninnemann,O.,
            Brauer,A.U., Franke,K., Schumacher,S., Techritz,S., Nitsch,R.,
            Schuelke,M. and Pohl,E.E.
  TITLE     Comparative analysis of uncoupling protein 4 distribution in
            various tissues under physiological conditions and during
            development
  JOURNAL   Biochim Biophys Acta 1788 (10), 2309-2319 (2009)
   PUBMED   19646951
REFERENCE   7  (bases 1 to 7047)
  AUTHORS   Liu,D., Chan,S.L., de Souza-Pinto,N.C., Slevin,J.R., Wersto,R.P.,
            Zhan,M., Mustafa,K., de Cabo,R. and Mattson,M.P.
  TITLE     Mitochondrial UCP4 mediates an adaptive shift in energy metabolism
            and increases the resistance of neurons to metabolic and oxidative
            stress
  JOURNAL   Neuromolecular Med 8 (3), 389-414 (2006)
   PUBMED   16775390
  REMARK    GeneRIF: Results suggest that mitochondrial UCP4 mediates an
            adaptive shift in energy metabolism and increases the resistance of
            neurons to metabolic and oxidative stress.
REFERENCE   8  (bases 1 to 7047)
  AUTHORS   Willnow,T., Antignac,C., Brandli,A., Christensen,E., Cox,R.,
            Davidson,D., Davies,J., Devuyst,O., Eichele,G., Hastie,N.,
            Verroust,P., Schedl,A. and Meij,I.
  TITLE     The European renal genome project: an integrated approach towards
            understanding the genetics of kidney development and disease
  JOURNAL   Organogenesis 2 (2), 42-47 (2005)
   PUBMED   19521566
REFERENCE   9  (bases 1 to 7047)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (bases 1 to 7047)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK043831.1, AC154647.2 and AU254602.1.
            
            On Oct 21, 2017 this sequence version replaced NM_028711.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043831.1, AK014394.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1719              AK043831.1         2-1720
            1720-6883           AC154647.2         112090-117253       c
            6884-7047           AU254602.1         1-164
FEATURES             Location/Qualifiers
     source          1..7047
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 19.75 cM"
     gene            1..7047
                     /gene="Slc25a27"
                     /gene_synonym="3632410G24Rik; 9430092A03Rik;
                     D530043E16Rik; UCP 4; Ucp4"
                     /note="solute carrier family 25, member 27"
                     /db_xref="GeneID:74011"
                     /db_xref="MGI:MGI:1921261"
     exon            1..315
                     /gene="Slc25a27"
                     /gene_synonym="3632410G24Rik; 9430092A03Rik;
                     D530043E16Rik; UCP 4; Ucp4"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..1181
                     /gene="Slc25a27"
                     /gene_synonym="3632410G24Rik; 9430092A03Rik;
                     D530043E16Rik; UCP 4; Ucp4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mitochondrial uncoupling protein 4"
                     /codon_start=1
                     /product="mitochondrial uncoupling protein 4 isoform 1"
