LOCUS       NM_001164357            3323 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus solute carrier family 25 (mitochondrial carrier,
            phosphate carrier), member 25 (Slc25a25), transcript variant 2,
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001164357
VERSION     NM_001164357.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3323)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3323)
  AUTHORS   Nakao,R., Shimba,S. and Oishi,K.
  TITLE     Ketogenic diet induces expression of the muscle circadian gene
            Slc25a25 via neural pathway that might be involved in muscle
            thermogenesis
  JOURNAL   Sci Rep 7 (1), 2885 (2017)
   PUBMED   28588221
  REMARK    GeneRIF: These findings suggest that KD feeding induces expression
            of the muscle circadian gene Slc25a25 via neural pathways, and that
            SLC25A25 might be involved in muscle thermogenesis under KD-induced
            hypothermia in mammals.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3323)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 3323)
  AUTHORS   Amigo,I., Traba,J., Gonzalez-Barroso,M.M., Rueda,C.B.,
            Fernandez,M., Rial,E., Sanchez,A., Satrustegui,J. and Del Arco,A.
  TITLE     Glucagon regulation of oxidative phosphorylation requires an
            increase in matrix adenine nucleotide content through Ca2+
            activation of the mitochondrial ATP-Mg/Pi carrier SCaMC-3
  JOURNAL   J Biol Chem 288 (11), 7791-7802 (2013)
   PUBMED   23344948
REFERENCE   5  (bases 1 to 3323)
  AUTHORS   Anunciado-Koza,R.P., Zhang,J., Ukropec,J., Bajpeyi,S., Koza,R.A.,
            Rogers,R.C., Cefalu,W.T., Mynatt,R.L. and Kozak,L.P.
  TITLE     Inactivation of the mitochondrial carrier SLC25A25 (ATP-Mg2+/Pi
            transporter) reduces physical endurance and metabolic efficiency in
            mice
  JOURNAL   J Biol Chem 286 (13), 11659-11671 (2011)
   PUBMED   21296886
  REMARK    GeneRIF: induction of Slc25a25 in mice with an intact gene may
            contribute to an alternative thermogenic pathway for the
            maintenance of body temperature during cold stress.
REFERENCE   6  (bases 1 to 3323)
  AUTHORS   del Arco,A. and Satrustegui,J.
  TITLE     Identification of a novel human subfamily of mitochondrial carriers
            with calcium-binding domains
  JOURNAL   J Biol Chem 279 (23), 24701-24713 (2004)
   PUBMED   15054102
REFERENCE   7  (bases 1 to 3323)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB653459.1, AK132204.1 and CO043296.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the central coding region, compared to variant 1, resulting
            in an isoform (2) that is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049392.1, AK082756.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                BB653459.1         2-48
            48-3302             AK132204.1         2-3256
            3303-3323           CO043296.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..3323
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 22.09 cM"
     gene            1..3323
                     /gene="Slc25a25"
                     /gene_synonym="1110030N17Rik; MCSC; mKIAA1896; SCaMC-2"
                     /note="solute carrier family 25 (mitochondrial carrier,
                     phosphate carrier), member 25"
                     /db_xref="GeneID:227731"
                     /db_xref="MGI:MGI:1915913"
     exon            1..404
                     /gene="Slc25a25"
                     /gene_synonym="1110030N17Rik; MCSC; mKIAA1896; SCaMC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            405..531
                     /gene="Slc25a25"
                     /gene_synonym="1110030N17Rik; MCSC; mKIAA1896; SCaMC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            532..619
                     /gene="Slc25a25"
                     /gene_synonym="1110030N17Rik; MCSC; mKIAA1896; SCaMC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            620..731
                     /gene="Slc25a25"
                     /gene_synonym="1110030N17Rik; MCSC; mKIAA1896; SCaMC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            732..890
                     /gene="Slc25a25"
                     /gene_synonym="1110030N17Rik; MCSC; mKIAA1896; SCaMC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1043
                     /gene="Slc25a25"
                     /gene_synonym="1110030N17Rik; MCSC; mKIAA1896; SCaMC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1151
                     /gene="Slc25a25"
                     /gene_synonym="1110030N17Rik; MCSC; mKIAA1896; SCaMC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1319
                     /gene="Slc25a25"
                     /gene_synonym="1110030N17Rik; MCSC; mKIAA1896; SCaMC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1470
                     /gene="Slc25a25"