                     /protein_id="NP_082987.1"
                     /db_xref="CCDS:CCDS28798.1"
                     /db_xref="GeneID:74011"
                     /db_xref="MGI:MGI:1921261"
                     /translation="MPIAEEEKLLPLTQRWPRTSKFLLSGCAATVAELATFPLDLTKT
                     RLQMQGEAALARLGDGAVDSAPYRGMVRTALGIVQEEGFLKLWQGVTPAIYRHVVYSG
                     GRMVTYEHLREVVFGKSEDKHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKR
                     RLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWIPNIQRAALVNMGDLTTYDTVKHYLV
                     LNTPLEDNISTHGLSSLCSGLVASILGTPADVIKSRIMNQPRDKQGRGLLYKSSADCL
                     IQAVQGEGFLSLYKGFLPSWLRMTPWSMVFWLTYEKIREMSGVSPF"
     exon            316..507
                     /gene="Slc25a27"
                     /gene_synonym="3632410G24Rik; 9430092A03Rik;
                     D530043E16Rik; UCP 4; Ucp4"
                     /inference="alignment:Splign:2.1.0"
     exon            508..592
                     /gene="Slc25a27"
                     /gene_synonym="3632410G24Rik; 9430092A03Rik;
                     D530043E16Rik; UCP 4; Ucp4"
                     /inference="alignment:Splign:2.1.0"
     exon            593..715
                     /gene="Slc25a27"
                     /gene_synonym="3632410G24Rik; 9430092A03Rik;
                     D530043E16Rik; UCP 4; Ucp4"
                     /inference="alignment:Splign:2.1.0"
     exon            716..828
                     /gene="Slc25a27"
                     /gene_synonym="3632410G24Rik; 9430092A03Rik;
                     D530043E16Rik; UCP 4; Ucp4"
                     /inference="alignment:Splign:2.1.0"
     exon            829..913
                     /gene="Slc25a27"
                     /gene_synonym="3632410G24Rik; 9430092A03Rik;
                     D530043E16Rik; UCP 4; Ucp4"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1006
                     /gene="Slc25a27"
                     /gene_synonym="3632410G24Rik; 9430092A03Rik;
                     D530043E16Rik; UCP 4; Ucp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1109
                     /gene="Slc25a27"
                     /gene_synonym="3632410G24Rik; 9430092A03Rik;
                     D530043E16Rik; UCP 4; Ucp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..7047
                     /gene="Slc25a27"
                     /gene_synonym="3632410G24Rik; 9430092A03Rik;
                     D530043E16Rik; UCP 4; Ucp4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1693..1698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a27"
                     /gene_synonym="3632410G24Rik; 9430092A03Rik;
                     D530043E16Rik; UCP 4; Ucp4"
                     /note="hexamer: AATAAA"
     polyA_site      1724
                     /gene="Slc25a27"
                     /gene_synonym="3632410G24Rik; 9430092A03Rik;
                     D530043E16Rik; UCP 4; Ucp4"
                     /note="major polyA site"
     regulatory      4134..4139
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a27"
                     /gene_synonym="3632410G24Rik; 9430092A03Rik;
                     D530043E16Rik; UCP 4; Ucp4"
                     /note="hexamer: ATTATA"
     polyA_site      4153
                     /gene="Slc25a27"
                     /gene_synonym="3632410G24Rik; 9430092A03Rik;
                     D530043E16Rik; UCP 4; Ucp4"
ORIGIN      
        1 acatttccca gaagcctctt gggtgcggct ttgtttttca gcacctgagg ccgccggacc
       61 ggtccagcta ccaggcgggc ggcgcctttg cagagcgtaa taaaggcaca tggtcctgac
      121 ctgacctctc tcgggctgaa aaggggcggc gccggcaggg tggcaggttc ccaggcgacc
      181 agcggtgccc agtggtcctg acttgctgct gaatgcctat cgccgaggag gagaagctgc
      241 tgccgctcac gcagagatgg ccccggacga gcaagttcct actgtccggc tgcgccgcaa
      301 ccgtggccga gctagcaacc tttcccctcg atctcacaaa aacccgactc cagatgcaag
      361 gagaagctgc ccttgctagg ttgggagatg gcgcagtgga ctctgcccct tataggggca
      421 tggtgcgcac ggccctggga attgttcagg aggaaggctt cctaaagctg tggcaaggag
      481 tgacgcccgc catttacaga cacgtagtgt actctggagg tcggatggtc acctatgaac
      541 atctacggga agtcgtgttt ggcaaaagtg aagataagca ttatcccctc tggaaatcgg
      601 tcattggagg gatgatggct ggtgtcatcg gacagttttt agccaacccc actgaccttg
      661 tgaaggtcca gatgcaaatg gaagggaaac gcagactgga agggaaaccc ttgagattcc
      721 gtggagtaca tcatgcattt gcaaaaatct tagctgaagg aggaatccgc gggctttggg
      781 caggctggat acccaatatt cagagagcag cgcttgtgaa catgggagat ctaaccactt
      841 acgacacagt gaaacactac ctggtattga acacaccgct tgaagacaat atttccaccc
      901 acggcttatc cagtttgtgt tctggacttg tggcttctat tctgggaaca ccagccgatg
      961 tcatcaaaag ccgaataatg aaccaacctc gagacaaaca aggaagggga cttttgtata
     1021 agtcatcagc tgactgcttg atccaggctg ttcaagggga aggcttcctg agcctgtata
     1081 aaggctttct accctcgtgg ctgagaatga ccccttggtc aatggtgttc tggctcactt
     1141 atgaaaaaat ccgagagatg agtggagtca gcccatttta agcccttaaa gctagagtgc
     1201 tcattgtcac tgaacaagag catctgcgac acacgcccct gttatttcta cctctttagg
     1261 aagatacttt actccacaga gactgcgatt tgcagggggc agcactttat ctctttatgg
     1321 aatccccatg gagctccctc tgactcctcc ttttacctaa gagcaatctg tctggtccaa
     1381 tctctcaaga ccaaccactg agacacagca aggcgtttgc taacggatgg aacccagacc
     1441 actttgacct tgggccagga ggtttggacg ttgagctgct gatctgtgca gaagcagcat
     1501 ctgccttaga ggagcagcag agacagccag catcccaggc ctggatagac gtcatccatg
     1561 tggaagacta gtgcttagga aacacattta acctttgagc cagttattta ttgttgccgt
     1621 ttgacaactc tcgcttttct gttcgtagag tgcacatatc gtaatctaca cagaggcaaa
     1681 tgagaagtca tgaataaaca tcttgagttt tcttagtgct gaaagaagtc gcttaacctt
     1741 ttcctgcaag gaggatggaa agataaaaga ggcaacttga agtgatgttg gattgcaagg
     1801 aaagaggcct cttgatcctg ggtctgctgc ctttgcaggt gtcctttact ggttgccact
     1861 gctttatgca tgctagaggc tagagatatc ccctgacagc cacagtctgt ccgtaagaac
     1921 agaacgcttg ctctggaaca cattccatta caaccacatt ggcccatagc tctgagaagc
     1981 ataaccaaga gaaccacaat atacttgtct gagactgagc tctcggggcg ttcttaggaa
     2041 gcgcctcata cggtcatcag cttttcagga atgttttggg agcaagctta ctctctcttg
     2101 tgtcaccctc tgcatctctc ttctctgtta cagagaggag agggcagaga gagagagaga