                     /gene_synonym="1110030N17Rik; MCSC; mKIAA1896; SCaMC-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..3306
                     /gene="Slc25a25"
                     /gene_synonym="1110030N17Rik; MCSC; mKIAA1896; SCaMC-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3285..3290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a25"
                     /gene_synonym="1110030N17Rik; MCSC; mKIAA1896; SCaMC-2"
                     /note="hexamer: AATAAA"
     polyA_site      3306
                     /gene="Slc25a25"
                     /gene_synonym="1110030N17Rik; MCSC; mKIAA1896; SCaMC-2"
                     /note="major polyA site"
ORIGIN      
        1 ggggctcccg gaagcggccc ctccctccag tcggccggct tctcggagcc cgcgctcgct
       61 gtctgaggaa agccggcgtg cttccgcgct cgggtcgctc tcctgccgcc ttcagcccgg
      121 cgtccggcgc ccccgcctcg cgcccgatgg tgagcagtgt gttgtgccgc tgcgtggcct
      181 ccccgccgcc ggacgccgcc gccaccgcct cgtcgtccgc ctcgtcgccg gcttctgtag
      241 gggacccgtg cggcggcgcc gtctgtggcg gcccggacca ccagctacgc ctgtggagcc
      301 tcttccagac actcgacgtc aaccgcgacg gcggcctgtg tgtcaacgac ctggcggtgg
      361 ggctgcggcg cctgggactg caccgcacgg agggcgagct ccggaaaatt gtgcaagcag
      421 gtgacaagga ccttgatggg caactggact ttgaagagtt tgtacattac ctccaagatc
      481 atgagaaaaa actgaggctg gtgttcaaga gtctggacaa aaagaatgat ggtcgaatcg
      541 atgctcagga gatcatgcag tccctgcggg acctgggtgt caagatctcg gaacagcagg
      601 cggagaagat tcttaagagc atggataaga atggcacgat gaccatcgac tggaacgagt
      661 ggagggacta ccacctcctg caccctgtgg agaacatccc ggagatcatc ctgtactgga
      721 agcactcgac gatcttcgat gtcggtgaga atctgacagt cccagatgag ttcacagtgg
      781 aggagaggca gacggggatg tggtggaggc acctggtggc aggaggtggg gcaggggcag
      841 tttccagaac ctgcactgcc cccctggaca gactgaaggt gctcatgcag gtccatgcct
      901 cccgcagcaa caacatgtgc atcgtaggtg gattcacaca gatgattcga gaagggggag
      961 ccaagtcact ctggcggggc aacggcatca atgtcctcaa aattgcccct gagtcggcca
     1021 tcaaattcat ggcatatgag cagatgaaac ggcttgtcgg tagtgatcag gagacgctga
     1081 ggatccacga aaggcttgtg gcaggctcct tggccggagc cattgcccag agtagcatct
     1141 acccaatgga ggttctgaag acccgaatgg ccctgcggaa aacaggacag tactccggca
     1201 tgctggactg tgccaggagg atcttggcta aagagggtgt agctgccttc tacaaaggct
     1261 acatccccaa catgctgggg atcatcccct atgctggcat cgacctagct gtctatgaga
     1321 cattgaaaaa tacctggctc cagcgctacg cagtaaacag tgcagacccc ggtgtgttcg
     1381 tgctcctggc ctgtggtact atctccagta cttgtggcca gctggccagc tacccactag
     1441 ccctggtcag gacccggatg caggcacaag cctccattga gggcgcacct gaggtaacca
     1501 tgagcagcct cttcaaacag attctgcgga ctgagggggc ctttgggctc taccgggggc
     1561 tggcccccaa cttcatgaag gtgatcccgg ctgtgagcat cagctacgtg gtctacgaaa
     1621 acctgaagat caccctgggc gtgcagtctc ggtgacggga gggtggtgga cttggtgagc
     1681 ctgggctgcg gcccagggta tgcagccacc tcattctgtg aatgtgccaa cactaagctg
     1741 acttacccaa gctgtgaaac ccaggatacc ataggggacg ggcagggagc tggcaagctc
     1801 tgggctggtt ctgctgacct ggcagacctt cgtgtctctt ccaaggaaga cctgtggatg
     1861 ttccttgggg ttcaggggtc agtaagatgt aggctcctgc actagagaca ggacgttttc
     1921 ctcagtgcct gccagatagc gagcttggat gccagcttag ttcttccatc tcgttcactc
     1981 agccggacct cagccacggc atccctctgg tccaaagagc attcctgtgc ccctcatatc
     2041 tttccactga tgcgctgtgg tagaaagtgg gcctgccccc actctttctt gtccttctgt
     2101 ccatctttcc tcagtgctgc tcttccaaac ctgtttccca agctgcagca tccatgcgga
     2161 cctgtggtac gggaagctga agaagtacca ttatgtcctc gcctattctg agcccaccag
     2221 caaggccacc tggctgtgcc caggtacagg cactggctgc ctgacagcgt ggtgcatggc
     2281 tttgctgaaa gctagtgcta ggacctggaa cccagaggac ttgtgctgcc tgcatgggcc
     2341 taacgtcctc tgagctgccc ctaagccctg tcaggactgg caccaactca tgcccacact
     2401 cattgttcag ttctgtgtgt gagggtaggc agggtacctg ccccatgtca gccgccctga
     2461 tgagaagaaa acgatgctga aggccttaat tatgtcttag tgggtaaagg atttggttca
     2521 gaaggacaag ctggacactg caagtgccac actcgctgtg agcccggggc aggtagtttc
     2581 cctgctctca aatctgttct gagagccctg tggggccaag cgggaccagc ctcacattcc
     2641 acgtgtgtac cactctgctt ggagcctatt tattttgtat ttatttgaac agagttatgt
     2701 cctaactatt tttatagatt tgtttaatta atagcctgtc attttcaagt tcattttttt
     2761 attcatattt atgttcatgg ttgattgtac cttcctgtca tcacctggtg gggcatggga
     2821 agacaagatg ggaaagtggc tacagagtga ccttgcctgc tgcccacact gacagtgtgt
     2881 ccgccccacc agaaacagag ggaacggcac agggaagacc acccaggccg ggtagggtag
     2941 tggggaaggt ggcagcttga cattctttcc tggaccggga ggatttcttt attttgccct
     3001 ttggaacgac aaggcagtga ggtgcttcac caggaatttg gtttgagggt gaggactgaa
     3061 ggacagggtg gcctgccttc cccaacccgt gacctggtct ccctcctggc ccacagctgc
     3121 ccatgctcaa tgagtggcct gctggccact tggcaattgt gcctccattg ccccagaatg
     3181 gcctgatgag gaaaatccaa acaggatgca aagatcaatg caaaaatcac cggtctgcat
     3241 agtctatgct gtaactggag tttgtcaaag gcaagcagcc ttctaataaa gtcgcttcaa
     3301 atgtgaaaaa aaaaaaaaaa aaa
//