     2161 gacagagaga gacagagaga gagagagaga gagagagaac tcagatgtcg tgaaactttc
     2221 agaaacctga gtgttaatca ttgagtctta ctcatcctcg cctgtggtgt ggcaagtgct
     2281 cgccgtccgt ggtccctggt agcctctcca gtctttgcat ccagtccttt tctctctttc
     2341 tagaaaggtt tctgcagatt cacactcccc cccccccccc agcctcagac acagggtgtt
     2401 ttaggatgga tggctacagc tcaggggtaa cagcttgggg atatgactag aaaaactccg
     2461 accactcagg cccaaggtag atctcagagc caaccgaata gctgctctga tgggcagatg
     2521 ctccgacacg gcagcggccc cgtcagcgct gtacgaatga gcggatgaag aatcactgcc
     2581 acttcaaagg aggaagcaca cttttaaggc cctttcaatg tgtgtaacaa tctcactttt
     2641 ctaccgacag aaggtggcgt ttgatccctg tacatcttca ggttacccac ctttctgttg
     2701 catctgtcag cctgcaattg agttgctaag taatatctgt tagcctatag tatgtgctta
     2761 agtccccaag cattctgctc cacaaacaaa atcactttgg gggagatttt ggtttttcta
     2821 tgttttctaa tgtttatgac taagtaaaaa atggaatcaa ataattacat gcaaacacaa
     2881 ctattgaaaa aaaaatggct cagcttcctt cttttggggg ctggggactg ggacaaggac
     2941 acgttgatcc ttggtttgga aactgaaacc cagagaaagg agggtgctgg tgctgcacag
     3001 tgccaaggtc ctgagtgtta tgggttttag agtagaccat aatatcccac actgacgagg
     3061 tacccaagca gaccccttac atcggcttca cagcagcccc gtctccgatc ctgcgtcgtc
     3121 tccggctttg tttttgttat tgttgttgag gatgatgttt cgtgtcatac gtcatcagta
     3181 tatctgtgtt gctcacagca taaagtttac gctgaaatgg acttgaccac taagagtcat
     3241 caccgtctgg atgcttgtca tgtctctggc acataaccca ttactcccat gctttattag
     3301 aaaatgcagc ctctttgtac ccacttggaa tacgctaggt tcttttcaaa gtaaacacat
     3361 gagaaagctc ccgtctgtga ctttcctact gtgtaactct gtagctggca cttctcggcc
     3421 tctgtagctc aattccaggc attttttcct tttctttctt ttctttttct ttttcttttt
     3481 ctttttgcac ttttaccttt tctctagtca aataatattt ttttcttttt aaaatctatg
     3541 catatttagt tataaattat gttctgatct ttaaaagcaa gttagcaagt atatctgatt
     3601 aaagggattg catttcttaa gtcttatttt agttagaaat aataagggtt tttatttagt
     3661 tcgttttggt gttgttttgt ttttgttttt gacatgtgtg ggtgatttgc ctggatgtgt
     3721 gtctctgtac cattgcatgt ggttcctaaa gaggccagaa gagggcatta gatctcctgg
     3781 aactagagtt acagatggtt gtgagctgcc atgtgggtgc tgggaattaa actcagacct
     3841 tctggaagag cagcctgcat gcactcttaa ccactaggcc atttctccag ccctgggaat
     3901 agcagctgtt gttacaaagc tccaggcctt gctgggttat aattcttcag gttgaggact
     3961 gggtaggtgc tttgttttaa tgtgaatcac agccttcatt aatagccttc tttgtttggt
     4021 tggttgttta tttattcatt tgtttgtcag cttacttatt tacttattta ttttggctgc
     4081 ttggtagcta agaaaaattg tttattgcta atataatatt aatatacaat aaaattatat
     4141 attgctaata taatctatat tagttatgtc atccttattt taagactagc tgtcatatga
     4201 gtctgagtgt acctcacctt gttaatgtaa aaaggaaaca aattgaatat ttaaatgaaa
     4261 tttttattat ttaatagatt ctcaggtaca ttgatttcca attgagttta tacttttttt
     4321 ccctctctat aaacaaaacc atatttctgc aagacatctc attgggaaaa tgcatacttt
     4381 tactatttga tgattcagag aatgagtttt gacatggcat ggtggcatat acctataatc
     4441 ctagttcttg ggagatggag ggggatagcc ttatagaagc tcagggtcat cctgaccact
     4501 tggcaggttc atggccagcc tgggctacat aaaagaccat gtctccaaat gaaacaaaac
     4561 cagaaaccaa atatttggta agaaaaccat tctcttttcc caggttaaac caaagctctt
     4621 ctttataaca attaccagtc aaacatgtac tgttactgcg tgccagctag tacacgcagt
     4681 aacagggaag gaagcctgac cctgaaatgt gaggatcccc cccccacttg cagtctgcac
     4741 ttttctttta acagagcaga actctgacac tgtggtctag cccttcacat ccctagattt
     4801 ctgtttcttt ataggaagga ctagagaaat cactgctgtc tttatcttaa tatactcggt
     4861 atctgacggg gacatcattt tgataggttt tttttttttt catttagatt ttcttttctc
     4921 tgagtataat tatttcctca tattccaagg ttgtaaaaag tcctaatcaa aataaatgtt
     4981 attcatatag catttgttat gttaatctgt gctgttaacc taggcctctg catctggtct
     5041 gtctcactgg gagctttgtt ctgtctcagg atagtttctc tcagtaactg ggatgcctca
     5101 ctgagtggta ttgccttcag ttgctccatc atatccacaa tagagttaaa ctccttagtg
     5161 acatgctcaa ggtcctctcc gtctgacccc accctttttt ctggccttca tctctccctg
     5221 cctttgcatc tcttcctcct ttcagatgca cagcccccag cttactcccc tagagatgta
     5281 tgtggtggcc cacttgtctg tgcattgtga ggccttcgtt ctgagtcctt cacctaactt
     5341 ctgtctgatc accccaccca tccatcttca tctagattgg ctaattagcc ttatcagaag
     5401 ctttccagag ccatagcacc caggggtccc attgtctccc caactaagtg gatagagatg
     5461 tttttctttc ctccacgagg gagctctctg aaagcaggga ttctataata gttctctgtg
     5521 agccacacgg aggacatctg ctgattcagg aggattttct cttttgtaag gaaatggaga
     5581 gaaaaacact tatggaccga ttgttgtatt ttattttccc ttctatcttc aaaagaatta
     5641 tgctgaatag cacctctaac ttcattaagt tatttacaaa atgtttaacc tcccactgaa
     5701 aggatcactg gtgctcaaac gtagtataat ttgtaagaaa ggccctcttc gtctatttaa
     5761 agccttccat aatgggctgg caggatctct cagcgaggac tggcacctgc taccaagctt
     5821 gacagcctgg gttctacccc aagctccaca tggtagaaca gacacccctg acctccacac
     5881 ccacattatg acacactcat gccctaccac acacacatta gacacataaa attaaaaaac
     5941 aaaaacaaaa agcaaaaaac caaaccaacc tgtggaggaa ggaggaggta aaggggacat
     6001 ttctagtctg tcctgtgatg cagactcaat gaggcaagac ccctgggagg gcatgtgatg
     6061 tttcgagaga gtataaatag gactcaaggg acagggactg gactcctgca tggctgcctg
     6121 tgcagctctc ccttggtctc cagtcttcgc tgatcttcac ttgttgagag aggcacggca
     6181 gagaactcct ggccttttca gctggtcctg gtcagtccca ccgactggtg ccagttcagc
     6241 agaggcatag cagtttctgc tggatcttgc caccattgct gattcgtggt tggtgacact
     6301 gttgaactag actgttgata tcctgacact acagaactgg actgctggta tcctgacaag
     6361 agtttggaat cactccgaag agctacttct aaacaggtcc acctccccgc ctcgtcctat
     6421 ttaccatctt ttctctccta tccttgaatg gtgggctaga aggggggtca aagtgcttga
     6481 gagcccttgt taaagtaggt tttgaaaaat ctaaacgtac tggtggggag gagcgatcgg
     6541 gatgtaaaat gaataaataa attaatgagg aaaagatgcc tcccagatag gcgactcaat
     6601 tttattacat tgggtagctt tacattaata tgttggttaa tagctaataa actggtatga
     6661 ttatgacatt tttcatttta gagtgggtct ggaaatttgc ccttcattta ataccagaca
     6721 aatgcagtgt cttagcattt ctgaccggtg aggggcacac ggattgtttt tctcatacac
     6781 acaccccacc cccatacttt acccccaact gagtgttgtg attgccagca gcagcaggag
     6841 ccactttgaa ggtttgatta aagcggatga aggtgcctaa agagatctgt ttgctgaaaa
     6901 tatctggtaa caaacaggaa cctatgtaag caaataaagt gtgctattct gaattttaaa
     6961 aataagtgac tttaaatgac tgactgatgt agtggttatt ttcaacccca gtatggtttc
     7021 gagataacaa taaaaatgta gaagttt
//
